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The map label for this gene is uxaB [H]

Identifier: 170022806

GI number: 170022806

Start: 606847

End: 608298

Strand: Direct

Name: uxaB [H]

Synonym: YPK_0555

Alternate gene names: 170022806

Gene position: 606847-608298 (Clockwise)

Preceding gene: 170022805

Following gene: 170022807

Centisome position: 12.94

GC content: 49.86

Gene sequence:

>1452_bases
ATGCAAACGCTGAACCGTCGTGACTTTCCTGGCCGTAGCCACCCTGACAAAATCATTCAATTTGGTGAAGGTAACTTTCT
GCGCGCCTTTGTGGACTGGCAAATTGATTTACTGAATGAACATACCGATCTGAACGCAGGGATCGTGGTGATCCGCCCAA
TTGACACCGATTTTCCACCGTCGCTCAGTACGCAGGATGGTTTATATACTGCCGTGATCCGTGGCCTGAACGAGCAGGGG
GAAGCGGTGCGTGAATCCCGCCTGATCCGCTCTGTAAACCGTGAAATCAATATTTATCGTCAGTTTGATGACTATCTGGC
GCTGGCGCGTGATGCCAATATTCGCTTTATGTTCTCTAACACCACGGAAGCGGGTATTGCCTGGAATGAAGCTGATCAAT
TCAGCGATGCGCCGCCAAGTTCTTTCCCTGCTAAATTGACTCGTTTATTATTTGAGCGTTTTGAGCATTTTGACGGTGCA
GCAGATAAAGGCTGGGTGCTATTGCCTTGCGAATTGATTGACTATAACGGTGAAGCATTACGTGAACTGGTGCTGCGTTA
TGCCAGTCATTGGCAGCTGCCAGCTGCCTTCACCCACTGGCTGACTGAAAATAATACCTTCTGCTCGACATTAGTTGACC
GTATTGTGACTGGCTATCCACGCGATGAAGTGGCGGCGTTGCAAACAGAATTGGGGTATCAGGACAGTTTCTTGGATACC
GCAGAATATTTCTATCTGTTTGTGATCCAAGGGCCACAAGGGTTGGCACAAGAACTGCGTTTAGATCAGTTAGATCTGAA
TGTGCGCATTGTCGATGACATCAAACCTTATAAAGAACGCAAAGTGGCCATCTTGAATGGCGCACACACCGCGCTGGTCC
CCGTGGCCTATTTGTCGGGTCTGGATACCGTTGGTCAGACGATGGATGATGCGCAGATCAGCCGCTTTGTGGAAAAAACC
ATTACGGAAGAGATTGTTCCGGTATTGGATCTGCCCGAAGACGAGTTGTTGTCGTTTTCTCAAGCGGTACTGAGCCGTTT
TCGTAACCCGTTTATTCAGCACCAATTGCTGTCGATTGCCTTGAATGGCATGACAAAATTCCGCACCCGTATCTTGCCGC
AATTACTGACCTATCAGCAGCAAAAAGGCCAATTACCCCCACGTCTGACCTTTGCACTGGCAGCACTTATCGCCTTTTAC
CGTGGTGAACGTGAGGGCCAAACCTACCCGTTGCAGGATGACGCCCACTGGCTGGAGTGTTATTCAACACTGTGGAATGG
TGTCAAGCACGGTGATATCGCGTTGGCTGAATTGGTTAACCGCGTGCTTTCTGATGCTAACCATTGGGGGCAGGATTTGA
CCGCGGTGCCTCAACTGGCTAATCAGGTGACAGAGCAACTGCAAACCATCCTTAGCCGTGGCATGAGAGCGGCGGTCGCG
GCATATAGCTAA

Upstream 100 bases:

>100_bases
ACTGCGGTAGATACCTTTCTGCAAAGAACGGACTGCTTGCAAAGCACGGACTGTCAGTGATGAACGGTCCAAAGCTGAAT
GCGTTATAAGGTGAACCCTG

Downstream 100 bases:

>100_bases
AGGCTTAACTATGCAAAATATTATAAAGATTCACCCGCTGGATAATGTGGCCGTTGCCCTGCAAGATCTGGCTGCAGATG
AGCGGATCGAGAGCGGTGAG

Product: altronate oxidoreductase

Products: NA

Alternate protein names: Tagaturonate dehydrogenase; Tagaturonate reductase [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MQTLNRRDFPGRSHPDKIIQFGEGNFLRAFVDWQIDLLNEHTDLNAGIVVIRPIDTDFPPSLSTQDGLYTAVIRGLNEQG
EAVRESRLIRSVNREINIYRQFDDYLALARDANIRFMFSNTTEAGIAWNEADQFSDAPPSSFPAKLTRLLFERFEHFDGA
ADKGWVLLPCELIDYNGEALRELVLRYASHWQLPAAFTHWLTENNTFCSTLVDRIVTGYPRDEVAALQTELGYQDSFLDT
AEYFYLFVIQGPQGLAQELRLDQLDLNVRIVDDIKPYKERKVAILNGAHTALVPVAYLSGLDTVGQTMDDAQISRFVEKT
ITEEIVPVLDLPEDELLSFSQAVLSRFRNPFIQHQLLSIALNGMTKFRTRILPQLLTYQQQKGQLPPRLTFALAALIAFY
RGEREGQTYPLQDDAHWLECYSTLWNGVKHGDIALAELVNRVLSDANHWGQDLTAVPQLANQVTEQLQTILSRGMRAAVA
AYS

Sequences:

>Translated_483_residues
MQTLNRRDFPGRSHPDKIIQFGEGNFLRAFVDWQIDLLNEHTDLNAGIVVIRPIDTDFPPSLSTQDGLYTAVIRGLNEQG
EAVRESRLIRSVNREINIYRQFDDYLALARDANIRFMFSNTTEAGIAWNEADQFSDAPPSSFPAKLTRLLFERFEHFDGA
ADKGWVLLPCELIDYNGEALRELVLRYASHWQLPAAFTHWLTENNTFCSTLVDRIVTGYPRDEVAALQTELGYQDSFLDT
AEYFYLFVIQGPQGLAQELRLDQLDLNVRIVDDIKPYKERKVAILNGAHTALVPVAYLSGLDTVGQTMDDAQISRFVEKT
ITEEIVPVLDLPEDELLSFSQAVLSRFRNPFIQHQLLSIALNGMTKFRTRILPQLLTYQQQKGQLPPRLTFALAALIAFY
RGEREGQTYPLQDDAHWLECYSTLWNGVKHGDIALAELVNRVLSDANHWGQDLTAVPQLANQVTEQLQTILSRGMRAAVA
AYS
>Mature_483_residues
MQTLNRRDFPGRSHPDKIIQFGEGNFLRAFVDWQIDLLNEHTDLNAGIVVIRPIDTDFPPSLSTQDGLYTAVIRGLNEQG
EAVRESRLIRSVNREINIYRQFDDYLALARDANIRFMFSNTTEAGIAWNEADQFSDAPPSSFPAKLTRLLFERFEHFDGA
ADKGWVLLPCELIDYNGEALRELVLRYASHWQLPAAFTHWLTENNTFCSTLVDRIVTGYPRDEVAALQTELGYQDSFLDT
AEYFYLFVIQGPQGLAQELRLDQLDLNVRIVDDIKPYKERKVAILNGAHTALVPVAYLSGLDTVGQTMDDAQISRFVEKT
ITEEIVPVLDLPEDELLSFSQAVLSRFRNPFIQHQLLSIALNGMTKFRTRILPQLLTYQQQKGQLPPRLTFALAALIAFY
RGEREGQTYPLQDDAHWLECYSTLWNGVKHGDIALAELVNRVLSDANHWGQDLTAVPQLANQVTEQLQTILSRGMRAAVA
AYS

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxaB subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994885, Length=479, Percent_Identity=72.2338204592902, Blast_Score=730, Evalue=0.0,
Organism=Escherichia coli, GI1787823, Length=478, Percent_Identity=23.4309623430962, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1790779, Length=492, Percent_Identity=25, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1788497, Length=383, Percent_Identity=24.2819843342037, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6324401, Length=499, Percent_Identity=22.2444889779559, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320765, Length=499, Percent_Identity=22.2444889779559, Blast_Score=95, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR013118
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.58 [H]

Molecular weight: Translated: 54855; Mature: 54855

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTLNRRDFPGRSHPDKIIQFGEGNFLRAFVDWQIDLLNEHTDLNAGIVVIRPIDTDFPP
CCCCCCCCCCCCCCCHHHHEECCCCEEEEEECHHHHHHCCCCCCCCCEEEEEECCCCCCC
SLSTQDGLYTAVIRGLNEQGEAVRESRLIRSVNREINIYRQFDDYLALARDANIRFMFSN
CCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
TTEAGIAWNEADQFSDAPPSSFPAKLTRLLFERFEHFDGAADKGWVLLPCELIDYNGEAL
CCCCCEEECCHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHEECCCHHHH
RELVLRYASHWQLPAAFTHWLTENNTFCSTLVDRIVTGYPRDEVAALQTELGYQDSFLDT
HHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHH
AEYFYLFVIQGPQGLAQELRLDQLDLNVRIVDDIKPYKERKVAILNGAHTALVPVAYLSG
CCEEEEEEEECCHHHHHHHCHHHHCCCEEEECCCCCHHHCEEEEECCCHHHHHHHHHHHC
LDTVGQTMDDAQISRFVEKTITEEIVPVLDLPEDELLSFSQAVLSRFRNPFIQHQLLSIA
HHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LNGMTKFRTRILPQLLTYQQQKGQLPPRLTFALAALIAFYRGEREGQTYPLQDDAHWLEC
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
YSTLWNGVKHGDIALAELVNRVLSDANHWGQDLTAVPQLANQVTEQLQTILSRGMRAAVA
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
AYS
CCC
>Mature Secondary Structure
MQTLNRRDFPGRSHPDKIIQFGEGNFLRAFVDWQIDLLNEHTDLNAGIVVIRPIDTDFPP
CCCCCCCCCCCCCCCHHHHEECCCCEEEEEECHHHHHHCCCCCCCCCEEEEEECCCCCCC
SLSTQDGLYTAVIRGLNEQGEAVRESRLIRSVNREINIYRQFDDYLALARDANIRFMFSN
CCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
TTEAGIAWNEADQFSDAPPSSFPAKLTRLLFERFEHFDGAADKGWVLLPCELIDYNGEAL
CCCCCEEECCHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHEECCCHHHH
RELVLRYASHWQLPAAFTHWLTENNTFCSTLVDRIVTGYPRDEVAALQTELGYQDSFLDT
HHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHH
AEYFYLFVIQGPQGLAQELRLDQLDLNVRIVDDIKPYKERKVAILNGAHTALVPVAYLSG
CCEEEEEEEECCHHHHHHHCHHHHCCCEEEECCCCCHHHCEEEEECCCHHHHHHHHHHHC
LDTVGQTMDDAQISRFVEKTITEEIVPVLDLPEDELLSFSQAVLSRFRNPFIQHQLLSIA
HHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LNGMTKFRTRILPQLLTYQQQKGQLPPRLTFALAALIAFYRGEREGQTYPLQDDAHWLEC
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
YSTLWNGVKHGDIALAELVNRVLSDANHWGQDLTAVPQLANQVTEQLQTILSRGMRAAVA
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
AYS
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA