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The map label for this gene is fucA [C]

Identifier: 162149591

GI number: 162149591

Start: 3912995

End: 3913735

Strand: Direct

Name: fucA [C]

Synonym: GDI_3830

Alternate gene names: 162149591

Gene position: 3912995-3913735 (Clockwise)

Preceding gene: 162149588

Following gene: 162149594

Centisome position: 99.21

GC content: 67.21

Gene sequence:

>741_bases
ATGGATACCATCCAGGCCGCCGAGCAGGCGTTGCGCGAGGATCTGGCCGCCGCCTATCGCCTGCTGGCCATCTTCGACAT
GACCGACATGGTCTATACCCACCTGTCGGTGCGCCTGCCGGGGCCGGACCATCGGTTCCTGGTCAACCCGTACGGCTATC
TGTTCGAGGAAATCACCGCCAGTTCGCTGGTGGTGGTCGATGCCGACGGCCTGCCGACGCAGCCGACGTCCCAGCCGGTC
AACCCGGCGGGGTTCGTGATCCATTCCGCCGTCCATCGCAGCCGGGCCGACGCCGCCTGCGTCATGCACACCCACACGCT
GGCCGGCATGGCGGTCGCGGCGCAGCAGGAGGGCATCCTGCCGCTGAACCAGATCAGCATGGAATTCCACGAGGACGTGG
CCTTCCACGCCTACGAGGGCATCGCGGCCGACGACAATCTGGGCGAGCGCGAGCGGCTGGTCCGCGACCTGGGGACGCGC
AATGCGATGATCCTGCAGAATCACGGCCTGCTGACGGTCGGGCGCACCGTGGCCGAGACGTTCTATCGCATCTATTACCT
GGAGCAGGCGTGCCGCATCCAGATCGCCGCGCAATCGACCGGCGTTCCGCTGCATGTGCCCTCGGCCGAGCGGATCGCAC
GGGCCCAGGCGCAGTTCGCCGCCGAGGAAGACAAGGGGGAACTGGTCTGGCGGGCGTTGCGCCGCAAGCTGGACCGCGAA
CAGCCGGATTACGTGGAATAG

Upstream 100 bases:

>100_bases
AACTTCACTTTGGGCGAATCATGTTTAATCTGCAACGAGGGCGGGCGAAGCCTCGAACCGTGCCCCCATCCTCCCTGTTG
CCATTCACCGGAGTTCCATC

Downstream 100 bases:

>100_bases
GAGCCGGTCAGGTCCCGGGCGCCAGGATATGGACGAAACGGGCCGCGCCGTCGGGCGGCGGGGCGGCCCGTGACGGAGTG
GCTGGTGAGGGAGTAGCCGG

Product: aldolase II superfamily protein

Products: Dihydroxyacetone phosphate; L-Lactaldehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MDTIQAAEQALREDLAAAYRLLAIFDMTDMVYTHLSVRLPGPDHRFLVNPYGYLFEEITASSLVVVDADGLPTQPTSQPV
NPAGFVIHSAVHRSRADAACVMHTHTLAGMAVAAQQEGILPLNQISMEFHEDVAFHAYEGIAADDNLGERERLVRDLGTR
NAMILQNHGLLTVGRTVAETFYRIYYLEQACRIQIAAQSTGVPLHVPSAERIARAQAQFAAEEDKGELVWRALRRKLDRE
QPDYVE

Sequences:

>Translated_246_residues
MDTIQAAEQALREDLAAAYRLLAIFDMTDMVYTHLSVRLPGPDHRFLVNPYGYLFEEITASSLVVVDADGLPTQPTSQPV
NPAGFVIHSAVHRSRADAACVMHTHTLAGMAVAAQQEGILPLNQISMEFHEDVAFHAYEGIAADDNLGERERLVRDLGTR
NAMILQNHGLLTVGRTVAETFYRIYYLEQACRIQIAAQSTGVPLHVPSAERIARAQAQFAAEEDKGELVWRALRRKLDRE
QPDYVE
>Mature_246_residues
MDTIQAAEQALREDLAAAYRLLAIFDMTDMVYTHLSVRLPGPDHRFLVNPYGYLFEEITASSLVVVDADGLPTQPTSQPV
NPAGFVIHSAVHRSRADAACVMHTHTLAGMAVAAQQEGILPLNQISMEFHEDVAFHAYEGIAADDNLGERERLVRDLGTR
NAMILQNHGLLTVGRTVAETFYRIYYLEQACRIQIAAQSTGVPLHVPSAERIARAQAQFAAEEDKGELVWRALRRKLDRE
QPDYVE

Specific function: Fucose metabolism; third step. [C]

COG id: COG0235

COG function: function code G; Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldolase class II family [H]

Homologues:

Organism=Homo sapiens, GI29826323, Length=192, Percent_Identity=41.1458333333333, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI29826325, Length=192, Percent_Identity=41.1458333333333, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI29826319, Length=192, Percent_Identity=41.1458333333333, Blast_Score=148, Evalue=5e-36,
Organism=Homo sapiens, GI29826321, Length=192, Percent_Identity=41.1458333333333, Blast_Score=144, Evalue=8e-35,
Organism=Homo sapiens, GI9257190, Length=201, Percent_Identity=33.3333333333333, Blast_Score=124, Evalue=5e-29,
Organism=Homo sapiens, GI89276787, Length=201, Percent_Identity=33.3333333333333, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI297307160, Length=201, Percent_Identity=33.3333333333333, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI297307158, Length=197, Percent_Identity=34.010152284264, Blast_Score=124, Evalue=9e-29,
Organism=Homo sapiens, GI9257192, Length=197, Percent_Identity=34.010152284264, Blast_Score=124, Evalue=9e-29,
Organism=Homo sapiens, GI9943848, Length=194, Percent_Identity=35.5670103092784, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI9951927, Length=194, Percent_Identity=35.5670103092784, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI62912453, Length=194, Percent_Identity=35.5670103092784, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI115533218, Length=258, Percent_Identity=36.4341085271318, Blast_Score=158, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI115533216, Length=256, Percent_Identity=36.71875, Blast_Score=157, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71989560, Length=245, Percent_Identity=31.0204081632653, Blast_Score=121, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71989550, Length=245, Percent_Identity=31.0204081632653, Blast_Score=121, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71989555, Length=245, Percent_Identity=31.0204081632653, Blast_Score=120, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71989541, Length=245, Percent_Identity=31.0204081632653, Blast_Score=120, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71989544, Length=245, Percent_Identity=31.0204081632653, Blast_Score=120, Evalue=5e-28,
Organism=Drosophila melanogaster, GI281363755, Length=199, Percent_Identity=36.6834170854271, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI281363751, Length=199, Percent_Identity=36.6834170854271, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24655690, Length=199, Percent_Identity=36.6834170854271, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24655685, Length=199, Percent_Identity=36.6834170854271, Blast_Score=120, Evalue=7e-28,
Organism=Drosophila melanogaster, GI281363761, Length=199, Percent_Identity=36.6834170854271, Blast_Score=120, Evalue=9e-28,
Organism=Drosophila melanogaster, GI281363759, Length=199, Percent_Identity=36.6834170854271, Blast_Score=120, Evalue=9e-28,
Organism=Drosophila melanogaster, GI281363753, Length=199, Percent_Identity=36.6834170854271, Blast_Score=120, Evalue=9e-28,
Organism=Drosophila melanogaster, GI281363763, Length=199, Percent_Identity=36.6834170854271, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI281363757, Length=199, Percent_Identity=36.6834170854271, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI17136738, Length=199, Percent_Identity=36.6834170854271, Blast_Score=119, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001303 [H]

Pfam domain/function: PF00596 Aldolase_II [H]

EC number: 4.1.2.17 [C]

Molecular weight: Translated: 27381; Mature: 27381

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTIQAAEQALREDLAAAYRLLAIFDMTDMVYTHLSVRLPGPDHRFLVNPYGYLFEEITA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEECHHHHHHHHHCC
SSLVVVDADGLPTQPTSQPVNPAGFVIHSAVHRSRADAACVMHTHTLAGMAVAAQQEGIL
CEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCC
PLNQISMEFHEDVAFHAYEGIAADDNLGERERLVRDLGTRNAMILQNHGLLTVGRTVAET
CHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCEEEEHHHHHHH
FYRIYYLEQACRIQIAAQSTGVPLHVPSAERIARAQAQFAAEEDKGELVWRALRRKLDRE
HHHHHHHHHHHEEEEEECCCCCEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
QPDYVE
CCCCCC
>Mature Secondary Structure
MDTIQAAEQALREDLAAAYRLLAIFDMTDMVYTHLSVRLPGPDHRFLVNPYGYLFEEITA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEECHHHHHHHHHCC
SSLVVVDADGLPTQPTSQPVNPAGFVIHSAVHRSRADAACVMHTHTLAGMAVAAQQEGIL
CEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCC
PLNQISMEFHEDVAFHAYEGIAADDNLGERERLVRDLGTRNAMILQNHGLLTVGRTVAET
CHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCEEEEHHHHHHH
FYRIYYLEQACRIQIAAQSTGVPLHVPSAERIARAQAQFAAEEDKGELVWRALRRKLDRE
HHHHHHHHHHHEEEEEECCCCCEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
QPDYVE
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Ca2+; Co2+; Mg2+; Mn2+; Zn2+ [C]

Kcat value (1/min): 19.3 [C]

Specific activity: 21.0

Km value (mM): 0.7 {L-fuculose} [C]

Substrates: L-Fuculose 1-phosphate [C]

Specific reaction: L-Fuculose 1-phosphate <==> Dihydroxyacetone phosphate + L-Lactaldehyde [C]

General reaction: Elimination of an aldehyde C-C bond; Cleavage [C]

Inhibitor: EDTA; Phosphoglycolohydroxamate [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]