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The map label for this gene is aceB [H]

Identifier: 170022619

GI number: 170022619

Start: 391672

End: 393270

Strand: Direct

Name: aceB [H]

Synonym: YPK_0364

Alternate gene names: 170022619

Gene position: 391672-393270 (Clockwise)

Preceding gene: 170022618

Following gene: 170022620

Centisome position: 8.35

GC content: 47.65

Gene sequence:

>1599_bases
ATGAGACAACAGTTAGCGGGCACAGAGTTAGTTTTTACCCAGCCTTTTAATGCTGCTGAGCGGCAGGTTTTACCGGATAA
AGCCATCGAGTTTCTAACCGAATTAGTGGTGAAATTTAGCGAATCGCGTAACAAACTCCTTGCTACAAGGGCATCTTGGC
AGCAGACCATCGATCAAGGGGCGTTACCCGATTTTATTTTGGAAACTAATTCCATTCGTGATGGTGATTGGAAAATCCAA
GGTATTCCTGCTGACTTACGCGATCGTAGAGTTGAGATCACCGGGCCAGTAGAGCGGAAAATGGTGATCAATGCGCTTAA
TGCCAACGTAAAAGTTTTTATGGCGGATTTCGAAGATTCACTGGCACCCAGTTGGGATAAAGTGATTGATGGTCAAATTA
ATCTGCATGATGCGGTGAAAGGGACAATTTCCTATACGAATGAATCGGGCAAGGTCTATCAATTAAAACCTAATCCCGCG
GTATTGATTGCACGTGTTCGTGGCCTGCACTTACCGGAAAAACATGTTAAATGGCAGGACGAGGCGATTCCCGGTGGTTT
ATTCGATTTCGCTTTGTATTTCTACCATAACTATCAGCAACTGCTGGCGAAGGGCAGCGGCCCTTATTTCTATTTGCCGA
AGATGCAGTCATATCAGGAAGCCGCTTGGTGGAGCGATGTGTTCAATTTTACCGAGCAGCGCTTTGGTCTATCGCAGGGC
ACCATTAAGGCGACGGTATTAATTGAGACATTACCCGCCGTTTTCCAAATGGATGAAATTCTCTACCACCTGCGCCATCA
CATTGTTGGTCTGAATTGTGGGCGCTGGGACTATATCTTTAGCTATATAAAAACATTGAAAAACCACCCTGACCGCGTGT
TACCAGATCGCCAGTCAGTCACGATGAATAAACCTTTTCTTAGCGCGTATTCCCGTTTGTTGATCAAGACATGCCATAAA
CGTGGCGCTTTGGCGATGGGGGGAATGGCCGCCTTCATCCCGGATAAAGACGCAGAAAAGAATAAGTTGGTGTTGGATAA
AGTTCGTGCCGACAAAGAGTTAGAAGCCAGTAACGGCCACGATGGAACTTGGGTGGCGCATCCGGGCTTGGCAGATACGG
TGATGGACGTTTTTAACAAAGTATTAGGTTCTCGGCCTAATCAATTAGAGGTTAGCCGCGAACAGGATAAACCTATCACC
GCCGCTGAGTTGCTGGAACCTTGTTCTGGCGAGCGCACTGAAGCAGGGATGCGGGCCAATATCAGAGTCGCGGTGCAGTA
CATTGAAGCATGGATATCGGGTAATGGTTGTGTGCCGATTTATGGCTTGATGGAGGATGCGGCTACTGCAGAGATTTCCC
GCACTTCTATCTGGCAATGGATACATCATCAGAAAAGCCTCAGTAATGGCCAGACGGTGACTAAAGAGCTGTTCCGCAGC
ATGTTGAGTGAAGAAATTCAGGTTGTGAAGCTTGAGCTTGGCGCAGAGCGTTTTGATCGCGGGCGGTTTGAAGAAGCTGC
ACGCTTGATGGAGCGTATTACAACACAAGACGAGCTTATCGACTTCCTGACGTTGCCGGGCTATGCATTGCTTGCCTGA

Upstream 100 bases:

>100_bases
GCCTTTTTTACTGGCAGGGACACGTTACCTGATGATAATCCAAGAGTGACGCGAGGTCAGCGTTAAGGTGGCAGCAGTAA
CATTGGGAAGGGGAATAGCA

Downstream 100 bases:

>100_bases
GCCATCCTATTGAACCCTACAAAATTGAATTATAAGGAACATCGCCATGACGATCTCTCGTACTCAACAAATTCAGCAGT
TGGAACAGGAATGGACATCG

Product: malate synthase

Products: NA

Alternate protein names: MSA [H]

Number of amino acids: Translated: 532; Mature: 532

Protein sequence:

>532_residues
MRQQLAGTELVFTQPFNAAERQVLPDKAIEFLTELVVKFSESRNKLLATRASWQQTIDQGALPDFILETNSIRDGDWKIQ
GIPADLRDRRVEITGPVERKMVINALNANVKVFMADFEDSLAPSWDKVIDGQINLHDAVKGTISYTNESGKVYQLKPNPA
VLIARVRGLHLPEKHVKWQDEAIPGGLFDFALYFYHNYQQLLAKGSGPYFYLPKMQSYQEAAWWSDVFNFTEQRFGLSQG
TIKATVLIETLPAVFQMDEILYHLRHHIVGLNCGRWDYIFSYIKTLKNHPDRVLPDRQSVTMNKPFLSAYSRLLIKTCHK
RGALAMGGMAAFIPDKDAEKNKLVLDKVRADKELEASNGHDGTWVAHPGLADTVMDVFNKVLGSRPNQLEVSREQDKPIT
AAELLEPCSGERTEAGMRANIRVAVQYIEAWISGNGCVPIYGLMEDAATAEISRTSIWQWIHHQKSLSNGQTVTKELFRS
MLSEEIQVVKLELGAERFDRGRFEEAARLMERITTQDELIDFLTLPGYALLA

Sequences:

>Translated_532_residues
MRQQLAGTELVFTQPFNAAERQVLPDKAIEFLTELVVKFSESRNKLLATRASWQQTIDQGALPDFILETNSIRDGDWKIQ
GIPADLRDRRVEITGPVERKMVINALNANVKVFMADFEDSLAPSWDKVIDGQINLHDAVKGTISYTNESGKVYQLKPNPA
VLIARVRGLHLPEKHVKWQDEAIPGGLFDFALYFYHNYQQLLAKGSGPYFYLPKMQSYQEAAWWSDVFNFTEQRFGLSQG
TIKATVLIETLPAVFQMDEILYHLRHHIVGLNCGRWDYIFSYIKTLKNHPDRVLPDRQSVTMNKPFLSAYSRLLIKTCHK
RGALAMGGMAAFIPDKDAEKNKLVLDKVRADKELEASNGHDGTWVAHPGLADTVMDVFNKVLGSRPNQLEVSREQDKPIT
AAELLEPCSGERTEAGMRANIRVAVQYIEAWISGNGCVPIYGLMEDAATAEISRTSIWQWIHHQKSLSNGQTVTKELFRS
MLSEEIQVVKLELGAERFDRGRFEEAARLMERITTQDELIDFLTLPGYALLA
>Mature_532_residues
MRQQLAGTELVFTQPFNAAERQVLPDKAIEFLTELVVKFSESRNKLLATRASWQQTIDQGALPDFILETNSIRDGDWKIQ
GIPADLRDRRVEITGPVERKMVINALNANVKVFMADFEDSLAPSWDKVIDGQINLHDAVKGTISYTNESGKVYQLKPNPA
VLIARVRGLHLPEKHVKWQDEAIPGGLFDFALYFYHNYQQLLAKGSGPYFYLPKMQSYQEAAWWSDVFNFTEQRFGLSQG
TIKATVLIETLPAVFQMDEILYHLRHHIVGLNCGRWDYIFSYIKTLKNHPDRVLPDRQSVTMNKPFLSAYSRLLIKTCHK
RGALAMGGMAAFIPDKDAEKNKLVLDKVRADKELEASNGHDGTWVAHPGLADTVMDVFNKVLGSRPNQLEVSREQDKPIT
AAELLEPCSGERTEAGMRANIRVAVQYIEAWISGNGCVPIYGLMEDAATAEISRTSIWQWIHHQKSLSNGQTVTKELFRS
MLSEEIQVVKLELGAERFDRGRFEEAARLMERITTQDELIDFLTLPGYALLA

Specific function: Glyoxylate bypass; second step. [C]

COG id: COG2225

COG function: function code C; Malate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malate synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790444, Length=533, Percent_Identity=79.7373358348968, Blast_Score=895, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17561814, Length=518, Percent_Identity=49.8069498069498, Blast_Score=498, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI71982926, Length=412, Percent_Identity=51.9417475728155, Blast_Score=407, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6324212, Length=522, Percent_Identity=46.551724137931, Blast_Score=453, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6322222, Length=521, Percent_Identity=46.4491362763916, Blast_Score=444, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011076
- InterPro:   IPR006252
- InterPro:   IPR001465
- InterPro:   IPR019830 [H]

Pfam domain/function: PF01274 Malate_synthase [H]

EC number: =2.3.3.9 [H]

Molecular weight: Translated: 60258; Mature: 60258

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQQLAGTELVFTQPFNAAERQVLPDKAIEFLTELVVKFSESRNKLLATRASWQQTIDQG
CCCCCCCCEEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCC
ALPDFILETNSIRDGDWKIQGIPADLRDRRVEITGPVERKMVINALNANVKVFMADFEDS
CCCHHHEECCCCCCCCEEEECCCCCHHCCEEEEECCHHHHHHHHHHCCCEEEEEECCCCC
LAPSWDKVIDGQINLHDAVKGTISYTNESGKVYQLKPNPAVLIARVRGLHLPEKHVKWQD
CCCCHHHHCCCCEEEHHHCCCEEEEECCCCEEEEECCCCEEEEEEHHCCCCCHHHCCCCC
EAIPGGLFDFALYFYHNYQQLLAKGSGPYFYLPKMQSYQEAAWWSDVFNFTEQRFGLSQG
CCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCC
TIKATVLIETLPAVFQMDEILYHLRHHIVGLNCGRWDYIFSYIKTLKNHPDRVLPDRQSV
CEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCE
TMNKPFLSAYSRLLIKTCHKRGALAMGGMAAFIPDKDAEKNKLVLDKVRADKELEASNGH
ECCCHHHHHHHHHHHHHHHHCCCEEECCEEEECCCCCCCCCCCHHHHHHCCCCCCCCCCC
DGTWVAHPGLADTVMDVFNKVLGSRPNQLEVSREQDKPITAAELLEPCSGERTEAGMRAN
CCCEEECCCHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCHHHHHCCCCCCCCCCCCCCH
IRVAVQYIEAWISGNGCVPIYGLMEDAATAEISRTSIWQWIHHQKSLSNGQTVTKELFRS
HHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
MLSEEIQVVKLELGAERFDRGRFEEAARLMERITTQDELIDFLTLPGYALLA
HHHHHHEEEEEHHCHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHCCCHHHCC
>Mature Secondary Structure
MRQQLAGTELVFTQPFNAAERQVLPDKAIEFLTELVVKFSESRNKLLATRASWQQTIDQG
CCCCCCCCEEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCC
ALPDFILETNSIRDGDWKIQGIPADLRDRRVEITGPVERKMVINALNANVKVFMADFEDS
CCCHHHEECCCCCCCCEEEECCCCCHHCCEEEEECCHHHHHHHHHHCCCEEEEEECCCCC
LAPSWDKVIDGQINLHDAVKGTISYTNESGKVYQLKPNPAVLIARVRGLHLPEKHVKWQD
CCCCHHHHCCCCEEEHHHCCCEEEEECCCCEEEEECCCCEEEEEEHHCCCCCHHHCCCCC
EAIPGGLFDFALYFYHNYQQLLAKGSGPYFYLPKMQSYQEAAWWSDVFNFTEQRFGLSQG
CCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCC
TIKATVLIETLPAVFQMDEILYHLRHHIVGLNCGRWDYIFSYIKTLKNHPDRVLPDRQSV
CEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCE
TMNKPFLSAYSRLLIKTCHKRGALAMGGMAAFIPDKDAEKNKLVLDKVRADKELEASNGH
ECCCHHHHHHHHHHHHHHHHCCCEEECCEEEECCCCCCCCCCCHHHHHHCCCCCCCCCCC
DGTWVAHPGLADTVMDVFNKVLGSRPNQLEVSREQDKPITAAELLEPCSGERTEAGMRAN
CCCEEECCCHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCHHHHHCCCCCCCCCCCCCCH
IRVAVQYIEAWISGNGCVPIYGLMEDAATAEISRTSIWQWIHHQKSLSNGQTVTKELFRS
HHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
MLSEEIQVVKLELGAERFDRGRFEEAARLMERITTQDELIDFLTLPGYALLA
HHHHHHEEEEEHHCHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3050899; 3060852; 8265357; 9278503 [H]