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The map label for this gene is cpxA [H]

Identifier: 170023667

GI number: 170023667

Start: 1574152

End: 1575501

Strand: Direct

Name: cpxA [H]

Synonym: YPK_1425

Alternate gene names: 170023667

Gene position: 1574152-1575501 (Clockwise)

Preceding gene: 170023666

Following gene: 170023673

Centisome position: 33.57

GC content: 48.44

Gene sequence:

>1350_bases
ATGCGCGGAAGATTATTCTGGAAAATCCTGTTGGGTTTTTGGCTGACGTTTATTTTGATGACTCAGATGTTGTGGGTGAT
TTTTTCCTTTTATGGTCATCGCCATGAGCCACCAGAGAATGACCTCGTTCGGCAGATTGCCCGGTTGCAGGTTGTTTCAG
CCGCATCAGTATTACATACCGGCGGTCAGCCAGCCTTAAACGCTATGATGGCTGATTGGCCAGAAGCGGACAAAAAATAT
TTTTCTGTCTTACCTGCCGAGATGGCAGATACGGCAGAAAAAGATATATCGGCTCTCTCTGGGGAAGAACCTAAGTTATA
CAGTAGCGAAATCGTCACTTGGGTCACCGCACCTGACAAGGAAAACTACCGTGTCAGCTACGACATTGAAGGTTTACGCG
CAGCAAACTTGGCAAATGCCCCTGATAAACATCGCCGTGAAATACTGAATGTTCCAATCCCAATGATCTGGATGGGGGTA
TTAGGGGGCTTATTTTTCAGTACGTTATTAGCCTGGAACTTGACACGGCCCATGCGCCAATTACGTGTCGGTTTTGAACG
GGTAGCACAGGGGGATTTATCTGTGCGGTTGCTTCCAGTGATGCGCCGTCGGCATGATGAACTTACTGAAGTCGCGCGGG
ACTTTGACTCGATGGCCGAACGCCTACAGGCACTGGTCAGTGCACGTGAGCAATTATTGCATGACGTTTCTCATGAATTA
CGTTCTCCATTAGCCCGTTTACAATTGGCTATCGGTTTAGCGCATCAAAACCCTGGCAACGTAGACAACGCATTACAGCG
CATCGAGCATGAGTCCGAACGGTTGGATAAAATGATTGGTGAATTATTGGCACTATCGCGTGCTGAAAATCACAGCTTGG
CCGATGATGATGAGTATTTTGACTTACAGGAATTAGTTAAAGTCGTGGTGAATGATGCCCGCTACGAAGCACAACTGCCG
GGAGTTGAAATCCAGTTAGAGGTCGCGGCACAGAGTGAGTATACCGTCAAAGGTAATGCTGAACTGATGCGGCGTGCTAT
CGAAAATATTGTCCGCAATGCGCTACGGTTTTCAGCAAGTGGCCAACAGGTTAAGGTGACACTCTCTGCGCTGGATAAGC
GCTATCAAATTCAGGTTATAGACCAAGGCCCAGGGGTTGAGGAAAACAAACTATCCAGTATTTTTGACCCTTTTGTTCGT
GTTAAATCAGCGATGTCCGGCAAAGGATACGGCTTGGGGCTGGCGATTACGGATAAGGTGATTCTGGCCCATGGTGGTCA
GGTTGAGGCGCGAAATGGCGAGCAGGGTGGTCTGGTGATAACATTACGAGTACCACGGTGGCAGGCTTGA

Upstream 100 bases:

>100_bases
CAGAAACTCGCCGCCCTACCGGGTAATCATTTAAATATTGAAACGGTACGTAGCATTGGCTATCGCATCCGATAACCGTC
ACTGCGGAGTGAGATAACCT

Downstream 100 bases:

>100_bases
GCGGTAAGCGATAGTGATTGAATAAGAGATAGTGAGTGAATAAGGTGTAGTGAGTGAATAAGGTGTAGTGAGTGGAGACG
AGAGAAGGCCACTACGATAA

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MRGRLFWKILLGFWLTFILMTQMLWVIFSFYGHRHEPPENDLVRQIARLQVVSAASVLHTGGQPALNAMMADWPEADKKY
FSVLPAEMADTAEKDISALSGEEPKLYSSEIVTWVTAPDKENYRVSYDIEGLRAANLANAPDKHRREILNVPIPMIWMGV
LGGLFFSTLLAWNLTRPMRQLRVGFERVAQGDLSVRLLPVMRRRHDELTEVARDFDSMAERLQALVSAREQLLHDVSHEL
RSPLARLQLAIGLAHQNPGNVDNALQRIEHESERLDKMIGELLALSRAENHSLADDDEYFDLQELVKVVVNDARYEAQLP
GVEIQLEVAAQSEYTVKGNAELMRRAIENIVRNALRFSASGQQVKVTLSALDKRYQIQVIDQGPGVEENKLSSIFDPFVR
VKSAMSGKGYGLGLAITDKVILAHGGQVEARNGEQGGLVITLRVPRWQA

Sequences:

>Translated_449_residues
MRGRLFWKILLGFWLTFILMTQMLWVIFSFYGHRHEPPENDLVRQIARLQVVSAASVLHTGGQPALNAMMADWPEADKKY
FSVLPAEMADTAEKDISALSGEEPKLYSSEIVTWVTAPDKENYRVSYDIEGLRAANLANAPDKHRREILNVPIPMIWMGV
LGGLFFSTLLAWNLTRPMRQLRVGFERVAQGDLSVRLLPVMRRRHDELTEVARDFDSMAERLQALVSAREQLLHDVSHEL
RSPLARLQLAIGLAHQNPGNVDNALQRIEHESERLDKMIGELLALSRAENHSLADDDEYFDLQELVKVVVNDARYEAQLP
GVEIQLEVAAQSEYTVKGNAELMRRAIENIVRNALRFSASGQQVKVTLSALDKRYQIQVIDQGPGVEENKLSSIFDPFVR
VKSAMSGKGYGLGLAITDKVILAHGGQVEARNGEQGGLVITLRVPRWQA
>Mature_449_residues
MRGRLFWKILLGFWLTFILMTQMLWVIFSFYGHRHEPPENDLVRQIARLQVVSAASVLHTGGQPALNAMMADWPEADKKY
FSVLPAEMADTAEKDISALSGEEPKLYSSEIVTWVTAPDKENYRVSYDIEGLRAANLANAPDKHRREILNVPIPMIWMGV
LGGLFFSTLLAWNLTRPMRQLRVGFERVAQGDLSVRLLPVMRRRHDELTEVARDFDSMAERLQALVSAREQLLHDVSHEL
RSPLARLQLAIGLAHQNPGNVDNALQRIEHESERLDKMIGELLALSRAENHSLADDDEYFDLQELVKVVVNDARYEAQLP
GVEIQLEVAAQSEYTVKGNAELMRRAIENIVRNALRFSASGQQVKVTLSALDKRYQIQVIDQGPGVEENKLSSIFDPFVR
VKSAMSGKGYGLGLAITDKVILAHGGQVEARNGEQGGLVITLRVPRWQA

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=275, Percent_Identity=34.5454545454545, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1788393, Length=279, Percent_Identity=29.0322580645161, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1786783, Length=286, Percent_Identity=28.6713286713287, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1787894, Length=277, Percent_Identity=28.8808664259928, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1789808, Length=306, Percent_Identity=28.7581699346405, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1786600, Length=258, Percent_Identity=27.906976744186, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1789403, Length=330, Percent_Identity=28.1818181818182, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1790861, Length=345, Percent_Identity=25.7971014492754, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1790551, Length=302, Percent_Identity=27.1523178807947, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI145693157, Length=245, Percent_Identity=28.5714285714286, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1786912, Length=281, Percent_Identity=24.5551601423488, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790436, Length=247, Percent_Identity=27.1255060728745, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789149, Length=227, Percent_Identity=28.1938325991189, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87081816, Length=313, Percent_Identity=25.8785942492013, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788713, Length=228, Percent_Identity=21.9298245614035, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI48994928, Length=253, Percent_Identity=23.3201581027668, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1788549, Length=233, Percent_Identity=28.3261802575107, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI87082128, Length=229, Percent_Identity=27.9475982532751, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1787374, Length=287, Percent_Identity=23.3449477351916, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50521; Mature: 50521

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGRLFWKILLGFWLTFILMTQMLWVIFSFYGHRHEPPENDLVRQIARLQVVSAASVLHT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GGQPALNAMMADWPEADKKYFSVLPAEMADTAEKDISALSGEEPKLYSSEIVTWVTAPDK
CCCHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEECCCEEEEEECCCC
ENYRVSYDIEGLRAANLANAPDKHRREILNVPIPMIWMGVLGGLFFSTLLAWNLTRPMRQ
CCCEEEEECCCHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRVGFERVAQGDLSVRLLPVMRRRHDELTEVARDFDSMAERLQALVSAREQLLHDVSHEL
HHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSPLARLQLAIGLAHQNPGNVDNALQRIEHESERLDKMIGELLALSRAENHSLADDDEYF
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHC
DLQELVKVVVNDARYEAQLPGVEIQLEVAAQSEYTVKGNAELMRRAIENIVRNALRFSAS
CHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHCCCC
GQQVKVTLSALDKRYQIQVIDQGPGVEENKLSSIFDPFVRVKSAMSGKGYGLGLAITDKV
CCEEEEEHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECEE
ILAHGGQVEARNGEQGGLVITLRVPRWQA
EEECCCEEEECCCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MRGRLFWKILLGFWLTFILMTQMLWVIFSFYGHRHEPPENDLVRQIARLQVVSAASVLHT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GGQPALNAMMADWPEADKKYFSVLPAEMADTAEKDISALSGEEPKLYSSEIVTWVTAPDK
CCCHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEECCCEEEEEECCCC
ENYRVSYDIEGLRAANLANAPDKHRREILNVPIPMIWMGVLGGLFFSTLLAWNLTRPMRQ
CCCEEEEECCCHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRVGFERVAQGDLSVRLLPVMRRRHDELTEVARDFDSMAERLQALVSAREQLLHDVSHEL
HHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSPLARLQLAIGLAHQNPGNVDNALQRIEHESERLDKMIGELLALSRAENHSLADDDEYF
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHC
DLQELVKVVVNDARYEAQLPGVEIQLEVAAQSEYTVKGNAELMRRAIENIVRNALRFSAS
CHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHCCCC
GQQVKVTLSALDKRYQIQVIDQGPGVEENKLSSIFDPFVRVKSAMSGKGYGLGLAITDKV
CCEEEEEHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECEE
ILAHGGQVEARNGEQGGLVITLRVPRWQA
EEECCCEEEECCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]