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The map label for this gene is folD [H]

Identifier: 169824272

GI number: 169824272

Start: 638454

End: 639257

Strand: Direct

Name: folD [H]

Synonym: FMG_0575

Alternate gene names: 169824272

Gene position: 638454-639257 (Clockwise)

Preceding gene: 169824271

Following gene: 169824273

Centisome position: 35.52

GC content: 32.34

Gene sequence:

>804_bases
ATGAACGTATTAGACATTAAAGAACTTAGAGAAGATTTAGGTAAAAGAATTATCGATGGTGTTGAAAAATTAGGCAGAGA
AGTTAAAGTTGCAACTGTAAGAGTCGGCGAAAACGCAGGAGATATTTCTTACGAAAAAGCTGTAAAAAACAACTGTGCTA
AGTTGAATATTACTTGTGATCAAATAGTTTTAGAAGAAGGAGAAAATGAAAAATTAATCCAAACTATCAAAGAACTAAAT
GAAACACACGATGGTATATTGATGTTTAGACCATTAAAAGATAAAAACTTGGAAAAAGAAATTCAATATATAATTGCACC
AGAAAAAGACATTGATGCAATGGGAATGGTTAACTTAGGAAAAGTTTTGGCAGCAGAAGAAGACGCATATTATCCAGCTA
CAGCAAGAGCTGTTGTAGAAATCGTAAAATACTATAACTTTGACGTTAAAAATGTGGTAATCGTAAACAGATCATTAGTT
TTAGGTAAGCCACTTTTCAATATGCTTATAAAAGAAAACAAGACTGTTACAATGTGCCACTCTAGAACAGAAGATATCAA
ATCATTTACTAAAAATGCTGATTTGGTTGTTACTGCAGTTGGAAAAGCTAAAATGTTTGACGATTCTTACTTTACTAAGG
ATTCATATGTAGTAGATGTTGGAGTTAGCTTGGATGAAAATGGCAAATTATCAGGCGATGTTAATCCAGAAGTTGACGTA
AAAGTATTGGCAAATAGCGTTGGTAAAATCACAACAAGAGTATTGTTGTTGCAAATGGTTGAAGGCGCTTTGAATAGACA
ATAG

Upstream 100 bases:

>100_bases
TTTGGGTTATTAATCCAGGCTCTGTAACTTATCCAAGAGATGGACAAGCTGGATTTGTAATATACGATACAAATAATGAA
AAAATAGAAAGGATACTTTT

Downstream 100 bases:

>100_bases
TTTTAATTAATAAGACCTCTTTATCATAATCGATAAAGGGGTTTTTGATTGCAATAAATTAAAAGTGTATAATATATTAG
GTGATAATTTTGAAAATAGG

Product: methylenetetrahydrofolate dehydrogenase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase [H]

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MNVLDIKELREDLGKRIIDGVEKLGREVKVATVRVGENAGDISYEKAVKNNCAKLNITCDQIVLEEGENEKLIQTIKELN
ETHDGILMFRPLKDKNLEKEIQYIIAPEKDIDAMGMVNLGKVLAAEEDAYYPATARAVVEIVKYYNFDVKNVVIVNRSLV
LGKPLFNMLIKENKTVTMCHSRTEDIKSFTKNADLVVTAVGKAKMFDDSYFTKDSYVVDVGVSLDENGKLSGDVNPEVDV
KVLANSVGKITTRVLLLQMVEGALNRQ

Sequences:

>Translated_267_residues
MNVLDIKELREDLGKRIIDGVEKLGREVKVATVRVGENAGDISYEKAVKNNCAKLNITCDQIVLEEGENEKLIQTIKELN
ETHDGILMFRPLKDKNLEKEIQYIIAPEKDIDAMGMVNLGKVLAAEEDAYYPATARAVVEIVKYYNFDVKNVVIVNRSLV
LGKPLFNMLIKENKTVTMCHSRTEDIKSFTKNADLVVTAVGKAKMFDDSYFTKDSYVVDVGVSLDENGKLSGDVNPEVDV
KVLANSVGKITTRVLLLQMVEGALNRQ
>Mature_267_residues
MNVLDIKELREDLGKRIIDGVEKLGREVKVATVRVGENAGDISYEKAVKNNCAKLNITCDQIVLEEGENEKLIQTIKELN
ETHDGILMFRPLKDKNLEKEIQYIIAPEKDIDAMGMVNLGKVLAAEEDAYYPATARAVVEIVKYYNFDVKNVVIVNRSLV
LGKPLFNMLIKENKTVTMCHSRTEDIKSFTKNADLVVTAVGKAKMFDDSYFTKDSYVVDVGVSLDENGKLSGDVNPEVDV
KVLANSVGKITTRVLLLQMVEGALNRQ

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate [H]

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=287, Percent_Identity=28.2229965156794, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI222418558, Length=280, Percent_Identity=30, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI94721354, Length=249, Percent_Identity=24.8995983935743, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786741, Length=233, Percent_Identity=28.755364806867, Blast_Score=100, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17568735, Length=221, Percent_Identity=26.6968325791855, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321643, Length=240, Percent_Identity=27.0833333333333, Blast_Score=89, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6319558, Length=216, Percent_Identity=26.8518518518519, Blast_Score=75, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24645718, Length=211, Percent_Identity=27.9620853080569, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI17137370, Length=211, Percent_Identity=27.9620853080569, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI62472483, Length=211, Percent_Identity=27.9620853080569, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI45551871, Length=211, Percent_Identity=27.9620853080569, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI17136818, Length=287, Percent_Identity=27.8745644599303, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17136816, Length=287, Percent_Identity=27.8745644599303, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020631 [H]

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C [H]

EC number: =1.5.1.5; =3.5.4.9 [H]

Molecular weight: Translated: 29785; Mature: 29785

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVLDIKELREDLGKRIIDGVEKLGREVKVATVRVGENAGDISYEKAVKNNCAKLNITCD
CCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCCHHHHHHHCCCEEEEEEHH
QIVLEEGENEKLIQTIKELNETHDGILMFRPLKDKNLEKEIQYIIAPEKDIDAMGMVNLG
HHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHEEECCCCCCCCCCCHHHH
KVLAAEEDAYYPATARAVVEIVKYYNFDVKNVVIVNRSLVLGKPLFNMLIKENKTVTMCH
HHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCEECCHHHHHHHHHCCCEEEEEC
SRTEDIKSFTKNADLVVTAVGKAKMFDDSYFTKDSYVVDVGVSLDENGKLSGDVNPEVDV
CCHHHHHHHHCCCCEEEEECCCCEECCCCCCCCCCEEEEEECEECCCCCCCCCCCCCCHH
KVLANSVGKITTRVLLLQMVEGALNRQ
HHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNVLDIKELREDLGKRIIDGVEKLGREVKVATVRVGENAGDISYEKAVKNNCAKLNITCD
CCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCCHHHHHHHCCCEEEEEEHH
QIVLEEGENEKLIQTIKELNETHDGILMFRPLKDKNLEKEIQYIIAPEKDIDAMGMVNLG
HHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHEEECCCCCCCCCCCHHHH
KVLAAEEDAYYPATARAVVEIVKYYNFDVKNVVIVNRSLVLGKPLFNMLIKENKTVTMCH
HHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCEECCHHHHHHHHHCCCEEEEEC
SRTEDIKSFTKNADLVVTAVGKAKMFDDSYFTKDSYVVDVGVSLDENGKLSGDVNPEVDV
CCHHHHHHHHCCCCEEEEECCCCEECCCCCCCCCCEEEEEECEECCCCCCCCCCCCCCHH
KVLANSVGKITTRVLLLQMVEGALNRQ
HHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA