Click here to switch to the map view.

The map label for this gene is metA [H]

Identifier: 170022618

GI number: 170022618

Start: 390322

End: 391251

Strand: Direct

Name: metA [H]

Synonym: YPK_0363

Alternate gene names: 170022618

Gene position: 390322-391251 (Clockwise)

Preceding gene: 170022616

Following gene: 170022619

Centisome position: 8.32

GC content: 44.41

Gene sequence:

>930_bases
ATGCCAATTCGGGTTCCTGATGAATTACCTGCAGTGAGTTTCTTGCGCAATGAGAATGTTTTTGTGATGGCTTCATCGCG
TGCTAAAACTCAGGAAATTCGGCCCCTGAAGGTATTGATTTTAAATCTGATGCCTAAAAAAATTGAGACGGAGAATCAAT
TCCTACGTTTACTCTCTAACTCGCCACTCCAGGTTGATATTCAATTGTTGAGGGTTGATAGTCGTGAGTCTAAAAATACG
CCTACGGAGCATCTGAACAACTTTTACTGCGATTTTGAGGACATTCAGGACCAGAATTTTGATGGCTTGATCGTAACCGG
CGCTCCTCTGGGTTTAGTCGATTTCTGTGATGTGGCTTATTGGCCACAAATTGAACGTATTATTGCCTGGGCAAAAGAGC
ATGTGACATCAACTCTATTTGTCTGTTGGGCGGTGCAGGCGGCGTTAAATATCTTGTATGGCATCCCGAAGATGACGCGC
GAGGTCAAACTCTCTGGTATCTATCAGCATCAAACACTCGAACCGCTGGCCTTATTGACGCGTGGTTTTGATGAAACATT
TCTGGCTCCTCATTCCCGCTATGCTGATTTTCCCGTTGAAGTCCTTCAACAATATACTGATTTGGATATCTTAGTGTCGT
CAGAAGAGGCTGGGGCTTATCTGTTTGCCAGTAAAGATAAGCGGGTGGCTTTTGTTACCGGTCATCCTGAGTATGATGTC
GATACGTTAGCGGGTGAATATCAGCGTGATCTGGCTGCAGGCCTTAACCCACAAGTTCCTCTTAATTATTTCCCTTCTGA
CGATGCATCGTTACGACCAAAAGCATCATGGCGCAGTCATGGGCATCTACTGTTTGCCAATTGGCTCAACTACTATGTTT
ACCAAATTACGCCATTTGATTTGCGACATATGAATCCTACCCTTGATTGA

Upstream 100 bases:

>100_bases
TTTCAGGTTGTTACAGTTCGCTCGACTTTTCATCTAAGATCCGCTATCTTCAGGCATCTAGAAGTCTAAACGTATAAACG
GATATATTGAGGATGTAGGC

Downstream 100 bases:

>100_bases
TTTTTCCCCTTCTCGATGTTCATCGTCGCATAGATGCTAATTATGGCGGCTGAATCGAGGCCGCCTATTATTTTCTTCCC
TTCCAATTACCTTTTTCCTT

Product: homoserine O-succinyltransferase

Products: NA

Alternate protein names: Homoserine O-transsuccinylase; HTS [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MPIRVPDELPAVSFLRNENVFVMASSRAKTQEIRPLKVLILNLMPKKIETENQFLRLLSNSPLQVDIQLLRVDSRESKNT
PTEHLNNFYCDFEDIQDQNFDGLIVTGAPLGLVDFCDVAYWPQIERIIAWAKEHVTSTLFVCWAVQAALNILYGIPKMTR
EVKLSGIYQHQTLEPLALLTRGFDETFLAPHSRYADFPVEVLQQYTDLDILVSSEEAGAYLFASKDKRVAFVTGHPEYDV
DTLAGEYQRDLAAGLNPQVPLNYFPSDDASLRPKASWRSHGHLLFANWLNYYVYQITPFDLRHMNPTLD

Sequences:

>Translated_309_residues
MPIRVPDELPAVSFLRNENVFVMASSRAKTQEIRPLKVLILNLMPKKIETENQFLRLLSNSPLQVDIQLLRVDSRESKNT
PTEHLNNFYCDFEDIQDQNFDGLIVTGAPLGLVDFCDVAYWPQIERIIAWAKEHVTSTLFVCWAVQAALNILYGIPKMTR
EVKLSGIYQHQTLEPLALLTRGFDETFLAPHSRYADFPVEVLQQYTDLDILVSSEEAGAYLFASKDKRVAFVTGHPEYDV
DTLAGEYQRDLAAGLNPQVPLNYFPSDDASLRPKASWRSHGHLLFANWLNYYVYQITPFDLRHMNPTLD
>Mature_308_residues
PIRVPDELPAVSFLRNENVFVMASSRAKTQEIRPLKVLILNLMPKKIETENQFLRLLSNSPLQVDIQLLRVDSRESKNTP
TEHLNNFYCDFEDIQDQNFDGLIVTGAPLGLVDFCDVAYWPQIERIIAWAKEHVTSTLFVCWAVQAALNILYGIPKMTRE
VKLSGIYQHQTLEPLALLTRGFDETFLAPHSRYADFPVEVLQQYTDLDILVSSEEAGAYLFASKDKRVAFVTGHPEYDVD
TLAGEYQRDLAAGLNPQVPLNYFPSDDASLRPKASWRSHGHLLFANWLNYYVYQITPFDLRHMNPTLD

Specific function: Methionine biosynthesis; HTS variant; first step. [C]

COG id: COG1897

COG function: function code E; Homoserine trans-succinylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HTS family [H]

Homologues:

Organism=Escherichia coli, GI1790443, Length=309, Percent_Identity=79.6116504854369, Blast_Score=526, Evalue=1e-151,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005697
- ProDom:   PD037892 [H]

Pfam domain/function: PF04204 HTS [H]

EC number: =2.3.1.46 [H]

Molecular weight: Translated: 35366; Mature: 35234

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIRVPDELPAVSFLRNENVFVMASSRAKTQEIRPLKVLILNLMPKKIETENQFLRLLSN
CCCCCCCCCCHHHHHCCCCEEEEECCCCCCHHCCHHHHHHHHHCCCCCCHHHHHHHHHCC
SPLQVDIQLLRVDSRESKNTPTEHLNNFYCDFEDIQDQNFDGLIVTGAPLGLVDFCDVAY
CCCEEEEEEEEECCCCCCCCCHHHHHCEECCHHHHCCCCCCEEEEECCCCCHHHHHHHHH
WPQIERIIAWAKEHVTSTLFVCWAVQAALNILYGIPKMTREVKLSGIYQHQTLEPLALLT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEECCCCCCHHHHHH
RGFDETFLAPHSRYADFPVEVLQQYTDLDILVSSEEAGAYLFASKDKRVAFVTGHPEYDV
CCCCHHHCCCCCCCCCCHHHHHHHHCCEEEEEECCCCCEEEEECCCCEEEEEECCCCCCH
DTLAGEYQRDLAAGLNPQVPLNYFPSDDASLRPKASWRSHGHLLFANWLNYYVYQITPFD
HHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEECCCH
LRHMNPTLD
HCCCCCCCC
>Mature Secondary Structure 
PIRVPDELPAVSFLRNENVFVMASSRAKTQEIRPLKVLILNLMPKKIETENQFLRLLSN
CCCCCCCCCHHHHHCCCCEEEEECCCCCCHHCCHHHHHHHHHCCCCCCHHHHHHHHHCC
SPLQVDIQLLRVDSRESKNTPTEHLNNFYCDFEDIQDQNFDGLIVTGAPLGLVDFCDVAY
CCCEEEEEEEEECCCCCCCCCHHHHHCEECCHHHHCCCCCCEEEEECCCCCHHHHHHHHH
WPQIERIIAWAKEHVTSTLFVCWAVQAALNILYGIPKMTREVKLSGIYQHQTLEPLALLT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEECCCCCCHHHHHH
RGFDETFLAPHSRYADFPVEVLQQYTDLDILVSSEEAGAYLFASKDKRVAFVTGHPEYDV
CCCCHHHCCCCCCCCCCHHHHHHHHCCEEEEEECCCCCEEEEECCCCEEEEEECCCCCCH
DTLAGEYQRDLAAGLNPQVPLNYFPSDDASLRPKASWRSHGHLLFANWLNYYVYQITPFD
HHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEECCCH
LRHMNPTLD
HCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA