Click here to switch to the map view.

The map label for this gene is cobB2 [H]

Identifier: 167040688

GI number: 167040688

Start: 2077264

End: 2078010

Strand: Reverse

Name: cobB2 [H]

Synonym: Teth514_2065

Alternate gene names: 167040688

Gene position: 2078010-2077264 (Counterclockwise)

Preceding gene: 167040689

Following gene: 167040687

Centisome position: 84.57

GC content: 35.61

Gene sequence:

>747_bases
ATGGGGGATAAAAATTTGTTTGAAAAAGCTGCTCGCCTCATTAAGCAGTCAAGAAAAACTATTGTATTGACAGGAGCAGG
TATATCAACGGAAAGTGGTATACCTGATTTTAGAAGTCCCGGAAGGGGTTTGTGGGAGAACTTAGATCCAATGGAGGTTT
TGTCAACGGGAGTATTGTACAATTTCCCGGAGGAATTTTATAAAGTTGGCTTCAAGATTTTGTCTTCAATGAGAAATGCT
GAGCCTAATGAAGCTCATTACATATTAAGCGAAATGGAGAAAGAAGGTATAATTTTTGGAGTAATTACACAAAATATAGA
CAATCTTCATCAAAAAGCTGGTTCTAAAAATGTATTTGAAGTCCACGGCAATACGAGAGAAGGAAGTTGTTTACGTTGTG
GTAAAAAAGTTTCTTTTGAAGTTTTAGAGGAAAAAGTAAGTAAAAAACAAATTCCTCCTCGCTGTGATGATTGTAATGGC
GTATTGCGCCCAGATGTGGTGCTTTTTGGAGACCCTATGCCTTATGCATTTGATTTGGCAGTAAAAGAAGTAAAGTCCAG
CGATTTATTAATAGTCATAGGTTCTTCCTTGGCAGTTTCGCCAGTGAACTTTTTGCCAGATACAGTAAGACATTTGATAA
TTATAAATGCGACAGAGACTCCCTATGATTATAAAGCTGATGTAGTTATAAGAGAAAAAGCAAGTTATGCTCTTAGAAAT
ATATGGGATATAATAAAATTTCAATAA

Upstream 100 bases:

>100_bases
ACAGGGAAGATAGGTTCAATAGTTAAGAAAAAGATGAAATTGCAACAAGAGGTAGGAAAAAAGGAAAAGTTGTGATATAC
TCTATTTGAGGTGAATTGCC

Downstream 100 bases:

>100_bases
AAAAATTTGACAATTTGATATATAAGTGCTATGATAGAGAAGTAAATTATTTATCAAGTTTGGAGGAAGATATAAATGGT
AAGAGGTAAAGTAAAATGGT

Product: silent information regulator protein Sir2

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog 2 [H]

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MGDKNLFEKAARLIKQSRKTIVLTGAGISTESGIPDFRSPGRGLWENLDPMEVLSTGVLYNFPEEFYKVGFKILSSMRNA
EPNEAHYILSEMEKEGIIFGVITQNIDNLHQKAGSKNVFEVHGNTREGSCLRCGKKVSFEVLEEKVSKKQIPPRCDDCNG
VLRPDVVLFGDPMPYAFDLAVKEVKSSDLLIVIGSSLAVSPVNFLPDTVRHLIIINATETPYDYKADVVIREKASYALRN
IWDIIKFQ

Sequences:

>Translated_248_residues
MGDKNLFEKAARLIKQSRKTIVLTGAGISTESGIPDFRSPGRGLWENLDPMEVLSTGVLYNFPEEFYKVGFKILSSMRNA
EPNEAHYILSEMEKEGIIFGVITQNIDNLHQKAGSKNVFEVHGNTREGSCLRCGKKVSFEVLEEKVSKKQIPPRCDDCNG
VLRPDVVLFGDPMPYAFDLAVKEVKSSDLLIVIGSSLAVSPVNFLPDTVRHLIIINATETPYDYKADVVIREKASYALRN
IWDIIKFQ
>Mature_247_residues
GDKNLFEKAARLIKQSRKTIVLTGAGISTESGIPDFRSPGRGLWENLDPMEVLSTGVLYNFPEEFYKVGFKILSSMRNAE
PNEAHYILSEMEKEGIIFGVITQNIDNLHQKAGSKNVFEVHGNTREGSCLRCGKKVSFEVLEEKVSKKQIPPRCDDCNGV
LRPDVVLFGDPMPYAFDLAVKEVKSSDLLIVIGSSLAVSPVNFLPDTVRHLIIINATETPYDYKADVVIREKASYALRNI
WDIIKFQ

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI6912660, Length=214, Percent_Identity=35.0467289719626, Blast_Score=138, Evalue=5e-33,
Organism=Homo sapiens, GI6912662, Length=226, Percent_Identity=35.8407079646018, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI63054862, Length=196, Percent_Identity=36.2244897959184, Blast_Score=134, Evalue=7e-32,
Organism=Homo sapiens, GI7657575, Length=253, Percent_Identity=35.1778656126482, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI13775602, Length=216, Percent_Identity=31.9444444444444, Blast_Score=120, Evalue=9e-28,
Organism=Homo sapiens, GI13775600, Length=216, Percent_Identity=31.9444444444444, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI300797705, Length=208, Percent_Identity=31.7307692307692, Blast_Score=117, Evalue=9e-27,
Organism=Homo sapiens, GI13787215, Length=224, Percent_Identity=32.5892857142857, Blast_Score=111, Evalue=6e-25,
Organism=Homo sapiens, GI6912664, Length=224, Percent_Identity=32.5892857142857, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI300795542, Length=208, Percent_Identity=32.6923076923077, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI300797577, Length=235, Percent_Identity=29.3617021276596, Blast_Score=98, Evalue=7e-21,
Organism=Homo sapiens, GI215982798, Length=185, Percent_Identity=34.5945945945946, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI7706712, Length=247, Percent_Identity=25.9109311740891, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI308199517, Length=191, Percent_Identity=35.6020942408377, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17541892, Length=254, Percent_Identity=34.251968503937, Blast_Score=128, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71990482, Length=274, Percent_Identity=28.4671532846715, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17567771, Length=274, Percent_Identity=27.7372262773723, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71990487, Length=276, Percent_Identity=28.2608695652174, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6325242, Length=235, Percent_Identity=32.7659574468085, Blast_Score=117, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324504, Length=252, Percent_Identity=28.968253968254, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6320163, Length=248, Percent_Identity=28.6290322580645, Blast_Score=101, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24648389, Length=214, Percent_Identity=32.7102803738318, Blast_Score=121, Evalue=4e-28,
Organism=Drosophila melanogaster, GI17137536, Length=237, Percent_Identity=32.9113924050633, Blast_Score=121, Evalue=4e-28,
Organism=Drosophila melanogaster, GI28571445, Length=182, Percent_Identity=34.0659340659341, Blast_Score=107, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24645650, Length=254, Percent_Identity=27.9527559055118, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24650933, Length=256, Percent_Identity=26.171875, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI28571443, Length=121, Percent_Identity=32.2314049586777, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI28571441, Length=121, Percent_Identity=32.2314049586777, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 27769; Mature: 27638

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDKNLFEKAARLIKQSRKTIVLTGAGISTESGIPDFRSPGRGLWENLDPMEVLSTGVLY
CCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCHHCCCCHHHHHHHCHHC
NFPEEFYKVGFKILSSMRNAEPNEAHYILSEMEKEGIIFGVITQNIDNLHQKAGSKNVFE
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCCCCEEE
VHGNTREGSCLRCGKKVSFEVLEEKVSKKQIPPRCDDCNGVLRPDVVLFGDPMPYAFDLA
ECCCCCCCHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCHHHHHH
VKEVKSSDLLIVIGSSLAVSPVNFLPDTVRHLIIINATETPYDYKADVVIREKASYALRN
HHHCCCCCEEEEECCCCEECCHHHHHHHHHEEEEEECCCCCCCCCCCEEEECHHHHHHHH
IWDIIKFQ
HHHHHHCC
>Mature Secondary Structure 
GDKNLFEKAARLIKQSRKTIVLTGAGISTESGIPDFRSPGRGLWENLDPMEVLSTGVLY
CCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCHHCCCCHHHHHHHCHHC
NFPEEFYKVGFKILSSMRNAEPNEAHYILSEMEKEGIIFGVITQNIDNLHQKAGSKNVFE
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCCCCEEE
VHGNTREGSCLRCGKKVSFEVLEEKVSKKQIPPRCDDCNGVLRPDVVLFGDPMPYAFDLA
ECCCCCCCHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCHHHHHH
VKEVKSSDLLIVIGSSLAVSPVNFLPDTVRHLIIINATETPYDYKADVVIREKASYALRN
HHHCCCCCEEEEECCCCEECCHHHHHHHHHEEEEEECCCCCCCCCCCEEEECHHHHHHHH
IWDIIKFQ
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]