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The map label for this gene is hisS [H]

Identifier: 167040110

GI number: 167040110

Start: 1504984

End: 1506240

Strand: Direct

Name: hisS [H]

Synonym: Teth514_1472

Alternate gene names: 167040110

Gene position: 1504984-1506240 (Clockwise)

Preceding gene: 167040108

Following gene: 167040111

Centisome position: 61.25

GC content: 35.32

Gene sequence:

>1257_bases
ATGCTTACAAAAGCGCCAAGAGGGACAAAGGACATTCTCCCTTCAGAATCATATAAATGGCAATATATAGAAGGACTCAT
AAGGGAGATATGTGATGTTTACGGTTTTAAAGAGATAAGAACGCCTGGCTTTGAACATACTGAGTTGTTTTTAAGGGGAG
TAGGGGAATCAACCGACATTGTGAGAAAAGAGATGTACACTTTTACTGATAAAGGTGGGAGAAGCATTACTTTAAAGGCT
GAAGGTACTTCTCCAGCTGTAAGAGCTTTTATAGAGCACAATTTGTACGCAGAAACACAGCCTACCAAATTGTACTATAT
AACTCCTGTTTACAGATATGAAAGGCCTCAATCAGGAAGGTTAAGAGAACATCACCAATTTGGAGTAGAAATTTTTGGTG
CTAAAAACGCTTCTGCAGATGCAGAAGTTATAAGTGTTGCTATGACTTTATTAAAAAAATTAGGGCTTAATAATTTGGAG
CTTAGAATAAACAGTGTAGGATGTCCTGTTTGTAGAAAAAATTATAATAAAGTACTTAAGGATTTTTTAAAGGACAATTT
GGAGTATTTGTGTGATGACTGTAAAGTCAGATATGAGATAAATCCTTTGAGGGTGTTGGATTGCAAAGTAGAAAGTTGTC
AGAGGATAACCAAAGATGCCCCTCTCATTACAGATTATTTGTGTGATGATTGCAAAAGTCATTTTGAAGAGCTACAAAAA
TATTTAGATATAATGGGCTATGATTATATAATTGACCCCAGAATTGTGAGAGGACTTGATTATTATACCAAAACTGCTTT
TGAAATAATTTCAAAAGACATCGGAGCTCAGGGGACTGTATGCGGTGGAGGAAGGTATGATGGTCTTATAGAAGAATGCG
GAGGGCCTTCTATGCCGGGAGTAGGTTTTGGAATGGGACTAGAGAGACTTTTACTTACTTTGGAGCAAAACGGCATTGAA
ATTCCAAAACCTGAAGGGATAGATTTGTTTATAGCTTATGTTGGTGAAGAAGCAAAATTATTTACTTTTGCTCTCGCAAA
TAAGTTGCGATTTAATGGATTAAAAGTAGAAAGAGACAATATGGATAGAAGCTTAAAAGCTCAAATGAAGTATGCCAATA
AGCTTAATGCGAAATTTGCCATTGTAATAGGGGAAGAAGAGATGAAGGAAAACAAAGTTAAATTGAAAAATATGAGAGAT
GGAAGCGAAGTAGAAATATCCATTGATGAGATAGAACAAAGGATAAAAAATATATAA

Upstream 100 bases:

>100_bases
GTGGCACCACGGGATTTAACCTCTCGTCCCTGCAAATTGTTGCAGACGAGGGGTTTTTAAATGTATAAAGTTTTTACAAA
ATGTAAAAGGAGTTGGTGAA

Downstream 100 bases:

>100_bases
ACGGAGGGAGTTAAATGGGAGAACAATTAAATGGACTTAAAAGAACTCACATGTGTGGAGAATTGACAGTTGAAGACGTA
GATAAATATGTTGTAGTTAT

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MLTKAPRGTKDILPSESYKWQYIEGLIREICDVYGFKEIRTPGFEHTELFLRGVGESTDIVRKEMYTFTDKGGRSITLKA
EGTSPAVRAFIEHNLYAETQPTKLYYITPVYRYERPQSGRLREHHQFGVEIFGAKNASADAEVISVAMTLLKKLGLNNLE
LRINSVGCPVCRKNYNKVLKDFLKDNLEYLCDDCKVRYEINPLRVLDCKVESCQRITKDAPLITDYLCDDCKSHFEELQK
YLDIMGYDYIIDPRIVRGLDYYTKTAFEIISKDIGAQGTVCGGGRYDGLIEECGGPSMPGVGFGMGLERLLLTLEQNGIE
IPKPEGIDLFIAYVGEEAKLFTFALANKLRFNGLKVERDNMDRSLKAQMKYANKLNAKFAIVIGEEEMKENKVKLKNMRD
GSEVEISIDEIEQRIKNI

Sequences:

>Translated_418_residues
MLTKAPRGTKDILPSESYKWQYIEGLIREICDVYGFKEIRTPGFEHTELFLRGVGESTDIVRKEMYTFTDKGGRSITLKA
EGTSPAVRAFIEHNLYAETQPTKLYYITPVYRYERPQSGRLREHHQFGVEIFGAKNASADAEVISVAMTLLKKLGLNNLE
LRINSVGCPVCRKNYNKVLKDFLKDNLEYLCDDCKVRYEINPLRVLDCKVESCQRITKDAPLITDYLCDDCKSHFEELQK
YLDIMGYDYIIDPRIVRGLDYYTKTAFEIISKDIGAQGTVCGGGRYDGLIEECGGPSMPGVGFGMGLERLLLTLEQNGIE
IPKPEGIDLFIAYVGEEAKLFTFALANKLRFNGLKVERDNMDRSLKAQMKYANKLNAKFAIVIGEEEMKENKVKLKNMRD
GSEVEISIDEIEQRIKNI
>Mature_418_residues
MLTKAPRGTKDILPSESYKWQYIEGLIREICDVYGFKEIRTPGFEHTELFLRGVGESTDIVRKEMYTFTDKGGRSITLKA
EGTSPAVRAFIEHNLYAETQPTKLYYITPVYRYERPQSGRLREHHQFGVEIFGAKNASADAEVISVAMTLLKKLGLNNLE
LRINSVGCPVCRKNYNKVLKDFLKDNLEYLCDDCKVRYEINPLRVLDCKVESCQRITKDAPLITDYLCDDCKSHFEELQK
YLDIMGYDYIIDPRIVRGLDYYTKTAFEIISKDIGAQGTVCGGGRYDGLIEECGGPSMPGVGFGMGLERLLLTLEQNGIE
IPKPEGIDLFIAYVGEEAKLFTFALANKLRFNGLKVERDNMDRSLKAQMKYANKLNAKFAIVIGEEEMKENKVKLKNMRD
GSEVEISIDEIEQRIKNI

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI15029520, Length=462, Percent_Identity=25.7575757575758, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI6996014, Length=477, Percent_Identity=24.9475890985325, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1788861, Length=418, Percent_Identity=41.6267942583732, Blast_Score=349, Evalue=2e-97,
Organism=Caenorhabditis elegans, GI71993693, Length=462, Percent_Identity=26.1904761904762, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71993686, Length=456, Percent_Identity=26.5350877192982, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6325290, Length=462, Percent_Identity=24.025974025974, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24643061, Length=468, Percent_Identity=23.5042735042735, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24643059, Length=487, Percent_Identity=22.5872689938398, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 47616; Mature: 47616

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTKAPRGTKDILPSESYKWQYIEGLIREICDVYGFKEIRTPGFEHTELFLRGVGESTDI
CCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHCCCCCHHH
VRKEMYTFTDKGGRSITLKAEGTSPAVRAFIEHNLYAETQPTKLYYITPVYRYERPQSGR
HHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCEEEEEEEEHCCCCCCCCC
LREHHQFGVEIFGAKNASADAEVISVAMTLLKKLGLNNLELRINSVGCPVCRKNYNKVLK
CHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHH
DFLKDNLEYLCDDCKVRYEINPLRVLDCKVESCQRITKDAPLITDYLCDDCKSHFEELQK
HHHHHHHHHHHCCCEEEEECCCEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
YLDIMGYDYIIDPRIVRGLDYYTKTAFEIISKDIGAQGTVCGGGRYDGLIEECGGPSMPG
HHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCHHHHCCCCCCCC
VGFGMGLERLLLTLEQNGIEIPKPEGIDLFIAYVGEEAKLFTFALANKLRFNGLKVERDN
CCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCEEEECCC
MDRSLKAQMKYANKLNAKFAIVIGEEEMKENKVKLKNMRDGSEVEISIDEIEQRIKNI
CCHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHCC
>Mature Secondary Structure
MLTKAPRGTKDILPSESYKWQYIEGLIREICDVYGFKEIRTPGFEHTELFLRGVGESTDI
CCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHCCCCCHHH
VRKEMYTFTDKGGRSITLKAEGTSPAVRAFIEHNLYAETQPTKLYYITPVYRYERPQSGR
HHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCEEEEEEEEHCCCCCCCCC
LREHHQFGVEIFGAKNASADAEVISVAMTLLKKLGLNNLELRINSVGCPVCRKNYNKVLK
CHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHH
DFLKDNLEYLCDDCKVRYEINPLRVLDCKVESCQRITKDAPLITDYLCDDCKSHFEELQK
HHHHHHHHHHHCCCEEEEECCCEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
YLDIMGYDYIIDPRIVRGLDYYTKTAFEIISKDIGAQGTVCGGGRYDGLIEECGGPSMPG
HHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCHHHHCCCCCCCC
VGFGMGLERLLLTLEQNGIEIPKPEGIDLFIAYVGEEAKLFTFALANKLRFNGLKVERDN
CCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCEEEECCC
MDRSLKAQMKYANKLNAKFAIVIGEEEMKENKVKLKNMRDGSEVEISIDEIEQRIKNI
CCHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA