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The map label for this gene is apt

Identifier: 167623520

GI number: 167623520

Start: 1905624

End: 1906175

Strand: Direct

Name: apt

Synonym: Shal_1589

Alternate gene names: 167623520

Gene position: 1905624-1906175 (Clockwise)

Preceding gene: 167623519

Following gene: 167623521

Centisome position: 36.46

GC content: 43.48

Gene sequence:

>552_bases
ATGGTAATGAATACTGACAGCTTGGCACTAATAAAGAACAGCATTAAAACCATCCCTAACTATCCTAAAGAGGGGATCTT
GTTTAGAGATGTGACTAGCTTATTAGAAGATCCACAAGCCTATAAACTCACCATTGGCCTTTTAGTGGAGCACTATAAAG
ATCAAGGCTTTACTAAAGTTGTCGGTACTGAAGCGCGCGGCTTTTTGTTTGGTGCGCCTTTAGCTCTAGAATTAGGTATT
GGCTTCGTGCCAGTTCGTAAGCCTGGTAAGCTACCAAGAGAAACGATTTCTGAGAGCTATGAGCTTGAATATGGTCATGA
CGTGCTAGAGATCCATGTTGATGCGATCAACGCCGAAGATAAGGTATTGGTTATCGATGACTTACTTGCAACTGGCGGCA
CTATCGAAGCGACAGTTAAACTTATTCGTCAGTTAGGCGGAAGTGTAAACGATGCCGCTTTCGTTATCTCATTGCCAGAC
CTTGGTGGTGAGCAGCGTCTTGAGAAGATGGATCTTAAGTTAGTGAGCCTTTGCGAATTCGAAGGCGAATAA

Upstream 100 bases:

>100_bases
AGCTTGATGCCGATTTTTACACTTCGATGACATCTATACTGGCATAATCAAATTTTTGGCTGGTGATGTCAGCAAACTAA
AGTAGATTAAGTAAAGAATT

Downstream 100 bases:

>100_bases
GCCATTAAGCAGCTGTCACTAGCAGCTGTGATAGAGAGTCGCACAAACTGTCGATTCTTTATCTTAAAAGGTGATTTAAT
CACCGCTAAATCGCTCCTCT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MVMNTDSLALIKNSIKTIPNYPKEGILFRDVTSLLEDPQAYKLTIGLLVEHYKDQGFTKVVGTEARGFLFGAPLALELGI
GFVPVRKPGKLPRETISESYELEYGHDVLEIHVDAINAEDKVLVIDDLLATGGTIEATVKLIRQLGGSVNDAAFVISLPD
LGGEQRLEKMDLKLVSLCEFEGE

Sequences:

>Translated_183_residues
MVMNTDSLALIKNSIKTIPNYPKEGILFRDVTSLLEDPQAYKLTIGLLVEHYKDQGFTKVVGTEARGFLFGAPLALELGI
GFVPVRKPGKLPRETISESYELEYGHDVLEIHVDAINAEDKVLVIDDLLATGGTIEATVKLIRQLGGSVNDAAFVISLPD
LGGEQRLEKMDLKLVSLCEFEGE
>Mature_183_residues
MVMNTDSLALIKNSIKTIPNYPKEGILFRDVTSLLEDPQAYKLTIGLLVEHYKDQGFTKVVGTEARGFLFGAPLALELGI
GFVPVRKPGKLPRETISESYELEYGHDVLEIHVDAINAEDKVLVIDDLLATGGTIEATVKLIRQLGGSVNDAAFVISLPD
LGGEQRLEKMDLKLVSLCEFEGE

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=182, Percent_Identity=40.1098901098901, Blast_Score=138, Evalue=2e-33,
Organism=Homo sapiens, GI71773201, Length=133, Percent_Identity=45.1127819548872, Blast_Score=121, Evalue=4e-28,
Organism=Escherichia coli, GI1786675, Length=183, Percent_Identity=73.7704918032787, Blast_Score=265, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI17509087, Length=173, Percent_Identity=42.1965317919075, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6323619, Length=161, Percent_Identity=42.2360248447205, Blast_Score=116, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6320649, Length=162, Percent_Identity=38.2716049382716, Blast_Score=98, Evalue=9e-22,
Organism=Drosophila melanogaster, GI17136334, Length=177, Percent_Identity=44.6327683615819, Blast_Score=137, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_SHEHH (B0TNZ8)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001673814.1
- ProteinModelPortal:   B0TNZ8
- SMR:   B0TNZ8
- GeneID:   5906009
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_1589
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   SHAL458817:SHAL_1589-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 20043; Mature: 20043

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMNTDSLALIKNSIKTIPNYPKEGILFRDVTSLLEDPQAYKLTIGLLVEHYKDQGFTKV
CCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCEEE
VGTEARGFLFGAPLALELGIGFVPVRKPGKLPRETISESYELEYGHDVLEIHVDAINAED
ECCCCCCEEEECCEEEEECCCEEECCCCCCCCHHHHCCCCCCCCCCEEEEEEEEEECCCC
KVLVIDDLLATGGTIEATVKLIRQLGGSVNDAAFVISLPDLGGEQRLEKMDLKLVSLCEF
CEEEEEHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCC
EGE
CCC
>Mature Secondary Structure
MVMNTDSLALIKNSIKTIPNYPKEGILFRDVTSLLEDPQAYKLTIGLLVEHYKDQGFTKV
CCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCEEE
VGTEARGFLFGAPLALELGIGFVPVRKPGKLPRETISESYELEYGHDVLEIHVDAINAED
ECCCCCCEEEECCEEEEECCCEEECCCCCCCCHHHHCCCCCCCCCCEEEEEEEEEECCCC
KVLVIDDLLATGGTIEATVKLIRQLGGSVNDAAFVISLPDLGGEQRLEKMDLKLVSLCEF
CEEEEEHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCC
EGE
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA