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The map label for this gene is acoC [H]

Identifier: 167040653

GI number: 167040653

Start: 2039473

End: 2040621

Strand: Reverse

Name: acoC [H]

Synonym: Teth514_2030

Alternate gene names: 167040653

Gene position: 2040621-2039473 (Counterclockwise)

Preceding gene: 167040654

Following gene: 167040652

Centisome position: 83.04

GC content: 33.42

Gene sequence:

>1149_bases
ATGCCGGTAAATGTAGTGATGCCTAAATTGGGACTTACAATGAAAGAAGGCAGAGTAGATAGATGGCTTAAAAAAGTTGG
TGATATTGTAAAAAAAGGAGAAGAGATTGTCGAGGTTTCTACAGATAAGATTACCAATGTTGTAGAATCTCCAGCGGATG
GAATTTTGGCGAAGATCTTAGTAAATGAAGGAGAAATTGTACCAGTAGCTACTCCTATTGGAATAATTACAGCTGAAGGG
GAAAAGTTAGAAGAAGTAGAAAAAAGTGAGGAAAAGTTTATAAAAGCTACTCCAGTAGCAAAAAGGTTGGCGAAGGAGAA
TAACATAGACCTTTCTTTAATAACTGGAACAGGACCAGGTGGAAGGATTACTGAAGAAGACGTAAAAAAGTTTATTTCTG
AGCAAAAAGTAAAAACAGAAGAAGAGGGACCAAAAAAAGAAGTAGCAGTAATAGAAGGACAAGCATTGGAAAAAGTTGAA
AGAATGCCAATGGACAATATTCGCAAAACCATAAGTCAAAGGATGAAAAAAAGCTGGTCAGAAATTCCTCATGTTACAGA
AGATATTAAAGTGGATGTCACAGAACTGGTTAACTTAAGAGAAAATTTAAATCATATTAGCGATAATAAATTTACTTATA
CCGATTTAATTGCAAAAGCATGTGTAATAGCTATAAAGAAAAATCCTGTAGTTAACTGGTCTATAGAAGGAGAATATATA
ATTAAAAATAGCAGTATAAATCTCGGAATTGCAGTGGCTTTAGATAATGGTTTAATAGTTCCTGTAGTGAAAGAGGCGGA
CAAAAAGAGTCTATTAGAATTGTCAAAAAATATAAAAGAATTAAGCGAAAGAGCGAGAAATAATAAGCTTACTCCAGACG
AAATAATCGGAAGTACATTTACTATCACTAACCTTGGAATGTATGAAATAGATAGTTTCACGCCTATTATAAATCCGCCC
GAAAGTGCTATATTGGGTGTCAACAAAATATATAAAGAACCAGTAGTTCTTGATAACAATATTGTTATAAGGCATATCAT
GAAACTTAGCCTTTCTTTTGACCATCGATTAATAGACGGGGCTACTGCTGCTAAATTTCTCCTTGACTTAAAGAAAACAT
TAGAGAATCCAGTATCTTTACTTATTTAA

Upstream 100 bases:

>100_bases
TTAATTTTTAGAATATCGCGGAGTGGACCTTATCGAGTTAATGTAACAAAAACGCTTGAAATTGCACAACAAATAGGATT
TTTTGTAAAGAGGTGATTTT

Downstream 100 bases:

>100_bases
ATTAAAATTTTAAATAAAACAAGCTGATGTTGAAAATAAGTTATATTTTCACCATTGGCTTGTTTTATTTAATGCCGAGA
TAGCCTAACAAATACTTTGA

Product: dehydrogenase catalytic domain-containing protein

Products: NA

Alternate protein names: Acetoin dehydrogenase E2 component; Dihydrolipoamide acetyltransferase component of acetoin cleaving system [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MPVNVVMPKLGLTMKEGRVDRWLKKVGDIVKKGEEIVEVSTDKITNVVESPADGILAKILVNEGEIVPVATPIGIITAEG
EKLEEVEKSEEKFIKATPVAKRLAKENNIDLSLITGTGPGGRITEEDVKKFISEQKVKTEEEGPKKEVAVIEGQALEKVE
RMPMDNIRKTISQRMKKSWSEIPHVTEDIKVDVTELVNLRENLNHISDNKFTYTDLIAKACVIAIKKNPVVNWSIEGEYI
IKNSSINLGIAVALDNGLIVPVVKEADKKSLLELSKNIKELSERARNNKLTPDEIIGSTFTITNLGMYEIDSFTPIINPP
ESAILGVNKIYKEPVVLDNNIVIRHIMKLSLSFDHRLIDGATAAKFLLDLKKTLENPVSLLI

Sequences:

>Translated_382_residues
MPVNVVMPKLGLTMKEGRVDRWLKKVGDIVKKGEEIVEVSTDKITNVVESPADGILAKILVNEGEIVPVATPIGIITAEG
EKLEEVEKSEEKFIKATPVAKRLAKENNIDLSLITGTGPGGRITEEDVKKFISEQKVKTEEEGPKKEVAVIEGQALEKVE
RMPMDNIRKTISQRMKKSWSEIPHVTEDIKVDVTELVNLRENLNHISDNKFTYTDLIAKACVIAIKKNPVVNWSIEGEYI
IKNSSINLGIAVALDNGLIVPVVKEADKKSLLELSKNIKELSERARNNKLTPDEIIGSTFTITNLGMYEIDSFTPIINPP
ESAILGVNKIYKEPVVLDNNIVIRHIMKLSLSFDHRLIDGATAAKFLLDLKKTLENPVSLLI
>Mature_381_residues
PVNVVMPKLGLTMKEGRVDRWLKKVGDIVKKGEEIVEVSTDKITNVVESPADGILAKILVNEGEIVPVATPIGIITAEGE
KLEEVEKSEEKFIKATPVAKRLAKENNIDLSLITGTGPGGRITEEDVKKFISEQKVKTEEEGPKKEVAVIEGQALEKVER
MPMDNIRKTISQRMKKSWSEIPHVTEDIKVDVTELVNLRENLNHISDNKFTYTDLIAKACVIAIKKNPVVNWSIEGEYII
KNSSINLGIAVALDNGLIVPVVKEADKKSLLELSKNIKELSERARNNKLTPDEIIGSTFTITNLGMYEIDSFTPIINPPE
SAILGVNKIYKEPVVLDNNIVIRHIMKLSLSFDHRLIDGATAAKFLLDLKKTLENPVSLLI

Specific function: The 2-Oxoglutarate Dehydrogenase Complex Catalyzes The Overall Conversion Of 2-Oxoglutarate To Succinyl-CoA And Co(2). It Contains Multiple Copies Of Three Enzymatic Components: 2- Oxoglutarate Dehydrogenase (E1), Dihydrolipoamide Succinyltransferase (E2)

COG id: COG0508

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI31711992, Length=434, Percent_Identity=32.9493087557604, Blast_Score=215, Evalue=7e-56,
Organism=Homo sapiens, GI203098753, Length=449, Percent_Identity=32.0712694877506, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI203098816, Length=449, Percent_Identity=32.0712694877506, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI110671329, Length=420, Percent_Identity=30.2380952380952, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI19923748, Length=236, Percent_Identity=33.4745762711864, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI260898739, Length=194, Percent_Identity=35.5670103092784, Blast_Score=119, Evalue=6e-27,
Organism=Escherichia coli, GI1786946, Length=402, Percent_Identity=33.5820895522388, Blast_Score=212, Evalue=4e-56,
Organism=Escherichia coli, GI1786305, Length=399, Percent_Identity=33.3333333333333, Blast_Score=199, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17560088, Length=441, Percent_Identity=32.8798185941043, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17538894, Length=319, Percent_Identity=31.6614420062696, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17537937, Length=421, Percent_Identity=26.8408551068884, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI25146366, Length=221, Percent_Identity=31.2217194570136, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6324258, Length=444, Percent_Identity=31.5315315315315, Blast_Score=199, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6320352, Length=398, Percent_Identity=31.9095477386935, Blast_Score=184, Evalue=2e-47,
Organism=Drosophila melanogaster, GI18859875, Length=426, Percent_Identity=28.8732394366197, Blast_Score=161, Evalue=7e-40,
Organism=Drosophila melanogaster, GI24582497, Length=295, Percent_Identity=31.5254237288136, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI20129315, Length=295, Percent_Identity=31.5254237288136, Blast_Score=154, Evalue=9e-38,
Organism=Drosophila melanogaster, GI24645909, Length=222, Percent_Identity=33.7837837837838, Blast_Score=149, Evalue=4e-36,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3096 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001078
- InterPro:   IPR000089
- InterPro:   IPR023213
- InterPro:   IPR004167
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00198 2-oxoacid_dh; PF00364 Biotin_lipoyl; PF02817 E3_binding [H]

EC number: =2.3.1.12 [H]

Molecular weight: Translated: 42396; Mature: 42265

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVNVVMPKLGLTMKEGRVDRWLKKVGDIVKKGEEIVEVSTDKITNVVESPADGILAKIL
CCCEEECCCCCCEECCCHHHHHHHHHHHHHHCCHHHEEEHHHHHHHHHHCCHHHHHHHEE
VNEGEIVPVATPIGIITAEGEKLEEVEKSEEKFIKATPVAKRLAKENNIDLSLITGTGPG
ECCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
GRITEEDVKKFISEQKVKTEEEGPKKEVAVIEGQALEKVERMPMDNIRKTISQRMKKSWS
CCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHCCHHHHHHHHHHHHHHHHH
EIPHVTEDIKVDVTELVNLRENLNHISDNKFTYTDLIAKACVIAIKKNPVVNWSIEGEYI
HCCCCCHHHEECHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHEEEECCCEEEEEECCCEE
IKNSSINLGIAVALDNGLIVPVVKEADKKSLLELSKNIKELSERARNNKLTPDEIIGSTF
EECCCCCEEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCEE
TITNLGMYEIDSFTPIINPPESAILGVNKIYKEPVVLDNNIVIRHIMKLSLSFDHRLIDG
EEECCCCEEECCCCCCCCCCHHHHHCHHHHHCCCEEECCCHHHHHHHHHHHCCCHHHHCH
ATAAKFLLDLKKTLENPVSLLI
HHHHHHHHHHHHHHCCHHHHCC
>Mature Secondary Structure 
PVNVVMPKLGLTMKEGRVDRWLKKVGDIVKKGEEIVEVSTDKITNVVESPADGILAKIL
CCEEECCCCCCEECCCHHHHHHHHHHHHHHCCHHHEEEHHHHHHHHHHCCHHHHHHHEE
VNEGEIVPVATPIGIITAEGEKLEEVEKSEEKFIKATPVAKRLAKENNIDLSLITGTGPG
ECCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
GRITEEDVKKFISEQKVKTEEEGPKKEVAVIEGQALEKVERMPMDNIRKTISQRMKKSWS
CCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHCCHHHHHHHHHHHHHHHHH
EIPHVTEDIKVDVTELVNLRENLNHISDNKFTYTDLIAKACVIAIKKNPVVNWSIEGEYI
HCCCCCHHHEECHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHEEEECCCEEEEEECCCEE
IKNSSINLGIAVALDNGLIVPVVKEADKKSLLELSKNIKELSERARNNKLTPDEIIGSTF
EECCCCCEEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCEE
TITNLGMYEIDSFTPIINPPESAILGVNKIYKEPVVLDNNIVIRHIMKLSLSFDHRLIDG
EEECCCCEEECCCCCCCCCCHHHHHCHHHHHCCCEEECCCHHHHHHHHHHHCCCHHHHCH
ATAAKFLLDLKKTLENPVSLLI
HHHHHHHHHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969503; 9384377 [H]