Click here to switch to the map view.

The map label for this gene is hemE [H]

Identifier: 170022609

GI number: 170022609

Start: 376792

End: 377859

Strand: Direct

Name: hemE [H]

Synonym: YPK_0351

Alternate gene names: 170022609

Gene position: 376792-377859 (Clockwise)

Preceding gene: 170022608

Following gene: 170022610

Centisome position: 8.03

GC content: 51.31

Gene sequence:

>1068_bases
ATGAATGAGTTGAAAAACGATCGCTATCTGCGTGCTTTGCTACGTCAGCCTGTAGACATGACACCGGTATGGATGATGCG
GCAGGCAGGCCGTTATTTGCCAGAATATAAAGCAACCCGCGCTATTGCTGGGGATTTTATGTCACTGTGCAAAAATGCAG
AGTTAGCCTGTGAGGTCACGATGCAGCCACTGCGTCGTTATCCGCTGGATGCAGCGATTCTGTTTTCCGACATTCTGACC
ATCCCTGATGCCATGGGGCTGGGGCTCTATTTTGAAACTGGCGAAGGCCCGCGTTTTCAATCCCCAATTACTTGCCGGGC
TGATGTTGAAAAATTGCCGATCCCCGATCCTGAGCAAGAATTGGGTTATGTGATGAATGCGGTGCGGACCATTCGTCGCG
AACTGGCCGGTTCGGTGCCCTTAATCGGTTTTTCCGGTAGCCCATGGACTCTGGCGACCTATATGGTTGAAGGCGGCAGT
AGTAAAGCCTTTACCAAACTGAAAAAAATGATGTATGCCGAACCGCAGACCTTGCACTTGCTGCTGGATAAACTGGCAGA
CAGTGTCATTTTGTATCTTAATGCCCAAATCAAGGCGGGGGCTCAATCGGTCATGATCTTTGATACCTGGGGAGGGGTAC
TGACAGGCCGTGATTATCATGAGTTCTCATTGAATTATATGCATAAAATTGTCGATGGTTTGATCCGCGAAAACGAAGGT
CGTCGGGTTCCTGTCACTTTGTTCACCAAGGGCGGGGGGCCGTGGCTGGAAGCGATGGCCGCCACCGGTTGTGATGCGCT
GGGTCTAGACTGGACAACGGATATCGCGGATGCGCGTCGTCGTGTTGGTGATAAAGTTGCCTTGCAAGGCAACATGGATC
CTTCGGTTCTGTATGCACCCCCTGCGCGTATTGAGCAGGAGGTTAGTACCATTCTGGCGAGCTTTGGCCAGGGTGAAGGG
CATGTATTTAATCTGGGCCACGGGATTCACCAAGATGTACCGCCAGCACATGCCGGTGCATTTGTGAACGCGGTACATGC
GCTATCACGGCCTTATCATCAAAAATAA

Upstream 100 bases:

>100_bases
GGTGATTCAGGAAAGAGCCATCTGACATGCTACAATTCCGTTTTGTAATATAATGCCACTTTATAATACAAGGCCGTCAG
ATCATTAAGGGAGCCCTATC

Downstream 100 bases:

>100_bases
TCAGCGTGTAGGATGGAGCCGATTGGTCAATGGTGAAGACTAAATCGAGGGTTGAGACTAAATCAATGTTTGATACTAAA
GCGCTACAGGCAGAGCAGCG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MNELKNDRYLRALLRQPVDMTPVWMMRQAGRYLPEYKATRAIAGDFMSLCKNAELACEVTMQPLRRYPLDAAILFSDILT
IPDAMGLGLYFETGEGPRFQSPITCRADVEKLPIPDPEQELGYVMNAVRTIRRELAGSVPLIGFSGSPWTLATYMVEGGS
SKAFTKLKKMMYAEPQTLHLLLDKLADSVILYLNAQIKAGAQSVMIFDTWGGVLTGRDYHEFSLNYMHKIVDGLIRENEG
RRVPVTLFTKGGGPWLEAMAATGCDALGLDWTTDIADARRRVGDKVALQGNMDPSVLYAPPARIEQEVSTILASFGQGEG
HVFNLGHGIHQDVPPAHAGAFVNAVHALSRPYHQK

Sequences:

>Translated_355_residues
MNELKNDRYLRALLRQPVDMTPVWMMRQAGRYLPEYKATRAIAGDFMSLCKNAELACEVTMQPLRRYPLDAAILFSDILT
IPDAMGLGLYFETGEGPRFQSPITCRADVEKLPIPDPEQELGYVMNAVRTIRRELAGSVPLIGFSGSPWTLATYMVEGGS
SKAFTKLKKMMYAEPQTLHLLLDKLADSVILYLNAQIKAGAQSVMIFDTWGGVLTGRDYHEFSLNYMHKIVDGLIRENEG
RRVPVTLFTKGGGPWLEAMAATGCDALGLDWTTDIADARRRVGDKVALQGNMDPSVLYAPPARIEQEVSTILASFGQGEG
HVFNLGHGIHQDVPPAHAGAFVNAVHALSRPYHQK
>Mature_355_residues
MNELKNDRYLRALLRQPVDMTPVWMMRQAGRYLPEYKATRAIAGDFMSLCKNAELACEVTMQPLRRYPLDAAILFSDILT
IPDAMGLGLYFETGEGPRFQSPITCRADVEKLPIPDPEQELGYVMNAVRTIRRELAGSVPLIGFSGSPWTLATYMVEGGS
SKAFTKLKKMMYAEPQTLHLLLDKLADSVILYLNAQIKAGAQSVMIFDTWGGVLTGRDYHEFSLNYMHKIVDGLIRENEG
RRVPVTLFTKGGGPWLEAMAATGCDALGLDWTTDIADARRRVGDKVALQGNMDPSVLYAPPARIEQEVSTILASFGQGEG
HVFNLGHGIHQDVPPAHAGAFVNAVHALSRPYHQK

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=359, Percent_Identity=47.9108635097493, Blast_Score=320, Evalue=1e-87,
Organism=Escherichia coli, GI2367337, Length=354, Percent_Identity=88.4180790960452, Blast_Score=659, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320252, Length=353, Percent_Identity=38.5269121813031, Blast_Score=258, Evalue=8e-70,
Organism=Drosophila melanogaster, GI221330099, Length=346, Percent_Identity=42.7745664739884, Blast_Score=286, Evalue=1e-77,
Organism=Drosophila melanogaster, GI19921920, Length=346, Percent_Identity=42.7745664739884, Blast_Score=286, Evalue=1e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39269; Mature: 39269

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNELKNDRYLRALLRQPVDMTPVWMMRQAGRYLPEYKATRAIAGDFMSLCKNAELACEVT
CCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEHHH
MQPLRRYPLDAAILFSDILTIPDAMGLGLYFETGEGPRFQSPITCRADVEKLPIPDPEQE
HHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCEEECCCCCCCCCCCCHHH
LGYVMNAVRTIRRELAGSVPLIGFSGSPWTLATYMVEGGSSKAFTKLKKMMYAEPQTLHL
HHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEEECCCHHHHHHHHHHHHCCCHHHHH
LLDKLADSVILYLNAQIKAGAQSVMIFDTWGGVLTGRDYHEFSLNYMHKIVDGLIRENEG
HHHHHHHHEEEEEECEECCCCCEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHCCCC
RRVPVTLFTKGGGPWLEAMAATGCDALGLDWTTDIADARRRVGDKVALQGNMDPSVLYAP
CEEEEEEEECCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCEEECC
PARIEQEVSTILASFGQGEGHVFNLGHGIHQDVPPAHAGAFVNAVHALSRPYHQK
HHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNELKNDRYLRALLRQPVDMTPVWMMRQAGRYLPEYKATRAIAGDFMSLCKNAELACEVT
CCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEHHH
MQPLRRYPLDAAILFSDILTIPDAMGLGLYFETGEGPRFQSPITCRADVEKLPIPDPEQE
HHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCEEECCCCCCCCCCCCHHH
LGYVMNAVRTIRRELAGSVPLIGFSGSPWTLATYMVEGGSSKAFTKLKKMMYAEPQTLHL
HHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEEECCCHHHHHHHHHHHHCCCHHHHH
LLDKLADSVILYLNAQIKAGAQSVMIFDTWGGVLTGRDYHEFSLNYMHKIVDGLIRENEG
HHHHHHHHEEEEEECEECCCCCEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHCCCC
RRVPVTLFTKGGGPWLEAMAATGCDALGLDWTTDIADARRRVGDKVALQGNMDPSVLYAP
CEEEEEEEECCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCEEECC
PARIEQEVSTILASFGQGEGHVFNLGHGIHQDVPPAHAGAFVNAVHALSRPYHQK
HHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA