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The map label for this gene is thrS [H]

Identifier: 167040680

GI number: 167040680

Start: 2069405

End: 2071309

Strand: Reverse

Name: thrS [H]

Synonym: Teth514_2057

Alternate gene names: 167040680

Gene position: 2071309-2069405 (Counterclockwise)

Preceding gene: 167040681

Following gene: 167040679

Centisome position: 84.29

GC content: 35.33

Gene sequence:

>1905_bases
ATGATTATAATATTAAAGGATGGCACACAAAGAGAATTTGAAAAGGGTATGACAGTTTATGAAATAGCTAAAAGTATAAG
TGAAAGATTAGCAAAAGAAGCCGTCGGTGGAAAGTTTAATGGCAAAGTAGTGGAACTTAATACAAAAATTGAAGAGGACG
GAAAATTAGAAATTTTGACTTTTGATGATGAAGAAGGAAAAAAAATTTATTGGCACACTTCTTCCCATATTTTAGCACAA
GCTGTAAAAAGGCTTTTTAAAGATGTGAAATTGGCAATTGGTCCGGCTATAGACAATGGCTTTTACTATGACTTCGACAC
AGATAGGCCTTTTACTACAGAAGACTTTGAAGCTATAGAGCAGGAAATGAATAAAATTATAAAAGAAGATTATAAGTTGG
AAAGATTTGTCCTTCCAAAGGATGAAGCAATAAAATTAATGGAGGAAAAAGGTGAACCTTATAAAGTGGAGCTAATTGAA
GAAATACCAGAAGGGGAGGAAATTTCTTTTTACAAGCAAGGAGAATTTACTGACCTTTGTGCTGGGCCCCATCTTATGTC
AACAGGCATGGTAAAAACTATTAAATTGTTGTCAGTTGCTGGCGCCTACTGGAAAGGCGACGAAAAAAATAAAATGCTTC
AAAGAATATATGGAATAAGCTTTCCTAAAAAAAGCATGTTAGATCAATATTTACATATGTTAGAGGAAGCTAAAAAGAGA
GACCATAGAAAATTAGGGAAAGAGTTAGATTTGTTTAGTATCCACCCTGAAGGACCAGGTTTTCCTTTTTTCCATCCTAA
GGGAATGATTATAAGAAACATTTTAGAAGATTTTTGGCGAAAAGAACATATAAAGCATGGTTATCAGGAAATAAAAACTC
CTATAATTTTGAATGAAGAATTATGGCGTAGGTCAGGACACTGGGACCACTATAAAGAGAATATGTATTTCACTGAAATA
GACGGAGAGACTTATGCAATAAAGCCTATGAATTGTCCTGGAGCAATGCTTGTTTACAAGTCTACAATGCACAGTTACAG
AGATTTACCCTTAAGACTTTGTGAATTGGGTTTAGTGCATAGACATGAACTCTCAGGAGTTTTGCATGGGCTTATGAGAG
TAAGAAGTTTTACTCAGGATGATGCTCACTTGTTTATGACTCCTGAGCAGGTTGAAGATGAAATTTTAGGGGTTATAAAT
TTAGTGGATTATTTCTATAAAATTTTTGGCTTTGAGTATTTTGTTGAATTGTCTACACGTCCTGAAAATTCTATGGGGTC
TGATGAAGACTGGGAATTGGCTACAAATGCTTTGATTTCTGCTTTAAATCGCGTGAATTTACCATATAAAGTTAATGAGG
GGGATGGTGCATTTTACGGACCCAAAATAGATTTTCATTTAAAAGACAGCATAGGTCGTACGTGGCAATGTGGAACTATC
CAATTAGATTTCCAGATGCCTGAAAGGTTTGAACTGGAGTATATAGGCCCAGATGGAGAAAAACACAGACCTATAATGTT
GCACAGGGTAATTTACGGAAGTATAGAAAGATTTATTGGAATTCTTACTGAACATTTTGCAGGGGCTTTCCCAACTTGGC
TGGCGCCAGTACAAGTTAGAGTTTTGCCTATATCTGATAAACACTATGCTTATGCCCAAAATGTATATGGGCGTCTGTTG
GAAAATGACATAAGAGCTGAATTGGACGACAGAAATGAAAAAGTAGGATACAAAATACGAGAGGCACAACTTCAAAAGAT
TCCCTATATGCTGATTGTAGGGGATAAAGAAGTAGAACAAGGGACAGTATCTTTAAGGTCAAGAAAAGAAGGGGATCTAG
GTGCTATTTCCTTAAGTGAGTTTATAGAAAAAATTCTTAAAGAAATCGCTACAAAAGCTTTATAA

Upstream 100 bases:

>100_bases
CCAGAGTATAAAAAAGAGTGGAACCGCAGATAACCTCTGCCTCTTTACGGGGTAAGAGGTTTTTTATTTAAGAGAAAAAT
TTTACAAAGGAGGTAATTGA

Downstream 100 bases:

>100_bases
AATCAAAATGCTCCTTTAAGGGGCATTTTGATTTATTGTTTATTGAAAGAATTTAAAAAACGTGATAATCTAAAATTAAA
ATATCAATTTTGAGGGAGAG

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 634; Mature: 634

Protein sequence:

>634_residues
MIIILKDGTQREFEKGMTVYEIAKSISERLAKEAVGGKFNGKVVELNTKIEEDGKLEILTFDDEEGKKIYWHTSSHILAQ
AVKRLFKDVKLAIGPAIDNGFYYDFDTDRPFTTEDFEAIEQEMNKIIKEDYKLERFVLPKDEAIKLMEEKGEPYKVELIE
EIPEGEEISFYKQGEFTDLCAGPHLMSTGMVKTIKLLSVAGAYWKGDEKNKMLQRIYGISFPKKSMLDQYLHMLEEAKKR
DHRKLGKELDLFSIHPEGPGFPFFHPKGMIIRNILEDFWRKEHIKHGYQEIKTPIILNEELWRRSGHWDHYKENMYFTEI
DGETYAIKPMNCPGAMLVYKSTMHSYRDLPLRLCELGLVHRHELSGVLHGLMRVRSFTQDDAHLFMTPEQVEDEILGVIN
LVDYFYKIFGFEYFVELSTRPENSMGSDEDWELATNALISALNRVNLPYKVNEGDGAFYGPKIDFHLKDSIGRTWQCGTI
QLDFQMPERFELEYIGPDGEKHRPIMLHRVIYGSIERFIGILTEHFAGAFPTWLAPVQVRVLPISDKHYAYAQNVYGRLL
ENDIRAELDDRNEKVGYKIREAQLQKIPYMLIVGDKEVEQGTVSLRSRKEGDLGAISLSEFIEKILKEIATKAL

Sequences:

>Translated_634_residues
MIIILKDGTQREFEKGMTVYEIAKSISERLAKEAVGGKFNGKVVELNTKIEEDGKLEILTFDDEEGKKIYWHTSSHILAQ
AVKRLFKDVKLAIGPAIDNGFYYDFDTDRPFTTEDFEAIEQEMNKIIKEDYKLERFVLPKDEAIKLMEEKGEPYKVELIE
EIPEGEEISFYKQGEFTDLCAGPHLMSTGMVKTIKLLSVAGAYWKGDEKNKMLQRIYGISFPKKSMLDQYLHMLEEAKKR
DHRKLGKELDLFSIHPEGPGFPFFHPKGMIIRNILEDFWRKEHIKHGYQEIKTPIILNEELWRRSGHWDHYKENMYFTEI
DGETYAIKPMNCPGAMLVYKSTMHSYRDLPLRLCELGLVHRHELSGVLHGLMRVRSFTQDDAHLFMTPEQVEDEILGVIN
LVDYFYKIFGFEYFVELSTRPENSMGSDEDWELATNALISALNRVNLPYKVNEGDGAFYGPKIDFHLKDSIGRTWQCGTI
QLDFQMPERFELEYIGPDGEKHRPIMLHRVIYGSIERFIGILTEHFAGAFPTWLAPVQVRVLPISDKHYAYAQNVYGRLL
ENDIRAELDDRNEKVGYKIREAQLQKIPYMLIVGDKEVEQGTVSLRSRKEGDLGAISLSEFIEKILKEIATKAL
>Mature_634_residues
MIIILKDGTQREFEKGMTVYEIAKSISERLAKEAVGGKFNGKVVELNTKIEEDGKLEILTFDDEEGKKIYWHTSSHILAQ
AVKRLFKDVKLAIGPAIDNGFYYDFDTDRPFTTEDFEAIEQEMNKIIKEDYKLERFVLPKDEAIKLMEEKGEPYKVELIE
EIPEGEEISFYKQGEFTDLCAGPHLMSTGMVKTIKLLSVAGAYWKGDEKNKMLQRIYGISFPKKSMLDQYLHMLEEAKKR
DHRKLGKELDLFSIHPEGPGFPFFHPKGMIIRNILEDFWRKEHIKHGYQEIKTPIILNEELWRRSGHWDHYKENMYFTEI
DGETYAIKPMNCPGAMLVYKSTMHSYRDLPLRLCELGLVHRHELSGVLHGLMRVRSFTQDDAHLFMTPEQVEDEILGVIN
LVDYFYKIFGFEYFVELSTRPENSMGSDEDWELATNALISALNRVNLPYKVNEGDGAFYGPKIDFHLKDSIGRTWQCGTI
QLDFQMPERFELEYIGPDGEKHRPIMLHRVIYGSIERFIGILTEHFAGAFPTWLAPVQVRVLPISDKHYAYAQNVYGRLL
ENDIRAELDDRNEKVGYKIREAQLQKIPYMLIVGDKEVEQGTVSLRSRKEGDLGAISLSEFIEKILKEIATKAL

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38202255, Length=636, Percent_Identity=44.3396226415094, Blast_Score=546, Evalue=1e-155,
Organism=Homo sapiens, GI38570111, Length=620, Percent_Identity=43.8709677419355, Blast_Score=543, Evalue=1e-154,
Organism=Homo sapiens, GI20070344, Length=635, Percent_Identity=38.8976377952756, Blast_Score=473, Evalue=1e-133,
Organism=Escherichia coli, GI1788013, Length=635, Percent_Identity=48.0314960629921, Blast_Score=640, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984184, Length=629, Percent_Identity=41.335453100159, Blast_Score=527, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI71984192, Length=629, Percent_Identity=41.335453100159, Blast_Score=527, Evalue=1e-150,
Organism=Saccharomyces cerevisiae, GI6322112, Length=647, Percent_Identity=41.8856259659969, Blast_Score=538, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6322654, Length=414, Percent_Identity=38.8888888888889, Blast_Score=303, Evalue=5e-83,
Organism=Drosophila melanogaster, GI24583839, Length=628, Percent_Identity=44.2675159235669, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24583842, Length=628, Percent_Identity=44.2675159235669, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI28574141, Length=628, Percent_Identity=44.2675159235669, Blast_Score=563, Evalue=1e-160,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 73516; Mature: 73516

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIILKDGTQREFEKGMTVYEIAKSISERLAKEAVGGKFNGKVVELNTKIEEDGKLEILT
CEEEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEE
FDDEEGKKIYWHTSSHILAQAVKRLFKDVKLAIGPAIDNGFYYDFDTDRPFTTEDFEAIE
ECCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCEECCCEEEECCCCCCCCCHHHHHHH
QEMNKIIKEDYKLERFVLPKDEAIKLMEEKGEPYKVELIEEIPEGEEISFYKQGEFTDLC
HHHHHHHHHCCCHHEEECCCHHHHHHHHHCCCCEEEHHHHHCCCCCCEEEEECCCCCHHC
AGPHLMSTGMVKTIKLLSVAGAYWKGDEKNKMLQRIYGISFPKKSMLDQYLHMLEEAKKR
CCCHHHHCCHHHHHHHHHHHCHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
DHRKLGKELDLFSIHPEGPGFPFFHPKGMIIRNILEDFWRKEHIKHGYQEIKTPIILNEE
HHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHH
LWRRSGHWDHYKENMYFTEIDGETYAIKPMNCPGAMLVYKSTMHSYRDLPLRLCELGLVH
HHHCCCCCCHHHCCEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHH
RHELSGVLHGLMRVRSFTQDDAHLFMTPEQVEDEILGVINLVDYFYKIFGFEYFVELSTR
HHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECC
PENSMGSDEDWELATNALISALNRVNLPYKVNEGDGAFYGPKIDFHLKDSIGRTWQCGTI
CCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCEECCEEEEEECCCCCCEEECCEE
QLDFQMPERFELEYIGPDGEKHRPIMLHRVIYGSIERFIGILTEHFAGAFPTWLAPVQVR
EEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCEEEE
VLPISDKHYAYAQNVYGRLLENDIRAELDDRNEKVGYKIREAQLQKIPYMLIVGDKEVEQ
EEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCEEEEECCCCCCC
GTVSLRSRKEGDLGAISLSEFIEKILKEIATKAL
CHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIIILKDGTQREFEKGMTVYEIAKSISERLAKEAVGGKFNGKVVELNTKIEEDGKLEILT
CEEEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEE
FDDEEGKKIYWHTSSHILAQAVKRLFKDVKLAIGPAIDNGFYYDFDTDRPFTTEDFEAIE
ECCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCEECCCEEEECCCCCCCCCHHHHHHH
QEMNKIIKEDYKLERFVLPKDEAIKLMEEKGEPYKVELIEEIPEGEEISFYKQGEFTDLC
HHHHHHHHHCCCHHEEECCCHHHHHHHHHCCCCEEEHHHHHCCCCCCEEEEECCCCCHHC
AGPHLMSTGMVKTIKLLSVAGAYWKGDEKNKMLQRIYGISFPKKSMLDQYLHMLEEAKKR
CCCHHHHCCHHHHHHHHHHHCHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
DHRKLGKELDLFSIHPEGPGFPFFHPKGMIIRNILEDFWRKEHIKHGYQEIKTPIILNEE
HHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHH
LWRRSGHWDHYKENMYFTEIDGETYAIKPMNCPGAMLVYKSTMHSYRDLPLRLCELGLVH
HHHCCCCCCHHHCCEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHH
RHELSGVLHGLMRVRSFTQDDAHLFMTPEQVEDEILGVINLVDYFYKIFGFEYFVELSTR
HHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECC
PENSMGSDEDWELATNALISALNRVNLPYKVNEGDGAFYGPKIDFHLKDSIGRTWQCGTI
CCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCEECCEEEEEECCCCCCEEECCEE
QLDFQMPERFELEYIGPDGEKHRPIMLHRVIYGSIERFIGILTEHFAGAFPTWLAPVQVR
EEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCEEEE
VLPISDKHYAYAQNVYGRLLENDIRAELDDRNEKVGYKIREAQLQKIPYMLIVGDKEVEQ
EEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCEEEEECCCCCCC
GTVSLRSRKEGDLGAISLSEFIEKILKEIATKAL
CHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]