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The map label for this gene is uppS [H]

Identifier: 169628766

GI number: 169628766

Start: 1703787

End: 1704695

Strand: Direct

Name: uppS [H]

Synonym: MAB_1676

Alternate gene names: 169628766

Gene position: 1703787-1704695 (Clockwise)

Preceding gene: 169628765

Following gene: 169628767

Centisome position: 33.62

GC content: 64.69

Gene sequence:

>909_bases
ATGGTGAAGAGCAGCCAGCCCGATCCGCAGCAGGATAAGTACTACACCGACTGGGCCGACGTCCCGCAGGGCTATAACCC
GACGTTCCCGGATAAGACGGTGTTTCCTGCTGTTTTCCCCAAGCTGCTGCCCGGCGTGGGTCCCGGCGGTACCCGCCCGC
ACCCCGCGCCGAAGCACCCGTCGGGTGCGGTGCCCCCGGCGATTCCCAAGGAACTGATTCCGCGCCACGTCGCGGTGGTG
ATGGACGGCAACGGGCGCTGGGCGCGGGCCCGTGGGCTGCCGCGTACCGAGGGCCACAAGATGGGCGAGGCCACCATGAT
GGACATGGTCTGCGGAGCCATCGAGATGGGCATCCCGTGGCTCACCACCTACGCGTTCTCCACGGAGAACTGGAGGAGGC
CCGCGGACGAGGTCCGATTTCTCATGGGCTTCAACCGCGACGTGGTCAAGCGGCGCCGCCATGATCTGAACAACATGGGT
GTGCGGTTCCGCTGGGCCGGGCAGAAGACGCGGTTGTGGAGCAGCGTCTACAAAGAGCTCGAGATCACTGAGGAGCTCAC
CAAGAACAACAGCACCCTGACGCTGACCACGTGTATCAACTACGGCGGCCGGGCTGAAATCGCCGAGGCGACAAGAAGAA
TCGCCCGGCTGGTGGAATCCGGGCAGCTCAAGCCGGATCGCATCACCGAGGAGACGATCGCCAAGTACCTCGACGAGCCG
GACATGCCCGATGTCGATCTGTTCCTGCGGCCTTCCGGCGAGTTCCGGTCCAGCAACTTCATGATGTGGCAGTCGGCGTA
CGCCGAGTTCGTGTTCCAGGAGAAGATGTACCCGGACTTCGACCGCCGTGACCTGTGGGCGGCCTGCCTCGAGTATGCCC
AGCGTGACCGGCGATTCGGGTCGGCGTGA

Upstream 100 bases:

>100_bases
CAGGCCAGCGGATTGATCGCGGCGCATTTGCAGTGGCATCTGGAACGCAAGCTACGGACACTCCCGCTCGTCGAACGTGG
CAGCAGGTTAAATATGAGCC

Downstream 100 bases:

>100_bases
TGACAGATCCCGAAGGCGCAGCCGGCAAGATCCTCGATCGGGTGTACCGCGTGCTGCACCCGGTGCTGCCGGTTACCAGG
GAAGCCGACGGGGCGCTGAC

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MVKSSQPDPQQDKYYTDWADVPQGYNPTFPDKTVFPAVFPKLLPGVGPGGTRPHPAPKHPSGAVPPAIPKELIPRHVAVV
MDGNGRWARARGLPRTEGHKMGEATMMDMVCGAIEMGIPWLTTYAFSTENWRRPADEVRFLMGFNRDVVKRRRHDLNNMG
VRFRWAGQKTRLWSSVYKELEITEELTKNNSTLTLTTCINYGGRAEIAEATRRIARLVESGQLKPDRITEETIAKYLDEP
DMPDVDLFLRPSGEFRSSNFMMWQSAYAEFVFQEKMYPDFDRRDLWAACLEYAQRDRRFGSA

Sequences:

>Translated_302_residues
MVKSSQPDPQQDKYYTDWADVPQGYNPTFPDKTVFPAVFPKLLPGVGPGGTRPHPAPKHPSGAVPPAIPKELIPRHVAVV
MDGNGRWARARGLPRTEGHKMGEATMMDMVCGAIEMGIPWLTTYAFSTENWRRPADEVRFLMGFNRDVVKRRRHDLNNMG
VRFRWAGQKTRLWSSVYKELEITEELTKNNSTLTLTTCINYGGRAEIAEATRRIARLVESGQLKPDRITEETIAKYLDEP
DMPDVDLFLRPSGEFRSSNFMMWQSAYAEFVFQEKMYPDFDRRDLWAACLEYAQRDRRFGSA
>Mature_302_residues
MVKSSQPDPQQDKYYTDWADVPQGYNPTFPDKTVFPAVFPKLLPGVGPGGTRPHPAPKHPSGAVPPAIPKELIPRHVAVV
MDGNGRWARARGLPRTEGHKMGEATMMDMVCGAIEMGIPWLTTYAFSTENWRRPADEVRFLMGFNRDVVKRRRHDLNNMG
VRFRWAGQKTRLWSSVYKELEITEELTKNNSTLTLTTCINYGGRAEIAEATRRIARLVESGQLKPDRITEETIAKYLDEP
DMPDVDLFLRPSGEFRSSNFMMWQSAYAEFVFQEKMYPDFDRRDLWAACLEYAQRDRRFGSA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=223, Percent_Identity=33.6322869955157, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI45580742, Length=223, Percent_Identity=33.6322869955157, Blast_Score=130, Evalue=1e-30,
Organism=Escherichia coli, GI1786371, Length=231, Percent_Identity=42.8571428571429, Blast_Score=192, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI71993029, Length=225, Percent_Identity=34.6666666666667, Blast_Score=123, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6319474, Length=197, Percent_Identity=34.5177664974619, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323748, Length=231, Percent_Identity=28.5714285714286, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI18857969, Length=228, Percent_Identity=34.2105263157895, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 34583; Mature: 34583

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKSSQPDPQQDKYYTDWADVPQGYNPTFPDKTVFPAVFPKLLPGVGPGGTRPHPAPKHP
CCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCC
SGAVPPAIPKELIPRHVAVVMDGNGRWARARGLPRTEGHKMGEATMMDMVCGAIEMGIPW
CCCCCCCCCHHHCCCEEEEEECCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCH
LTTYAFSTENWRRPADEVRFLMGFNRDVVKRRRHDLNNMGVRFRWAGQKTRLWSSVYKEL
HHHEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHH
EITEELTKNNSTLTLTTCINYGGRAEIAEATRRIARLVESGQLKPDRITEETIAKYLDEP
HHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHCCCC
DMPDVDLFLRPSGEFRSSNFMMWQSAYAEFVFQEKMYPDFDRRDLWAACLEYAQRDRRFG
CCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCC
SA
CC
>Mature Secondary Structure
MVKSSQPDPQQDKYYTDWADVPQGYNPTFPDKTVFPAVFPKLLPGVGPGGTRPHPAPKHP
CCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCC
SGAVPPAIPKELIPRHVAVVMDGNGRWARARGLPRTEGHKMGEATMMDMVCGAIEMGIPW
CCCCCCCCCHHHCCCEEEEEECCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCH
LTTYAFSTENWRRPADEVRFLMGFNRDVVKRRRHDLNNMGVRFRWAGQKTRLWSSVYKEL
HHHEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHH
EITEELTKNNSTLTLTTCINYGGRAEIAEATRRIARLVESGQLKPDRITEETIAKYLDEP
HHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHCCCC
DMPDVDLFLRPSGEFRSSNFMMWQSAYAEFVFQEKMYPDFDRRDLWAACLEYAQRDRRFG
CCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCC
SA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]