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The map label for this gene is mbtI [H]

Identifier: 169629331

GI number: 169629331

Start: 2271954

End: 2273315

Strand: Direct

Name: mbtI [H]

Synonym: MAB_2245

Alternate gene names: 169629331

Gene position: 2271954-2273315 (Clockwise)

Preceding gene: 169629330

Following gene: 169629332

Centisome position: 44.84

GC content: 63.73

Gene sequence:

>1362_bases
GTGTCGAAGATGAGTGCGGTTGTAGATCCCGATACCGGCGCCCGGACCTGGGTTTCTGTGCAGGAGGGACTGCCGGATGG
CTTTGCCCCGGCCGACCTCGCCGGTGCGCTCGCGCAGGAAATCCCGGAGCGCCACGGCGACGAATACTTGATTTACGAGC
GCGATGGCGAATGGGTACTCGCCATCGGCGCGCGCGCCTCCGTTGAGCTCGACAGTGACGGACTGCGTATCGTCCGGGAC
GGAACCATCGAGAAACGCGATTGGTCCGGACACCCAGGGGCTGCCCTCGAACAGGCCGTGAACGAGATCTCCGACGGCAC
GCATCGAGTTTTTGGATGGGTCGCCTTTGAGTTCGGCACCTACCGATTCAATCTTCAGCACCGGCTGGCTCCTGGTACGC
CGTTGGCTCGGGTCTTCGCTCCCCGCGCCGAGGTCGTGATCACTGCGGACGGGGTGTCGGTCTCTGATGAGAGCTATGTG
GAGGACATCAGCCGGCTGATCGAGCAGGGCGTACCGGCGATTCCGGCTCCGGCCTCGATCGATCTGGCCCCGGACCCATC
CGATTATCGGGGGCGTGTCGGCATCGCGACCGCCGAGATCCGGTCGGGCCTGTACCACAAGGTGATCCTGTCGCGGCGGG
TAGAAGTGCCTTTCGCCATGGACTTTCCGTCCACCTACCGTCTTGGACGGCATAACAACACACCGGTTCGTTCCTTCCTA
TTACGGCTCGGAGGTATACGAGCTCTTGGCTACAGCCCAGAGCTCGTCACCGCGGTCGAGGCCGACGGAACTGTTGTCAC
CCAGCCGCTGGCGGGAACCCGTGCCTTCGGACGTGGTGAGGACGCAGACCGTGTCGCCCGCGATGACCTCGAATCGAATG
CGAAAGAGATTGTCGAGCATGCGATCTCAGTGCGAAGCTCGCTTGCCGAGATCGCCGAGGTGGTGGATCCCAGCAGTACC
AAGGTGACCGACTTCATGACCGTGCGTGAGCGTGGCAGTGTTCAGCACCTGGGATCGACAGTCAGTGGTGAGCTGAGTGC
CGGCATGACGCGGATGGATGCGCTGGAGGCGCTGTTTCCTGCCGTGACGGCTTCGGGCATCCCGAAGGCGGAAGGTGTCG
ACGCCATCCTTCGGCTCGATGATCACCCGCGCGGCCTTTACTCCGGTGCGGTTGTCATGCTGTCGCCGAACGGCGGCTTG
GACGCCGCGCTGACACTGCGCTCGGCCTACGAACAGGACGGCCACACCTGGCTGCGGGCCGGTGCAGGCATCATCGAGGC
ATCCACCCCCGAGCGGGAGTTCGAGGAGACCTGCGAGAAGCTCGGCAGTATTGCCCCGTACGTGATCAAGCGCGAGGCAT
AG

Upstream 100 bases:

>100_bases
TCGGGAGATCCCAAGCACAGTGGATTCCGTCCGGCAACGTGGCGGAGGTCATGTTACGGGCGGGTTCCGGGGGCACTTAG
CATAGGCTAGGCTTACTCAG

Downstream 100 bases:

>100_bases
CTCTTCGCGACTGACTATCCGCGCCGCCGCCTCGCCCGGATTGACCCTACCCCTGAGGGCAGGGTCTACGGTCCCGGTGA
GGATTAAGCATGCAGATTTC

Product: salicylate synthase MbtI

Products: NA

Alternate protein names: Mycobactin synthase protein I; Salicylate synthase mbtI [H]

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MSKMSAVVDPDTGARTWVSVQEGLPDGFAPADLAGALAQEIPERHGDEYLIYERDGEWVLAIGARASVELDSDGLRIVRD
GTIEKRDWSGHPGAALEQAVNEISDGTHRVFGWVAFEFGTYRFNLQHRLAPGTPLARVFAPRAEVVITADGVSVSDESYV
EDISRLIEQGVPAIPAPASIDLAPDPSDYRGRVGIATAEIRSGLYHKVILSRRVEVPFAMDFPSTYRLGRHNNTPVRSFL
LRLGGIRALGYSPELVTAVEADGTVVTQPLAGTRAFGRGEDADRVARDDLESNAKEIVEHAISVRSSLAEIAEVVDPSST
KVTDFMTVRERGSVQHLGSTVSGELSAGMTRMDALEALFPAVTASGIPKAEGVDAILRLDDHPRGLYSGAVVMLSPNGGL
DAALTLRSAYEQDGHTWLRAGAGIIEASTPEREFEETCEKLGSIAPYVIKREA

Sequences:

>Translated_453_residues
MSKMSAVVDPDTGARTWVSVQEGLPDGFAPADLAGALAQEIPERHGDEYLIYERDGEWVLAIGARASVELDSDGLRIVRD
GTIEKRDWSGHPGAALEQAVNEISDGTHRVFGWVAFEFGTYRFNLQHRLAPGTPLARVFAPRAEVVITADGVSVSDESYV
EDISRLIEQGVPAIPAPASIDLAPDPSDYRGRVGIATAEIRSGLYHKVILSRRVEVPFAMDFPSTYRLGRHNNTPVRSFL
LRLGGIRALGYSPELVTAVEADGTVVTQPLAGTRAFGRGEDADRVARDDLESNAKEIVEHAISVRSSLAEIAEVVDPSST
KVTDFMTVRERGSVQHLGSTVSGELSAGMTRMDALEALFPAVTASGIPKAEGVDAILRLDDHPRGLYSGAVVMLSPNGGL
DAALTLRSAYEQDGHTWLRAGAGIIEASTPEREFEETCEKLGSIAPYVIKREA
>Mature_452_residues
SKMSAVVDPDTGARTWVSVQEGLPDGFAPADLAGALAQEIPERHGDEYLIYERDGEWVLAIGARASVELDSDGLRIVRDG
TIEKRDWSGHPGAALEQAVNEISDGTHRVFGWVAFEFGTYRFNLQHRLAPGTPLARVFAPRAEVVITADGVSVSDESYVE
DISRLIEQGVPAIPAPASIDLAPDPSDYRGRVGIATAEIRSGLYHKVILSRRVEVPFAMDFPSTYRLGRHNNTPVRSFLL
RLGGIRALGYSPELVTAVEADGTVVTQPLAGTRAFGRGEDADRVARDDLESNAKEIVEHAISVRSSLAEIAEVVDPSSTK
VTDFMTVRERGSVQHLGSTVSGELSAGMTRMDALEALFPAVTASGIPKAEGVDAILRLDDHPRGLYSGAVVMLSPNGGLD
AALTLRSAYEQDGHTWLRAGAGIIEASTPEREFEETCEKLGSIAPYVIKREA

Specific function: Mediates the production of salicylate from chorismate via an isochorismate intermediate. Presents both isochorismate synthase and isochorismate-pyruvate lyase activities. Salycilate is the starter unit in the production of the virulence-conferring salicyl

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family. Salicylate synthase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=262, Percent_Identity=31.6793893129771, Blast_Score=109, Evalue=5e-25,
Organism=Escherichia coli, GI1788114, Length=249, Percent_Identity=28.9156626506024, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1786809, Length=271, Percent_Identity=28.0442804428044, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320935, Length=341, Percent_Identity=29.3255131964809, Blast_Score=132, Evalue=8e-32,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR015890
- InterPro:   IPR019996 [H]

Pfam domain/function: PF00425 Chorismate_bind [H]

EC number: =5.4.4.2 [H]

Molecular weight: Translated: 48756; Mature: 48625

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKMSAVVDPDTGARTWVSVQEGLPDGFAPADLAGALAQEIPERHGDEYLIYERDGEWVL
CCCCCCEECCCCCCEEEEEHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCEEE
AIGARASVELDSDGLRIVRDGTIEKRDWSGHPGAALEQAVNEISDGTHRVFGWVAFEFGT
EECCCEEEEECCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEEEECE
YRFNLQHRLAPGTPLARVFAPRAEVVITADGVSVSDESYVEDISRLIEQGVPAIPAPASI
EEEEEEEECCCCCCHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCEE
DLAPDPSDYRGRVGIATAEIRSGLYHKVILSRRVEVPFAMDFPSTYRLGRHNNTPVRSFL
ECCCCCCCCCCEEEEEHHHHHHCHHHHHHHHHCCCCCEEECCCCHHCCCCCCCCHHHHHH
LRLGGIRALGYSPELVTAVEADGTVVTQPLAGTRAFGRGEDADRVARDDLESNAKEIVEH
HHHCCEEEECCCCCEEEEEECCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AISVRSSLAEIAEVVDPSSTKVTDFMTVRERGSVQHLGSTVSGELSAGMTRMDALEALFP
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHCCCCCCHHHHCHHHHHHHHHHHH
AVTASGIPKAEGVDAILRLDDHPRGLYSGAVVMLSPNGGLDAALTLRSAYEQDGHTWLRA
HHHHCCCCCCCCCEEEEEECCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCEEHH
GAGIIEASTPEREFEETCEKLGSIAPYVIKREA
CCCEEECCCCHHHHHHHHHHHCCCCCEEEEECC
>Mature Secondary Structure 
SKMSAVVDPDTGARTWVSVQEGLPDGFAPADLAGALAQEIPERHGDEYLIYERDGEWVL
CCCCCEECCCCCCEEEEEHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCEEE
AIGARASVELDSDGLRIVRDGTIEKRDWSGHPGAALEQAVNEISDGTHRVFGWVAFEFGT
EECCCEEEEECCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEEEECE
YRFNLQHRLAPGTPLARVFAPRAEVVITADGVSVSDESYVEDISRLIEQGVPAIPAPASI
EEEEEEEECCCCCCHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCEE
DLAPDPSDYRGRVGIATAEIRSGLYHKVILSRRVEVPFAMDFPSTYRLGRHNNTPVRSFL
ECCCCCCCCCCEEEEEHHHHHHCHHHHHHHHHCCCCCEEECCCCHHCCCCCCCCHHHHHH
LRLGGIRALGYSPELVTAVEADGTVVTQPLAGTRAFGRGEDADRVARDDLESNAKEIVEH
HHHCCEEEECCCCCEEEEEECCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AISVRSSLAEIAEVVDPSSTKVTDFMTVRERGSVQHLGSTVSGELSAGMTRMDALEALFP
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHCCCCCCHHHHCHHHHHHHHHHHH
AVTASGIPKAEGVDAILRLDDHPRGLYSGAVVMLSPNGGLDAALTLRSAYEQDGHTWLRA
HHHHCCCCCCCCCEEEEEECCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCEEHH
GAGIIEASTPEREFEETCEKLGSIAPYVIKREA
CCCEEECCCCHHHHHHHHHHHCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA