The gene/protein map for NC_010320 is currently unavailable.
Definition Thermoanaerobacter sp. X514 chromosome, complete genome.
Accession NC_010320
Length 2,457,259

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The map label for this gene is ldh

Identifier: 167038885

GI number: 167038885

Start: 226042

End: 226977

Strand: Direct

Name: ldh

Synonym: Teth514_0216

Alternate gene names: 167038885

Gene position: 226042-226977 (Clockwise)

Preceding gene: 167038882

Following gene: 167038886

Centisome position: 9.2

GC content: 37.61

Gene sequence:

>936_bases
ATGAACAAAATATCTATAATAGGTTCTGGATTTGTCGGTGCTACTACTGCATACACACTGGCTTTGAGTGGGATTGCCAA
AACTATTGTATTAATAGATATTAATAAAGACAAAGCAGAAGGCGATGCTCTTGATATAAGCCACGGCGTACCGTTTATTA
GTCCAGTTGAATTGTACGCGGGAGATTATAGTGATGTTTCAGGTTCTGACATAATAATCATTACAGCGGGAGCAGCACAA
AAACCGGGAGAAACCAGACTTGACTTAGTGAAGAGAAATACGATGATTTTTAAAGACATAGTGGCAAAACTTATTAAAGT
AAATGACACAGCAATATACCTTATAGTTACAAATCCAGTAGATATTCTTACATACGTTACCTATAAAATATCTGGCTTGC
CATACGGAAGAGTATTGGGGTCTGGCACAGTTCTCGACAGTGCGAGATTCAGATATCTTTTAAGCAAACATTGTAACATA
GATCCGAGGAATATACACGGATATATAATTGGGGAGCATGGCGATTCTGAGCTTGCAGCTTGGAGCATTACGAACATAGC
AGGCATACCAATTGATAATTACTGCAATTTATGTGGAAAAGCATGTGAAAAAGATTTTAGAGAGGAGATTTTTAATAATG
TTGTAAGAGCTGCCTATACGATAATAGAAAAAAAGGGTGCGACATATTATGCGGTTGCTCTCGCAGTAAGAAGAATCGTA
GAAGCTATTTTCAGAGATGAAAATTCCATTTTGACTGTGTCATCTCCGCTAACCGGCCAATATGGTGTTACAAATGTGGC
TTTGAGCCTTCCCTCCGTTGTTGGACGAAATGGAATCGTAAATATACTTGAATTACCACTTTCACAGGAAGAAATTGCTG
CTTTTAGAAGATCAGCCGAAGTTATCAAAAGTGTAATACAAGAGCTTGATATATAA

Upstream 100 bases:

>100_bases
GAATATTTTAAATTATTAGAGAAAAAATAGACTTGACTATTTTTTGAAATTTGATAGACTATTATTAATAGAAAATTAAT
ATTGAAAAGGAGAAGATATT

Downstream 100 bases:

>100_bases
GAGGGGAAACCCTCTTTTTTTGTATATAAAAAGTCACAGCGTGAAAATATAATAATTAAAATAATGATTTTTTAGGGTGT
GATAGTCGTGCAGAAAATAA

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: L-LDH

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MNKISIIGSGFVGATTAYTLALSGIAKTIVLIDINKDKAEGDALDISHGVPFISPVELYAGDYSDVSGSDIIIITAGAAQ
KPGETRLDLVKRNTMIFKDIVAKLIKVNDTAIYLIVTNPVDILTYVTYKISGLPYGRVLGSGTVLDSARFRYLLSKHCNI
DPRNIHGYIIGEHGDSELAAWSITNIAGIPIDNYCNLCGKACEKDFREEIFNNVVRAAYTIIEKKGATYYAVALAVRRIV
EAIFRDENSILTVSSPLTGQYGVTNVALSLPSVVGRNGIVNILELPLSQEEIAAFRRSAEVIKSVIQELDI

Sequences:

>Translated_311_residues
MNKISIIGSGFVGATTAYTLALSGIAKTIVLIDINKDKAEGDALDISHGVPFISPVELYAGDYSDVSGSDIIIITAGAAQ
KPGETRLDLVKRNTMIFKDIVAKLIKVNDTAIYLIVTNPVDILTYVTYKISGLPYGRVLGSGTVLDSARFRYLLSKHCNI
DPRNIHGYIIGEHGDSELAAWSITNIAGIPIDNYCNLCGKACEKDFREEIFNNVVRAAYTIIEKKGATYYAVALAVRRIV
EAIFRDENSILTVSSPLTGQYGVTNVALSLPSVVGRNGIVNILELPLSQEEIAAFRRSAEVIKSVIQELDI
>Mature_311_residues
MNKISIIGSGFVGATTAYTLALSGIAKTIVLIDINKDKAEGDALDISHGVPFISPVELYAGDYSDVSGSDIIIITAGAAQ
KPGETRLDLVKRNTMIFKDIVAKLIKVNDTAIYLIVTNPVDILTYVTYKISGLPYGRVLGSGTVLDSARFRYLLSKHCNI
DPRNIHGYIIGEHGDSELAAWSITNIAGIPIDNYCNLCGKACEKDFREEIFNNVVRAAYTIIEKKGATYYAVALAVRRIV
EAIFRDENSILTVSSPLTGQYGVTNVALSLPSVVGRNGIVNILELPLSQEEIAAFRRSAEVIKSVIQELDI

Specific function: Catalyzes The Reversible Oxidation Of Malate To Oxaloacetate. [C]

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. LDH family

Homologues:

Organism=Homo sapiens, GI47059044, Length=312, Percent_Identity=40.3846153846154, Blast_Score=253, Evalue=1e-67,
Organism=Homo sapiens, GI221136809, Length=312, Percent_Identity=40.3846153846154, Blast_Score=253, Evalue=1e-67,
Organism=Homo sapiens, GI9257228, Length=309, Percent_Identity=41.4239482200647, Blast_Score=252, Evalue=4e-67,
Organism=Homo sapiens, GI4504973, Length=309, Percent_Identity=41.4239482200647, Blast_Score=252, Evalue=4e-67,
Organism=Homo sapiens, GI5031857, Length=312, Percent_Identity=39.7435897435897, Blast_Score=251, Evalue=6e-67,
Organism=Homo sapiens, GI260099723, Length=312, Percent_Identity=39.7435897435897, Blast_Score=251, Evalue=6e-67,
Organism=Homo sapiens, GI291575128, Length=310, Percent_Identity=39.0322580645161, Blast_Score=248, Evalue=6e-66,
Organism=Homo sapiens, GI4557032, Length=310, Percent_Identity=39.0322580645161, Blast_Score=248, Evalue=6e-66,
Organism=Homo sapiens, GI15082234, Length=312, Percent_Identity=39.1025641025641, Blast_Score=248, Evalue=7e-66,
Organism=Homo sapiens, GI260099727, Length=220, Percent_Identity=42.2727272727273, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI260099725, Length=227, Percent_Identity=41.8502202643172, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI207028494, Length=196, Percent_Identity=40.3061224489796, Blast_Score=164, Evalue=9e-41,
Organism=Homo sapiens, GI103472011, Length=318, Percent_Identity=25.7861635220126, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI103472015, Length=182, Percent_Identity=29.6703296703297, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17535107, Length=292, Percent_Identity=42.4657534246575, Blast_Score=244, Evalue=5e-65,
Organism=Saccharomyces cerevisiae, GI6322765, Length=298, Percent_Identity=26.1744966442953, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17136226, Length=306, Percent_Identity=39.5424836601307, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI45550422, Length=309, Percent_Identity=34.9514563106796, Blast_Score=187, Evalue=8e-48,
Organism=Drosophila melanogaster, GI24647881, Length=298, Percent_Identity=26.510067114094, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24663599, Length=252, Percent_Identity=24.6031746031746, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: 2640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2380 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). 260 Molecules/Cell In: Stationary Phase

Swissprot (AC and ID): LDH_THEP3 (B0KDA4)

Other databases:

- EMBL:   CP000924
- RefSeq:   YP_001665959.1
- ProteinModelPortal:   B0KDA4
- SMR:   B0KDA4
- GeneID:   5875364
- GenomeReviews:   CP000924_GR
- KEGG:   tpd:Teth39_1997
- HOGENOM:   HBG566126
- OMA:   MDLNHGV
- ProtClustDB:   CLSK986029
- BioCyc:   TPSE340099:TETH39_1997-MONOMER
- GO:   GO:0005737
- GO:   GO:0005488
- GO:   GO:0006096
- HAMAP:   MF_00488
- InterPro:   IPR001557
- InterPro:   IPR011304
- InterPro:   IPR018177
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.90.110.10
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000102
- PRINTS:   PR00086
- TIGRFAMs:   TIGR01771

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N; SSF56327 Lactate_DH/Glyco_hydro_4_C

EC number: =1.1.1.27

Molecular weight: Translated: 33715; Mature: 33715

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00064 L_LDH

Important sites: ACT_SITE 173-173 BINDING 86-86 BINDING 118-118 BINDING 149-149 BINDING 228-228

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MNKISIIGSGFVGATTAYTLALSGIAKTIVLIDINKDKAEGDALDISHGVPFISPVELYA
CCEEEEEECCCCHHHHHHHHHHHHHEEEEEEEEECCCCCCCCEEECCCCCCCCCCHHHHC
GDYSDVSGSDIIIITAGAAQKPGETRLDLVKRNTMIFKDIVAKLIKVNDTAIYLIVTNPV
CCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCH
DILTYVTYKISGLPYGRVLGSGTVLDSARFRYLLSKHCNIDPRNIHGYIIGEHGDSELAA
HHHHEEEEEECCCCHHHHCCCCCEEHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCEEE
WSITNIAGIPIDNYCNLCGKACEKDFREEIFNNVVRAAYTIIEKKGATYYAVALAVRRIV
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
EAIFRDENSILTVSSPLTGQYGVTNVALSLPSVVGRNGIVNILELPLSQEEIAAFRRSAE
HHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHH
VIKSVIQELDI
HHHHHHHHHCC
>Mature Secondary Structure
MNKISIIGSGFVGATTAYTLALSGIAKTIVLIDINKDKAEGDALDISHGVPFISPVELYA
CCEEEEEECCCCHHHHHHHHHHHHHEEEEEEEEECCCCCCCCEEECCCCCCCCCCHHHHC
GDYSDVSGSDIIIITAGAAQKPGETRLDLVKRNTMIFKDIVAKLIKVNDTAIYLIVTNPV
CCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCH
DILTYVTYKISGLPYGRVLGSGTVLDSARFRYLLSKHCNIDPRNIHGYIIGEHGDSELAA
HHHHEEEEEECCCCHHHHCCCCCEEHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCEEE
WSITNIAGIPIDNYCNLCGKACEKDFREEIFNNVVRAAYTIIEKKGATYYAVALAVRRIV
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
EAIFRDENSILTVSSPLTGQYGVTNVALSLPSVVGRNGIVNILELPLSQEEIAAFRRSAE
HHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHH
VIKSVIQELDI
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA