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The map label for this gene is lepB [H]

Identifier: 162149280

GI number: 162149280

Start: 3614339

End: 3615076

Strand: Direct

Name: lepB [H]

Synonym: GDI_3512

Alternate gene names: 162149280

Gene position: 3614339-3615076 (Clockwise)

Preceding gene: 162149278

Following gene: 162149282

Centisome position: 91.64

GC content: 69.11

Gene sequence:

>738_bases
GTGCGCGACAGGTTCGGATGGGTCAAAGGCTGGGGTCTCTTTACCGGCTTCATTCTCCTCAGCCGCGTCGCCCTCGCGAC
GCCCTATGTGGTGCCGTCGGGCTCCATGCAGCCCACCCTGCTGATCGGCGATCGCCTGATGGCCCAGCCCCTCGCCTACG
GCTTCAGCACCGCCAACCTGCCGTTCGGCGACCATCTGCCGCAGGGCGCCCGGCTGTTCGGCCGTATGCCGGCACGTGGC
GACGTCATCGTCTTTCGCAGCCCGGCCGAACCGGGCACCACCTTCGTCAAGCGCGTGATCGGGCTGCCGGGTGACAGGAT
CGGCCTTTCCGGCGGGCGGGTCCGGCTGAACGGCGCCGAACTGCCGTGGACGGACGAGGGACCGGCGCGGGAAGAACTGT
CCGACGGCAGCACCGCCCCGGCGGAGCGTTTTTCCGAAACGCTGCCCGGCGGCGTCCGGCACCTTCTGCTGAAGACGCCG
GACGGCACGCCGCTGGACGACATGGCGGATATCACGATCCCCGCCGGGCATCTGTTCGTGATGGGCGACAATCGCGACAA
TTCGGCCGACAGCCGCGTGCCGCAGGCACAAGGCGGCGTGGGCCTGCTGCCGCTCTGGAACCTTCAGGGCAAGGTGGAGG
TCATCACCGCCTCGCGCGACAGCGCGGCGCCGGTCGGTAGCGTCGGCCAGTATCTGGCTTCGGTCCGTCCGGACCGGTTC
CTGAAATGGGTGCGCTGA

Upstream 100 bases:

>100_bases
ACGATGCCGTTGCCGACGTCATCCCGCTTTCTGATCTTTAACTTTACAGAAGAAATACCGGCAAATTACAGTCCTCACTC
CAAGCGAGGAGTACAGACCG

Downstream 100 bases:

>100_bases
TCACGCGCCCGATGCCGGCAGCAGGTGCGACACCCATTCCGCCACCGTGTCGCCGCTGCTCATGGACGGCTGCACCAGTC
CGTCAATCATGAAGGTCGGC

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MRDRFGWVKGWGLFTGFILLSRVALATPYVVPSGSMQPTLLIGDRLMAQPLAYGFSTANLPFGDHLPQGARLFGRMPARG
DVIVFRSPAEPGTTFVKRVIGLPGDRIGLSGGRVRLNGAELPWTDEGPAREELSDGSTAPAERFSETLPGGVRHLLLKTP
DGTPLDDMADITIPAGHLFVMGDNRDNSADSRVPQAQGGVGLLPLWNLQGKVEVITASRDSAAPVGSVGQYLASVRPDRF
LKWVR

Sequences:

>Translated_245_residues
MRDRFGWVKGWGLFTGFILLSRVALATPYVVPSGSMQPTLLIGDRLMAQPLAYGFSTANLPFGDHLPQGARLFGRMPARG
DVIVFRSPAEPGTTFVKRVIGLPGDRIGLSGGRVRLNGAELPWTDEGPAREELSDGSTAPAERFSETLPGGVRHLLLKTP
DGTPLDDMADITIPAGHLFVMGDNRDNSADSRVPQAQGGVGLLPLWNLQGKVEVITASRDSAAPVGSVGQYLASVRPDRF
LKWVR
>Mature_245_residues
MRDRFGWVKGWGLFTGFILLSRVALATPYVVPSGSMQPTLLIGDRLMAQPLAYGFSTANLPFGDHLPQGARLFGRMPARG
DVIVFRSPAEPGTTFVKRVIGLPGDRIGLSGGRVRLNGAELPWTDEGPAREELSDGSTAPAERFSETLPGGVRHLLLKTP
DGTPLDDMADITIPAGHLFVMGDNRDNSADSRVPQAQGGVGLLPLWNLQGKVEVITASRDSAAPVGSVGQYLASVRPDRF
LKWVR

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=263, Percent_Identity=30.4182509505703, Blast_Score=104, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 26326; Mature: 26326

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDRFGWVKGWGLFTGFILLSRVALATPYVVPSGSMQPTLLIGDRLMAQPLAYGFSTANL
CCCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCEEEECCHHHHHHHHHCCCCCCC
PFGDHLPQGARLFGRMPARGDVIVFRSPAEPGTTFVKRVIGLPGDRIGLSGGRVRLNGAE
CCCCCCCCHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCEEECCCCEEEECCCC
LPWTDEGPAREELSDGSTAPAERFSETLPGGVRHLLLKTPDGTPLDDMADITIPAGHLFV
CCCCCCCCCHHHHCCCCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEECCCEEEE
MGDNRDNSADSRVPQAQGGVGLLPLWNLQGKVEVITASRDSAAPVGSVGQYLASVRPDRF
EECCCCCCHHHCCCCCCCCEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHCCHHHH
LKWVR
HHHCC
>Mature Secondary Structure
MRDRFGWVKGWGLFTGFILLSRVALATPYVVPSGSMQPTLLIGDRLMAQPLAYGFSTANL
CCCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCEEEECCHHHHHHHHHCCCCCCC
PFGDHLPQGARLFGRMPARGDVIVFRSPAEPGTTFVKRVIGLPGDRIGLSGGRVRLNGAE
CCCCCCCCHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCEEECCCCEEEECCCC
LPWTDEGPAREELSDGSTAPAERFSETLPGGVRHLLLKTPDGTPLDDMADITIPAGHLFV
CCCCCCCCCHHHHCCCCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEECCCEEEE
MGDNRDNSADSRVPQAQGGVGLLPLWNLQGKVEVITASRDSAAPVGSVGQYLASVRPDRF
EECCCCCCHHHCCCCCCCCEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHCCHHHH
LKWVR
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA