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The map label for this gene is codB [H]

Identifier: 167040592

GI number: 167040592

Start: 1975408

End: 1976727

Strand: Reverse

Name: codB [H]

Synonym: Teth514_1965

Alternate gene names: 167040592

Gene position: 1976727-1975408 (Counterclockwise)

Preceding gene: 167040596

Following gene: 167040591

Centisome position: 80.44

GC content: 36.36

Gene sequence:

>1320_bases
ATGGCTTTTAAGACTGCTGATGACTATTCTTTAAGTCGTGTTCCATTAGATGCACGACGTCCTATGTGGGAGGTTTTCAT
GATTCGTTTTGGCAGTGTGGTTTGTTTGCCTTTACTTATGACTGGTGCCACTATAGGCTATGGCATGACAATGAAAGATG
TAATTATTGCTACTTTATTGGGTGTTACAATTATGGAAATTGTCAGTTTTTTAACTGGGGTAGCTGGAGCTTTAGAAGGA
ATGTCTACTAGTTTTCTTTCTCGCTGGGCAGGCTTTGGTCAACTAGGTTCGAGTCTTATTGGACTTGTAATTTCAATTAC
GGCTACGGGTTGGTTTGGTATTCAAAATTCTGTTTTTGCTGAGGGACTTTATAGTGCTTTTAGGGGTAAGGTTAATATTC
AGTTATTAATGCTTATAAGTGGTATTGCAATTACATTAATTGTAGTTTATGGTTATAAAATGCTTAGCTATACAGCAAAT
ATTGCTGTTCCTGCTTTTATAGCCGGAGTATTGTGGGCTACATTTAAAATGTTAGGTAACTACAATATGAGCGAAATTCT
TTCATCTCCCCCTCCGGGTCCGCATCTTACTATTGGTGTTGCTGCAACTATGATAGCGGGTGGCTTTATGGTAGGTTCGG
TTATAACGCCTGATCTGAGTAGGTTTAACAGAAATGCCAAAGATGTTTTTTGGATGACTTTACTAAGTCTACTTTTAGGA
GAAATATTACTAAACTTTATAGGAGCCACGATGGCACATGCAGCAAGTACAAGCGATGTTGTTAAGATAATGTATAATCT
AGGTGGTTGGTTTGCTGCATTGTTGGTTATTTTTTCAACTATAAAAATTAATGATTTAAATCTTTATGCTGCTTCATTGG
GTGTTACTAATTTTTTAGATGCTGCCTTTAATGTAAAAGTTAACCGAGGAATAGTTACATTGATTATTGGAATAATAGGA
ACAGCACTTTCTATGATGGGAATATTAGAGAAATTTACAAGTTTTTTGATGATATTAGGAATTGCAATACCACCTATTGC
AGGAATCATGGTTGTTGATTATTTTATCTTAAGGCGTTTCAAAAAAGAACTTGAGGAAAGTCGTGCAGAGGGCAAATTAC
CGGAGATTGTGGAGCATATCAATCCTATTGCATTATTAGCTTGGTTAATTGGAGCTTTAATAGGTTATTATGTTCAGTGG
GGTATTCCAGCATTAAATTCTTTAGTGGCTGCTGGTTTAGCACACTGGTTAATATCGAAAATGTGGGCTATAACCACAGG
CCGTAAAATGATTCGTTTTGTAAAAGGTGAGAATGCATGA

Upstream 100 bases:

>100_bases
GTTTGGCGAAGAAATTGGCATGATTTTTGCTAAACTATTGCTTCACAGAATTAACTTTTTAAACTTTAAAAAATTAACTT
TTTAAAGAGGAGGAGTCAAA

Downstream 100 bases:

>100_bases
AAAGGATGGTAGTAAAATATAACTTTTTCAGGAAAATTTACAAAAAATCTATTAAAAATGTTTAAAAGGAGGTACAACAA
AAAATGAAAAAGGATATAGA

Product: cytosine/purines, uracil, thiamine, allantoin permease

Products: Proton [Cytoplasm]; cytosine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MAFKTADDYSLSRVPLDARRPMWEVFMIRFGSVVCLPLLMTGATIGYGMTMKDVIIATLLGVTIMEIVSFLTGVAGALEG
MSTSFLSRWAGFGQLGSSLIGLVISITATGWFGIQNSVFAEGLYSAFRGKVNIQLLMLISGIAITLIVVYGYKMLSYTAN
IAVPAFIAGVLWATFKMLGNYNMSEILSSPPPGPHLTIGVAATMIAGGFMVGSVITPDLSRFNRNAKDVFWMTLLSLLLG
EILLNFIGATMAHAASTSDVVKIMYNLGGWFAALLVIFSTIKINDLNLYAASLGVTNFLDAAFNVKVNRGIVTLIIGIIG
TALSMMGILEKFTSFLMILGIAIPPIAGIMVVDYFILRRFKKELEESRAEGKLPEIVEHINPIALLAWLIGALIGYYVQW
GIPALNSLVAAGLAHWLISKMWAITTGRKMIRFVKGENA

Sequences:

>Translated_439_residues
MAFKTADDYSLSRVPLDARRPMWEVFMIRFGSVVCLPLLMTGATIGYGMTMKDVIIATLLGVTIMEIVSFLTGVAGALEG
MSTSFLSRWAGFGQLGSSLIGLVISITATGWFGIQNSVFAEGLYSAFRGKVNIQLLMLISGIAITLIVVYGYKMLSYTAN
IAVPAFIAGVLWATFKMLGNYNMSEILSSPPPGPHLTIGVAATMIAGGFMVGSVITPDLSRFNRNAKDVFWMTLLSLLLG
EILLNFIGATMAHAASTSDVVKIMYNLGGWFAALLVIFSTIKINDLNLYAASLGVTNFLDAAFNVKVNRGIVTLIIGIIG
TALSMMGILEKFTSFLMILGIAIPPIAGIMVVDYFILRRFKKELEESRAEGKLPEIVEHINPIALLAWLIGALIGYYVQW
GIPALNSLVAAGLAHWLISKMWAITTGRKMIRFVKGENA
>Mature_438_residues
AFKTADDYSLSRVPLDARRPMWEVFMIRFGSVVCLPLLMTGATIGYGMTMKDVIIATLLGVTIMEIVSFLTGVAGALEGM
STSFLSRWAGFGQLGSSLIGLVISITATGWFGIQNSVFAEGLYSAFRGKVNIQLLMLISGIAITLIVVYGYKMLSYTANI
AVPAFIAGVLWATFKMLGNYNMSEILSSPPPGPHLTIGVAATMIAGGFMVGSVITPDLSRFNRNAKDVFWMTLLSLLLGE
ILLNFIGATMAHAASTSDVVKIMYNLGGWFAALLVIFSTIKINDLNLYAASLGVTNFLDAAFNVKVNRGIVTLIIGIIGT
ALSMMGILEKFTSFLMILGIAIPPIAGIMVVDYFILRRFKKELEESRAEGKLPEIVEHINPIALLAWLIGALIGYYVQWG
IPALNSLVAAGLAHWLISKMWAITTGRKMIRFVKGENA

Specific function: Required for cytosine transport into the cell [H]

COG id: COG1457

COG function: function code F; Purine-cytosine permease and related proteins

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine-cytosine permease family [H]

Homologues:

Organism=Escherichia coli, GI1786530, Length=416, Percent_Identity=27.8846153846154, Blast_Score=134, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001248
- InterPro:   IPR012681 [H]

Pfam domain/function: PF02133 Transp_cyt_pur [H]

EC number: NA

Molecular weight: Translated: 47497; Mature: 47366

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AFKTADDYSLSRVPLDARRPMWEVFMIRFGSVVCLPLLMTGATIGYGMTMKDVIIATLL
CCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHH
GVTIMEIVSFLTGVAGALEGMSTSFLSRWAGFGQLGSSLIGLVISITATGWFGIQNSVFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
EGLYSAFRGKVNIQLLMLISGIAITLIVVYGYKMLSYTANIAVPAFIAGVLWATFKMLGN
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YNMSEILSSPPPGPHLTIGVAATMIAGGFMVGSVITPDLSRFNRNAKDVFWMTLLSLLLG
CCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHH
EILLNFIGATMAHAASTSDVVKIMYNLGGWFAALLVIFSTIKINDLNLYAASLGVTNFLD
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHH
AAFNVKVNRGIVTLIIGIIGTALSMMGILEKFTSFLMILGIAIPPIAGIMVVDYFILRRF
HHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKELEESRAEGKLPEIVEHINPIALLAWLIGALIGYYVQWGIPALNSLVAAGLAHWLISK
HHHHHHHHHCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
MWAITTGRKMIRFVKGENA
HHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; cytosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + cytosine [Periplasm] = Proton [Cytoplasm] + cytosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]