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The map label for this gene is mltC [H]

Identifier: 167622009

GI number: 167622009

Start: 76436

End: 77485

Strand: Reverse

Name: mltC [H]

Synonym: Shal_0068

Alternate gene names: 167622009

Gene position: 77485-76436 (Counterclockwise)

Preceding gene: 167622012

Following gene: 167622008

Centisome position: 1.48

GC content: 48.19

Gene sequence:

>1050_bases
ATGTCTAAATACTTATTCCAGCTACTCATTGCGATCTACTGCCTAATCGCTATCACCCTAGCGAATATCGCTAGCGCTAA
CAGTAGTGAATTAGACTTGAGTGACTACGATGCCGACGTCGCGGCATTGCTACTCGAATATCAGGGGCAAGACTCCTATT
CTCGGCCAATTATGCCATCGGTTTTGGTGTTTAACGAGAGCGAACAGGCCTCGACCTATGTCGACTTTAAACGCGGCTTA
ATATTGGTCGAAACCCGCAGCAAAACGCAGCTTAAAGACGCGGTTGTGCAGGTACTGCTGACTCAAATCGATCCAAAAGT
GATTGATGCACAAACCGCACAAGACTTTGGTCTGATCAGCAAAAAGAAAAAGCCATTCTTTTGGGGACAAGTGCTCGATA
GAGAGGGCAAGGAGATTGAGTTCCAATGGCGTGCATCGCGTTACGCCGACGACTTGGTCGCGAAAAGTAAACGAGTGAAC
TCGCGCTTTCGGGTGGCGATCCATATGGTGAAAGAACACACCCAGATTGCCGGTAATAAGTATATCAACTATGCCCGCAG
TGCCAGCCGCAAACACGGCATCAGCACTGATTTGATCATGGCGATTATGGAGACCGAAAGCTCGTTTAACCCACTGGCGC
GCTCACGTTCTAACGCTCTTGGACTCATGCAGATTAAGGCCAATACCGCAGGTCGTGACTATTTCAGCTTAATCCAAGGC
TATACACATACGCCCTCATCGGCTTATCTCTATGATCCCGCCAAAAATATCGAAGTTGGCACCGGCTATCTAAAGATCTT
ATCGACGCGTTATCTTGCGGGCATTAAACACCCAAAGAAACGTGAATACGCAGTGATCTCAAGTTACAACGGCGGCGCGG
GTAACCTGTGGAAGAGCCTCGACCCACGGGGTAATCGCACCAAGGCACTGGCGCGAATTAATAAGATGACCGTTAGCGAG
TTTTATTGGTTTTTGACCCACCGCCACAACCGCCAAGAGACACGTAACTACTTGAAGAAAGTCAGTAGTAGGCAGAAAAA
GTATCTTTAA

Upstream 100 bases:

>100_bases
TACACAAAAAACAACCAAAGTTTGAAAAATAAAACCTCAACTATGAGGGTTATGCCCAACCATTGTATAATCAAGCCACA
AAAACCTAACCCTCTGATAA

Downstream 100 bases:

>100_bases
CTCAGTAGTAAAAATACAACAACTTTAAAACGACTCAGTCCTCCAGCCAGATAGCGCAAGGTTGGCATACCGTTAATCAA
TAACTCAGACTCGGCCATTA

Product: lytic transglycosylase

Products: N-Acetylmuramic Acid Residues; N-Acetylglucosamine Residues [C]

Alternate protein names: Murein hydrolase C [H]

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MSKYLFQLLIAIYCLIAITLANIASANSSELDLSDYDADVAALLLEYQGQDSYSRPIMPSVLVFNESEQASTYVDFKRGL
ILVETRSKTQLKDAVVQVLLTQIDPKVIDAQTAQDFGLISKKKKPFFWGQVLDREGKEIEFQWRASRYADDLVAKSKRVN
SRFRVAIHMVKEHTQIAGNKYINYARSASRKHGISTDLIMAIMETESSFNPLARSRSNALGLMQIKANTAGRDYFSLIQG
YTHTPSSAYLYDPAKNIEVGTGYLKILSTRYLAGIKHPKKREYAVISSYNGGAGNLWKSLDPRGNRTKALARINKMTVSE
FYWFLTHRHNRQETRNYLKKVSSRQKKYL

Sequences:

>Translated_349_residues
MSKYLFQLLIAIYCLIAITLANIASANSSELDLSDYDADVAALLLEYQGQDSYSRPIMPSVLVFNESEQASTYVDFKRGL
ILVETRSKTQLKDAVVQVLLTQIDPKVIDAQTAQDFGLISKKKKPFFWGQVLDREGKEIEFQWRASRYADDLVAKSKRVN
SRFRVAIHMVKEHTQIAGNKYINYARSASRKHGISTDLIMAIMETESSFNPLARSRSNALGLMQIKANTAGRDYFSLIQG
YTHTPSSAYLYDPAKNIEVGTGYLKILSTRYLAGIKHPKKREYAVISSYNGGAGNLWKSLDPRGNRTKALARINKMTVSE
FYWFLTHRHNRQETRNYLKKVSSRQKKYL
>Mature_348_residues
SKYLFQLLIAIYCLIAITLANIASANSSELDLSDYDADVAALLLEYQGQDSYSRPIMPSVLVFNESEQASTYVDFKRGLI
LVETRSKTQLKDAVVQVLLTQIDPKVIDAQTAQDFGLISKKKKPFFWGQVLDREGKEIEFQWRASRYADDLVAKSKRVNS
RFRVAIHMVKEHTQIAGNKYINYARSASRKHGISTDLIMAIMETESSFNPLARSRSNALGLMQIKANTAGRDYFSLIQGY
THTPSSAYLYDPAKNIEVGTGYLKILSTRYLAGIKHPKKREYAVISSYNGGAGNLWKSLDPRGNRTKALARINKMTVSEF
YWFLTHRHNRQETRNYLKKVSSRQKKYL

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG0741

COG function: function code M; Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transglycosylase slt family [H]

Homologues:

Organism=Escherichia coli, GI87082191, Length=296, Percent_Identity=42.2297297297297, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI87081855, Length=162, Percent_Identity=37.6543209876543, Blast_Score=115, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008258
- InterPro:   IPR000189 [H]

Pfam domain/function: PF01464 SLT [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 39726; Mature: 39595

Theoretical pI: Translated: 10.21; Mature: 10.21

Prosite motif: PS00922 TRANSGLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKYLFQLLIAIYCLIAITLANIASANSSELDLSDYDADVAALLLEYQGQDSYSRPIMPS
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCE
VLVFNESEQASTYVDFKRGLILVETRSKTQLKDAVVQVLLTQIDPKVIDAQTAQDFGLIS
EEEECCCCHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHCCCHHCCCCCHHHHCCCC
KKKKPFFWGQVLDREGKEIEFQWRASRYADDLVAKSKRVNSRFRVAIHMVKEHTQIAGNK
CCCCCCHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
YINYARSASRKHGISTDLIMAIMETESSFNPLARSRSNALGLMQIKANTAGRDYFSLIQG
HHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHCCCCCEEEEEEECCCCCHHHHHHHHC
YTHTPSSAYLYDPAKNIEVGTGYLKILSTRYLAGIKHPKKREYAVISSYNGGAGNLWKSL
CCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHCC
DPRGNRTKALARINKMTVSEFYWFLTHRHNRQETRNYLKKVSSRQKKYL
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKYLFQLLIAIYCLIAITLANIASANSSELDLSDYDADVAALLLEYQGQDSYSRPIMPS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCE
VLVFNESEQASTYVDFKRGLILVETRSKTQLKDAVVQVLLTQIDPKVIDAQTAQDFGLIS
EEEECCCCHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHCCCHHCCCCCHHHHCCCC
KKKKPFFWGQVLDREGKEIEFQWRASRYADDLVAKSKRVNSRFRVAIHMVKEHTQIAGNK
CCCCCCHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
YINYARSASRKHGISTDLIMAIMETESSFNPLARSRSNALGLMQIKANTAGRDYFSLIQG
HHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHCCCCCEEEEEEECCCCCHHHHHHHHC
YTHTPSSAYLYDPAKNIEVGTGYLKILSTRYLAGIKHPKKREYAVISSYNGGAGNLWKSL
CCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHCC
DPRGNRTKALARINKMTVSEFYWFLTHRHNRQETRNYLKKVSSRQKKYL
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond Between N-Acetylmuramic Acid And N-Acetylglucosamine Residues, Thereby Conserving The Energy In A Newly Synthesized 1,6-Anhydrobond In The Muramic Acid Residue. [C]

General reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA