| Definition | Yersinia pestis Angola, complete genome. |
|---|---|
| Accession | NC_010159 |
| Length | 4,504,254 |
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The map label for this gene is dkgA [H]
Identifier: 162418281
GI number: 162418281
Start: 282808
End: 283641
Strand: Direct
Name: dkgA [H]
Synonym: YpAngola_A0272
Alternate gene names: 162418281
Gene position: 282808-283641 (Clockwise)
Preceding gene: 162418790
Following gene: 162418145
Centisome position: 6.28
GC content: 48.8
Gene sequence:
>834_bases ATGACAATGCAACCCCTTATCAAGTTGTACGATGGGCGCTTGATGCCACAACTCGGCCTCGGCGTTTGGCAGGCAAGTAT CCAAGAAACAGAGCTTGCGGTCAGTAAGGCGCTGGAAGTCGGTTACCGCTCAATTGATACCGCCGCTATTTATAAAAATG AAGAAGGTGTGGGCAAGGCGCTGAAAGCGGCGGCTGTTGCCCGTGATGAACTGTTTATCACCACAAAACTGTGGAACGAT GATCAACATAATCCTCAGCAAGCCCTGGAAAACAGCCTGCAAAAGCTCCAACTGGATTATGTAGATCTCTACCTGATCCA TTGGCCAGACCCGAAACAAGACCATTATGTCAGTGCCTGGCGTGAACTGGTCACACTAAAAGAGCAAGGTTTGATCCGCA GTATCGGCGTGTGTAACTTCCATATTCCTCATCTGCAACGGTTGATTGATGAGACGGGTATCGCCCCTACCGTCAATCAG ATTGAACTGCATCCGTTGCTGCAACAACGTCAGCTCCATGCCTGGAATGCCACCCATCATATTGCAACCGAGTCTTGGAG CCCGTTAGCACAAGGTGGCAAAGGCGTTTTTGATCAAGAAATTATCCGCAAGCTCGCTCAGCAATATAATAAAACGCCTG CACAAATCGTGATCCGTTGGCATCTGGACAGTGGGCTGATTGTTATCCCCAAATCTGTCACACCAGCACGTATCAGAGAA AACTTTGAGGTTTTTGATTTTAAGCTACAAAAAGAGGAGTTGCTGGCAATTACCAAACTGGATTGCGGTAAACGGCTGGG GCCAGACCCGGAAGTTTTCGGATCTGACCGCTGA
Upstream 100 bases:
>100_bases ACTTAATAATTAGCAAGGTCATAAATAAAATGATAACGACTAAACTTACGTTATCAGCAACGGGCTAATACAGCCCAATC AGTAAGCCAAGGAGATCAAC
Downstream 100 bases:
>100_bases TTTCAGGCCAGCAATAACCCCTTAATGCTGCCTGTTTTTCCCTCTGGATCCGGCAGATGGCTTATTGACCGCAGCTTTAT TTACGCCCGTTTTACCCGCT
Product: 2,5-diketo-D-gluconate reductase A
Products: NA
Alternate protein names: 2,5-DKG reductase A; 2,5-DKGR A; 25DKGR-A; AKR5C [H]
Number of amino acids: Translated: 277; Mature: 276
Protein sequence:
>277_residues MTMQPLIKLYDGRLMPQLGLGVWQASIQETELAVSKALEVGYRSIDTAAIYKNEEGVGKALKAAAVARDELFITTKLWND DQHNPQQALENSLQKLQLDYVDLYLIHWPDPKQDHYVSAWRELVTLKEQGLIRSIGVCNFHIPHLQRLIDETGIAPTVNQ IELHPLLQQRQLHAWNATHHIATESWSPLAQGGKGVFDQEIIRKLAQQYNKTPAQIVIRWHLDSGLIVIPKSVTPARIRE NFEVFDFKLQKEELLAITKLDCGKRLGPDPEVFGSDR
Sequences:
>Translated_277_residues MTMQPLIKLYDGRLMPQLGLGVWQASIQETELAVSKALEVGYRSIDTAAIYKNEEGVGKALKAAAVARDELFITTKLWND DQHNPQQALENSLQKLQLDYVDLYLIHWPDPKQDHYVSAWRELVTLKEQGLIRSIGVCNFHIPHLQRLIDETGIAPTVNQ IELHPLLQQRQLHAWNATHHIATESWSPLAQGGKGVFDQEIIRKLAQQYNKTPAQIVIRWHLDSGLIVIPKSVTPARIRE NFEVFDFKLQKEELLAITKLDCGKRLGPDPEVFGSDR >Mature_276_residues TMQPLIKLYDGRLMPQLGLGVWQASIQETELAVSKALEVGYRSIDTAAIYKNEEGVGKALKAAAVARDELFITTKLWNDD QHNPQQALENSLQKLQLDYVDLYLIHWPDPKQDHYVSAWRELVTLKEQGLIRSIGVCNFHIPHLQRLIDETGIAPTVNQI ELHPLLQQRQLHAWNATHHIATESWSPLAQGGKGVFDQEIIRKLAQQYNKTPAQIVIRWHLDSGLIVIPKSVTPARIREN FEVFDFKLQKEELLAITKLDCGKRLGPDPEVFGSDR
Specific function: Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG) [H]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI24497577, Length=288, Percent_Identity=36.4583333333333, Blast_Score=195, Evalue=4e-50, Organism=Homo sapiens, GI5174391, Length=288, Percent_Identity=36.4583333333333, Blast_Score=195, Evalue=4e-50, Organism=Homo sapiens, GI223468663, Length=293, Percent_Identity=35.8361774744027, Blast_Score=190, Evalue=1e-48, Organism=Homo sapiens, GI93277124, Length=303, Percent_Identity=33.6633663366337, Blast_Score=178, Evalue=6e-45, Organism=Homo sapiens, GI310109922, Length=276, Percent_Identity=36.231884057971, Blast_Score=171, Evalue=5e-43, Organism=Homo sapiens, GI310109920, Length=294, Percent_Identity=35.0340136054422, Blast_Score=171, Evalue=8e-43, Organism=Homo sapiens, GI5453543, Length=294, Percent_Identity=35.0340136054422, Blast_Score=171, Evalue=9e-43, Organism=Homo sapiens, GI45446745, Length=294, Percent_Identity=35.0340136054422, Blast_Score=170, Evalue=1e-42, Organism=Homo sapiens, GI4503285, Length=294, Percent_Identity=35.0340136054422, Blast_Score=170, Evalue=1e-42, Organism=Homo sapiens, GI24497583, Length=298, Percent_Identity=34.8993288590604, Blast_Score=166, Evalue=2e-41, Organism=Homo sapiens, GI291291012, Length=263, Percent_Identity=34.9809885931559, Blast_Score=163, Evalue=1e-40, Organism=Homo sapiens, GI5174695, Length=300, Percent_Identity=34, Blast_Score=163, Evalue=1e-40, Organism=Homo sapiens, GI24497585, Length=301, Percent_Identity=33.2225913621262, Blast_Score=160, Evalue=2e-39, Organism=Homo sapiens, GI4502049, Length=289, Percent_Identity=35.6401384083045, Blast_Score=157, Evalue=7e-39, Organism=Homo sapiens, GI300116273, Length=278, Percent_Identity=33.8129496402878, Blast_Score=149, Evalue=4e-36, Organism=Homo sapiens, GI300116271, Length=280, Percent_Identity=32.5, Blast_Score=129, Evalue=2e-30, Organism=Homo sapiens, GI310109926, Length=127, Percent_Identity=43.3070866141732, Blast_Score=96, Evalue=3e-20, Organism=Homo sapiens, GI207028673, Length=127, Percent_Identity=43.3070866141732, Blast_Score=96, Evalue=4e-20, Organism=Homo sapiens, GI310109924, Length=146, Percent_Identity=32.8767123287671, Blast_Score=89, Evalue=3e-18, Organism=Escherichia coli, GI87082198, Length=275, Percent_Identity=73.4545454545455, Blast_Score=426, Evalue=1e-121, Organism=Escherichia coli, GI1786400, Length=256, Percent_Identity=41.796875, Blast_Score=187, Evalue=5e-49, Organism=Escherichia coli, GI1788081, Length=276, Percent_Identity=31.1594202898551, Blast_Score=111, Evalue=4e-26, Organism=Escherichia coli, GI48994888, Length=273, Percent_Identity=25.6410256410256, Blast_Score=61, Evalue=1e-10, Organism=Caenorhabditis elegans, GI17537075, Length=299, Percent_Identity=39.1304347826087, Blast_Score=189, Evalue=2e-48, Organism=Caenorhabditis elegans, GI17537077, Length=294, Percent_Identity=38.4353741496599, Blast_Score=187, Evalue=6e-48, Organism=Caenorhabditis elegans, GI17550248, Length=293, Percent_Identity=37.542662116041, Blast_Score=180, Evalue=8e-46, Organism=Caenorhabditis elegans, GI71998625, Length=273, Percent_Identity=34.7985347985348, Blast_Score=167, Evalue=8e-42, Organism=Caenorhabditis elegans, GI17562292, Length=280, Percent_Identity=35, Blast_Score=165, Evalue=2e-41, Organism=Caenorhabditis elegans, GI17566692, Length=283, Percent_Identity=33.2155477031802, Blast_Score=164, Evalue=6e-41, Organism=Caenorhabditis elegans, GI17561298, Length=273, Percent_Identity=32.6007326007326, Blast_Score=162, Evalue=1e-40, Organism=Caenorhabditis elegans, GI17564128, Length=299, Percent_Identity=34.1137123745819, Blast_Score=161, Evalue=3e-40, Organism=Caenorhabditis elegans, GI17538386, Length=273, Percent_Identity=31.8681318681319, Blast_Score=154, Evalue=5e-38, Organism=Caenorhabditis elegans, GI17561300, Length=272, Percent_Identity=31.9852941176471, Blast_Score=146, Evalue=1e-35, Organism=Caenorhabditis elegans, GI17552492, Length=275, Percent_Identity=30.5454545454545, Blast_Score=142, Evalue=1e-34, Organism=Caenorhabditis elegans, GI17537079, Length=304, Percent_Identity=27.6315789473684, Blast_Score=133, Evalue=9e-32, Organism=Saccharomyces cerevisiae, GI6324694, Length=283, Percent_Identity=38.5159010600707, Blast_Score=202, Evalue=3e-53, Organism=Saccharomyces cerevisiae, GI6320576, Length=275, Percent_Identity=37.4545454545455, Blast_Score=195, Evalue=5e-51, Organism=Saccharomyces cerevisiae, GI6319625, Length=289, Percent_Identity=35.6401384083045, Blast_Score=160, Evalue=3e-40, Organism=Saccharomyces cerevisiae, GI6321896, Length=316, Percent_Identity=32.5949367088608, Blast_Score=149, Evalue=5e-37, Organism=Saccharomyces cerevisiae, GI6322556, Length=260, Percent_Identity=30.3846153846154, Blast_Score=138, Evalue=1e-33, Organism=Saccharomyces cerevisiae, GI6320079, Length=290, Percent_Identity=31.3793103448276, Blast_Score=125, Evalue=5e-30, Organism=Drosophila melanogaster, GI24644950, Length=307, Percent_Identity=37.4592833876222, Blast_Score=202, Evalue=2e-52, Organism=Drosophila melanogaster, GI221378297, Length=327, Percent_Identity=35.1681957186544, Blast_Score=195, Evalue=3e-50, Organism=Drosophila melanogaster, GI20129731, Length=295, Percent_Identity=37.2881355932203, Blast_Score=191, Evalue=3e-49, Organism=Drosophila melanogaster, GI24663317, Length=300, Percent_Identity=35.6666666666667, Blast_Score=186, Evalue=1e-47, Organism=Drosophila melanogaster, GI24662789, Length=306, Percent_Identity=34.9673202614379, Blast_Score=182, Evalue=3e-46, Organism=Drosophila melanogaster, GI45553081, Length=297, Percent_Identity=36.7003367003367, Blast_Score=179, Evalue=2e-45, Organism=Drosophila melanogaster, GI24657054, Length=290, Percent_Identity=37.5862068965517, Blast_Score=179, Evalue=3e-45, Organism=Drosophila melanogaster, GI21356425, Length=297, Percent_Identity=35.6902356902357, Blast_Score=178, Evalue=3e-45, Organism=Drosophila melanogaster, GI24662781, Length=297, Percent_Identity=39.0572390572391, Blast_Score=170, Evalue=1e-42, Organism=Drosophila melanogaster, GI24662785, Length=297, Percent_Identity=38.7205387205387, Blast_Score=167, Evalue=1e-41, Organism=Drosophila melanogaster, GI281366140, Length=258, Percent_Identity=35.6589147286822, Blast_Score=148, Evalue=4e-36,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: =1.1.1.274 [H]
Molecular weight: Translated: 31534; Mature: 31402
Theoretical pI: Translated: 6.68; Mature: 6.68
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 1.1 %Met (Translated Protein) 1.8 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 0.7 %Met (Mature Protein) 1.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTMQPLIKLYDGRLMPQLGLGVWQASIQETELAVSKALEVGYRSIDTAAIYKNEEGVGKA CCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEECCCHHHHH LKAAAVARDELFITTKLWNDDQHNPQQALENSLQKLQLDYVDLYLIHWPDPKQDHYVSAW HHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHH RELVTLKEQGLIRSIGVCNFHIPHLQRLIDETGIAPTVNQIELHPLLQQRQLHAWNATHH HHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHCCCHHC IATESWSPLAQGGKGVFDQEIIRKLAQQYNKTPAQIVIRWHLDSGLIVIPKSVTPARIRE CCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEECCCCHHHHHC NFEVFDFKLQKEELLAITKLDCGKRLGPDPEVFGSDR CCEEEEEEECHHHHHHHHHCCCCCCCCCCCCCCCCCC >Mature Secondary Structure TMQPLIKLYDGRLMPQLGLGVWQASIQETELAVSKALEVGYRSIDTAAIYKNEEGVGKA CHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEECCCHHHHH LKAAAVARDELFITTKLWNDDQHNPQQALENSLQKLQLDYVDLYLIHWPDPKQDHYVSAW HHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHH RELVTLKEQGLIRSIGVCNFHIPHLQRLIDETGIAPTVNQIELHPLLQQRQLHAWNATHH HHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHCCCHHC IATESWSPLAQGGKGVFDQEIIRKLAQQYNKTPAQIVIRWHLDSGLIVIPKSVTPARIRE CCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEECCCCHHHHHC NFEVFDFKLQKEELLAITKLDCGKRLGPDPEVFGSDR CCEEEEEEECHHHHHHHHHCCCCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 11586360; 12142430 [H]