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The map label for this gene is yjcE [H]

Identifier: 170022679

GI number: 170022679

Start: 468170

End: 469819

Strand: Direct

Name: yjcE [H]

Synonym: YPK_0428

Alternate gene names: 170022679

Gene position: 468170-469819 (Clockwise)

Preceding gene: 170022677

Following gene: 170022682

Centisome position: 9.98

GC content: 52.36

Gene sequence:

>1650_bases
ATGGAAATCTTTTTTACAATCCTCATTTTGATTTTAGTGGTATCGCTTTCTGGCGTTGTCACTCGAATGTTACCGTTTCA
AGTCCCTCTTCCTCTGATGCAAATTGTCTGCGGTGCTTTGCTGGCTTGGCCCAATTTTGGGTTGCATGTCAATTTTGACC
CAGAGCTATTCCTGGTGCTGTTCATTCCGCCGCTGCTATTTGCCGATGGTTGGAAAACACCGACACGGGAATTTATTCAT
CATGGGCGAGAAATATTGGGTCTGGCACTGGCATTAGTTTTGGTGACCATCGTGGGTATCGGTTATCTGATTTACTGGAT
GGTACCGGGTATTCCGCTGGTGGCGGCCTTTGCGTTGGCGGCGGTGTTATCGCCGACCGATGCCGTAGCGCTATCCGGTA
TCGTGGGTAAAGGGCGGATCCCGAAATCCATTATGGGCGTACTGGAAGGAGAGGCGTTGATGAACGATGCCTCCGGTCTG
GTGGCGCTGAAATTTGCCATTGCAGTGGCGATGGGGACGATGATCTTTACCGTTTCCGGTGCCACGCTGGAGTTCTTAAA
AGTCGCGATCGGTGGTCTGCTGGCGGGTGTGGCGATAACCTGGTTGTACAGTAAATCGCTGCGTATTATGAGCCGCTGGA
GCGGCGATGATCCAGCGACACAAATTGTCTTGTTGCTGTTGTTACCGTTCGCCTCCTATTTGGTTGCAGAGCACCTTGGC
GTCTCCGGCATCTTGGCGGCGGTGGCGGCGGGGATGACCATCAGCCAGTCGGGTATTATTCGTAATGCCCCGTTGGCGAT
GCGGCTGCGTGCTGACAGTGTGTGGTCGATGTTGGAGTTTGTGTTTAACGGCATGGTATTTATCCTGTTGGGTCTGCAAT
TACCGGGGATCCTCGAAACCTCCATCACACAAGCAGAACTGGACCCGACCATTCAAACCTGGAACCTGTTCGCTGATGTT
GCCATTATTTATGGCGCGTTGTTGTTGCTGCGTTTCGGTTGGTTGTGGTCGATGAAGAAAATCAGTAAGCGGGTGCTGAC
CAAGCGGCCACTGCAATTTAGCGATTACACCACCCGTGAGCTGTGGGTTGCTTCATTCGCCGGGGTGCGTGGGGCGATAA
CCCTTGCCGGTGTGCTGTCGATTCCCTTATTCCTTAGCGATGGCTCAGCCTTCCCATCCCGCTACCAATTGGTCTTTATC
GCCACTGGCGTGATCTTGTTGTCGGTGATTATTGGGGTGATCGCCTTGCCGCCGTTATTACGCGGGGTGGTGGTTGCGGA
TAAGAGTGCCAGCCGTGAAGAAATTCGTCTGGCTCGGGCGGCGATGGCAGAAGTCGCGATTGTTAGCCTGAATAAGATGG
AAGAGCGGCTAATGACCAGTAGTGAGGAGAATATTGACTCAGAGTTACTGAAGGAGGTTAGCTCACGGGTCATTGGTACA
TTGCGGCGGCGCACGGGCAGTAAAGATGAAGTTGAGAATACGCTGCTGATTGAAAATCTGGAACGGCGTTTTCGCTTAAC
CGCCCTGCGGGCCGAACGTGGTGAGTTATATCACCTGCGCGCCACGCAGAAAATCAGCAATGAAACCCTGCAAAAGCTGC
TGCATGATTTGGATTTGCTGGAAGCGTTGCTGATCGAAAAAGAAGGTTAA

Upstream 100 bases:

>100_bases
CGCTTCACAAAAAAGTGATCTACTATCGAAAGCGATGCCCGGCCTTGGCTTCGGGCGGGTATGATCACAAAATTATGTCG
TGTGGAGTCTTAAGGAAAGC

Downstream 100 bases:

>100_bases
TATCTTACGGACGGGGCTATTTGGCCCCGTTTACCGATTACATGAGACTTAAAACGTAATCGACTCATCGGGGTTTGTCA
GCCGTCTGACAGTACTGTGC

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MEIFFTILILILVVSLSGVVTRMLPFQVPLPLMQIVCGALLAWPNFGLHVNFDPELFLVLFIPPLLFADGWKTPTREFIH
HGREILGLALALVLVTIVGIGYLIYWMVPGIPLVAAFALAAVLSPTDAVALSGIVGKGRIPKSIMGVLEGEALMNDASGL
VALKFAIAVAMGTMIFTVSGATLEFLKVAIGGLLAGVAITWLYSKSLRIMSRWSGDDPATQIVLLLLLPFASYLVAEHLG
VSGILAAVAAGMTISQSGIIRNAPLAMRLRADSVWSMLEFVFNGMVFILLGLQLPGILETSITQAELDPTIQTWNLFADV
AIIYGALLLLRFGWLWSMKKISKRVLTKRPLQFSDYTTRELWVASFAGVRGAITLAGVLSIPLFLSDGSAFPSRYQLVFI
ATGVILLSVIIGVIALPPLLRGVVVADKSASREEIRLARAAMAEVAIVSLNKMEERLMTSSEENIDSELLKEVSSRVIGT
LRRRTGSKDEVENTLLIENLERRFRLTALRAERGELYHLRATQKISNETLQKLLHDLDLLEALLIEKEG

Sequences:

>Translated_549_residues
MEIFFTILILILVVSLSGVVTRMLPFQVPLPLMQIVCGALLAWPNFGLHVNFDPELFLVLFIPPLLFADGWKTPTREFIH
HGREILGLALALVLVTIVGIGYLIYWMVPGIPLVAAFALAAVLSPTDAVALSGIVGKGRIPKSIMGVLEGEALMNDASGL
VALKFAIAVAMGTMIFTVSGATLEFLKVAIGGLLAGVAITWLYSKSLRIMSRWSGDDPATQIVLLLLLPFASYLVAEHLG
VSGILAAVAAGMTISQSGIIRNAPLAMRLRADSVWSMLEFVFNGMVFILLGLQLPGILETSITQAELDPTIQTWNLFADV
AIIYGALLLLRFGWLWSMKKISKRVLTKRPLQFSDYTTRELWVASFAGVRGAITLAGVLSIPLFLSDGSAFPSRYQLVFI
ATGVILLSVIIGVIALPPLLRGVVVADKSASREEIRLARAAMAEVAIVSLNKMEERLMTSSEENIDSELLKEVSSRVIGT
LRRRTGSKDEVENTLLIENLERRFRLTALRAERGELYHLRATQKISNETLQKLLHDLDLLEALLIEKEG
>Mature_549_residues
MEIFFTILILILVVSLSGVVTRMLPFQVPLPLMQIVCGALLAWPNFGLHVNFDPELFLVLFIPPLLFADGWKTPTREFIH
HGREILGLALALVLVTIVGIGYLIYWMVPGIPLVAAFALAAVLSPTDAVALSGIVGKGRIPKSIMGVLEGEALMNDASGL
VALKFAIAVAMGTMIFTVSGATLEFLKVAIGGLLAGVAITWLYSKSLRIMSRWSGDDPATQIVLLLLLPFASYLVAEHLG
VSGILAAVAAGMTISQSGIIRNAPLAMRLRADSVWSMLEFVFNGMVFILLGLQLPGILETSITQAELDPTIQTWNLFADV
AIIYGALLLLRFGWLWSMKKISKRVLTKRPLQFSDYTTRELWVASFAGVRGAITLAGVLSIPLFLSDGSAFPSRYQLVFI
ATGVILLSVIIGVIALPPLLRGVVVADKSASREEIRLARAAMAEVAIVSLNKMEERLMTSSEENIDSELLKEVSSRVIGT
LRRRTGSKDEVENTLLIENLERRFRLTALRAERGELYHLRATQKISNETLQKLLHDLDLLEALLIEKEG

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI15529998, Length=455, Percent_Identity=23.956043956044, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI148727259, Length=457, Percent_Identity=23.4135667396061, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI27734935, Length=267, Percent_Identity=23.9700374531835, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI41872703, Length=506, Percent_Identity=24.1106719367589, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI14211919, Length=260, Percent_Identity=24.2307692307692, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI294997330, Length=264, Percent_Identity=23.4848484848485, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI110227626, Length=264, Percent_Identity=23.4848484848485, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI5454070, Length=264, Percent_Identity=23.4848484848485, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1790501, Length=548, Percent_Identity=75, Blast_Score=832, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71980847, Length=396, Percent_Identity=23.989898989899, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25150332, Length=385, Percent_Identity=23.8961038961039, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71999819, Length=445, Percent_Identity=21.5730337078652, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71999817, Length=445, Percent_Identity=21.5730337078652, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71990932, Length=401, Percent_Identity=22.1945137157107, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71999821, Length=419, Percent_Identity=21.7183770883055, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71990924, Length=401, Percent_Identity=22.1945137157107, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71992107, Length=337, Percent_Identity=21.9584569732938, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71992101, Length=337, Percent_Identity=21.9584569732938, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320663, Length=364, Percent_Identity=23.0769230769231, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221473215, Length=469, Percent_Identity=21.3219616204691, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281364513, Length=440, Percent_Identity=21.5909090909091, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221473222, Length=440, Percent_Identity=21.5909090909091, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221473212, Length=384, Percent_Identity=22.3958333333333, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI281360447, Length=491, Percent_Identity=21.7922606924644, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI221510738, Length=390, Percent_Identity=22.0512820512821, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI221510734, Length=390, Percent_Identity=22.0512820512821, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 59938; Mature: 59938

Theoretical pI: Translated: 7.75; Mature: 7.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIFFTILILILVVSLSGVVTRMLPFQVPLPLMQIVCGALLAWPNFGLHVNFDPELFLVL
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEECCHHHHHHH
FIPPLLFADGWKTPTREFIHHGREILGLALALVLVTIVGIGYLIYWMVPGIPLVAAFALA
HHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
AVLSPTDAVALSGIVGKGRIPKSIMGVLEGEALMNDASGLVALKFAIAVAMGTMIFTVSG
HHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHEEECC
ATLEFLKVAIGGLLAGVAITWLYSKSLRIMSRWSGDDPATQIVLLLLLPFASYLVAEHLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCC
VSGILAAVAAGMTISQSGIIRNAPLAMRLRADSVWSMLEFVFNGMVFILLGLQLPGILET
HHHHHHHHHHCCEECCCCCEECCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
SITQAELDPTIQTWNLFADVAIIYGALLLLRFGWLWSMKKISKRVLTKRPLQFSDYTTRE
CCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
LWVASFAGVRGAITLAGVLSIPLFLSDGSAFPSRYQLVFIATGVILLSVIIGVIALPPLL
HHHHHHHCCHHHHHHHHHHHHHHEEECCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
RGVVVADKSASREEIRLARAAMAEVAIVSLNKMEERLMTSSEENIDSELLKEVSSRVIGT
HCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
LRRRTGSKDEVENTLLIENLERRFRLTALRAERGELYHLRATQKISNETLQKLLHDLDLL
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
EALLIEKEG
HHHHHCCCC
>Mature Secondary Structure
MEIFFTILILILVVSLSGVVTRMLPFQVPLPLMQIVCGALLAWPNFGLHVNFDPELFLVL
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEECCHHHHHHH
FIPPLLFADGWKTPTREFIHHGREILGLALALVLVTIVGIGYLIYWMVPGIPLVAAFALA
HHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
AVLSPTDAVALSGIVGKGRIPKSIMGVLEGEALMNDASGLVALKFAIAVAMGTMIFTVSG
HHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHEEECC
ATLEFLKVAIGGLLAGVAITWLYSKSLRIMSRWSGDDPATQIVLLLLLPFASYLVAEHLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCC
VSGILAAVAAGMTISQSGIIRNAPLAMRLRADSVWSMLEFVFNGMVFILLGLQLPGILET
HHHHHHHHHHCCEECCCCCEECCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
SITQAELDPTIQTWNLFADVAIIYGALLLLRFGWLWSMKKISKRVLTKRPLQFSDYTTRE
CCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
LWVASFAGVRGAITLAGVLSIPLFLSDGSAFPSRYQLVFIATGVILLSVIIGVIALPPLL
HHHHHHHCCHHHHHHHHHHHHHHEEECCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
RGVVVADKSASREEIRLARAAMAEVAIVSLNKMEERLMTSSEENIDSELLKEVSSRVIGT
HCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
LRRRTGSKDEVENTLLIENLERRFRLTALRAERGELYHLRATQKISNETLQKLLHDLDLL
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
EALLIEKEG
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]