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The map label for this gene is selA [H]

Identifier: 167622437

GI number: 167622437

Start: 598563

End: 600011

Strand: Direct

Name: selA [H]

Synonym: Shal_0497

Alternate gene names: 167622437

Gene position: 598563-600011 (Clockwise)

Preceding gene: 167622436

Following gene: 167622438

Centisome position: 11.45

GC content: 51.41

Gene sequence:

>1449_bases
ATGACTCAAGCTATCAACTCAACCCAAGCCCTCTACCGTTGTTTACCTGCAATGGACAGTTTGCTACTGATACCTCAAGT
GATACGTTTTACCGACCAACAGGGCAAGCCTTGGATTAAATCTTTATTAGCACAAATGCTCAAAGATGCGCGCCAGCAAA
TCGCAAAGAGTCGAAGCCTGCCAAGCTGGTGCTTGAATCAAACAAAGATAGTCACTGAGCTTGAGCGCAGGCTTGTTTTA
GCCCTGCGCCAAAGTATGACGCCGGTTTTCAACCTCACTGGCACCATATTGCATACCAACTTGGGGCGTTCGCAGATGTG
CGAAGCCGCTATCGATGCCGTGACTAAGGTGATGCGTCATCCGGTGCCGCTGGAGTTTGATATGGGCCAAGGTAAGCGTG
GCCACCGTGATAGCGCAATATCGGCGCTTATTCATGAGCTTACAGGCGCACAGAGTTGCTGCATCGTTAATAATAATGCC
GCTGCAGTGCTGTTGATGTTAGCCGCAACCTCGGCAGGCAAAGAGGTGATCGTCTCTCGCGGTGAACTGGTGGAGATTGG
CGGCGCATTTCGTATTCCCGACATTATGGCGCAGGCGGGTTGCAAGCTGGTGGAAGTGGGCTGCACTAATCGTACTCACC
TTAAAGATTACGCCGCAGCGATTACCGACAACACCGCCGCCATCATGAAGGTGCACACCAGTAACTATCATATCTCTGGT
TTTACTAAGGTGACCGAAGAAGCTGAACTTGCCGCATTGTGCCAAGAGCGAGGCATCGCGCTCATCTCAGACCTTGGTAG
CGGTGCACTCACCGACCTGTCGCGCTTTGGGCTATCAAAAGAGCCGATGCCGCAGCAGATGCTGAGCGATGGTGTTAACT
TAGTGAGTTTTTCGGGCGATAAACTACTAGGTGGCCCGCAAGCTGGGTTAGTGGTTGGTGATTCAGAGTTAATCGCCAAG
CTGCAAGCGCACCCACTCAAGCGGGCGCTGCGCTGCGACAAGATGACCTTGGCGGCACTTGAAGCCACCTTGATGCAATA
CCGTAACCCTGAATCATTAGATAGCCTGCTGCCGATCTTTAAAAAGTTATCGCGGCCACAGCCAGAGCTTGAGCAACTTG
CAGAGCAACTGCTCATTGTCTGTACCGAGTTTTTATCCCATTTCAATGTGACGATTAAGGCAAGTCAAACCCAGGTGGGA
AGCGGCTCTCAGCCCGATGTATTGCTGGATTCGGTATCACTTTGCTTTAGCCAAAAACCTGATAGTCAGTTAAGCCTGCA
GCAACTCGATAGCCACTTTAAAACCGCTCAGATCCCGATCATCGGCCGCATTACCGCGAATCAGCTTTGGCTCGATCTGC
GTGGGAGTGATAACGATGAACAACTGGCTCAGGTATTAGTACAGATAGCCGCCAATATCGCTGCGCAGTGCTCAGGAGTG
AGCCAATGA

Upstream 100 bases:

>100_bases
TTTTATTAACTGAGTTAAATCAACCCAGTTCAGTTAACTCGCTCAATTAACAAATTTTTATAACTCATTTTTTTATAAAC
AGACGACCAGACGAAGACCT

Downstream 100 bases:

>100_bases
TTATCGTCACCTCTGGCCATGTAGATCACGGCAAAACAAGTTTAATTCAAGCACTAACCGGTACAGATGCCGACCGCTTA
CCGGAAGAGAAACAGCGTGG

Product: selenocysteine synthase

Products: NA

Alternate protein names: Selenocysteine synthase; Sec synthase; Selenocysteinyl-tRNA(Sec) synthase [H]

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MTQAINSTQALYRCLPAMDSLLLIPQVIRFTDQQGKPWIKSLLAQMLKDARQQIAKSRSLPSWCLNQTKIVTELERRLVL
ALRQSMTPVFNLTGTILHTNLGRSQMCEAAIDAVTKVMRHPVPLEFDMGQGKRGHRDSAISALIHELTGAQSCCIVNNNA
AAVLLMLAATSAGKEVIVSRGELVEIGGAFRIPDIMAQAGCKLVEVGCTNRTHLKDYAAAITDNTAAIMKVHTSNYHISG
FTKVTEEAELAALCQERGIALISDLGSGALTDLSRFGLSKEPMPQQMLSDGVNLVSFSGDKLLGGPQAGLVVGDSELIAK
LQAHPLKRALRCDKMTLAALEATLMQYRNPESLDSLLPIFKKLSRPQPELEQLAEQLLIVCTEFLSHFNVTIKASQTQVG
SGSQPDVLLDSVSLCFSQKPDSQLSLQQLDSHFKTAQIPIIGRITANQLWLDLRGSDNDEQLAQVLVQIAANIAAQCSGV
SQ

Sequences:

>Translated_482_residues
MTQAINSTQALYRCLPAMDSLLLIPQVIRFTDQQGKPWIKSLLAQMLKDARQQIAKSRSLPSWCLNQTKIVTELERRLVL
ALRQSMTPVFNLTGTILHTNLGRSQMCEAAIDAVTKVMRHPVPLEFDMGQGKRGHRDSAISALIHELTGAQSCCIVNNNA
AAVLLMLAATSAGKEVIVSRGELVEIGGAFRIPDIMAQAGCKLVEVGCTNRTHLKDYAAAITDNTAAIMKVHTSNYHISG
FTKVTEEAELAALCQERGIALISDLGSGALTDLSRFGLSKEPMPQQMLSDGVNLVSFSGDKLLGGPQAGLVVGDSELIAK
LQAHPLKRALRCDKMTLAALEATLMQYRNPESLDSLLPIFKKLSRPQPELEQLAEQLLIVCTEFLSHFNVTIKASQTQVG
SGSQPDVLLDSVSLCFSQKPDSQLSLQQLDSHFKTAQIPIIGRITANQLWLDLRGSDNDEQLAQVLVQIAANIAAQCSGV
SQ
>Mature_481_residues
TQAINSTQALYRCLPAMDSLLLIPQVIRFTDQQGKPWIKSLLAQMLKDARQQIAKSRSLPSWCLNQTKIVTELERRLVLA
LRQSMTPVFNLTGTILHTNLGRSQMCEAAIDAVTKVMRHPVPLEFDMGQGKRGHRDSAISALIHELTGAQSCCIVNNNAA
AVLLMLAATSAGKEVIVSRGELVEIGGAFRIPDIMAQAGCKLVEVGCTNRTHLKDYAAAITDNTAAIMKVHTSNYHISGF
TKVTEEAELAALCQERGIALISDLGSGALTDLSRFGLSKEPMPQQMLSDGVNLVSFSGDKLLGGPQAGLVVGDSELIAKL
QAHPLKRALRCDKMTLAALEATLMQYRNPESLDSLLPIFKKLSRPQPELEQLAEQLLIVCTEFLSHFNVTIKASQTQVGS
GSQPDVLLDSVSLCFSQKPDSQLSLQQLDSHFKTAQIPIIGRITANQLWLDLRGSDNDEQLAQVLVQIAANIAAQCSGVS
Q

Specific function: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis [H]

COG id: COG1921

COG function: function code E; Selenocysteine synthase [seryl-tRNASer selenium transferase]

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the selA family [H]

Homologues:

Organism=Escherichia coli, GI2367248, Length=462, Percent_Identity=51.9480519480519, Blast_Score=441, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR018319
- InterPro:   IPR004534 [H]

Pfam domain/function: PF03841 SelA [H]

EC number: =2.9.1.1 [H]

Molecular weight: Translated: 52315; Mature: 52184

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQAINSTQALYRCLPAMDSLLLIPQVIRFTDQQGKPWIKSLLAQMLKDARQQIAKSRSL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
PSWCLNQTKIVTELERRLVLALRQSMTPVFNLTGTILHTNLGRSQMCEAAIDAVTKVMRH
CHHHHCHHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHC
PVPLEFDMGQGKRGHRDSAISALIHELTGAQSCCIVNNNAAAVLLMLAATSAGKEVIVSR
CCCCEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHCCCCCHHHHCC
GELVEIGGAFRIPDIMAQAGCKLVEVGCTNRTHLKDYAAAITDNTAAIMKVHTSNYHISG
CCEEEECCCCCCHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEEECCCEEECC
FTKVTEEAELAALCQERGIALISDLGSGALTDLSRFGLSKEPMPQQMLSDGVNLVSFSGD
HHHHHHHHHHHHHHHHCCCEEEHHCCCCHHHHHHHCCCCCCCCHHHHHHCCCCEEEECCC
KLLGGPQAGLVVGDSELIAKLQAHPLKRALRCDKMTLAALEATLMQYRNPESLDSLLPIF
CCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
KKLSRPQPELEQLAEQLLIVCTEFLSHFNVTIKASQTQVGSGSQPDVLLDSVSLCFSQKP
HHHCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCC
DSQLSLQQLDSHFKTAQIPIIGRITANQLWLDLRGSDNDEQLAQVLVQIAANIAAQCSGV
CCCHHHHHHHHHHCEECCCEEEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCC
SQ
CC
>Mature Secondary Structure 
TQAINSTQALYRCLPAMDSLLLIPQVIRFTDQQGKPWIKSLLAQMLKDARQQIAKSRSL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
PSWCLNQTKIVTELERRLVLALRQSMTPVFNLTGTILHTNLGRSQMCEAAIDAVTKVMRH
CHHHHCHHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHC
PVPLEFDMGQGKRGHRDSAISALIHELTGAQSCCIVNNNAAAVLLMLAATSAGKEVIVSR
CCCCEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHCCCCCHHHHCC
GELVEIGGAFRIPDIMAQAGCKLVEVGCTNRTHLKDYAAAITDNTAAIMKVHTSNYHISG
CCEEEECCCCCCHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEEECCCEEECC
FTKVTEEAELAALCQERGIALISDLGSGALTDLSRFGLSKEPMPQQMLSDGVNLVSFSGD
HHHHHHHHHHHHHHHHCCCEEEHHCCCCHHHHHHHCCCCCCCCHHHHHHCCCCEEEECCC
KLLGGPQAGLVVGDSELIAKLQAHPLKRALRCDKMTLAALEATLMQYRNPESLDSLLPIF
CCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
KKLSRPQPELEQLAEQLLIVCTEFLSHFNVTIKASQTQVGSGSQPDVLLDSVSLCFSQKP
HHHCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCC
DSQLSLQQLDSHFKTAQIPIIGRITANQLWLDLRGSDNDEQLAQVLVQIAANIAAQCSGV
CCCHHHHHHHHHHCEECCCEEEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCC
SQ
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]