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The map label for this gene is patB [H]

Identifier: 170023659

GI number: 170023659

Start: 1563817

End: 1564998

Strand: Direct

Name: patB [H]

Synonym: YPK_1417

Alternate gene names: 170023659

Gene position: 1563817-1564998 (Clockwise)

Preceding gene: 170023655

Following gene: 170023660

Centisome position: 33.35

GC content: 39.51

Gene sequence:

>1182_bases
ATGGACTACAATTTTGATGAAGTCATCGATAGAAGTAATACAGCATGTGAAAAGTGGGATGCTCATTATTTAAATGCTCG
ATTTGGTATGACTGATTTAACGCCTATGTGGGTTGCGGATATGGACTTTAGATCTCCGGACTCAGTGATTAGTGCACTTT
CCGAAAGAGTTAACCACGGTATTTATGGCTATACTTTCAGACCTGATAGTTTTTTAGATGCCATTACACAGTGGGTTAAA
AAAAGACATCAATGGTTAATTAAGCCTGAGTGGATCTCTCATAGCCCCGGCGTTGTTCCTGGATTAGCCATGGCTATTCG
TGGGTTAACAAAACCGGGAGATAAAATACTCATTCAATCCCCTGTTTATCATCACTTCGCCAATGTTATTGCACGAAATG
ATCGTGAAGTTGTCGCGAGTGAATTGCTCTATGGTAACGAAAAATATGATATAGATTTTGCACATTTTGAAGCGTGTATC
GCCACTGGCGTGAAACTGTTTATCCTTTGCAATCCTCATAACCCAGTGGGAAGAGTATGGACACGGGATGAACTGACGAC
CATGGGTAATATATGTTTACGGCATAACGTGATTGTCATCGCAGATGAAATACATTGTGATATTGTTTTTAAAGGCAGTA
AATTCACTCCTTTTGCCGCTATCTCACCTGATTTCGAAAATAATTCAATTACCTGCATGGCACCCAGTAAAACCTTCAAT
CTTTTAGGGACACAAACTTCAGCGATCATTATCCCTAATCAAGAATTACGTAATAAATATGAAACCGAATTAAATAGCCT
GGCATTAGGGAATCCTAATCCCTTTGGCGTGATAGCATTGGAAACAGCATATAAAGAAGGTGAGGAGTGGTTAGAGAGTT
TGCTGGGTTACTTACAACATAATCTAGACTTTGCTGTGGACTTCTTTAAAAAATATATACCGAAGATCACATTGGTTAAG
CCTGAGGGAACGTATCTACTCTGGTTAGATTGCCGTGGGCTAGGGTTGACTCCGTATGAACTGGAGCAATTCATACTAAC
AAAAGCAAAATTAGCCTTAAACGAAGGCCACATCTTTGGCGAAAGTGGTGAAAACTTCATGAGGATGAATATTGGTTGTC
CAAAATCAGTCCTCACCAGTGCATTAATACAACTAAAATACGCGGTAGATGATTTAAACTAG

Upstream 100 bases:

>100_bases
TTTTTCTAAAAAAACCACCAATTAGGAGTATTAATAGTAAGAAATTATCAAGATAATGGTATTAAATTTCCTTACAAGTC
GAACCAGTGAGGAAAGGGAC

Downstream 100 bases:

>100_bases
AATAGCGTATAGGTTATTTTGCAGGGGATAAAAATGAACAGTGAAAAAAAAGAACATCTTAATACAGTATCAAGAAAGTT
AAGAACGATCATGGAGCGTG

Product: class I and II aminotransferase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MDYNFDEVIDRSNTACEKWDAHYLNARFGMTDLTPMWVADMDFRSPDSVISALSERVNHGIYGYTFRPDSFLDAITQWVK
KRHQWLIKPEWISHSPGVVPGLAMAIRGLTKPGDKILIQSPVYHHFANVIARNDREVVASELLYGNEKYDIDFAHFEACI
ATGVKLFILCNPHNPVGRVWTRDELTTMGNICLRHNVIVIADEIHCDIVFKGSKFTPFAAISPDFENNSITCMAPSKTFN
LLGTQTSAIIIPNQELRNKYETELNSLALGNPNPFGVIALETAYKEGEEWLESLLGYLQHNLDFAVDFFKKYIPKITLVK
PEGTYLLWLDCRGLGLTPYELEQFILTKAKLALNEGHIFGESGENFMRMNIGCPKSVLTSALIQLKYAVDDLN

Sequences:

>Translated_393_residues
MDYNFDEVIDRSNTACEKWDAHYLNARFGMTDLTPMWVADMDFRSPDSVISALSERVNHGIYGYTFRPDSFLDAITQWVK
KRHQWLIKPEWISHSPGVVPGLAMAIRGLTKPGDKILIQSPVYHHFANVIARNDREVVASELLYGNEKYDIDFAHFEACI
ATGVKLFILCNPHNPVGRVWTRDELTTMGNICLRHNVIVIADEIHCDIVFKGSKFTPFAAISPDFENNSITCMAPSKTFN
LLGTQTSAIIIPNQELRNKYETELNSLALGNPNPFGVIALETAYKEGEEWLESLLGYLQHNLDFAVDFFKKYIPKITLVK
PEGTYLLWLDCRGLGLTPYELEQFILTKAKLALNEGHIFGESGENFMRMNIGCPKSVLTSALIQLKYAVDDLN
>Mature_393_residues
MDYNFDEVIDRSNTACEKWDAHYLNARFGMTDLTPMWVADMDFRSPDSVISALSERVNHGIYGYTFRPDSFLDAITQWVK
KRHQWLIKPEWISHSPGVVPGLAMAIRGLTKPGDKILIQSPVYHHFANVIARNDREVVASELLYGNEKYDIDFAHFEACI
ATGVKLFILCNPHNPVGRVWTRDELTTMGNICLRHNVIVIADEIHCDIVFKGSKFTPFAAISPDFENNSITCMAPSKTFN
LLGTQTSAIIIPNQELRNKYETELNSLALGNPNPFGVIALETAYKEGEEWLESLLGYLQHNLDFAVDFFKKYIPKITLVK
PEGTYLLWLDCRGLGLTPYELEQFILTKAKLALNEGHIFGESGENFMRMNIGCPKSVLTSALIQLKYAVDDLN

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=179, Percent_Identity=25.1396648044693, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI56713254, Length=179, Percent_Identity=25.1396648044693, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1787909, Length=390, Percent_Identity=33.5897435897436, Blast_Score=247, Evalue=8e-67,
Organism=Escherichia coli, GI1786816, Length=297, Percent_Identity=21.8855218855219, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788627, Length=296, Percent_Identity=23.6486486486486, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71994476, Length=166, Percent_Identity=30.7228915662651, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71994472, Length=165, Percent_Identity=30.9090909090909, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17567663, Length=295, Percent_Identity=23.0508474576271, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322401, Length=301, Percent_Identity=27.906976744186, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI28573069, Length=247, Percent_Identity=25.9109311740891, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24646114, Length=247, Percent_Identity=25.9109311740891, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28573067, Length=247, Percent_Identity=25.9109311740891, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28573065, Length=247, Percent_Identity=25.9109311740891, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44506; Mature: 44506

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYNFDEVIDRSNTACEKWDAHYLNARFGMTDLTPMWVADMDFRSPDSVISALSERVNHG
CCCCHHHHHCCCCCCHHHCCCCEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCC
IYGYTFRPDSFLDAITQWVKKRHQWLIKPEWISHSPGVVPGLAMAIRGLTKPGDKILIQS
EEEEEECCHHHHHHHHHHHHHHHCEEECCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEC
PVYHHFANVIARNDREVVASELLYGNEKYDIDFAHFEACIATGVKLFILCNPHNPVGRVW
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCEEEEEEECCCCCCCCCE
TRDELTTMGNICLRHNVIVIADEIHCDIVFKGSKFTPFAAISPDFENNSITCMAPSKTFN
ECHHHHHHHCCHHHCCEEEEEECEEEEEEEECCCCCCEEEECCCCCCCEEEEEECCCCEE
LLGTQTSAIIIPNQELRNKYETELNSLALGNPNPFGVIALETAYKEGEEWLESLLGYLQH
EECCCCEEEEECCHHHHHHHHHHHHHEECCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHH
NLDFAVDFFKKYIPKITLVKPEGTYLLWLDCRGLGLTPYELEQFILTKAKLALNEGHIFG
CHHHHHHHHHHHCCEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHEECCCEEEC
ESGENFMRMNIGCPKSVLTSALIQLKYAVDDLN
CCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDYNFDEVIDRSNTACEKWDAHYLNARFGMTDLTPMWVADMDFRSPDSVISALSERVNHG
CCCCHHHHHCCCCCCHHHCCCCEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCC
IYGYTFRPDSFLDAITQWVKKRHQWLIKPEWISHSPGVVPGLAMAIRGLTKPGDKILIQS
EEEEEECCHHHHHHHHHHHHHHHCEEECCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEC
PVYHHFANVIARNDREVVASELLYGNEKYDIDFAHFEACIATGVKLFILCNPHNPVGRVW
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCEEEEEEECCCCCCCCCE
TRDELTTMGNICLRHNVIVIADEIHCDIVFKGSKFTPFAAISPDFENNSITCMAPSKTFN
ECHHHHHHHCCHHHCCEEEEEECEEEEEEEECCCCCCEEEECCCCCCCEEEEEECCCCEE
LLGTQTSAIIIPNQELRNKYETELNSLALGNPNPFGVIALETAYKEGEEWLESLLGYLQH
EECCCCEEEEECCHHHHHHHHHHHHHEECCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHH
NLDFAVDFFKKYIPKITLVKPEGTYLLWLDCRGLGLTPYELEQFILTKAKLALNEGHIFG
CHHHHHHHHHHHCCEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHEECCCEEEC
ESGENFMRMNIGCPKSVLTSALIQLKYAVDDLN
CCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]