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The map label for this gene is glxR [C]

Identifier: 167623712

GI number: 167623712

Start: 2132568

End: 2133443

Strand: Direct

Name: glxR [C]

Synonym: Shal_1782

Alternate gene names: 167623712

Gene position: 2132568-2133443 (Clockwise)

Preceding gene: 167623711

Following gene: 167623715

Centisome position: 40.8

GC content: 49.32

Gene sequence:

>876_bases
ATGGCTAAGGTTGCGTTTATAGGTTTAGGTGTGATGGGTTATCCCATGGCTGGTCATTTAGTTAAGCATGGTCATCAGGT
TACGGTTTATAACCGTACTGAAGCAAAAGCTAAGGCTTGGACTAAAGAGTTTTGCGGTGAGTATCAGCTTACCCCTAGAG
AGGCCGCAGTCGGCCAAGATATGGTTTTCATCTGTGTCGGTAATGATGATGATCTGCGCCAAGTGACTCTGGGTGATAAC
GGTGTATTGGCGGGAATGAGTACAGGGAGTATTTTGGTTGACCATACCACCGCATCTGCCGATGTGGCTCGAGAGATCGC
AGCTATTGCTAAGCCATTAGATATAGGCTTTATCGATGCTCCGGTATCGGGCGGACAAGCTGGCGCCGAAAACGGCGTAC
TGACTGTGATGGCGGGAGGCGAGCAAGCAACGTTTGAGCGGGCTAAGCCTGTTATTGACTCTTATGCGCGATGCGTGGAG
CTGCTAGGCGAGGTTGGTGCGGGACAGCTTACTAAGATGGTTAATCAAATTTGTATTGCTGGTGTGGTTCAGGGGCTTGC
TGAGGGCCTTCATTTTGCTCGAAGTGCCGGGTTAGACGGTGAAAAAGTTGTAGAAGTGATCAGTAAAGGCGCGGCGCAAT
CTTGGCAGATGGAAAACCGTTATCAAACCATGTGGAAAGGCGAATACGATTTTGGCTTTGCCGTAGATTGGATGCGTAAA
GACTTAGGCATCGCGCTTGAAGAAGCTCGTCGCAATGGCTCACATCTGCCTTTAACGGCACTGGTCGATCAGTTTTACTC
AGAAGTGCAGTCCATCGGTGGTAAGCGTTGGGATACGTCTAGCTTACTAGCCAAGCTTGAGAAGAATCGAGGTTAA

Upstream 100 bases:

>100_bases
AGCCCTCGGGCTAGCTTTTTTATTGCCTCAATAAAGTTGTTTTCTATCACTTCTAGCCTTTAGAATGGGGCAAAAAATAT
TCCCTACAATAGGAGATAAA

Downstream 100 bases:

>100_bases
GATTCTAGTTTAAAGTAACCAATAAAAAAGGACCATTTATATGGTCCTTTTTAGTCACACAAGCCTAGCCGTCCTGAGGT
CAGTTACTCAGGCTCTACAA

Product: 6-phosphogluconate dehydrogenase

Products: 2-methyl-3-oxopropanoate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MAKVAFIGLGVMGYPMAGHLVKHGHQVTVYNRTEAKAKAWTKEFCGEYQLTPREAAVGQDMVFICVGNDDDLRQVTLGDN
GVLAGMSTGSILVDHTTASADVAREIAAIAKPLDIGFIDAPVSGGQAGAENGVLTVMAGGEQATFERAKPVIDSYARCVE
LLGEVGAGQLTKMVNQICIAGVVQGLAEGLHFARSAGLDGEKVVEVISKGAAQSWQMENRYQTMWKGEYDFGFAVDWMRK
DLGIALEEARRNGSHLPLTALVDQFYSEVQSIGGKRWDTSSLLAKLEKNRG

Sequences:

>Translated_291_residues
MAKVAFIGLGVMGYPMAGHLVKHGHQVTVYNRTEAKAKAWTKEFCGEYQLTPREAAVGQDMVFICVGNDDDLRQVTLGDN
GVLAGMSTGSILVDHTTASADVAREIAAIAKPLDIGFIDAPVSGGQAGAENGVLTVMAGGEQATFERAKPVIDSYARCVE
LLGEVGAGQLTKMVNQICIAGVVQGLAEGLHFARSAGLDGEKVVEVISKGAAQSWQMENRYQTMWKGEYDFGFAVDWMRK
DLGIALEEARRNGSHLPLTALVDQFYSEVQSIGGKRWDTSSLLAKLEKNRG
>Mature_290_residues
AKVAFIGLGVMGYPMAGHLVKHGHQVTVYNRTEAKAKAWTKEFCGEYQLTPREAAVGQDMVFICVGNDDDLRQVTLGDNG
VLAGMSTGSILVDHTTASADVAREIAAIAKPLDIGFIDAPVSGGQAGAENGVLTVMAGGEQATFERAKPVIDSYARCVEL
LGEVGAGQLTKMVNQICIAGVVQGLAEGLHFARSAGLDGEKVVEVISKGAAQSWQMENRYQTMWKGEYDFGFAVDWMRKD
LGIALEEARRNGSHLPLTALVDQFYSEVQSIGGKRWDTSSLLAKLEKNRG

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=280, Percent_Identity=27.5, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI23308751, Length=299, Percent_Identity=29.7658862876254, Blast_Score=129, Evalue=3e-30,
Organism=Escherichia coli, GI1786719, Length=286, Percent_Identity=33.5664335664336, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI145693186, Length=294, Percent_Identity=33.6734693877551, Blast_Score=161, Evalue=5e-41,
Organism=Escherichia coli, GI1790315, Length=296, Percent_Identity=29.7297297297297, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1789092, Length=285, Percent_Identity=33.3333333333333, Blast_Score=111, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17557316, Length=274, Percent_Identity=28.8321167883212, Blast_Score=114, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24655230, Length=295, Percent_Identity=28.8135593220339, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI19922568, Length=295, Percent_Identity=28.8135593220339, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI28574115, Length=281, Percent_Identity=23.8434163701068, Blast_Score=111, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: 1.1.1.31

Molecular weight: Translated: 31212; Mature: 31081

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVAFIGLGVMGYPMAGHLVKHGHQVTVYNRTEAKAKAWTKEFCGEYQLTPREAAVGQD
CCEEEEEECCHHCCCHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCCCCCCCHHHHCCCC
MVFICVGNDDDLRQVTLGDNGVLAGMSTGSILVDHTTASADVAREIAAIAKPLDIGFIDA
EEEEEECCCCCCEEEEECCCCEEEECCCCCEEEECCCCHHHHHHHHHHHHCCCCCCEEEC
PVSGGQAGAENGVLTVMAGGEQATFERAKPVIDSYARCVELLGEVGAGQLTKMVNQICIA
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
GVVQGLAEGLHFARSAGLDGEKVVEVISKGAAQSWQMENRYQTMWKGEYDFGFAVDWMRK
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
DLGIALEEARRNGSHLPLTALVDQFYSEVQSIGGKRWDTSSLLAKLEKNRG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
AKVAFIGLGVMGYPMAGHLVKHGHQVTVYNRTEAKAKAWTKEFCGEYQLTPREAAVGQD
CEEEEEECCHHCCCHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCCCCCCCHHHHCCCC
MVFICVGNDDDLRQVTLGDNGVLAGMSTGSILVDHTTASADVAREIAAIAKPLDIGFIDA
EEEEEECCCCCCEEEEECCCCEEEECCCCCEEEECCCCHHHHHHHHHHHHCCCCCCEEEC
PVSGGQAGAENGVLTVMAGGEQATFERAKPVIDSYARCVELLGEVGAGQLTKMVNQICIA
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
GVVQGLAEGLHFARSAGLDGEKVVEVISKGAAQSWQMENRYQTMWKGEYDFGFAVDWMRK
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
DLGIALEEARRNGSHLPLTALVDQFYSEVQSIGGKRWDTSSLLAKLEKNRG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-hydroxy-2-methylpropanoate; NAD+

Specific reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA