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The map label for this gene is pgi [H]

Identifier: 170022626

GI number: 170022626

Start: 407050

End: 408696

Strand: Direct

Name: pgi [H]

Synonym: YPK_0373

Alternate gene names: 170022626

Gene position: 407050-408696 (Clockwise)

Preceding gene: 170022623

Following gene: 170022628

Centisome position: 8.68

GC content: 48.51

Gene sequence:

>1647_bases
ATGAAAAATATCAATCCTAGTCAAACCGCTGCCTGGAAAGCGTTACAGCAACACTTTGAACAGATGAAAGATGTCACAAT
CAGCAGTCTGTTTGCCAAGGACGACCAGCGTTTTAACCGGTTCTCTGCGACTTTTGACGATCAAATGCTGGTGGATTTCT
CAAAAAACCGTATTACCAGCGAAACCTTGGAAAAATTGCAGGATCTGGCGAAAGAGACCGATCTGGCTGGTGCAATAAAA
TCCATGTTTTCTGGTGAGAAAATTAACCGCACAGAAGACCGTGCGGTATTGCATATTGCTCTGCGTAACCGCAGTAACAC
CCCAATTGTGGTGGATGGCAAAGATGTGATGCCAGAAGTGAATGCGGTTCTGGCCAAAATGAAACAGTTCTGTGACCGTG
TGATTAGCGGTGACTGGAAAGGCTATACCGGCAAAGCGATTACCGATGTAGTCAATATTGGTATCGGGGGGTCAGACCTC
GGCCCTTACATGGTGACCGAAGCGTTACGTCCGTATAAAAATCACCTGAATATGCATTTTGTTTCTAACGTCGATGGCAC
TCATATTGCCGAAGCGTTGAAACCCCTGAACCCGGAAACCACGCTGTTCCTGGTGGCATCAAAAACCTTCACCACACAAG
AAACCATGACCAACGCTCACAGCGCGCGTGATTGGTTCCTGTCTGCCGCCGGTGATCCGGCGCACGTTGCCAAGCACTTT
GCGGCTTTATCGACCAATGCCAAAGCCGTTGGTGAGTTTGGTATTGATACCAATAATATGTTTGAGTTCTGGGATTGGGT
TGGTGGCCGTTACTCGCTATGGTCTGCTATTGGTTTATCTATCGCCTTGTCGGTTGGTTTTGAACACTTCGAACAACTGC
TCAGTGGCGCACATGCCATGGATAAGCATTTTGCCGAAACACCGGCAGAGAAGAACCTGCCTGTCCTGTTGGCACTGATT
GGTATCTGGTACAACAACTTCTTTGGTGCAGAAACGGAAGCTATCCTGCCTTACGACCAATATATGCATCGTTTCCCGGC
TTACTTCCAGCAGGGTAACATGGAGTCGAATGGTAAATATGTTGATCGTAACGGTCATCCGGTTGATTACCAAACTGGCC
CGATTATCTGGGGCGAGCCGGGTACTAACGGCCAGCATGCGTTTTATCAGTTGATTCACCAAGGCACCAAACTGATCCCG
TGTGATTTTATCGCACCGGCGATCAGCCATAACCCATTAAGCGATCACCACGCGAAGCTGTTGTCTAACTTCTTTGCACA
GACAGAAGCATTGGCTTTCGGTAAATCCCTGGAAGACGTTGAAGCGGAGTTTGCGGCAGCGGGTAAAACCCCTGAACAAG
TCGCGCACGTAGCGCCGTTCAAAGTCTTCGAGGGTAACCGCCCAACTAACTCCATTTTGCTGCGCGAAATTACCCCGTTC
AGCTTGGGGGCGCTGATTGCCTTGTATGAACACAAAATCTTCACCCAAGGGGTTATTCTGAATATCTACACCTTCGACCA
ATGGGGTGTCGAACTGGGTAAACAACTGGCTAACCGTATCCTGCCAGAACTGGCAGATGACCAAGAAGTGACCAGTCATG
ACAGTTCAACCAATGCGTTGATTAACCGTTTCAAGAACTGGCGTTAA

Upstream 100 bases:

>100_bases
AGATAATACCTATTGCAAGAAAAGAGATCTCAATCACAGGGTAACAGGATACAATCAATGTATTCGTTTCATTAATCCTT
AAGCCTAGAAGAGCGCCGCT

Downstream 100 bases:

>100_bases
GCTAACAGGCTCTTAAGCTCTTTGATCTGTACTTTATTAGGCCTCTTATTCTGTAAGGGGCCTTTTTTTTGGCTTGAGTG
CAACATGGCTATGATAGGCT

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 548; Mature: 548

Protein sequence:

>548_residues
MKNINPSQTAAWKALQQHFEQMKDVTISSLFAKDDQRFNRFSATFDDQMLVDFSKNRITSETLEKLQDLAKETDLAGAIK
SMFSGEKINRTEDRAVLHIALRNRSNTPIVVDGKDVMPEVNAVLAKMKQFCDRVISGDWKGYTGKAITDVVNIGIGGSDL
GPYMVTEALRPYKNHLNMHFVSNVDGTHIAEALKPLNPETTLFLVASKTFTTQETMTNAHSARDWFLSAAGDPAHVAKHF
AALSTNAKAVGEFGIDTNNMFEFWDWVGGRYSLWSAIGLSIALSVGFEHFEQLLSGAHAMDKHFAETPAEKNLPVLLALI
GIWYNNFFGAETEAILPYDQYMHRFPAYFQQGNMESNGKYVDRNGHPVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKLIP
CDFIAPAISHNPLSDHHAKLLSNFFAQTEALAFGKSLEDVEAEFAAAGKTPEQVAHVAPFKVFEGNRPTNSILLREITPF
SLGALIALYEHKIFTQGVILNIYTFDQWGVELGKQLANRILPELADDQEVTSHDSSTNALINRFKNWR

Sequences:

>Translated_548_residues
MKNINPSQTAAWKALQQHFEQMKDVTISSLFAKDDQRFNRFSATFDDQMLVDFSKNRITSETLEKLQDLAKETDLAGAIK
SMFSGEKINRTEDRAVLHIALRNRSNTPIVVDGKDVMPEVNAVLAKMKQFCDRVISGDWKGYTGKAITDVVNIGIGGSDL
GPYMVTEALRPYKNHLNMHFVSNVDGTHIAEALKPLNPETTLFLVASKTFTTQETMTNAHSARDWFLSAAGDPAHVAKHF
AALSTNAKAVGEFGIDTNNMFEFWDWVGGRYSLWSAIGLSIALSVGFEHFEQLLSGAHAMDKHFAETPAEKNLPVLLALI
GIWYNNFFGAETEAILPYDQYMHRFPAYFQQGNMESNGKYVDRNGHPVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKLIP
CDFIAPAISHNPLSDHHAKLLSNFFAQTEALAFGKSLEDVEAEFAAAGKTPEQVAHVAPFKVFEGNRPTNSILLREITPF
SLGALIALYEHKIFTQGVILNIYTFDQWGVELGKQLANRILPELADDQEVTSHDSSTNALINRFKNWR
>Mature_548_residues
MKNINPSQTAAWKALQQHFEQMKDVTISSLFAKDDQRFNRFSATFDDQMLVDFSKNRITSETLEKLQDLAKETDLAGAIK
SMFSGEKINRTEDRAVLHIALRNRSNTPIVVDGKDVMPEVNAVLAKMKQFCDRVISGDWKGYTGKAITDVVNIGIGGSDL
GPYMVTEALRPYKNHLNMHFVSNVDGTHIAEALKPLNPETTLFLVASKTFTTQETMTNAHSARDWFLSAAGDPAHVAKHF
AALSTNAKAVGEFGIDTNNMFEFWDWVGGRYSLWSAIGLSIALSVGFEHFEQLLSGAHAMDKHFAETPAEKNLPVLLALI
GIWYNNFFGAETEAILPYDQYMHRFPAYFQQGNMESNGKYVDRNGHPVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKLIP
CDFIAPAISHNPLSDHHAKLLSNFFAQTEALAFGKSLEDVEAEFAAAGKTPEQVAHVAPFKVFEGNRPTNSILLREITPF
SLGALIALYEHKIFTQGVILNIYTFDQWGVELGKQLANRILPELADDQEVTSHDSSTNALINRFKNWR

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=544, Percent_Identity=65.9926470588235, Blast_Score=745, Evalue=0.0,
Organism=Homo sapiens, GI296080693, Length=544, Percent_Identity=61.3970588235294, Blast_Score=677, Evalue=0.0,
Organism=Escherichia coli, GI1790457, Length=548, Percent_Identity=87.4087591240876, Blast_Score=1013, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996708, Length=551, Percent_Identity=64.4283121597096, Blast_Score=734, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996703, Length=546, Percent_Identity=64.8351648351648, Blast_Score=732, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319673, Length=549, Percent_Identity=58.6520947176685, Blast_Score=659, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651916, Length=550, Percent_Identity=64, Blast_Score=728, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651914, Length=550, Percent_Identity=64, Blast_Score=728, Evalue=0.0,
Organism=Drosophila melanogaster, GI17737445, Length=550, Percent_Identity=64, Blast_Score=728, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 61162; Mature: 61162

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNINPSQTAAWKALQQHFEQMKDVTISSLFAKDDQRFNRFSATFDDQMLVDFSKNRITS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEECHHCCCCH
ETLEKLQDLAKETDLAGAIKSMFSGEKINRTEDRAVLHIALRNRSNTPIVVDGKDVMPEV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCEEECCHHHHHHH
NAVLAKMKQFCDRVISGDWKGYTGKAITDVVNIGIGGSDLGPYMVTEALRPYKNHLNMHF
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEE
VSNVDGTHIAEALKPLNPETTLFLVASKTFTTQETMTNAHSARDWFLSAAGDPAHVAKHF
ECCCCHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHEECCCCHHHHHHHH
AALSTNAKAVGEFGIDTNNMFEFWDWVGGRYSLWSAIGLSIALSVGFEHFEQLLSGAHAM
HHHCCCCHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DKHFAETPAEKNLPVLLALIGIWYNNFFGAETEAILPYDQYMHRFPAYFQQGNMESNGKY
HHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHCCCCCCCCCE
VDRNGHPVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKLIPCDFIAPAISHNPLSDHHAKL
ECCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHH
LSNFFAQTEALAFGKSLEDVEAEFAAAGKTPEQVAHVAPFKVFEGNRPTNSILLREITPF
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHCCCEEECCCCCCCCEEEECCCCH
SLGALIALYEHKIFTQGVILNIYTFDQWGVELGKQLANRILPELADDQEVTSHDSSTNAL
HHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHH
INRFKNWR
HHHHCCCC
>Mature Secondary Structure
MKNINPSQTAAWKALQQHFEQMKDVTISSLFAKDDQRFNRFSATFDDQMLVDFSKNRITS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEECHHCCCCH
ETLEKLQDLAKETDLAGAIKSMFSGEKINRTEDRAVLHIALRNRSNTPIVVDGKDVMPEV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCEEECCHHHHHHH
NAVLAKMKQFCDRVISGDWKGYTGKAITDVVNIGIGGSDLGPYMVTEALRPYKNHLNMHF
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEE
VSNVDGTHIAEALKPLNPETTLFLVASKTFTTQETMTNAHSARDWFLSAAGDPAHVAKHF
ECCCCHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHEECCCCHHHHHHHH
AALSTNAKAVGEFGIDTNNMFEFWDWVGGRYSLWSAIGLSIALSVGFEHFEQLLSGAHAM
HHHCCCCHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DKHFAETPAEKNLPVLLALIGIWYNNFFGAETEAILPYDQYMHRFPAYFQQGNMESNGKY
HHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHCCCCCCCCCE
VDRNGHPVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKLIPCDFIAPAISHNPLSDHHAKL
ECCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHH
LSNFFAQTEALAFGKSLEDVEAEFAAAGKTPEQVAHVAPFKVFEGNRPTNSILLREITPF
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHCCCEEECCCCCCCCEEEECCCCH
SLGALIALYEHKIFTQGVILNIYTFDQWGVELGKQLANRILPELADDQEVTSHDSSTNAL
HHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHH
INRFKNWR
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA