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The map label for this gene is gabD [C]

Identifier: 169629363

GI number: 169629363

Start: 2324929

End: 2326551

Strand: Direct

Name: gabD [C]

Synonym: MAB_2277

Alternate gene names: 169629363

Gene position: 2324929-2326551 (Clockwise)

Preceding gene: 169629361

Following gene: 169629364

Centisome position: 45.88

GC content: 61.0

Gene sequence:

>1623_bases
ATGACGATCAGCGACACCGCGCCCGCGGCCACACTGGTCTCCTACGGGAGCTATATCGGCGGTGAACAAGTAACTGAAGA
CCGGTGGATTTATGTTGCTGACCCACGTGCAGTACTTCAGGACTCATTTGCTACATTGACGCTGAAGCGACGCCTGGATT
CCGGTGAGCAGCAATACGGCGAGGACATGGCCGGCATCGTCGGCCGAGTCGCCGTTGGAACAGACAGGCATATGCAGGCC
GCCTTGGCGGCCGCGACACGGGCCGCCAAGGTGTGGCGCGGAGCTCCACTGCAGGTGCGGGTGGATGACTTCCTGGCGCA
CCTGGGTGCGCGGATCCTCGGTCATCGCGAGCAGATTGAGCAGATGGCTCTTTACGAGGGCCATCCGCGGGAGTTGGTGA
AGTGGGAAGTCTCGGGCTGGTTGGCCACCACGACCGCACAGTCCAGAGACTTCTACCGCAGTCAGCTGTGGTACGAGACA
TTCGACGGTGACTCGCGGCGCATCGTGCGCCGTTGCGCCGATGGTGTGGTGTGCATCAACCCACCGGCCAACGCTCCGAT
GTCCAGCGCAATGCTCGCGGCCACCAGTGTGATGGCAGGCAACGCGGTGGTAATCCGCGCGCCCCGGTCCGTGCCGTTGG
GTGTCTTCTACAGCATGATCGAGATCATTGCGCCGGTCCTCGAAGAGATCGGTGCGCCCGTGGGAACGATCAACGTGGTC
TGCTCCGAGCCTGCGCCTACCTTCGAGCAGTGGCTAGGTAGCCCGCTGGTCAACGACATCATGTACTTCGGTGCGGTCGA
ACCGGGGCTCGAAATCGAGCGCCGATGTGTGGCTGCCGGCAAGAAGCCGATCCTCGAGCTGGCCGGTAACGATGTCGTCG
TGGTGTGGTCAGATGCCAATCTCGACTATGCCTCCGATGCGCTTCTCGAAGCGTTCTTCGGTTCCGGGCAGCTCTGCATG
ATCCCGAACCTTGTTGTTGCACACCCTGATATCGCAGAGGAGCTTATCGCCCTAGTCATCGCGAAGGCGGCGAGCATCCG
CATTGGATATCCCGACGAAGACGGTGTACTCCTGTCGCCGGTGCTTCGCCATGACAAGTTCCACAGCGCGCTCGGCGACG
CCCTGGACAACGGGGCTCAACTGCTGGCCGGCGGCGGCAGCGTCCATGTCGACGGCTCCCCGTCCGAGGCCGGAATGTTT
CTGCAGCCCACCGTAATCCGCGTTGACGGTTTGAAAAACTCGCGACGCGTAAAGGCTGTCGAACACGAGACCTTCTTTCC
GCTGCTGCCGATCGTGGTGCCGGACACTAGCGACGGTGACCTGGCTCTCTCGACTGTCATTGATTTCGTGAATACAAACC
TCTATGGCCTGCGAAATTCGTTATGGTCAAGTAGCGCAACGGTTATCGATACCTATGTGGCCAATGTCACCAACAGCGGC
ATCATCAAGGTGAACGAGTCTCATATCGCCTTCGGCGCGCCGCTACCCACACATGGTGGCACCGCCCTGACCGGTGGGGC
ATTCGGAGAAGCCAACTATCCGGCGCTGCGGACCTCTCATATCCAGGGTGTGTCCGTCTCGTATGTCCCGCATCCGCCGC
GGTACTACAAGGAGCAGGCATGA

Upstream 100 bases:

>100_bases
GCCGATATCCCCGATTTCAGAGACAAGTCAGCATCGTTTCAGAGGGCTCTGGCACTGTCCTGGCGAAGGTCGGAAGAGAA
CCATGAATAGAGGGGCACAT

Downstream 100 bases:

>100_bases
TTCTCGAAACTACGGGTGCTGCATACGAAATCACCGAGAACCTGTTGCCGGGAATCCTTGATGCCCTGTCTGACGATCCG
TTGCACGAGTTGGAGTCCCC

Product: aldehyde dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 540; Mature: 539

Protein sequence:

>540_residues
MTISDTAPAATLVSYGSYIGGEQVTEDRWIYVADPRAVLQDSFATLTLKRRLDSGEQQYGEDMAGIVGRVAVGTDRHMQA
ALAAATRAAKVWRGAPLQVRVDDFLAHLGARILGHREQIEQMALYEGHPRELVKWEVSGWLATTTAQSRDFYRSQLWYET
FDGDSRRIVRRCADGVVCINPPANAPMSSAMLAATSVMAGNAVVIRAPRSVPLGVFYSMIEIIAPVLEEIGAPVGTINVV
CSEPAPTFEQWLGSPLVNDIMYFGAVEPGLEIERRCVAAGKKPILELAGNDVVVVWSDANLDYASDALLEAFFGSGQLCM
IPNLVVAHPDIAEELIALVIAKAASIRIGYPDEDGVLLSPVLRHDKFHSALGDALDNGAQLLAGGGSVHVDGSPSEAGMF
LQPTVIRVDGLKNSRRVKAVEHETFFPLLPIVVPDTSDGDLALSTVIDFVNTNLYGLRNSLWSSSATVIDTYVANVTNSG
IIKVNESHIAFGAPLPTHGGTALTGGAFGEANYPALRTSHIQGVSVSYVPHPPRYYKEQA

Sequences:

>Translated_540_residues
MTISDTAPAATLVSYGSYIGGEQVTEDRWIYVADPRAVLQDSFATLTLKRRLDSGEQQYGEDMAGIVGRVAVGTDRHMQA
ALAAATRAAKVWRGAPLQVRVDDFLAHLGARILGHREQIEQMALYEGHPRELVKWEVSGWLATTTAQSRDFYRSQLWYET
FDGDSRRIVRRCADGVVCINPPANAPMSSAMLAATSVMAGNAVVIRAPRSVPLGVFYSMIEIIAPVLEEIGAPVGTINVV
CSEPAPTFEQWLGSPLVNDIMYFGAVEPGLEIERRCVAAGKKPILELAGNDVVVVWSDANLDYASDALLEAFFGSGQLCM
IPNLVVAHPDIAEELIALVIAKAASIRIGYPDEDGVLLSPVLRHDKFHSALGDALDNGAQLLAGGGSVHVDGSPSEAGMF
LQPTVIRVDGLKNSRRVKAVEHETFFPLLPIVVPDTSDGDLALSTVIDFVNTNLYGLRNSLWSSSATVIDTYVANVTNSG
IIKVNESHIAFGAPLPTHGGTALTGGAFGEANYPALRTSHIQGVSVSYVPHPPRYYKEQA
>Mature_539_residues
TISDTAPAATLVSYGSYIGGEQVTEDRWIYVADPRAVLQDSFATLTLKRRLDSGEQQYGEDMAGIVGRVAVGTDRHMQAA
LAAATRAAKVWRGAPLQVRVDDFLAHLGARILGHREQIEQMALYEGHPRELVKWEVSGWLATTTAQSRDFYRSQLWYETF
DGDSRRIVRRCADGVVCINPPANAPMSSAMLAATSVMAGNAVVIRAPRSVPLGVFYSMIEIIAPVLEEIGAPVGTINVVC
SEPAPTFEQWLGSPLVNDIMYFGAVEPGLEIERRCVAAGKKPILELAGNDVVVVWSDANLDYASDALLEAFFGSGQLCMI
PNLVVAHPDIAEELIALVIAKAASIRIGYPDEDGVLLSPVLRHDKFHSALGDALDNGAQLLAGGGSVHVDGSPSEAGMFL
QPTVIRVDGLKNSRRVKAVEHETFFPLLPIVVPDTSDGDLALSTVIDFVNTNLYGLRNSLWSSSATVIDTYVANVTNSGI
IKVNESHIAFGAPLPTHGGTALTGGAFGEANYPALRTSHIQGVSVSYVPHPPRYYKEQA

Specific function: Involved in F420 biosynthesis through the oxidation of lactaldehyde to lactate. The substrate preference order is propionaldehyde > DL-lactaldehyde, DL-glyceraldehyde > crotonaldehyde > glycolaldehyde > acetaldehyde, acrolein > formaldehyde. No activity w

COG id: COG1012

COG function: function code C; NAD-dependent aldehyde dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldehyde dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI25777732, Length=382, Percent_Identity=27.2251308900524, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI25777730, Length=376, Percent_Identity=25.531914893617, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI115387104, Length=494, Percent_Identity=25.1012145748988, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI25777728, Length=376, Percent_Identity=25.7978723404255, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI25777724, Length=376, Percent_Identity=25.7978723404255, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI11095441, Length=461, Percent_Identity=23.4273318872017, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI153266822, Length=346, Percent_Identity=23.9884393063584, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI12007648, Length=467, Percent_Identity=23.5546038543897, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI21614513, Length=324, Percent_Identity=24.3827160493827, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI21361176, Length=376, Percent_Identity=24.7340425531915, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI4507229, Length=338, Percent_Identity=25.1479289940828, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI238814322, Length=317, Percent_Identity=23.6593059936909, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI25777721, Length=346, Percent_Identity=24.2774566473988, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI310128093, Length=323, Percent_Identity=25.077399380805, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI310128103, Length=323, Percent_Identity=24.7678018575851, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI188035924, Length=323, Percent_Identity=24.7678018575851, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI310128091, Length=323, Percent_Identity=24.7678018575851, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI310128089, Length=340, Percent_Identity=24.4117647058824, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI301500698, Length=267, Percent_Identity=25.0936329588015, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI1789015, Length=437, Percent_Identity=26.5446224256293, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1787684, Length=418, Percent_Identity=24.4019138755981, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI87082295, Length=305, Percent_Identity=25.5737704918033, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1787715, Length=360, Percent_Identity=24.1666666666667, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87081926, Length=456, Percent_Identity=23.2456140350877, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI87081896, Length=346, Percent_Identity=25.1445086705202, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1787250, Length=464, Percent_Identity=23.9224137931034, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786504, Length=294, Percent_Identity=26.530612244898, Blast_Score=64, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI25143874, Length=383, Percent_Identity=26.6318537859008, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25143876, Length=383, Percent_Identity=26.6318537859008, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17551164, Length=439, Percent_Identity=24.1457858769932, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI115534176, Length=323, Percent_Identity=25.6965944272446, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI133930964, Length=317, Percent_Identity=25.2365930599369, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71995606, Length=370, Percent_Identity=24.8648648648649, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71995613, Length=368, Percent_Identity=25, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI32564736, Length=385, Percent_Identity=24.4155844155844, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25144435, Length=385, Percent_Identity=24.4155844155844, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562198, Length=371, Percent_Identity=23.989218328841, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71986308, Length=461, Percent_Identity=22.9934924078091, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17534119, Length=349, Percent_Identity=25.7879656160458, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17534447, Length=421, Percent_Identity=23.9904988123515, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32564151, Length=421, Percent_Identity=23.9904988123515, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319478, Length=372, Percent_Identity=26.8817204301075, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324950, Length=311, Percent_Identity=25.7234726688103, Blast_Score=87, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6320917, Length=336, Percent_Identity=25.297619047619, Blast_Score=81, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6325196, Length=329, Percent_Identity=24.0121580547112, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321828, Length=330, Percent_Identity=23.9393939393939, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24666674, Length=456, Percent_Identity=24.1228070175439, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI281362580, Length=358, Percent_Identity=25.9776536312849, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI62472918, Length=358, Percent_Identity=25.9776536312849, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI62472926, Length=358, Percent_Identity=25.9776536312849, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI62472936, Length=358, Percent_Identity=25.9776536312849, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21356737, Length=358, Percent_Identity=25.9776536312849, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24650465, Length=383, Percent_Identity=26.6318537859008, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24585660, Length=303, Percent_Identity=24.4224422442244, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI20129399, Length=380, Percent_Identity=25.5263157894737, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24638876, Length=472, Percent_Identity=23.728813559322, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24638878, Length=472, Percent_Identity=23.728813559322, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.22 [H]

Molecular weight: Translated: 58035; Mature: 57903

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTISDTAPAATLVSYGSYIGGEQVTEDRWIYVADPRAVLQDSFATLTLKRRLDSGEQQYG
CCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCHHHHH
EDMAGIVGRVAVGTDRHMQAALAAATRAAKVWRGAPLQVRVDDFLAHLGARILGHREQIE
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHCCHHHHH
QMALYEGHPRELVKWEVSGWLATTTAQSRDFYRSQLWYETFDGDSRRIVRRCADGVVCIN
HHHHHCCCCHHEEEEEECCEEEECCHHHHHHHHHHHHHEECCCCHHHHHHHHHCCEEEEC
PPANAPMSSAMLAATSVMAGNAVVIRAPRSVPLGVFYSMIEIIAPVLEEIGAPVGTINVV
CCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEE
CSEPAPTFEQWLGSPLVNDIMYFGAVEPGLEIERRCVAAGKKPILELAGNDVVVVWSDAN
ECCCCCHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEECCCCEEEEEECCC
LDYASDALLEAFFGSGQLCMIPNLVVAHPDIAEELIALVIAKAASIRIGYPDEDGVLLSP
CCHHHHHHHHHHHCCCCEEECCCEEEECCCHHHHHHHHHHHHHCEEEECCCCCCCEEEHH
VLRHDKFHSALGDALDNGAQLLAGGGSVHVDGSPSEAGMFLQPTVIRVDGLKNSRRVKAV
HHHHHHHHHHHHHHHCCCCEEEECCCEEEECCCCCCCCEEECCEEEEEECCCCCCCEEEE
EHETFFPLLPIVVPDTSDGDLALSTVIDFVNTNLYGLRNSLWSSSATVIDTYVANVTNSG
CCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHCCCCC
IIKVNESHIAFGAPLPTHGGTALTGGAFGEANYPALRTSHIQGVSVSYVPHPPRYYKEQA
EEEECCCEEEECCCCCCCCCCEEECCCCCCCCCCCEECCCCCCEEEEECCCCCHHHCCCC
>Mature Secondary Structure 
TISDTAPAATLVSYGSYIGGEQVTEDRWIYVADPRAVLQDSFATLTLKRRLDSGEQQYG
CCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCHHHHH
EDMAGIVGRVAVGTDRHMQAALAAATRAAKVWRGAPLQVRVDDFLAHLGARILGHREQIE
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHCCHHHHH
QMALYEGHPRELVKWEVSGWLATTTAQSRDFYRSQLWYETFDGDSRRIVRRCADGVVCIN
HHHHHCCCCHHEEEEEECCEEEECCHHHHHHHHHHHHHEECCCCHHHHHHHHHCCEEEEC
PPANAPMSSAMLAATSVMAGNAVVIRAPRSVPLGVFYSMIEIIAPVLEEIGAPVGTINVV
CCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEE
CSEPAPTFEQWLGSPLVNDIMYFGAVEPGLEIERRCVAAGKKPILELAGNDVVVVWSDAN
ECCCCCHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEECCCCEEEEEECCC
LDYASDALLEAFFGSGQLCMIPNLVVAHPDIAEELIALVIAKAASIRIGYPDEDGVLLSP
CCHHHHHHHHHHHCCCCEEECCCEEEECCCHHHHHHHHHHHHHCEEEECCCCCCCEEEHH
VLRHDKFHSALGDALDNGAQLLAGGGSVHVDGSPSEAGMFLQPTVIRVDGLKNSRRVKAV
HHHHHHHHHHHHHHHCCCCEEEECCCEEEECCCCCCCCEEECCEEEEEECCCCCCCEEEE
EHETFFPLLPIVVPDTSDGDLALSTVIDFVNTNLYGLRNSLWSSSATVIDTYVANVTNSG
CCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHCCCCC
IIKVNESHIAFGAPLPTHGGTALTGGAFGEANYPALRTSHIQGVSVSYVPHPPRYYKEQA
EEEECCCEEEECCCCCCCCCCEEECCCCCCCCCCCEECCCCCCEEEEECCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]