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The map label for this gene is phhA [H]

Identifier: 167623462

GI number: 167623462

Start: 1846792

End: 1847583

Strand: Direct

Name: phhA [H]

Synonym: Shal_1531

Alternate gene names: 167623462

Gene position: 1846792-1847583 (Clockwise)

Preceding gene: 167623457

Following gene: 167623463

Centisome position: 35.33

GC content: 45.58

Gene sequence:

>792_bases
ATGAGTAAACAACCAAATTACATAGCACACTTGCCTGATGCCGATGGGTATATTGATTACCCTCAACCAGAACATGATAT
TTGGTCTGAGCTGTATGCGCGGCAGCGGGTAAACCTTCCCGGTCGAGCCTGTCCAGAATATCTAGATGGTTTAGATAAGT
TGAGCTTACCAGTTGATAGAATCCCACAGTTGGCGCACATTGATAATGTGTTACAGCAAACCACGGGCTGGAAAACGTCA
GCGGTGCCTGCATTAATTTCATTTGGTGATTTTTTTCAGCTGCTTGCGAATAAGTCATTCCCTGTGGCGACCTTTATTCG
TCGTCGAGAGGAGTTTGAATACTTGCAAGAGCCTGACATTTTCCATGAAGTGTTTGGTCATTGTCCGTTGTTAACTAATC
CATCATTTGCTCATTTTTCTCATTTGTATGGACGGTTAGGGCTCGCAGCGAGTAGGGAGGAACGTGTCTTCTTAGCGAGA
CTTTATTGGTTTACCGTAGAGTTCGGTGTGCTGCGTTCATCCAGTAACCAACTGCGGATCTATGGTGGGGGGATCTTAAG
CTCTCCAGGGGAGACCCTGTTTGTGATGAGCGAAGAACCTGAGATAAGGCCATTTGATTTAGTCGATGTAATGCGCACGC
CTTACCGGATTGATATTATGCAGCCAATCTATTATGCAATTGAGAGTATCAGCGATTTAGGCGCGATAGCCGAGATGGAT
ATTATGGCTGCAGTTAAAGAGGCACAACAGTTGGGGCTGTTTAAACCGACATTCCCAGCTAAAGCGGGTTAA

Upstream 100 bases:

>100_bases
TTAGCTGGAAAATAAACCGTGATCTAGTTAACAAAACATTAGCTTTAGTTAAGTATGAAGTAAGAGCTTATCTTGCGTCT
TAGGACTATTACCTAGAATT

Downstream 100 bases:

>100_bases
GTAAAGAATCAGCCTTCAAATATTGAATGCTGAGTATTGAATAATAAATAACGAATCATTAAAGGAATAAAAATGACAGA
ATTAGCCCAGATGAAATGCG

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MSKQPNYIAHLPDADGYIDYPQPEHDIWSELYARQRVNLPGRACPEYLDGLDKLSLPVDRIPQLAHIDNVLQQTTGWKTS
AVPALISFGDFFQLLANKSFPVATFIRRREEFEYLQEPDIFHEVFGHCPLLTNPSFAHFSHLYGRLGLAASREERVFLAR
LYWFTVEFGVLRSSSNQLRIYGGGILSSPGETLFVMSEEPEIRPFDLVDVMRTPYRIDIMQPIYYAIESISDLGAIAEMD
IMAAVKEAQQLGLFKPTFPAKAG

Sequences:

>Translated_263_residues
MSKQPNYIAHLPDADGYIDYPQPEHDIWSELYARQRVNLPGRACPEYLDGLDKLSLPVDRIPQLAHIDNVLQQTTGWKTS
AVPALISFGDFFQLLANKSFPVATFIRRREEFEYLQEPDIFHEVFGHCPLLTNPSFAHFSHLYGRLGLAASREERVFLAR
LYWFTVEFGVLRSSSNQLRIYGGGILSSPGETLFVMSEEPEIRPFDLVDVMRTPYRIDIMQPIYYAIESISDLGAIAEMD
IMAAVKEAQQLGLFKPTFPAKAG
>Mature_262_residues
SKQPNYIAHLPDADGYIDYPQPEHDIWSELYARQRVNLPGRACPEYLDGLDKLSLPVDRIPQLAHIDNVLQQTTGWKTSA
VPALISFGDFFQLLANKSFPVATFIRRREEFEYLQEPDIFHEVFGHCPLLTNPSFAHFSHLYGRLGLAASREERVFLARL
YWFTVEFGVLRSSSNQLRIYGGGILSSPGETLFVMSEEPEIRPFDLVDVMRTPYRIDIMQPIYYAIESISDLGAIAEMDI
MAAVKEAQQLGLFKPTFPAKAG

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI88900503, Length=219, Percent_Identity=38.3561643835616, Blast_Score=143, Evalue=1e-34,
Organism=Homo sapiens, GI88900505, Length=219, Percent_Identity=38.3561643835616, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI88900501, Length=219, Percent_Identity=38.3561643835616, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI4557819, Length=219, Percent_Identity=36.0730593607306, Blast_Score=134, Evalue=8e-32,
Organism=Homo sapiens, GI4759248, Length=219, Percent_Identity=35.6164383561644, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI31795563, Length=219, Percent_Identity=33.3333333333333, Blast_Score=120, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI71980736, Length=224, Percent_Identity=33.9285714285714, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17531391, Length=218, Percent_Identity=36.697247706422, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI115533973, Length=223, Percent_Identity=31.8385650224215, Blast_Score=107, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI115532103, Length=223, Percent_Identity=31.8385650224215, Blast_Score=107, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI71980731, Length=155, Percent_Identity=32.9032258064516, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI17136774, Length=220, Percent_Identity=36.8181818181818, Blast_Score=140, Evalue=7e-34,
Organism=Drosophila melanogaster, GI17136776, Length=220, Percent_Identity=36.8181818181818, Blast_Score=140, Evalue=9e-34,
Organism=Drosophila melanogaster, GI24660393, Length=217, Percent_Identity=34.1013824884793, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI62472054, Length=217, Percent_Identity=34.1013824884793, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24654994, Length=219, Percent_Identity=32.8767123287671, Blast_Score=115, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 29891; Mature: 29760

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQPNYIAHLPDADGYIDYPQPEHDIWSELYARQRVNLPGRACPEYLDGLDKLSLPVDR
CCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHCCCCHHH
IPQLAHIDNVLQQTTGWKTSAVPALISFGDFFQLLANKSFPVATFIRRREEFEYLQEPDI
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHH
FHEVFGHCPLLTNPSFAHFSHLYGRLGLAASREERVFLARLYWFTVEFGVLRSSSNQLRI
HHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEE
YGGGILSSPGETLFVMSEEPEIRPFDLVDVMRTPYRIDIMQPIYYAIESISDLGAIAEMD
EECCEECCCCCEEEEECCCCCCCCHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHH
IMAAVKEAQQLGLFKPTFPAKAG
HHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SKQPNYIAHLPDADGYIDYPQPEHDIWSELYARQRVNLPGRACPEYLDGLDKLSLPVDR
CCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHCCCCHHH
IPQLAHIDNVLQQTTGWKTSAVPALISFGDFFQLLANKSFPVATFIRRREEFEYLQEPDI
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHH
FHEVFGHCPLLTNPSFAHFSHLYGRLGLAASREERVFLARLYWFTVEFGVLRSSSNQLRI
HHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEE
YGGGILSSPGETLFVMSEEPEIRPFDLVDVMRTPYRIDIMQPIYYAIESISDLGAIAEMD
EECCEECCCCCEEEEECCCCCCCCHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHH
IMAAVKEAQQLGLFKPTFPAKAG
HHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8108417; 10984043 [H]