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The map label for this gene is clpA [C]

Identifier: 162149244

GI number: 162149244

Start: 3573353

End: 3575689

Strand: Direct

Name: clpA [C]

Synonym: GDI_3476

Alternate gene names: 162149244

Gene position: 3573353-3575689 (Clockwise)

Preceding gene: 162149242

Following gene: 162149245

Centisome position: 90.6

GC content: 64.78

Gene sequence:

>2337_bases
ATGTTGTCACGCAATCTCGAACAGACGCTTCACCGTGCCCTTACCCTGGCGGGCGAGCGTCGCCACGAATATGCGACACT
GGAACACCTGCTGCTGGCCCTGGTCGACGACAGCGACGCCGTCACCGTTTTCCGCGCCTGCGGTGTCGATCTGGACAAGC
TGCGGTCGGACCTGACCGAATTCCTCGACAAGGACCTGGCCGGCCTGGCGTCCGACCGGACCGTCGATCCCAAGCCCACG
GCCGCGTTCCAGCGCGTGATCCAGCGTGCCGCGATCCATGTCCAGTCCACCGGGCGGGACGAGGTCACGGGATCGAACGT
GCTGGTCGCCCTGTTCGCCGAGCGTGAGAGCCATGCCGTCTATTTCCTGCAGTTGCAGGACATGACCCGTCTGGACGCCG
TCAATTTCATCTCGCACGGGATCGCCAAGGCCCCCGACCGGTCCACGCGCCGCCCGATCACCGGCAGCGCGCAGGACGGT
TCCGAGTCCGAACGCGAGGAGCGCGGCGGCAAGGGCAGCCAGAAGAACCAGGACGCGCTGACCGCCTATTGCACCAACCT
GAACCGCAAGGCCGAGGACGGGAAGATCGACCCGCTGATCGGCCGCGACCCGGAAATCGAGCGCACGATCCAGATCCTGT
GCCGGCGCACGAAGAACAATCCGCTTTACGTGGGTGATCCGGGCGTGGGCAAGACCGCCATTGCCGAAGGCCTGGCCAAG
CGCATCGTCGAGGGCGACGTACCCGAGGTGCTGCTGAAATCCACGATCTATTCGCTGGACATGGGCGCCCTGCTGGCCGG
AACCCGCTATCGCGGTGATTTCGAGGAACGGCTGAAGGCCGTCGTCACCGAACTGGACAACAATCCGGGCAGCATCCTGT
TCATCGACGAGATCCATACCGTGATCGGCGCGGGCGCGACCTCGGGCGGGGCGATGGATGCGTCCAACCTGCTGAAGCCG
GCGCTGGCGGCGGGAACGCTGCGCTGCATCGGGTCCACGACCTACAAGGAATACCGCCAGCATTTCGAGAAGGACCGCGC
GCTGGTGCGCCGGTTCCAAAAGATCGACGTGGCCGAGCCGACGCTGGAGGACGCGGTCAAGATCCTGCGCGGCCTGAAGG
GCAATTACGAAAAGCACCACAAGGTCCGCTACACCGAGGAAGCCATTCGCGGCGCGGTGGAACTGGCGGCGAAATACATC
CATGACCGCAAGCTGCCGGACAAGGCGATCGACGTGATCGACGAGGTCGGCGCCTCGCGGATGCTGGTGCCCGAGAACCG
CCGCCGCAAGACCGTGACCCTGAAGGATGTCGAGGATATCGTGGCGAAGATCGCCCGCATCCCGCCCAAGAGCGTGTCGT
CCGACGACAAGGAGACGCTGCGCACGCTGGAGCGCGACCTGAAGGGCATGGTCTATGGCCAGGATCGCGCGATCGAGGCC
CTGACGGCGGCGATCAAGCTGTCGCGGGCCGGGCTGCGCGACCCGGAAAAGCCGATCGGCAACTACCTCTTCTCGGGCCC
GACGGGCGTGGGCAAGACCGAGGTCGCCAAGCAGCTGGCCAAGACGCTGGGCATCGAGCTGATCCGCTTCGACATGTCCG
AGTATATGGAGCGTCATTCGATCTCGCGCCTGATCGGCGCCCCGCCGGGCTATGTCGGCTTCGACCAGGGCGGATTGCTG
ACCGACGCGATCGACCAGCATCCGCACGCCGTGCTGCTGCTGGACGAGATCGAGAAGGCACATCAGGACCTGTATAACGT
CCTGCTGCAGGTCATGGATCATGGCCGCCTGACCGATCACAACGGCAAGACGGTGGATTTCCGCAATGTCGTCCTGATCA
TGACGACCAATGCGGGCGCCGCCGACCTCAGCAAGGAGGCCATCGGGTTTGCCCGCGACGTTCGCAGCGGCGAGGACGAG
GAGGCGATCAAGCGCATCTTCACCCCCGAATTCCGCAACCGTCTGGACGCGGTCATCCCGTTCGCCAACCTGACGCCCGA
AATCGTCGGCCGGGTAGTCGAAAAGTTCGTCTTCCAACTGGAAGCGCAGCTTGCGGACCGCAACGTCACGATCGAGATCT
CGTCGGCGGCGAAGGAATGGCTGGCCGAACGCGGCTACGACCGCCTGTATGGCGCCCGCCCGCTGGGCCGCGTCATCCAG
GAACACATCAAGAAGCCGCTGGCCGAGGAACTGCTGTTCGGCCGCCTGGTGAAGGGTGGCGCGGTCAAGATCACGCTGAA
GGACGGGGCGCTGGATTTCGAATATATCGAAGCCAACGCCGAAACCCCGGCCGAAGGCGATGAAGGCAGCGAGCGGGAGT
CCGAAGCCGCGAACTGA

Upstream 100 bases:

>100_bases
ACGAAAACACACCAAATATAGTCCTGATTAGCCGACTACCGCCTCCGGGCCCTGGACCGACCCTGGGAAAGGCCCGACCC
TGGAAAAGGAGCGTCATGGC

Downstream 100 bases:

>100_bases
GTTCTTTCCGAAACAGAACGGGCCACGCGGCATATGTCGCGTGGCCTTTTTTATTGGCCGCCCCGTCATAGCGTCCCCGC
TGTTCAAAGGGAGAACGGCG

Product: ATP-dependent Clp protease ATP-binding subunit clpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 778; Mature: 778

Protein sequence:

>778_residues
MLSRNLEQTLHRALTLAGERRHEYATLEHLLLALVDDSDAVTVFRACGVDLDKLRSDLTEFLDKDLAGLASDRTVDPKPT
AAFQRVIQRAAIHVQSTGRDEVTGSNVLVALFAERESHAVYFLQLQDMTRLDAVNFISHGIAKAPDRSTRRPITGSAQDG
SESEREERGGKGSQKNQDALTAYCTNLNRKAEDGKIDPLIGRDPEIERTIQILCRRTKNNPLYVGDPGVGKTAIAEGLAK
RIVEGDVPEVLLKSTIYSLDMGALLAGTRYRGDFEERLKAVVTELDNNPGSILFIDEIHTVIGAGATSGGAMDASNLLKP
ALAAGTLRCIGSTTYKEYRQHFEKDRALVRRFQKIDVAEPTLEDAVKILRGLKGNYEKHHKVRYTEEAIRGAVELAAKYI
HDRKLPDKAIDVIDEVGASRMLVPENRRRKTVTLKDVEDIVAKIARIPPKSVSSDDKETLRTLERDLKGMVYGQDRAIEA
LTAAIKLSRAGLRDPEKPIGNYLFSGPTGVGKTEVAKQLAKTLGIELIRFDMSEYMERHSISRLIGAPPGYVGFDQGGLL
TDAIDQHPHAVLLLDEIEKAHQDLYNVLLQVMDHGRLTDHNGKTVDFRNVVLIMTTNAGAADLSKEAIGFARDVRSGEDE
EAIKRIFTPEFRNRLDAVIPFANLTPEIVGRVVEKFVFQLEAQLADRNVTIEISSAAKEWLAERGYDRLYGARPLGRVIQ
EHIKKPLAEELLFGRLVKGGAVKITLKDGALDFEYIEANAETPAEGDEGSERESEAAN

Sequences:

>Translated_778_residues
MLSRNLEQTLHRALTLAGERRHEYATLEHLLLALVDDSDAVTVFRACGVDLDKLRSDLTEFLDKDLAGLASDRTVDPKPT
AAFQRVIQRAAIHVQSTGRDEVTGSNVLVALFAERESHAVYFLQLQDMTRLDAVNFISHGIAKAPDRSTRRPITGSAQDG
SESEREERGGKGSQKNQDALTAYCTNLNRKAEDGKIDPLIGRDPEIERTIQILCRRTKNNPLYVGDPGVGKTAIAEGLAK
RIVEGDVPEVLLKSTIYSLDMGALLAGTRYRGDFEERLKAVVTELDNNPGSILFIDEIHTVIGAGATSGGAMDASNLLKP
ALAAGTLRCIGSTTYKEYRQHFEKDRALVRRFQKIDVAEPTLEDAVKILRGLKGNYEKHHKVRYTEEAIRGAVELAAKYI
HDRKLPDKAIDVIDEVGASRMLVPENRRRKTVTLKDVEDIVAKIARIPPKSVSSDDKETLRTLERDLKGMVYGQDRAIEA
LTAAIKLSRAGLRDPEKPIGNYLFSGPTGVGKTEVAKQLAKTLGIELIRFDMSEYMERHSISRLIGAPPGYVGFDQGGLL
TDAIDQHPHAVLLLDEIEKAHQDLYNVLLQVMDHGRLTDHNGKTVDFRNVVLIMTTNAGAADLSKEAIGFARDVRSGEDE
EAIKRIFTPEFRNRLDAVIPFANLTPEIVGRVVEKFVFQLEAQLADRNVTIEISSAAKEWLAERGYDRLYGARPLGRVIQ
EHIKKPLAEELLFGRLVKGGAVKITLKDGALDFEYIEANAETPAEGDEGSERESEAAN
>Mature_778_residues
MLSRNLEQTLHRALTLAGERRHEYATLEHLLLALVDDSDAVTVFRACGVDLDKLRSDLTEFLDKDLAGLASDRTVDPKPT
AAFQRVIQRAAIHVQSTGRDEVTGSNVLVALFAERESHAVYFLQLQDMTRLDAVNFISHGIAKAPDRSTRRPITGSAQDG
SESEREERGGKGSQKNQDALTAYCTNLNRKAEDGKIDPLIGRDPEIERTIQILCRRTKNNPLYVGDPGVGKTAIAEGLAK
RIVEGDVPEVLLKSTIYSLDMGALLAGTRYRGDFEERLKAVVTELDNNPGSILFIDEIHTVIGAGATSGGAMDASNLLKP
ALAAGTLRCIGSTTYKEYRQHFEKDRALVRRFQKIDVAEPTLEDAVKILRGLKGNYEKHHKVRYTEEAIRGAVELAAKYI
HDRKLPDKAIDVIDEVGASRMLVPENRRRKTVTLKDVEDIVAKIARIPPKSVSSDDKETLRTLERDLKGMVYGQDRAIEA
LTAAIKLSRAGLRDPEKPIGNYLFSGPTGVGKTEVAKQLAKTLGIELIRFDMSEYMERHSISRLIGAPPGYVGFDQGGLL
TDAIDQHPHAVLLLDEIEKAHQDLYNVLLQVMDHGRLTDHNGKTVDFRNVVLIMTTNAGAADLSKEAIGFARDVRSGEDE
EAIKRIFTPEFRNRLDAVIPFANLTPEIVGRVVEKFVFQLEAQLADRNVTIEISSAAKEWLAERGYDRLYGARPLGRVIQ
EHIKKPLAEELLFGRLVKGGAVKITLKDGALDFEYIEANAETPAEGDEGSERESEAAN

Specific function: ATP-Dependent Specificity Component Of The Clpp Protease. It Directs The Protease To Specific Substrates. The Primary Function Of The Clpa-Clpp Complex Appears To Be The Degradation Of Unfolded Or Abnormal Proteins. [C]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=321, Percent_Identity=33.6448598130841, Blast_Score=170, Evalue=4e-42,
Organism=Escherichia coli, GI1787109, Length=747, Percent_Identity=59.8393574297189, Blast_Score=918, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=423, Percent_Identity=42.789598108747, Blast_Score=308, Evalue=6e-85,
Organism=Saccharomyces cerevisiae, GI6320464, Length=335, Percent_Identity=42.9850746268657, Blast_Score=279, Evalue=1e-75,
Organism=Saccharomyces cerevisiae, GI6323002, Length=236, Percent_Identity=50.4237288135593, Blast_Score=245, Evalue=3e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 85989; Mature: 85989

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSRNLEQTLHRALTLAGERRHEYATLEHLLLALVDDSDAVTVFRACGVDLDKLRSDLTE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHH
FLDKDLAGLASDRTVDPKPTAAFQRVIQRAAIHVQSTGRDEVTGSNVLVALFAERESHAV
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCEE
YFLQLQDMTRLDAVNFISHGIAKAPDRSTRRPITGSAQDGSESEREERGGKGSQKNQDAL
EEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHH
TAYCTNLNRKAEDGKIDPLIGRDPEIERTIQILCRRTKNNPLYVGDPGVGKTAIAEGLAK
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHH
RIVEGDVPEVLLKSTIYSLDMGALLAGTRYRGDFEERLKAVVTELDNNPGSILFIDEIHT
HHHCCCHHHHHHHHHHHHHCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHH
VIGAGATSGGAMDASNLLKPALAAGTLRCIGSTTYKEYRQHFEKDRALVRRFQKIDVAEP
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TLEDAVKILRGLKGNYEKHHKVRYTEEAIRGAVELAAKYIHDRKLPDKAIDVIDEVGASR
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
MLVPENRRRKTVTLKDVEDIVAKIARIPPKSVSSDDKETLRTLERDLKGMVYGQDRAIEA
EECCCCCCCCEEEHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCEECCCHHHHHH
LTAAIKLSRAGLRDPEKPIGNYLFSGPTGVGKTEVAKQLAKTLGIELIRFDMSEYMERHS
HHHHHHHHHCCCCCCCHHHHCCEECCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
ISRLIGAPPGYVGFDQGGLLTDAIDQHPHAVLLLDEIEKAHQDLYNVLLQVMDHGRLTDH
HHHHHCCCCCCCCCCCCCCCHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCC
NGKTVDFRNVVLIMTTNAGAADLSKEAIGFARDVRSGEDEEAIKRIFTPEFRNRLDAVIP
CCCEEEECCEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHCC
FANLTPEIVGRVVEKFVFQLEAQLADRNVTIEISSAAKEWLAERGYDRLYGARPLGRVIQ
CCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCCHHHHHCCCHHHHHHH
EHIKKPLAEELLFGRLVKGGAVKITLKDGALDFEYIEANAETPAEGDEGSERESEAAN
HHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCCCCCCCCCCCHHCCCC
>Mature Secondary Structure
MLSRNLEQTLHRALTLAGERRHEYATLEHLLLALVDDSDAVTVFRACGVDLDKLRSDLTE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHH
FLDKDLAGLASDRTVDPKPTAAFQRVIQRAAIHVQSTGRDEVTGSNVLVALFAERESHAV
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCEE
YFLQLQDMTRLDAVNFISHGIAKAPDRSTRRPITGSAQDGSESEREERGGKGSQKNQDAL
EEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHH
TAYCTNLNRKAEDGKIDPLIGRDPEIERTIQILCRRTKNNPLYVGDPGVGKTAIAEGLAK
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHH
RIVEGDVPEVLLKSTIYSLDMGALLAGTRYRGDFEERLKAVVTELDNNPGSILFIDEIHT
HHHCCCHHHHHHHHHHHHHCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHH
VIGAGATSGGAMDASNLLKPALAAGTLRCIGSTTYKEYRQHFEKDRALVRRFQKIDVAEP
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TLEDAVKILRGLKGNYEKHHKVRYTEEAIRGAVELAAKYIHDRKLPDKAIDVIDEVGASR
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
MLVPENRRRKTVTLKDVEDIVAKIARIPPKSVSSDDKETLRTLERDLKGMVYGQDRAIEA
EECCCCCCCCEEEHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCEECCCHHHHHH
LTAAIKLSRAGLRDPEKPIGNYLFSGPTGVGKTEVAKQLAKTLGIELIRFDMSEYMERHS
HHHHHHHHHCCCCCCCHHHHCCEECCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
ISRLIGAPPGYVGFDQGGLLTDAIDQHPHAVLLLDEIEKAHQDLYNVLLQVMDHGRLTDH
HHHHHCCCCCCCCCCCCCCCHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCC
NGKTVDFRNVVLIMTTNAGAADLSKEAIGFARDVRSGEDEEAIKRIFTPEFRNRLDAVIP
CCCEEEECCEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHCC
FANLTPEIVGRVVEKFVFQLEAQLADRNVTIEISSAAKEWLAERGYDRLYGARPLGRVIQ
CCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCCHHHHHCCCHHHHHHH
EHIKKPLAEELLFGRLVKGGAVKITLKDGALDFEYIEANAETPAEGDEGSERESEAAN
HHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCCCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6209404 [H]