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The map label for this gene is caiB [H]

Identifier: 167622163

GI number: 167622163

Start: 268532

End: 269767

Strand: Direct

Name: caiB [H]

Synonym: Shal_0222

Alternate gene names: 167622163

Gene position: 268532-269767 (Clockwise)

Preceding gene: 167622162

Following gene: 167622164

Centisome position: 5.14

GC content: 46.44

Gene sequence:

>1236_bases
ATGGGTATCATGTCAAATAAATTGTCCACACCTACGTTCGGTCCTCTTGCTGGTTTGAGAGTGGTTTTTTCCGGAATTGA
AATCGCGGGCCCATTCGCAGCGCAAATGCTAGCCGAGTGGGGCGCTGAAGTGATCTGGATTGAAAACGTAGCCTATGCGG
ATACTATCCGTGTACAGCCAAACTACCCAGAGCTATCACGCCGTAACCTGCATGCATTGTCGTTAAATATTTTTAAAGAT
GAAGGCCGCGATGCATTCCTGAAATTGATGGAAACAACAGATATCTTTATTGAAGCCAGTAAAGGTCCTGCGTTTGCACG
TCGTGGTATTACCGATGAAGTGTTATGGGAACAAAATAAAAAGTTAGTTATCGCACACTTATCTGGTTTCGGCCAGTACG
GCACGGATGAGTATACTAATCTGCCAGCCTACAACACGATTGCTCAGGCATTTAGTGGCTACCTTATTCAAAATGGTGAT
GTTGACCAGCCAATGCCTGCCTTCCCTTACACGGCAGACTATTTCTCTGGTATGACAGCAACCACCTCGGCACTTGCGGC
GCTATACCGTGTACGCGAAACCGGTGTCGGCGAAAGTATCGACATCGCCATGTACGAAGTCATGCTGCGCATGGGTCAGT
ACTTCATGATGGATCATTTCAATGGCGGCGAAGTTTGCCCACGTATGACCAAGGGTAAAGACCCTTACTACGCAGGTTGT
GGCCTATATAAGTGTGAAGATGGCTATATCGTGATGGAGCTTGTTGGCGGCAACCAGATTAAAGAGATGTTCAAGGATAT
GAATATCATGCACCTATATGGTGGCGAAGAGGTACCTGAAGGCACTCAATTGATCCACCGTATTGAATGTCCATTCGGCT
ATCAAGTTGAAGATGCATTAGACGGATACCTAGCGCAAAAGAGCATCGAAGAAGTATTGGCACGATTTGCAGAGCTCAAT
GTGGCGTGTGCAAAGGTATTAACGATCCCTGAGCTTGATAGCAACCCACAATACATTGCTCGTGAGTCTATTACCGAGTG
GCAGAACATCGACGGTAAGACCTACAGAGGCCCTAACGTCATGCCTAAGTTCAAGAACAATCCTGGCCAAATTTGGCGTG
GTATGCCAAAGCACGGTATGGATACTGCTGCAATCTTGGAAGATATCGGCTACTCACAAGAGCAAATTCAGAGCTTAAGC
GAAAAAGGCTTAGCAAAAGTATCTGAGTGTAAGTGA

Upstream 100 bases:

>100_bases
ACTCGACTCCATTGAGCCATGTTGCGTTAGATAACCCCCAATAATGACTATCTTCCCGGCGCTGTTGCTGTGATGAGTTT
TTGTTCGAATATTAAGAGAG

Downstream 100 bases:

>100_bases
GGCTAGAAGAATGGATATCGTTGGTAGCAAAACATTAAGATGCATGTGGGAAGAGCGTGCTCGCAAATTCAGTAATAACA
CAGCGTTGGTTTATGAGGAT

Product: crotonobetainyl-CoA:carnitine CoA-transferase

Products: 4-(Trimethylammonio)But-2-Enoate; H2O; crotonobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MGIMSNKLSTPTFGPLAGLRVVFSGIEIAGPFAAQMLAEWGAEVIWIENVAYADTIRVQPNYPELSRRNLHALSLNIFKD
EGRDAFLKLMETTDIFIEASKGPAFARRGITDEVLWEQNKKLVIAHLSGFGQYGTDEYTNLPAYNTIAQAFSGYLIQNGD
VDQPMPAFPYTADYFSGMTATTSALAALYRVRETGVGESIDIAMYEVMLRMGQYFMMDHFNGGEVCPRMTKGKDPYYAGC
GLYKCEDGYIVMELVGGNQIKEMFKDMNIMHLYGGEEVPEGTQLIHRIECPFGYQVEDALDGYLAQKSIEEVLARFAELN
VACAKVLTIPELDSNPQYIARESITEWQNIDGKTYRGPNVMPKFKNNPGQIWRGMPKHGMDTAAILEDIGYSQEQIQSLS
EKGLAKVSECK

Sequences:

>Translated_411_residues
MGIMSNKLSTPTFGPLAGLRVVFSGIEIAGPFAAQMLAEWGAEVIWIENVAYADTIRVQPNYPELSRRNLHALSLNIFKD
EGRDAFLKLMETTDIFIEASKGPAFARRGITDEVLWEQNKKLVIAHLSGFGQYGTDEYTNLPAYNTIAQAFSGYLIQNGD
VDQPMPAFPYTADYFSGMTATTSALAALYRVRETGVGESIDIAMYEVMLRMGQYFMMDHFNGGEVCPRMTKGKDPYYAGC
GLYKCEDGYIVMELVGGNQIKEMFKDMNIMHLYGGEEVPEGTQLIHRIECPFGYQVEDALDGYLAQKSIEEVLARFAELN
VACAKVLTIPELDSNPQYIARESITEWQNIDGKTYRGPNVMPKFKNNPGQIWRGMPKHGMDTAAILEDIGYSQEQIQSLS
EKGLAKVSECK
>Mature_410_residues
GIMSNKLSTPTFGPLAGLRVVFSGIEIAGPFAAQMLAEWGAEVIWIENVAYADTIRVQPNYPELSRRNLHALSLNIFKDE
GRDAFLKLMETTDIFIEASKGPAFARRGITDEVLWEQNKKLVIAHLSGFGQYGTDEYTNLPAYNTIAQAFSGYLIQNGDV
DQPMPAFPYTADYFSGMTATTSALAALYRVRETGVGESIDIAMYEVMLRMGQYFMMDHFNGGEVCPRMTKGKDPYYAGCG
LYKCEDGYIVMELVGGNQIKEMFKDMNIMHLYGGEEVPEGTQLIHRIECPFGYQVEDALDGYLAQKSIEEVLARFAELNV
ACAKVLTIPELDSNPQYIARESITEWQNIDGKTYRGPNVMPKFKNNPGQIWRGMPKHGMDTAAILEDIGYSQEQIQSLSE
KGLAKVSECK

Specific function: Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl- CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl- CoA or L-

COG id: COG1804

COG function: function code C; Predicted acyl-CoA transferases/carnitine dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CaiB/BaiF CoA-transferase family [H]

Homologues:

Organism=Homo sapiens, GI42794625, Length=408, Percent_Identity=25, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI266456254, Length=397, Percent_Identity=25.4408060453401, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI300863128, Length=273, Percent_Identity=24.9084249084249, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI300863124, Length=273, Percent_Identity=24.9084249084249, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI266458397, Length=273, Percent_Identity=26.3736263736264, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI266458393, Length=265, Percent_Identity=26.7924528301887, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1786222, Length=404, Percent_Identity=82.6732673267327, Blast_Score=692, Evalue=0.0,
Organism=Escherichia coli, GI87082093, Length=392, Percent_Identity=26.0204081632653, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788717, Length=420, Percent_Identity=24.7619047619048, Blast_Score=95, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI32564160, Length=347, Percent_Identity=24.4956772334294, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI115535051, Length=339, Percent_Identity=22.7138643067847, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24648431, Length=272, Percent_Identity=26.1029411764706, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003673 [H]

Pfam domain/function: PF02515 CoA_transf_3 [H]

EC number: 2.8.3.- [C]

Molecular weight: Translated: 45857; Mature: 45726

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIMSNKLSTPTFGPLAGLRVVFSGIEIAGPFAAQMLAEWGAEVIWIENVAYADTIRVQP
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECEEEEEEEEECC
NYPELSRRNLHALSLNIFKDEGRDAFLKLMETTDIFIEASKGPAFARRGITDEVLWEQNK
CCCCHHHCCEEEEEEEEEECCCHHHHHHHHHHCEEEEECCCCCHHHHCCCCHHHHHCCCC
KLVIAHLSGFGQYGTDEYTNLPAYNTIAQAFSGYLIQNGDVDQPMPAFPYTADYFSGMTA
EEEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCCCCCCCCCCCHHHHCCCHH
TTSALAALYRVRETGVGESIDIAMYEVMLRMGQYFMMDHFNGGEVCPRMTKGKDPYYAGC
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCHHHEEECCCCCCCCCCCCCCCCCCEECC
GLYKCEDGYIVMELVGGNQIKEMFKDMNIMHLYGGEEVPEGTQLIHRIECPFGYQVEDAL
CEEEECCCEEEEEECCCHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHCCCCCCCHHHHH
DGYLAQKSIEEVLARFAELNVACAKVLTIPELDSNPQYIARESITEWQNIDGKTYRGPNV
HHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHCCCCCEECCCCC
MPKFKNNPGQIWRGMPKHGMDTAAILEDIGYSQEQIQSLSEKGLAKVSECK
CCCCCCCHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCHHHCCC
>Mature Secondary Structure 
GIMSNKLSTPTFGPLAGLRVVFSGIEIAGPFAAQMLAEWGAEVIWIENVAYADTIRVQP
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECEEEEEEEEECC
NYPELSRRNLHALSLNIFKDEGRDAFLKLMETTDIFIEASKGPAFARRGITDEVLWEQNK
CCCCHHHCCEEEEEEEEEECCCHHHHHHHHHHCEEEEECCCCCHHHHCCCCHHHHHCCCC
KLVIAHLSGFGQYGTDEYTNLPAYNTIAQAFSGYLIQNGDVDQPMPAFPYTADYFSGMTA
EEEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCCCCCCCCCCCHHHHCCCHH
TTSALAALYRVRETGVGESIDIAMYEVMLRMGQYFMMDHFNGGEVCPRMTKGKDPYYAGC
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCHHHEEECCCCCCCCCCCCCCCCCCEECC
GLYKCEDGYIVMELVGGNQIKEMFKDMNIMHLYGGEEVPEGTQLIHRIECPFGYQVEDAL
CEEEECCCEEEEEECCCHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHCCCCCCCHHHHH
DGYLAQKSIEEVLARFAELNVACAKVLTIPELDSNPQYIARESITEWQNIDGKTYRGPNV
HHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHCCCCCEECCCCC
MPKFKNNPGQIWRGMPKHGMDTAAILEDIGYSQEQIQSLSEKGLAKVSECK
CCCCCCCHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-Carnitine; L-carnitinyl-CoA [C]

Specific reaction: L-Carnitine = 4-(Trimethylammonio)But-2-Enoate + H2O. L-carnitinyl-CoA = H2O + crotonobetainyl-CoA [C]

General reaction: Carbon-Oxygen Lyases; Hydro-Lyases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA