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The map label for this gene is murC [H]

Identifier: 229597116

GI number: 229597116

Start: 1764583

End: 1765989

Strand: Reverse

Name: murC [H]

Synonym: NMCC_1721

Alternate gene names: 229597116

Gene position: 1765989-1764583 (Counterclockwise)

Preceding gene: 161870652

Following gene: 161870650

Centisome position: 82.01

GC content: 56.22

Gene sequence:

>1407_bases
ATGAAAAATCGAGTGACCAACATCCATTTTGTCGGTATCGGCGGCGTCGGCATGAGCGGTATCGCCGAAGTCTTGCACAA
TTTGGGTTTTAAAGTTTCCGGTTCGGATCAGGCGCGAAATGCCGCTACCGAGCATTTGGGCAGCCTGGGTATTCAAGTTT
ATCCCGGCCATACCGCAGAACACGTTAACGGTGCGGATGTCGTCGTTACCTCTACCGCCGTCAAAAAAGAAAATCCCGAA
GTTGTCGCTGCGTTGGAGCAGCAAATTCCCGTTATTCCGCGCGCCCTGATGTTGGCGGAGTTGATGCGCTTCCGTGACGG
CATCGCCATTGCCGGCACGCACGGCAAAACCACGACCACCAGCCTGACCGCCTCCATCCTCGGCGCGGCAGGACTTGACC
CGACTTTCGTTATCGGCGGCAAACTCAACGCCGCAGGCACCAACGCCCGCTTGGGCAAAGGCGAATACATCGTTGCCGAA
GCCGACGAGTCGGATGCATCCTTTCTGCACCTGACACCGATTATGTCCGTCGTTACCAATATCGACGAAGACCATATGGA
TACCTACGGGCACAGCGTCGAAAAACTGCATCAGGCGTTTATCGATTTCATCCACCGTATGCCCTTCTACGGCAAAGCCT
TTTTGTGTATTGACAGCGAACACGTCCGCGCGATTTTGCCCAAAGTGAGCAAACCTTATGCTACTTACGGTTTGGACGAT
ACCGCCGACATCTACGCCACCGACATCGAAAACGTCGGCGCGCAAATGAAATTCACCGTCCATGTTCAAATGAAAGGACA
TGAGCAGGGGTCGTTTGAAGTCGTGCTGAATATGCCCGGCAGACACAACGTGCTGAACGCATTGGCAGCCATCGGCGTGG
CGCTGGAAGTCGGCGCATCGGTTGAAGCGATCCAAAAAGGCTTGCTCGGCTTTGAAGGTGTCGGCCGCCGCTTCCAAAAA
TACGGCGACATCAAGTTGCCAAACGGCGGGACCGCGCTCTTGGTGGACGACTACGGACACCACCCCGTCGAAATGGCGGC
GACCCTTGCCGCCGCACGCGGCGCGTATCCGGAAAAACGTTTGGTACTCGCCTTCCAGCCGCACCGCTATACCCGCACGC
GCGATTTGTTTGAAGACTTTACCAAAGTCCTCAATACCGTTGACGCGCTGGTGCTGACCGAAGTTTATGCCGCCGGTGAA
GAGCCGATTGCCGCCGCCGATTCCCGCGCTCTTGCCCGCGCCATCCGCGTGTTGGGCAAACTCGAGCCGATTTACTGCGA
AAACGTTGCCGATCTGCCCGAAATGCTGTTGAACGTTTTGCAGGACGGCGACATCGTGTTGAATATGGGTGCGGGAAGCA
TCAACCGCGTCCCCGCCGCGCTGCTGGAATTGTCGAAACAGATTTGA

Upstream 100 bases:

>100_bases
CAATCCGCTATATATTTGTCAGAAAACTATGGCGCGCAAACGGTCAGCCCTTTAAAATAACGCCTTTACGCATCGAAATC
CACCGGAACGCAACATTATG

Downstream 100 bases:

>100_bases
GGCACACCCGCCTGACAGACGGAACATCATATAAAGGTCGTCTGAAACCGCAAATCAGGTTTCAGACGACCTCTGGCAAC
AAGCATAAAGCAATCAGGAA

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MKNRVTNIHFVGIGGVGMSGIAEVLHNLGFKVSGSDQARNAATEHLGSLGIQVYPGHTAEHVNGADVVVTSTAVKKENPE
VVAALEQQIPVIPRALMLAELMRFRDGIAIAGTHGKTTTTSLTASILGAAGLDPTFVIGGKLNAAGTNARLGKGEYIVAE
ADESDASFLHLTPIMSVVTNIDEDHMDTYGHSVEKLHQAFIDFIHRMPFYGKAFLCIDSEHVRAILPKVSKPYATYGLDD
TADIYATDIENVGAQMKFTVHVQMKGHEQGSFEVVLNMPGRHNVLNALAAIGVALEVGASVEAIQKGLLGFEGVGRRFQK
YGDIKLPNGGTALLVDDYGHHPVEMAATLAAARGAYPEKRLVLAFQPHRYTRTRDLFEDFTKVLNTVDALVLTEVYAAGE
EPIAAADSRALARAIRVLGKLEPIYCENVADLPEMLLNVLQDGDIVLNMGAGSINRVPAALLELSKQI

Sequences:

>Translated_468_residues
MKNRVTNIHFVGIGGVGMSGIAEVLHNLGFKVSGSDQARNAATEHLGSLGIQVYPGHTAEHVNGADVVVTSTAVKKENPE
VVAALEQQIPVIPRALMLAELMRFRDGIAIAGTHGKTTTTSLTASILGAAGLDPTFVIGGKLNAAGTNARLGKGEYIVAE
ADESDASFLHLTPIMSVVTNIDEDHMDTYGHSVEKLHQAFIDFIHRMPFYGKAFLCIDSEHVRAILPKVSKPYATYGLDD
TADIYATDIENVGAQMKFTVHVQMKGHEQGSFEVVLNMPGRHNVLNALAAIGVALEVGASVEAIQKGLLGFEGVGRRFQK
YGDIKLPNGGTALLVDDYGHHPVEMAATLAAARGAYPEKRLVLAFQPHRYTRTRDLFEDFTKVLNTVDALVLTEVYAAGE
EPIAAADSRALARAIRVLGKLEPIYCENVADLPEMLLNVLQDGDIVLNMGAGSINRVPAALLELSKQI
>Mature_468_residues
MKNRVTNIHFVGIGGVGMSGIAEVLHNLGFKVSGSDQARNAATEHLGSLGIQVYPGHTAEHVNGADVVVTSTAVKKENPE
VVAALEQQIPVIPRALMLAELMRFRDGIAIAGTHGKTTTTSLTASILGAAGLDPTFVIGGKLNAAGTNARLGKGEYIVAE
ADESDASFLHLTPIMSVVTNIDEDHMDTYGHSVEKLHQAFIDFIHRMPFYGKAFLCIDSEHVRAILPKVSKPYATYGLDD
TADIYATDIENVGAQMKFTVHVQMKGHEQGSFEVVLNMPGRHNVLNALAAIGVALEVGASVEAIQKGLLGFEGVGRRFQK
YGDIKLPNGGTALLVDDYGHHPVEMAATLAAARGAYPEKRLVLAFQPHRYTRTRDLFEDFTKVLNTVDALVLTEVYAAGE
EPIAAADSRALARAIRVLGKLEPIYCENVADLPEMLLNVLQDGDIVLNMGAGSINRVPAALLELSKQI

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=466, Percent_Identity=54.7210300429184, Blast_Score=449, Evalue=1e-127,
Organism=Escherichia coli, GI1790680, Length=480, Percent_Identity=28.3333333333333, Blast_Score=139, Evalue=5e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 50190; Mature: 50190

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNRVTNIHFVGIGGVGMSGIAEVLHNLGFKVSGSDQARNAATEHLGSLGIQVYPGHTAE
CCCCEEEEEEEEECCCCHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHCCEEEECCCCCC
HVNGADVVVTSTAVKKENPEVVAALEQQIPVIPRALMLAELMRFRDGIAIAGTHGKTTTT
CCCCCCEEEEEHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCHH
SLTASILGAAGLDPTFVIGGKLNAAGTNARLGKGEYIVAEADESDASFLHLTPIMSVVTN
HHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEHHHHHHHHHC
IDEDHMDTYGHSVEKLHQAFIDFIHRMPFYGKAFLCIDSEHVRAILPKVSKPYATYGLDD
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHCCCCCCCEECCCCC
TADIYATDIENVGAQMKFTVHVQMKGHEQGSFEVVLNMPGRHNVLNALAAIGVALEVGAS
CCCEEEECHHHCCCEEEEEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCC
VEAIQKGLLGFEGVGRRFQKYGDIKLPNGGTALLVDDYGHHPVEMAATLAAARGAYPEKR
HHHHHHHCCCHHHHHHHHHHCCCEECCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCE
LVLAFQPHRYTRTRDLFEDFTKVLNTVDALVLTEVYAAGEEPIAAADSRALARAIRVLGK
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHC
LEPIYCENVADLPEMLLNVLQDGDIVLNMGAGSINRVPAALLELSKQI
CCCHHHCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNRVTNIHFVGIGGVGMSGIAEVLHNLGFKVSGSDQARNAATEHLGSLGIQVYPGHTAE
CCCCEEEEEEEEECCCCHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHCCEEEECCCCCC
HVNGADVVVTSTAVKKENPEVVAALEQQIPVIPRALMLAELMRFRDGIAIAGTHGKTTTT
CCCCCCEEEEEHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCHH
SLTASILGAAGLDPTFVIGGKLNAAGTNARLGKGEYIVAEADESDASFLHLTPIMSVVTN
HHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEHHHHHHHHHC
IDEDHMDTYGHSVEKLHQAFIDFIHRMPFYGKAFLCIDSEHVRAILPKVSKPYATYGLDD
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHCCCCCCCEECCCCC
TADIYATDIENVGAQMKFTVHVQMKGHEQGSFEVVLNMPGRHNVLNALAAIGVALEVGAS
CCCEEEECHHHCCCEEEEEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCC
VEAIQKGLLGFEGVGRRFQKYGDIKLPNGGTALLVDDYGHHPVEMAATLAAARGAYPEKR
HHHHHHHCCCHHHHHHHHHHCCCEECCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCE
LVLAFQPHRYTRTRDLFEDFTKVLNTVDALVLTEVYAAGEEPIAAADSRALARAIRVLGK
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHC
LEPIYCENVADLPEMLLNVLQDGDIVLNMGAGSINRVPAALLELSKQI
CCCHHHCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]