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The map label for this gene is ftsI [H]

Identifier: 167622389

GI number: 167622389

Start: 526021

End: 527757

Strand: Direct

Name: ftsI [H]

Synonym: Shal_0449

Alternate gene names: 167622389

Gene position: 526021-527757 (Clockwise)

Preceding gene: 167622388

Following gene: 167622390

Centisome position: 10.06

GC content: 47.5

Gene sequence:

>1737_bases
ATGAGCAAACAGGCAAAGCGTAAACAGAAACCACAGTTAATCCAATGGCGTTTATACGTCGTGGTGGCTTTTGTCTGCCT
GTTGTTTACAAGTTTGGTTGGTCGAGCCGCTTACATTCAAATCATCGAGCCCGAAATGCTACGCCACCAAAGTGACATGC
GCACATTGCGTACCACGAGTCGTGAAGTGCAACGTGGCTTAATCACCGACCGTAATGGTGAAATGTTAGCGGTGAGTGTG
CCAGTAAAAGCGGTATACGCCGATCCTAAAGTTATACATGATGAGGATGGTTTTGCCGATATGCGTCGTTGGCAAGCATT
AGCAGACGTACTGCATGAACCGAAAGAAGATATCCTTAAACGAGTTCAATCGAATCCTCGTAAGCGTTTTACCTACCTTA
AACGTCAAGTAACCCCTGCAGTTGCTAATTATATTCAGCAATTGGATTTACCGGGTGTTTACCTTAAACCTGAGTCACGT
CGCTACTATCCAACTGGTGAGATCACGGCGCAATTGGTGGGGATCACCAATATCGATGACAAAGGCATCGAAGGGCTAGA
AAATACCTATGACGACTGGCTTACTGGCACGCCGAGTAAGCAAAAAGTACGTAAGTCTCGTGATGGTCACGTAGTTGAGC
GCCTAGACATGGTGCAAGAGGGTGAAAGCCCTAATGACTTAGTGCTGAGTATCGATCAGCGCATCCAGCAGCTGGCTTAT
CGAGAGCTTAAAAAAGCCACTGAGATCAACCAAGCCACATCGGGCTCAATCGTGGTGCTAGATGTACTAACGGGGGAAGT
GTTAGCGATGGCAAATACGCCATCATATAATCCCAACTCTCGTGAAAACCTACAGAGCTATCGCATGCGAAATAGGGCTT
TGACTGATGCCTATGAACCGGGTTCAACCATCAAACCATTTGTGGTTGCTGCAGCACTCGATGCCGGAACAATTAAGACA
GATCAAATCATTAAGACCAACCCCGGGCGTATGCGTATCGGTGGCAAAATTGTACGTGATGGGCGTAACTACGGTGATTT
ATCTTTGAGCGGCGTATTAGTTCACTCAAGCAACGTTGGTATGACTAAAATTGCGTTGTCTATGCCAGTACAAGAGTTAT
TGGGCGCCTACCAAACAATGGGGCTCGGTAATTATTCAGGGATTAATTTAGAGGGTGAAAGCGCAGGCCTTATCCATGAC
CGTCGTCGCTGGTCTGAATTTGAGCGCGCCACTTTGTCATTTGGTTATGGCTTGATGGCCACACCACTGCAGCTTGCCAG
AATGTATGCCACTTTGGGAAATAAAGGCGTGCAGTATCCCGTGTCAATTTTAAAACTAAAACAAGCGCCACAAGGCACAC
AAGTCATTTCACCACAGGTCGCGCAAGATGTCATGGAGATGCTGGTGGGGGTGACCGAAAAAGGTGGCACCGCACGTAAG
GCACACATTGAAGGTTATCCTGTTGCGGGTAAAACCGGTACCGCTCGTAAGGCTGTTGCTGGCGGGTATGGTGAAGACTA
TGTGGCAATATTTGCCGGTGTGGCCCCTGTACATACACCGAAATTAGCCATTACCGTGGTGATAAATGAACCTAAAGGTG
ATCGTTATTACGGTGGCGATGTCGCCGCTCCGGTTTTTGCGGCCGTCATGTCAGGTGCCTTACAAATGCTAAACGTTGAG
CCTATTTCAAAACGTGAGAAGGTCCGTTTAGCAGCTAATTCTAGGAGTGTTGAATAA

Upstream 100 bases:

>100_bases
AGCAGTCACGTTCTGAACATAGCCGGATAACTCGGATAGCGACCAAAGAGCTAAATATGAATCGTCCGCTACCCAAAGAT
GAGGTTGTCGTAAGAGTGCC

Downstream 100 bases:

>100_bases
TGCTAATTCGCGATCTATTAGCGCCTTGGTTTCATTATTCGGGAGCCGAAGAGTTCTCTGAGCTCACATTAGATAGTCGT
GCTGTTCAGTCCGGCTCGCT

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]

Number of amino acids: Translated: 578; Mature: 577

Protein sequence:

>578_residues
MSKQAKRKQKPQLIQWRLYVVVAFVCLLFTSLVGRAAYIQIIEPEMLRHQSDMRTLRTTSREVQRGLITDRNGEMLAVSV
PVKAVYADPKVIHDEDGFADMRRWQALADVLHEPKEDILKRVQSNPRKRFTYLKRQVTPAVANYIQQLDLPGVYLKPESR
RYYPTGEITAQLVGITNIDDKGIEGLENTYDDWLTGTPSKQKVRKSRDGHVVERLDMVQEGESPNDLVLSIDQRIQQLAY
RELKKATEINQATSGSIVVLDVLTGEVLAMANTPSYNPNSRENLQSYRMRNRALTDAYEPGSTIKPFVVAAALDAGTIKT
DQIIKTNPGRMRIGGKIVRDGRNYGDLSLSGVLVHSSNVGMTKIALSMPVQELLGAYQTMGLGNYSGINLEGESAGLIHD
RRRWSEFERATLSFGYGLMATPLQLARMYATLGNKGVQYPVSILKLKQAPQGTQVISPQVAQDVMEMLVGVTEKGGTARK
AHIEGYPVAGKTGTARKAVAGGYGEDYVAIFAGVAPVHTPKLAITVVINEPKGDRYYGGDVAAPVFAAVMSGALQMLNVE
PISKREKVRLAANSRSVE

Sequences:

>Translated_578_residues
MSKQAKRKQKPQLIQWRLYVVVAFVCLLFTSLVGRAAYIQIIEPEMLRHQSDMRTLRTTSREVQRGLITDRNGEMLAVSV
PVKAVYADPKVIHDEDGFADMRRWQALADVLHEPKEDILKRVQSNPRKRFTYLKRQVTPAVANYIQQLDLPGVYLKPESR
RYYPTGEITAQLVGITNIDDKGIEGLENTYDDWLTGTPSKQKVRKSRDGHVVERLDMVQEGESPNDLVLSIDQRIQQLAY
RELKKATEINQATSGSIVVLDVLTGEVLAMANTPSYNPNSRENLQSYRMRNRALTDAYEPGSTIKPFVVAAALDAGTIKT
DQIIKTNPGRMRIGGKIVRDGRNYGDLSLSGVLVHSSNVGMTKIALSMPVQELLGAYQTMGLGNYSGINLEGESAGLIHD
RRRWSEFERATLSFGYGLMATPLQLARMYATLGNKGVQYPVSILKLKQAPQGTQVISPQVAQDVMEMLVGVTEKGGTARK
AHIEGYPVAGKTGTARKAVAGGYGEDYVAIFAGVAPVHTPKLAITVVINEPKGDRYYGGDVAAPVFAAVMSGALQMLNVE
PISKREKVRLAANSRSVE
>Mature_577_residues
SKQAKRKQKPQLIQWRLYVVVAFVCLLFTSLVGRAAYIQIIEPEMLRHQSDMRTLRTTSREVQRGLITDRNGEMLAVSVP
VKAVYADPKVIHDEDGFADMRRWQALADVLHEPKEDILKRVQSNPRKRFTYLKRQVTPAVANYIQQLDLPGVYLKPESRR
YYPTGEITAQLVGITNIDDKGIEGLENTYDDWLTGTPSKQKVRKSRDGHVVERLDMVQEGESPNDLVLSIDQRIQQLAYR
ELKKATEINQATSGSIVVLDVLTGEVLAMANTPSYNPNSRENLQSYRMRNRALTDAYEPGSTIKPFVVAAALDAGTIKTD
QIIKTNPGRMRIGGKIVRDGRNYGDLSLSGVLVHSSNVGMTKIALSMPVQELLGAYQTMGLGNYSGINLEGESAGLIHDR
RRWSEFERATLSFGYGLMATPLQLARMYATLGNKGVQYPVSILKLKQAPQGTQVISPQVAQDVMEMLVGVTEKGGTARKA
HIEGYPVAGKTGTARKAVAGGYGEDYVAIFAGVAPVHTPKLAITVVINEPKGDRYYGGDVAAPVFAAVMSGALQMLNVEP
ISKREKVRLAANSRSVE

Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein; Periplasmic side. Note=The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space, where it acts on murein (By similarity) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=567, Percent_Identity=48.1481481481481, Blast_Score=554, Evalue=1e-159,
Organism=Escherichia coli, GI1786854, Length=590, Percent_Identity=27.1186440677966, Blast_Score=139, Evalue=5e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: =2.4.1.129 [H]

Molecular weight: Translated: 63804; Mature: 63673

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQAKRKQKPQLIQWRLYVVVAFVCLLFTSLVGRAAYIQIIEPEMLRHQSDMRTLRTTS
CCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECHHHHHHHHHHHHHHHHH
REVQRGLITDRNGEMLAVSVPVKAVYADPKVIHDEDGFADMRRWQALADVLHEPKEDILK
HHHHHCCCCCCCCCEEEEECCEEEEECCCCEEECCCCHHHHHHHHHHHHHHHCCHHHHHH
RVQSNPRKRFTYLKRQVTPAVANYIQQLDLPGVYLKPESRRYYPTGEITAQLVGITNIDD
HHHCCHHHHHHHHHHHHCHHHHHHHHHCCCCCEEECCCCCCCCCCCCCEEEEEEECCCCC
KGIEGLENTYDDWLTGTPSKQKVRKSRDGHVVERLDMVQEGESPNDLVLSIDQRIQQLAY
CCCCHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHH
RELKKATEINQATSGSIVVLDVLTGEVLAMANTPSYNPNSRENLQSYRMRNRALTDAYEP
HHHHHHHHHCCCCCCCEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCC
GSTIKPFVVAAALDAGTIKTDQIIKTNPGRMRIGGKIVRDGRNYGDLSLSGVLVHSSNVG
CCCCCHHHEEEECCCCCCCCCCEEECCCCCEEECCEEEECCCCCCCEEEEEEEEECCCCC
MTKIALSMPVQELLGAYQTMGLGNYSGINLEGESAGLIHDRRRWSEFERATLSFGYGLMA
HHHHHHHCCHHHHHHHHHHCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHH
TPLQLARMYATLGNKGVQYPVSILKLKQAPQGTQVISPQVAQDVMEMLVGVTEKGGTARK
HHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEE
AHIEGYPVAGKTGTARKAVAGGYGEDYVAIFAGVAPVHTPKLAITVVINEPKGDRYYGGD
EECCCCCCCCCCCCCHHHHCCCCCCCHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCCC
VAAPVFAAVMSGALQMLNVEPISKREKVRLAANSRSVE
HHHHHHHHHHHHHHHHCCCCCCCCCHHEEEECCCCCCC
>Mature Secondary Structure 
SKQAKRKQKPQLIQWRLYVVVAFVCLLFTSLVGRAAYIQIIEPEMLRHQSDMRTLRTTS
CCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECHHHHHHHHHHHHHHHHH
REVQRGLITDRNGEMLAVSVPVKAVYADPKVIHDEDGFADMRRWQALADVLHEPKEDILK
HHHHHCCCCCCCCCEEEEECCEEEEECCCCEEECCCCHHHHHHHHHHHHHHHCCHHHHHH
RVQSNPRKRFTYLKRQVTPAVANYIQQLDLPGVYLKPESRRYYPTGEITAQLVGITNIDD
HHHCCHHHHHHHHHHHHCHHHHHHHHHCCCCCEEECCCCCCCCCCCCCEEEEEEECCCCC
KGIEGLENTYDDWLTGTPSKQKVRKSRDGHVVERLDMVQEGESPNDLVLSIDQRIQQLAY
CCCCHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHH
RELKKATEINQATSGSIVVLDVLTGEVLAMANTPSYNPNSRENLQSYRMRNRALTDAYEP
HHHHHHHHHCCCCCCCEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCC
GSTIKPFVVAAALDAGTIKTDQIIKTNPGRMRIGGKIVRDGRNYGDLSLSGVLVHSSNVG
CCCCCHHHEEEECCCCCCCCCCEEECCCCCEEECCEEEECCCCCCCEEEEEEEEECCCCC
MTKIALSMPVQELLGAYQTMGLGNYSGINLEGESAGLIHDRRRWSEFERATLSFGYGLMA
HHHHHHHCCHHHHHHHHHHCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHH
TPLQLARMYATLGNKGVQYPVSILKLKQAPQGTQVISPQVAQDVMEMLVGVTEKGGTARK
HHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEE
AHIEGYPVAGKTGTARKAVAGGYGEDYVAIFAGVAPVHTPKLAITVVINEPKGDRYYGGD
EECCCCCCCCCCCCCHHHHCCCCCCCHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCCC
VAAPVFAAVMSGALQMLNVEPISKREKVRLAANSRSVE
HHHHHHHHHHHHHHHHCCCCCCCCCHHEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]