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The map label for this gene is clcA [H]

Identifier: 169824143

GI number: 169824143

Start: 504232

End: 505770

Strand: Direct

Name: clcA [H]

Synonym: FMG_0446

Alternate gene names: 169824143

Gene position: 504232-505770 (Clockwise)

Preceding gene: 169824142

Following gene: 169824144

Centisome position: 28.05

GC content: 33.33

Gene sequence:

>1539_bases
ATGAATAAAAAGTTTAAAATAGGATCTTCGATGTCGCTTTTCTTAGCAAGTTTATCCATAGGAGTATTTTCAGGTGGATT
GGCTGTTTTTTACAGATTTTTGCTAAGTAAATTAGAAGTGGTTAGAAATACTATTTACTCAAACAACAGTTTTCCAAGAG
CAATTTTGATTATTGCAGTATCATTTGTACTTGGAATTTGTGTTAGTAAATTACTTAAATGGGCTCCATTATCGGGTGGT
AGTGGTATTCCACAAGTTCAAGGAGAACTTATTGGAGCTTTTAATCAAAATAGTTTCAGAGTTACTGTATCCAAAATTGT
TGGAGGTGCGATTGCATCGTTAGTGGGACTTTCTTTGGGAAGAGAAGGCCCATCAATACAATTGGGAGCAAGCAGTGCGA
AGTGGCTTTCTGAAAAATTTGGAAAAAGCAAAACAGAAGAAAAATTGTACTTGACTGCAGGAGCTGCGGCGGGGCTTTCG
GCTGCATTCTCGGCGCCGATTTCTGGGCTTGTGTTTATACTGGAAGAACTTCATAAATCTTTCTCGAAAAAAGTTGTTGC
AATTAGCTTTTCAGCAGCGGTAATTGCAGATGTTATTGCAGTTTGGGTTTTCAAAATAAAACCAGTGTTTTCTTTTGGAA
TGACACATGTTCTTCCTACAAAATATTATTTGTTGATTTTCCCAATGATAATTATTTGCTCTGTTGTTGGGAAATTATTC
AACTGTTCAATAACATTTTTCCAAGATATATTTGCAAAGATTAAGCTAGAACAAGATATAAAAATTGCGATATTTTTTGC
ATTTGTTTCAGTTGTTGGATTATTTTATAAAGATATTTTAGGTGGTGGACATTCTTTCATAGAAAATATGGCAACACACA
ATTACAATTCATTTTTTGTTTTGATAATACTTTTATTGTTCAAAATGTTTATGACATCGACATCTTATGCAACAGGAACT
CAAGGTGGTATTTTCTTGCCTGTTTTAGTATTAGGTGGAATTACTGGGTTGTTTTATTTTAATTTAATGAGTGCGTTTGG
ATTCGTACAAGATGTTTATTTATCAAATTTTGTTGTTCTCGCTATGGTTTGCGTTTTAACAGCTGTTGTTAGAAGTCCAC
TGTTGAGTGTTGTCTTGGTATTGGAATTAAATGGTAACATGACACATTTATTGGGACTGGCATTTTGTTCAATCATGGCA
TATTTTATATGCAAGGCGTTGGATTTCGAACCAATTTACGATATTTTGTTGAAGAGAATGTTGAATAAAAGAGTCGAAGG
GAATGGTGTAAACGACGAATTCACAATGTTCGATATAAAACTTGGGTATAATAATGGTGTTTCCAACAAAAAAATCAAAG
ATATTGATTTTCCAAAAGATGCATTGATTGCTGAAGTGGATTCAAATGGAGAAAAATACGTTCCAAATGGAGATAGCGTA
CTAAAAACAGGAGATATTGTCACTGTTTTAGTAAAAGATGAACAACTTTACGATACTAGAATGAAAGTTCTCGAAGTTTT
TGGAGAAAATAATGGATAA

Upstream 100 bases:

>100_bases
AAGAAAATAATTTGATAGAAGGCGAAGGAATTGATACATATATTTCAGTTACATATAATATCGACAGATTTAGAGAATTT
TTAGAAAGCGTGATTATTTA

Downstream 100 bases:

>100_bases
AATAAAAGAAAACTTGAACTATATATTGCTTGCGATAGTTGCACTTCTCGTATGTATCTTGGTAGTAATGATGTTTTCTA
AGAAAAATGTCTACACTATT

Product: chloride channel protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MNKKFKIGSSMSLFLASLSIGVFSGGLAVFYRFLLSKLEVVRNTIYSNNSFPRAILIIAVSFVLGICVSKLLKWAPLSGG
SGIPQVQGELIGAFNQNSFRVTVSKIVGGAIASLVGLSLGREGPSIQLGASSAKWLSEKFGKSKTEEKLYLTAGAAAGLS
AAFSAPISGLVFILEELHKSFSKKVVAISFSAAVIADVIAVWVFKIKPVFSFGMTHVLPTKYYLLIFPMIIICSVVGKLF
NCSITFFQDIFAKIKLEQDIKIAIFFAFVSVVGLFYKDILGGGHSFIENMATHNYNSFFVLIILLLFKMFMTSTSYATGT
QGGIFLPVLVLGGITGLFYFNLMSAFGFVQDVYLSNFVVLAMVCVLTAVVRSPLLSVVLVLELNGNMTHLLGLAFCSIMA
YFICKALDFEPIYDILLKRMLNKRVEGNGVNDEFTMFDIKLGYNNGVSNKKIKDIDFPKDALIAEVDSNGEKYVPNGDSV
LKTGDIVTVLVKDEQLYDTRMKVLEVFGENNG

Sequences:

>Translated_512_residues
MNKKFKIGSSMSLFLASLSIGVFSGGLAVFYRFLLSKLEVVRNTIYSNNSFPRAILIIAVSFVLGICVSKLLKWAPLSGG
SGIPQVQGELIGAFNQNSFRVTVSKIVGGAIASLVGLSLGREGPSIQLGASSAKWLSEKFGKSKTEEKLYLTAGAAAGLS
AAFSAPISGLVFILEELHKSFSKKVVAISFSAAVIADVIAVWVFKIKPVFSFGMTHVLPTKYYLLIFPMIIICSVVGKLF
NCSITFFQDIFAKIKLEQDIKIAIFFAFVSVVGLFYKDILGGGHSFIENMATHNYNSFFVLIILLLFKMFMTSTSYATGT
QGGIFLPVLVLGGITGLFYFNLMSAFGFVQDVYLSNFVVLAMVCVLTAVVRSPLLSVVLVLELNGNMTHLLGLAFCSIMA
YFICKALDFEPIYDILLKRMLNKRVEGNGVNDEFTMFDIKLGYNNGVSNKKIKDIDFPKDALIAEVDSNGEKYVPNGDSV
LKTGDIVTVLVKDEQLYDTRMKVLEVFGENNG
>Mature_512_residues
MNKKFKIGSSMSLFLASLSIGVFSGGLAVFYRFLLSKLEVVRNTIYSNNSFPRAILIIAVSFVLGICVSKLLKWAPLSGG
SGIPQVQGELIGAFNQNSFRVTVSKIVGGAIASLVGLSLGREGPSIQLGASSAKWLSEKFGKSKTEEKLYLTAGAAAGLS
AAFSAPISGLVFILEELHKSFSKKVVAISFSAAVIADVIAVWVFKIKPVFSFGMTHVLPTKYYLLIFPMIIICSVVGKLF
NCSITFFQDIFAKIKLEQDIKIAIFFAFVSVVGLFYKDILGGGHSFIENMATHNYNSFFVLIILLLFKMFMTSTSYATGT
QGGIFLPVLVLGGITGLFYFNLMSAFGFVQDVYLSNFVVLAMVCVLTAVVRSPLLSVVLVLELNGNMTHLLGLAFCSIMA
YFICKALDFEPIYDILLKRMLNKRVEGNGVNDEFTMFDIKLGYNNGVSNKKIKDIDFPKDALIAEVDSNGEKYVPNGDSV
LKTGDIVTVLVKDEQLYDTRMKVLEVFGENNG

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786350, Length=435, Percent_Identity=27.1264367816092, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI87081943, Length=304, Percent_Identity=25.9868421052632, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24665008, Length=410, Percent_Identity=25.3658536585366, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 55888; Mature: 55888

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKFKIGSSMSLFLASLSIGVFSGGLAVFYRFLLSKLEVVRNTIYSNNSFPRAILIIAV
CCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
SFVLGICVSKLLKWAPLSGGSGIPQVQGELIGAFNQNSFRVTVSKIVGGAIASLVGLSLG
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHC
REGPSIQLGASSAKWLSEKFGKSKTEEKLYLTAGAAAGLSAAFSAPISGLVFILEELHKS
CCCCCEEECCCHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHCCHHHHHHHHHHHHHH
FSKKVVAISFSAAVIADVIAVWVFKIKPVFSFGMTHVLPTKYYLLIFPMIIICSVVGKLF
HCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
NCSITFFQDIFAKIKLEQDIKIAIFFAFVSVVGLFYKDILGGGHSFIENMATHNYNSFFV
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHH
LIILLLFKMFMTSTSYATGTQGGIFLPVLVLGGITGLFYFNLMSAFGFVQDVYLSNFVVL
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMVCVLTAVVRSPLLSVVLVLELNGNMTHLLGLAFCSIMAYFICKALDFEPIYDILLKRM
HHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LNKRVEGNGVNDEFTMFDIKLGYNNGVSNKKIKDIDFPKDALIAEVDSNGEKYVPNGDSV
HHCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCHHHEEEECCCCCEECCCCCCE
LKTGDIVTVLVKDEQLYDTRMKVLEVFGENNG
EECCCEEEEEEECCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNKKFKIGSSMSLFLASLSIGVFSGGLAVFYRFLLSKLEVVRNTIYSNNSFPRAILIIAV
CCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
SFVLGICVSKLLKWAPLSGGSGIPQVQGELIGAFNQNSFRVTVSKIVGGAIASLVGLSLG
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHC
REGPSIQLGASSAKWLSEKFGKSKTEEKLYLTAGAAAGLSAAFSAPISGLVFILEELHKS
CCCCCEEECCCHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHCCHHHHHHHHHHHHHH
FSKKVVAISFSAAVIADVIAVWVFKIKPVFSFGMTHVLPTKYYLLIFPMIIICSVVGKLF
HCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
NCSITFFQDIFAKIKLEQDIKIAIFFAFVSVVGLFYKDILGGGHSFIENMATHNYNSFFV
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHH
LIILLLFKMFMTSTSYATGTQGGIFLPVLVLGGITGLFYFNLMSAFGFVQDVYLSNFVVL
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMVCVLTAVVRSPLLSVVLVLELNGNMTHLLGLAFCSIMAYFICKALDFEPIYDILLKRM
HHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LNKRVEGNGVNDEFTMFDIKLGYNNGVSNKKIKDIDFPKDALIAEVDSNGEKYVPNGDSV
HHCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCHHHEEEECCCCCEECCCCCCE
LKTGDIVTVLVKDEQLYDTRMKVLEVFGENNG
EECCCEEEEEEECCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA