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The map label for this gene is fabR [H]

Identifier: 167626060

GI number: 167626060

Start: 5056491

End: 5057168

Strand: Reverse

Name: fabR [H]

Synonym: Shal_4155

Alternate gene names: 167626060

Gene position: 5057168-5056491 (Counterclockwise)

Preceding gene: 167626064

Following gene: 167626058

Centisome position: 96.75

GC content: 46.02

Gene sequence:

>678_bases
ATGCTGCGTTTTGTATTAAAAAGCGGTATTATTCAAGGAATAATTTTCGTAAGTAGGTTCAACATGGGCATTAGAGCACA
ACAAAAAGAAAAGACTCGGCGGGCACTTGTCGATGCGGCGTTTAATCAATTAAGCGCAGAACGTAGCTTTTCTAGTCTGA
GTCTGCGCGAAGTAGCCCGTGAGGCAAATATTGCTCCAACATCTTTCTATCGCCACTTTAAAGATATGAATGAGCTGGGC
TTAACCATGGTTGATGAGGGTGGCTTAACCCTAAGGCAGATGATGCGTAAAGGCCGTCAACGTGCTGAGGCCGGCGGTAG
TGTTATTCGCATTTCGGTTGAAACCTTTATGGAAGTGCTAGAGTCAAACCCAAACGTGTTTCGTATTCTACTGCACGAGC
GTTCAGGGACATCAGCGCCTTTTAGAGGTGCTGTAGCGCGTGAGATTGAACATTTTATTTCGGAATTGGCCCATTACACC
GAAGCGACGGCAAATAGGACACCGGACTTGGCTCATGCTCAAGCTGAAGCGTTAGTGACTTTGGTATTTAATGCGGGGGC
CGCAGCTCTAGATATGAAACGTGCCGATCGCAAGATCTTAGCTGATAGGTTAGTTATTCAGTTACGTATGATAGCGATGG
GATCTGAGGCGTTACAACAGAAGATGGATAGTCGTTAG

Upstream 100 bases:

>100_bases
CAGATGATGGGAGGTTTTTTCATTATAGTTTTAAATCCCTTGTTGAGCGTACATCTGTACGCTAATTTAGCTTGGATAGT
GATCTGGGTCAAGTTTGTAG

Downstream 100 bases:

>100_bases
ATTTTAAATCGTTACACATGCTTGTGAACTGCCATTAAGTCCTGAATCGCTAACTGGATTTTAGCTTTTTAGCGACATGG
TATCGTTGATGAGACAAAAA

Product: DNA-binding transcriptional repressor FabR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MLRFVLKSGIIQGIIFVSRFNMGIRAQQKEKTRRALVDAAFNQLSAERSFSSLSLREVAREANIAPTSFYRHFKDMNELG
LTMVDEGGLTLRQMMRKGRQRAEAGGSVIRISVETFMEVLESNPNVFRILLHERSGTSAPFRGAVAREIEHFISELAHYT
EATANRTPDLAHAQAEALVTLVFNAGAAALDMKRADRKILADRLVIQLRMIAMGSEALQQKMDSR

Sequences:

>Translated_225_residues
MLRFVLKSGIIQGIIFVSRFNMGIRAQQKEKTRRALVDAAFNQLSAERSFSSLSLREVAREANIAPTSFYRHFKDMNELG
LTMVDEGGLTLRQMMRKGRQRAEAGGSVIRISVETFMEVLESNPNVFRILLHERSGTSAPFRGAVAREIEHFISELAHYT
EATANRTPDLAHAQAEALVTLVFNAGAAALDMKRADRKILADRLVIQLRMIAMGSEALQQKMDSR
>Mature_225_residues
MLRFVLKSGIIQGIIFVSRFNMGIRAQQKEKTRRALVDAAFNQLSAERSFSSLSLREVAREANIAPTSFYRHFKDMNELG
LTMVDEGGLTLRQMMRKGRQRAEAGGSVIRISVETFMEVLESNPNVFRILLHERSGTSAPFRGAVAREIEHFISELAHYT
EATANRTPDLAHAQAEALVTLVFNAGAAALDMKRADRKILADRLVIQLRMIAMGSEALQQKMDSR

Specific function: Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, fabR directly influences the physical properties of the membrane bilayer [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI145693209, Length=194, Percent_Identity=69.0721649484536, Blast_Score=267, Evalue=5e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 25211; Mature: 25211

Theoretical pI: Translated: 10.78; Mature: 10.78

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRFVLKSGIIQGIIFVSRFNMGIRAQQKEKTRRALVDAAFNQLSAERSFSSLSLREVAR
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EANIAPTSFYRHFKDMNELGLTMVDEGGLTLRQMMRKGRQRAEAGGSVIRISVETFMEVL
HCCCCHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHH
ESNPNVFRILLHERSGTSAPFRGAVAREIEHFISELAHYTEATANRTPDLAHAQAEALVT
HCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LVFNAGAAALDMKRADRKILADRLVIQLRMIAMGSEALQQKMDSR
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCC
>Mature Secondary Structure
MLRFVLKSGIIQGIIFVSRFNMGIRAQQKEKTRRALVDAAFNQLSAERSFSSLSLREVAR
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EANIAPTSFYRHFKDMNELGLTMVDEGGLTLRQMMRKGRQRAEAGGSVIRISVETFMEVL
HCCCCHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHH
ESNPNVFRILLHERSGTSAPFRGAVAREIEHFISELAHYTEATANRTPDLAHAQAEALVT
HCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LVFNAGAAALDMKRADRKILADRLVIQLRMIAMGSEALQQKMDSR
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA