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The map label for this gene is apt

Identifier: 169824094

GI number: 169824094

Start: 454325

End: 454843

Strand: Direct

Name: apt

Synonym: FMG_0397

Alternate gene names: 169824094

Gene position: 454325-454843 (Clockwise)

Preceding gene: 169824092

Following gene: 169824096

Centisome position: 25.27

GC content: 33.72

Gene sequence:

>519_bases
ATGGAATTAAAAGAAAAAATTAGAGTTATAGATGGATTTCCAAAAGAAGGAATTTCATTCAAAGATATTACTACATTATT
AAACGACAAAGATGCATACAAATACGCAGTAGATCTTATGGTAGATGATTTAAAAGATAAAGGTATTACCGCAATAGCAG
CTCCAGAAGCTAGGGGATTTTTATTTGGATCAGCTGTTGCATATGCTCTTGGAGTTAGATTTATTCCAGTAAGAAAACCT
GGAAAGCTTCCTGGTGAAGTTTCAGAATATTCTTATGATTTGGAATATGGTACTGACAAGTTAGAAGTTCACAGAGATGC
AATTAAAAAAGGTGACAAGGTTGCTATCGTTGACGATTTATTGGCAACAGGTGGTACTGTGAATGCAGTAGCTAAGTTAA
TTGAAAAAAACGGCGGCGAAATCACTGCTATGGAATTTTTGATTGAACTTACTGAACTTGGCGGAAGAGATATCAACAAA
AATTATTACATCAACACTTTAGTACAATACGAATCATAA

Upstream 100 bases:

>100_bases
AATGATTTGCAAAACTAAAGAAGATTTAACAACAAACAAATCTCACAATATGGTATACTATATATGTAGATAATACAGTA
AAAAAGAAACGGTGATGAAA

Downstream 100 bases:

>100_bases
AATTATATCCACATGATAAGCATGTGGATTTTTTATTGTAAAAAAGCACAACCTTTAATCAAAGGTTGTGCTAGATTGAT
TATTTACTTTGCATTAATAA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 172; Mature: 172

Protein sequence:

>172_residues
MELKEKIRVIDGFPKEGISFKDITTLLNDKDAYKYAVDLMVDDLKDKGITAIAAPEARGFLFGSAVAYALGVRFIPVRKP
GKLPGEVSEYSYDLEYGTDKLEVHRDAIKKGDKVAIVDDLLATGGTVNAVAKLIEKNGGEITAMEFLIELTELGGRDINK
NYYINTLVQYES

Sequences:

>Translated_172_residues
MELKEKIRVIDGFPKEGISFKDITTLLNDKDAYKYAVDLMVDDLKDKGITAIAAPEARGFLFGSAVAYALGVRFIPVRKP
GKLPGEVSEYSYDLEYGTDKLEVHRDAIKKGDKVAIVDDLLATGGTVNAVAKLIEKNGGEITAMEFLIELTELGGRDINK
NYYINTLVQYES
>Mature_172_residues
MELKEKIRVIDGFPKEGISFKDITTLLNDKDAYKYAVDLMVDDLKDKGITAIAAPEARGFLFGSAVAYALGVRFIPVRKP
GKLPGEVSEYSYDLEYGTDKLEVHRDAIKKGDKVAIVDDLLATGGTVNAVAKLIEKNGGEITAMEFLIELTELGGRDINK
NYYINTLVQYES

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=172, Percent_Identity=40.6976744186046, Blast_Score=133, Evalue=7e-32,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=42.4, Blast_Score=103, Evalue=5e-23,
Organism=Escherichia coli, GI1786675, Length=153, Percent_Identity=58.1699346405229, Blast_Score=181, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17509087, Length=173, Percent_Identity=42.7745664739884, Blast_Score=139, Evalue=9e-34,
Organism=Saccharomyces cerevisiae, GI6323619, Length=160, Percent_Identity=40, Blast_Score=105, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6320649, Length=160, Percent_Identity=36.25, Blast_Score=86, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17136334, Length=170, Percent_Identity=43.5294117647059, Blast_Score=124, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_FINM2 (B0S0M3)

Other databases:

- EMBL:   AP008971
- RefSeq:   YP_001691705.1
- ProteinModelPortal:   B0S0M3
- SMR:   B0S0M3
- GeneID:   6019385
- GenomeReviews:   AP008971_GR
- KEGG:   fma:FMG_0397
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- BioCyc:   FMAG334413:FMG_0397-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18970; Mature: 18970

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELKEKIRVIDGFPKEGISFKDITTLLNDKDAYKYAVDLMVDDLKDKGITAIAAPEARGF
CCHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCH
LFGSAVAYALGVRFIPVRKPGKLPGEVSEYSYDLEYGTDKLEVHRDAIKKGDKVAIVDDL
HHHHHHHHHHCCEEEECCCCCCCCCCHHHEEEECCCCCCHHHHHHHHHHCCCEEEEEHHH
LATGGTVNAVAKLIEKNGGEITAMEFLIELTELGGRDINKNYYINTLVQYES
HHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEEECC
>Mature Secondary Structure
MELKEKIRVIDGFPKEGISFKDITTLLNDKDAYKYAVDLMVDDLKDKGITAIAAPEARGF
CCHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCH
LFGSAVAYALGVRFIPVRKPGKLPGEVSEYSYDLEYGTDKLEVHRDAIKKGDKVAIVDDL
HHHHHHHHHHCCEEEECCCCCCCCCCHHHEEEECCCCCCHHHHHHHHHHCCCEEEEEHHH
LATGGTVNAVAKLIEKNGGEITAMEFLIELTELGGRDINKNYYINTLVQYES
HHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA