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The map label for this gene is ttcA [H]

Identifier: 169824156

GI number: 169824156

Start: 515431

End: 516258

Strand: Direct

Name: ttcA [H]

Synonym: FMG_0459

Alternate gene names: 169824156

Gene position: 515431-516258 (Clockwise)

Preceding gene: 169824155

Following gene: 169824157

Centisome position: 28.67

GC content: 31.28

Gene sequence:

>828_bases
ATGCAAAGAACTGTACAAGAAGTTGAAAGAGCAATAATAAAAAAATATAGAAAACACATTTGGTCGAAGTTTATCAAGGC
TATAAAAGAGTATGATTTAATTCAAGACGGAGATAAAATCGCCGTTTGTATGAGTGGAGGCAAGGATAGTTTGCTTCTTG
CGAAATTATTCCAAGAACTTCAAAAACACGGAATGAATAATTTTGATCTTGAATTTATAGCTATGAATCCAGGATACAGC
GAAGAAAACACTAGACTTGAAAAGGAAAATTTTGAAAAGCTTAACATCCCTTATCACATGTACGATACAGATGTTTTTAG
TGTTAGTGAGAAAATTTCATCGAACAATCCATGCTACATGTGTGCAAGAATGAGAAGAGGAGCACTTTATTCCAAAGCAA
AAGAGCTCGGCTGTAACAAAATGGCATTAGGACATCACTTTGATGATGTTATAGAGACTATTTTATTGAATGTTTTGTGT
TCTGGAAATTACAAAACAATGATGCCAAAACTTCATTCGAATAATTTTGAAGGAATTGAACTTATCAGACCGATGTATTT
GATTAGAGAAGAATCTGTAAAAAGTTGGTTGAATTATTCAGGATTAAAAGCATTAGATTGTGCTTGTTCTGTAACTAAAA
AAACAGAAGGATCCATGAGAAAACAAATTAAACTATTAATTGCAGAACTTTCAGATAGAGGATTTACGAATGTAGAAAAT
TCGATTTTTAAATCTAGTGAAAATGTTGATGTATCCAGAATACTTGGGTATGAATATAATGGAGAAAAGCATAACTTTTT
GGATACTTATGGTGAAAATGATTTATAA

Upstream 100 bases:

>100_bases
TTGAAAAGTTTAGGACTTGATGTTGGAGAATCTGTAACTTTGGAAGTTGCAGAAAGATACAGTCCTAGTAACATAGTGGA
TTTAGAAAAAATGGAGATAT

Downstream 100 bases:

>100_bases
TCGTTAATTTATAGGAGGAAATATGGGAGTAGAACCAATTAAAATCCAAGAAAATTTGTATTACTTGGGTGTAAACGACA
GACAGACAGAATTTTTTGAG

Product: PP family ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MQRTVQEVERAIIKKYRKHIWSKFIKAIKEYDLIQDGDKIAVCMSGGKDSLLLAKLFQELQKHGMNNFDLEFIAMNPGYS
EENTRLEKENFEKLNIPYHMYDTDVFSVSEKISSNNPCYMCARMRRGALYSKAKELGCNKMALGHHFDDVIETILLNVLC
SGNYKTMMPKLHSNNFEGIELIRPMYLIREESVKSWLNYSGLKALDCACSVTKKTEGSMRKQIKLLIAELSDRGFTNVEN
SIFKSSENVDVSRILGYEYNGEKHNFLDTYGENDL

Sequences:

>Translated_275_residues
MQRTVQEVERAIIKKYRKHIWSKFIKAIKEYDLIQDGDKIAVCMSGGKDSLLLAKLFQELQKHGMNNFDLEFIAMNPGYS
EENTRLEKENFEKLNIPYHMYDTDVFSVSEKISSNNPCYMCARMRRGALYSKAKELGCNKMALGHHFDDVIETILLNVLC
SGNYKTMMPKLHSNNFEGIELIRPMYLIREESVKSWLNYSGLKALDCACSVTKKTEGSMRKQIKLLIAELSDRGFTNVEN
SIFKSSENVDVSRILGYEYNGEKHNFLDTYGENDL
>Mature_275_residues
MQRTVQEVERAIIKKYRKHIWSKFIKAIKEYDLIQDGDKIAVCMSGGKDSLLLAKLFQELQKHGMNNFDLEFIAMNPGYS
EENTRLEKENFEKLNIPYHMYDTDVFSVSEKISSNNPCYMCARMRRGALYSKAKELGCNKMALGHHFDDVIETILLNVLC
SGNYKTMMPKLHSNNFEGIELIRPMYLIREESVKSWLNYSGLKALDCACSVTKKTEGSMRKQIKLLIAELSDRGFTNVEN
SIFKSSENVDVSRILGYEYNGEKHNFLDTYGENDL

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) [H]

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family [H]

Homologues:

Organism=Escherichia coli, GI1787606, Length=261, Percent_Identity=30.2681992337165, Blast_Score=133, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI193211090, Length=217, Percent_Identity=30.8755760368664, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17540090, Length=143, Percent_Identity=30.0699300699301, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24651972, Length=255, Percent_Identity=26.2745098039216, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063 [H]

Pfam domain/function: PF01171 ATP_bind_3 [H]

EC number: NA

Molecular weight: Translated: 31740; Mature: 31740

Theoretical pI: Translated: 7.46; Mature: 7.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRTVQEVERAIIKKYRKHIWSKFIKAIKEYDLIQDGDKIAVCMSGGKDSLLLAKLFQEL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHH
QKHGMNNFDLEFIAMNPGYSEENTRLEKENFEKLNIPYHMYDTDVFSVSEKISSNNPCYM
HHCCCCCCCEEEEEECCCCCCCCCCCCHHCCCEECCCEEEECCHHHHHHHHHCCCCCEEE
CARMRRGALYSKAKELGCNKMALGHHFDDVIETILLNVLCSGNYKTMMPKLHSNNFEGIE
HHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHCCCCHHHCCHHCCCCCCHHH
LIRPMYLIREESVKSWLNYSGLKALDCACSVTKKTEGSMRKQIKLLIAELSDRGFTNVEN
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
SIFKSSENVDVSRILGYEYNGEKHNFLDTYGENDL
HHHCCCCCCCHHHHHCCCCCCCCCCCHHCCCCCCC
>Mature Secondary Structure
MQRTVQEVERAIIKKYRKHIWSKFIKAIKEYDLIQDGDKIAVCMSGGKDSLLLAKLFQEL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHH
QKHGMNNFDLEFIAMNPGYSEENTRLEKENFEKLNIPYHMYDTDVFSVSEKISSNNPCYM
HHCCCCCCCEEEEEECCCCCCCCCCCCHHCCCEECCCEEEECCHHHHHHHHHCCCCCEEE
CARMRRGALYSKAKELGCNKMALGHHFDDVIETILLNVLCSGNYKTMMPKLHSNNFEGIE
HHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHCCCCHHHCCHHCCCCCCHHH
LIRPMYLIREESVKSWLNYSGLKALDCACSVTKKTEGSMRKQIKLLIAELSDRGFTNVEN
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
SIFKSSENVDVSRILGYEYNGEKHNFLDTYGENDL
HHHCCCCCCCHHHHHCCCCCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA