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The map label for this gene is lpxC

Identifier: 167622400

GI number: 167622400

Start: 540323

End: 541243

Strand: Direct

Name: lpxC

Synonym: Shal_0460

Alternate gene names: 167622400

Gene position: 540323-541243 (Clockwise)

Preceding gene: 167622399

Following gene: 167622402

Centisome position: 10.34

GC content: 45.06

Gene sequence:

>921_bases
ATGATTTTTCAAAGAACTGTCAAAGAAATGGTTAAGACTACTGGTGTTGGATTGCATTCCGGCAACAAGGTGACTTTGAC
CATTAAGCCCGCACCCGTTAATACCGGCATTAAGCTAGTTCGTACTGACTTATCGCCAGCAGTGGAAATCCCAGCTGTTG
CCGATCAAGTGCGTGAGACGACTATGTGTACTGCTTTGGTAAATGATGACGGTGTTCGTATCTCAACAATTGAGCATCTA
TTTGCAGCGCTAGCCGGACTAGGTATTGATAACGCAGTTATCGAAGTTGACGCGCCTGAAATCCCGATTATGGATGGCAG
TGCGAGTCCTTTTGTTTTCCTACTTCAGTCTGTAGGTATTCAAGAGCAAAGCGCAGCTAAGAAATACATTAAAATCACTA
AACCTATTCGTGTTGAAGACGGTGATAAGTGGGCAGAGTTGAAACCGTTTAAAGGTTTCAGAGTCGATTTCGCAATTGAC
TTTAATCACCCAGAGATCGCTCGTAGTCAACAGCATATGGTTATGGATTTTTCATCGTCTGCTTTTATTAAAGATATCAG
CCGTGCAAGAACCTTTGGTTTTATGCGGGATATTGAATACCTAAGAGCGAATAACCTTGCACTAGGTGGCAGCATGGAAA
ATGCTGTGGTACTTGACGAGTATCGCGTCCTCAACCCCGATGGCCTGCGTTATGAGGACGAGTTCGTTAAGCATAAGATC
CTTGATGCCTTTGGTGACCTATATGTAGCGGGTCACGCGATTGTTGGTGAGTTCTGTGCATTTAAGACAGGACATGCACT
TAATAATCAGTTAGTGCGCGCCATGCTTGCACAGCAAGACGCTTGGGAAATCGTGAGCTTTGAAAAAGAAGCCGACGCAC
CCGTCAGCTTCTCAGTACCTGCGGGTGCTGTATTCGCTTAA

Upstream 100 bases:

>100_bases
TTTGCAAAGATATGCTAAGATATCCGACCAGCATCGCCTATACACGACTAAAACGTGTGTAGTTAGTGCTTTTTTGTTGA
GATAATAAACGGGTAAACAC

Downstream 100 bases:

>100_bases
TCGCGAATTAAGATTGCCTTGAACGGCTGGCTAATGCAGCCAGCCGTTTTAGTTTTACCGCTAATGTCCCTTCAGTATGT
TCAGCTAATGCTTCAATATG

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MIFQRTVKEMVKTTGVGLHSGNKVTLTIKPAPVNTGIKLVRTDLSPAVEIPAVADQVRETTMCTALVNDDGVRISTIEHL
FAALAGLGIDNAVIEVDAPEIPIMDGSASPFVFLLQSVGIQEQSAAKKYIKITKPIRVEDGDKWAELKPFKGFRVDFAID
FNHPEIARSQQHMVMDFSSSAFIKDISRARTFGFMRDIEYLRANNLALGGSMENAVVLDEYRVLNPDGLRYEDEFVKHKI
LDAFGDLYVAGHAIVGEFCAFKTGHALNNQLVRAMLAQQDAWEIVSFEKEADAPVSFSVPAGAVFA

Sequences:

>Translated_306_residues
MIFQRTVKEMVKTTGVGLHSGNKVTLTIKPAPVNTGIKLVRTDLSPAVEIPAVADQVRETTMCTALVNDDGVRISTIEHL
FAALAGLGIDNAVIEVDAPEIPIMDGSASPFVFLLQSVGIQEQSAAKKYIKITKPIRVEDGDKWAELKPFKGFRVDFAID
FNHPEIARSQQHMVMDFSSSAFIKDISRARTFGFMRDIEYLRANNLALGGSMENAVVLDEYRVLNPDGLRYEDEFVKHKI
LDAFGDLYVAGHAIVGEFCAFKTGHALNNQLVRAMLAQQDAWEIVSFEKEADAPVSFSVPAGAVFA
>Mature_306_residues
MIFQRTVKEMVKTTGVGLHSGNKVTLTIKPAPVNTGIKLVRTDLSPAVEIPAVADQVRETTMCTALVNDDGVRISTIEHL
FAALAGLGIDNAVIEVDAPEIPIMDGSASPFVFLLQSVGIQEQSAAKKYIKITKPIRVEDGDKWAELKPFKGFRVDFAID
FNHPEIARSQQHMVMDFSSSAFIKDISRARTFGFMRDIEYLRANNLALGGSMENAVVLDEYRVLNPDGLRYEDEFVKHKI
LDAFGDLYVAGHAIVGEFCAFKTGHALNNQLVRAMLAQQDAWEIVSFEKEADAPVSFSVPAGAVFA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family

Homologues:

Organism=Escherichia coli, GI1786285, Length=304, Percent_Identity=62.5, Blast_Score=419, Evalue=1e-118,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXC_SHEHH (B0TQP2)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001672694.1
- ProteinModelPortal:   B0TQP2
- SMR:   B0TQP2
- GeneID:   5906319
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_0460
- HOGENOM:   HBG482342
- OMA:   KAYKSGH
- ProtClustDB:   PRK13186
- BioCyc:   SHAL458817:SHAL_0460-MONOMER
- HAMAP:   MF_00388
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870
- Gene3D:   G3DSA:3.30.1700.10
- Gene3D:   G3DSA:3.30.230.20
- TIGRFAMs:   TIGR00325

Pfam domain/function: PF03331 LpxC; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.5.1.-

Molecular weight: Translated: 33605; Mature: 33605

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFQRTVKEMVKTTGVGLHSGNKVTLTIKPAPVNTGIKLVRTDLSPAVEIPAVADQVRET
CCHHHHHHHHHHHCCCCEECCCEEEEEEECCCCCCCCEEEEECCCCCEECCHHHHHHHHH
TMCTALVNDDGVRISTIEHLFAALAGLGIDNAVIEVDAPEIPIMDGSASPFVFLLQSVGI
HHEEEEECCCCCEEHHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCCCHHHHHHHHCCC
QEQSAAKKYIKITKPIRVEDGDKWAELKPFKGFRVDFAIDFNHPEIARSQQHMVMDFSSS
CHHHHHHHHEEECCCEEECCCCCCCCCCCCCCEEEEEEEECCCCHHHCCCCEEEEECCCC
AFIKDISRARTFGFMRDIEYLRANNLALGGSMENAVVLDEYRVLNPDGLRYEDEFVKHKI
HHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEECEEEECCCCCCCHHHHHHHHH
LDAFGDLYVAGHAIVGEFCAFKTGHALNNQLVRAMLAQQDAWEIVSFEKEADAPVSFSVP
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHEEECCCCCCCEEEECC
AGAVFA
CCCCCC
>Mature Secondary Structure
MIFQRTVKEMVKTTGVGLHSGNKVTLTIKPAPVNTGIKLVRTDLSPAVEIPAVADQVRET
CCHHHHHHHHHHHCCCCEECCCEEEEEEECCCCCCCCEEEEECCCCCEECCHHHHHHHHH
TMCTALVNDDGVRISTIEHLFAALAGLGIDNAVIEVDAPEIPIMDGSASPFVFLLQSVGI
HHEEEEECCCCCEEHHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCCCHHHHHHHHCCC
QEQSAAKKYIKITKPIRVEDGDKWAELKPFKGFRVDFAIDFNHPEIARSQQHMVMDFSSS
CHHHHHHHHEEECCCEEECCCCCCCCCCCCCCEEEEEEEECCCCHHHCCCCEEEEECCCC
AFIKDISRARTFGFMRDIEYLRANNLALGGSMENAVVLDEYRVLNPDGLRYEDEFVKHKI
HHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEECEEEECCCCCCCHHHHHHHHH
LDAFGDLYVAGHAIVGEFCAFKTGHALNNQLVRAMLAQQDAWEIVSFEKEADAPVSFSVP
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHEEECCCCCCCEEEECC
AGAVFA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA