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The map label for this gene is caiT [H]

Identifier: 167622161

GI number: 167622161

Start: 265540

End: 267129

Strand: Direct

Name: caiT [H]

Synonym: Shal_0220

Alternate gene names: 167622161

Gene position: 265540-267129 (Clockwise)

Preceding gene: 167622153

Following gene: 167622162

Centisome position: 5.08

GC content: 44.78

Gene sequence:

>1590_bases
ATGAACGATAAAACGATGGATGTAAATGCCACAGAAGTAAAAAAGAAGAAGGTTACTATTGACCCGACTATCTTTTTTCC
TTCATTGCTTGCCGTCATATTACTGTCTTATTTGACAGTAAGAGACTTGGATGCCGCTAATTTAGCTATCAGCGAAGTCT
TCCACTATCTAACTCACTCTTGGGGGTGGCTTTTTGAGTGGTACATGATCTTCATGGGAGCCGGTTGGGCTTGGTTGACC
TGGGGACCTTATTCTAATAATCGCTTAGGTCAGGAAAAACCAGAATTTAGTACAGCTAGCTGGATCTTCCTGATGTTTGC
CTCTTGTACCTCGGCTGCAGTGCTGTTCTGGGGGTCTTTAGAGGTTTACTACTATGTTACCTATCCTCCTTTTGATATTG
AGCCTTTGTCTATTCAAGCCAAAGAGCTAGGACTCGCATATAGTCTATTCCATTGGGGACCTTTACCTTGGATGGGATAT
GGCTTCTTTACTGTTGCTTTGGGTTACTTCCTGTTTGTAAAGAAAATGGATGTGGTTCGCCCGAGTGGCACCTTAGAGCC
TATTTTGGGTAAGCACCATAAAGGCTTTATCGGTACCTTTATCGATAACGTCTACGTTGTTGCTTTAATCCTTGCTATGG
GTACCAGTCTTGGCTTGGCCACACCTTTGGTAACTGAATGTATTCAATGGTTATTTGGTATCCCACGCACCCCAGCAGTT
GACACAATCGTTATCTCTTCATGGATTGTTTTCAACGCAATTTGTGTGGCCTTTGGTCTGACTAAAGGCATTAAGATCGC
CAGTGATTTGAGAAGTTATTTAAGTATCATCATGCTTGTTTGGGTATTTCTTATTGGCGCAACCAGTTTCACTGTGAACT
ATTTCACTGACTCAGTGGGCATCATGTTAGAACTACTTCCTCGTATGTTGTTCAACACCGCTTCGGTCAGTGAAGGCAGC
TTCCCGCAAGACTGGACCGTATTCTACTGGGCTTGGTGGGTCGTGTATGGCATCCAGATGTGTATCTTCTTAGCGAAGAT
CTCTCGTGGGCGTACCGTTCGTGAGCTTTGTCTGACTATGGTTGCTGGTTTAACTGCTTCAACTTGGTTCCTCTGGACCA
TCCTTGGCAGTAACACTATGAATTTGATGAATGAAAACCTCATCAACATGCCGCAACTTATCGAACAGTATGGTGCCGCC
AGGGCCATTATTGAAACCTGGGCCGCATTACCGTTCAGCACTATCACCATGTGGGGCTTCTTCATTCTATGTTTCCTCGC
AACGGTCACCTTAGTTAATGCCTGTTCTTACACCCTAGCCATGTCGACCTGTAAAGGCGCCGATGCTGATAACGAGCCAC
CAATCTGGGTTCGTGTTGGTTGGTCTGTACTTGTGGGTGTTATCGGCATCGTTCTGTTGTCACTCGGCGGCTTGAAGCCA
CTGCAAACAGCAATCATTGCCGGTGGCGCACCACTAATCATAGTTAACGTTATGATTATATTCTCTTTCTTAAAAGATGC
CCGTAAAAATAATTGGAAACCTGTCGGTGAAGAGGCTAAGCCACACCTAGGTTCCACAGCTAAAATTTAG

Upstream 100 bases:

>100_bases
GGTATTCGTTTGGCTAAAAACGAATAAAGTTGGTTCGATAGCTACTCAGTTTAAAACTTTAACTATTATCCTCCTAAAAC
AGAGAGGGAGAAGTATTGAT

Downstream 100 bases:

>100_bases
AGGAATAAATAATGGATTTTAAATTAACCGACGAACAAGAGTTATTTGTAGCAGGTATCCGTGACCTGATGGCTAAAGAG
AACTGGGAAAGCTATTTCGC

Product: L-carnitine/gamma-butyrobetaine antiporter

Products: Proton [Cytoplasm]; L-carnitine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 529; Mature: 529

Protein sequence:

>529_residues
MNDKTMDVNATEVKKKKVTIDPTIFFPSLLAVILLSYLTVRDLDAANLAISEVFHYLTHSWGWLFEWYMIFMGAGWAWLT
WGPYSNNRLGQEKPEFSTASWIFLMFASCTSAAVLFWGSLEVYYYVTYPPFDIEPLSIQAKELGLAYSLFHWGPLPWMGY
GFFTVALGYFLFVKKMDVVRPSGTLEPILGKHHKGFIGTFIDNVYVVALILAMGTSLGLATPLVTECIQWLFGIPRTPAV
DTIVISSWIVFNAICVAFGLTKGIKIASDLRSYLSIIMLVWVFLIGATSFTVNYFTDSVGIMLELLPRMLFNTASVSEGS
FPQDWTVFYWAWWVVYGIQMCIFLAKISRGRTVRELCLTMVAGLTASTWFLWTILGSNTMNLMNENLINMPQLIEQYGAA
RAIIETWAALPFSTITMWGFFILCFLATVTLVNACSYTLAMSTCKGADADNEPPIWVRVGWSVLVGVIGIVLLSLGGLKP
LQTAIIAGGAPLIIVNVMIIFSFLKDARKNNWKPVGEEAKPHLGSTAKI

Sequences:

>Translated_529_residues
MNDKTMDVNATEVKKKKVTIDPTIFFPSLLAVILLSYLTVRDLDAANLAISEVFHYLTHSWGWLFEWYMIFMGAGWAWLT
WGPYSNNRLGQEKPEFSTASWIFLMFASCTSAAVLFWGSLEVYYYVTYPPFDIEPLSIQAKELGLAYSLFHWGPLPWMGY
GFFTVALGYFLFVKKMDVVRPSGTLEPILGKHHKGFIGTFIDNVYVVALILAMGTSLGLATPLVTECIQWLFGIPRTPAV
DTIVISSWIVFNAICVAFGLTKGIKIASDLRSYLSIIMLVWVFLIGATSFTVNYFTDSVGIMLELLPRMLFNTASVSEGS
FPQDWTVFYWAWWVVYGIQMCIFLAKISRGRTVRELCLTMVAGLTASTWFLWTILGSNTMNLMNENLINMPQLIEQYGAA
RAIIETWAALPFSTITMWGFFILCFLATVTLVNACSYTLAMSTCKGADADNEPPIWVRVGWSVLVGVIGIVLLSLGGLKP
LQTAIIAGGAPLIIVNVMIIFSFLKDARKNNWKPVGEEAKPHLGSTAKI
>Mature_529_residues
MNDKTMDVNATEVKKKKVTIDPTIFFPSLLAVILLSYLTVRDLDAANLAISEVFHYLTHSWGWLFEWYMIFMGAGWAWLT
WGPYSNNRLGQEKPEFSTASWIFLMFASCTSAAVLFWGSLEVYYYVTYPPFDIEPLSIQAKELGLAYSLFHWGPLPWMGY
GFFTVALGYFLFVKKMDVVRPSGTLEPILGKHHKGFIGTFIDNVYVVALILAMGTSLGLATPLVTECIQWLFGIPRTPAV
DTIVISSWIVFNAICVAFGLTKGIKIASDLRSYLSIIMLVWVFLIGATSFTVNYFTDSVGIMLELLPRMLFNTASVSEGS
FPQDWTVFYWAWWVVYGIQMCIFLAKISRGRTVRELCLTMVAGLTASTWFLWTILGSNTMNLMNENLINMPQLIEQYGAA
RAIIETWAALPFSTITMWGFFILCFLATVTLVNACSYTLAMSTCKGADADNEPPIWVRVGWSVLVGVIGIVLLSLGGLKP
LQTAIIAGGAPLIIVNVMIIFSFLKDARKNNWKPVGEEAKPHLGSTAKI

Specific function: Catalyzes the exchange of L-carnitine for gamma- butyrobetaine and related betaines [H]

COG id: COG1292

COG function: function code M; Choline-glycine betaine transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCCT transporter (TC 2.A.15) family. CaiT subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786224, Length=501, Percent_Identity=69.4610778443114, Blast_Score=729, Evalue=0.0,
Organism=Escherichia coli, GI1788102, Length=459, Percent_Identity=26.1437908496732, Blast_Score=208, Evalue=7e-55,
Organism=Escherichia coli, GI1786506, Length=510, Percent_Identity=26.8627450980392, Blast_Score=175, Evalue=7e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000060
- InterPro:   IPR018093 [H]

Pfam domain/function: PF02028 BCCT [H]

EC number: NA

Molecular weight: Translated: 59069; Mature: 59069

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS01303 BCCT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDKTMDVNATEVKKKKVTIDPTIFFPSLLAVILLSYLTVRDLDAANLAISEVFHYLTHS
CCCCEECCCHHHHHHCEEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
WGWLFEWYMIFMGAGWAWLTWGPYSNNRLGQEKPEFSTASWIFLMFASCTSAAVLFWGSL
HHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECE
EVYYYVTYPPFDIEPLSIQAKELGLAYSLFHWGPLPWMGYGFFTVALGYFLFVKKMDVVR
EEEEEEEECCCCCCCCEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
PSGTLEPILGKHHKGFIGTFIDNVYVVALILAMGTSLGLATPLVTECIQWLFGIPRTPAV
CCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCH
DTIVISSWIVFNAICVAFGLTKGIKIASDLRSYLSIIMLVWVFLIGATSFTVNYFTDSVG
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHEEEEHHHHHHH
IMLELLPRMLFNTASVSEGSFPQDWTVFYWAWWVVYGIQMCIFLAKISRGRTVRELCLTM
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
VAGLTASTWFLWTILGSNTMNLMNENLINMPQLIEQYGAARAIIETWAALPFSTITMWGF
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHH
FILCFLATVTLVNACSYTLAMSTCKGADADNEPPIWVRVGWSVLVGVIGIVLLSLGGLKP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCH
LQTAIIAGGAPLIIVNVMIIFSFLKDARKNNWKPVGEEAKPHLGSTAKI
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNDKTMDVNATEVKKKKVTIDPTIFFPSLLAVILLSYLTVRDLDAANLAISEVFHYLTHS
CCCCEECCCHHHHHHCEEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
WGWLFEWYMIFMGAGWAWLTWGPYSNNRLGQEKPEFSTASWIFLMFASCTSAAVLFWGSL
HHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECE
EVYYYVTYPPFDIEPLSIQAKELGLAYSLFHWGPLPWMGYGFFTVALGYFLFVKKMDVVR
EEEEEEEECCCCCCCCEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
PSGTLEPILGKHHKGFIGTFIDNVYVVALILAMGTSLGLATPLVTECIQWLFGIPRTPAV
CCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCH
DTIVISSWIVFNAICVAFGLTKGIKIASDLRSYLSIIMLVWVFLIGATSFTVNYFTDSVG
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHEEEEHHHHHHH
IMLELLPRMLFNTASVSEGSFPQDWTVFYWAWWVVYGIQMCIFLAKISRGRTVRELCLTM
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
VAGLTASTWFLWTILGSNTMNLMNENLINMPQLIEQYGAARAIIETWAALPFSTITMWGF
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHH
FILCFLATVTLVNACSYTLAMSTCKGADADNEPPIWVRVGWSVLVGVIGIVLLSLGGLKP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCH
LQTAIIAGGAPLIIVNVMIIFSFLKDARKNNWKPVGEEAKPHLGSTAKI
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-carnitine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-carnitine [Periplasm] = Proton [Cytoplasm] + L-carnitine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA