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The map label for this gene is lpxD

Identifier: 161870883

GI number: 161870883

Start: 2024134

End: 2025180

Strand: Direct

Name: lpxD

Synonym: NMCC_1972

Alternate gene names: 161870883

Gene position: 2024134-2025180 (Clockwise)

Preceding gene: 161870882

Following gene: 161870884

Centisome position: 94.0

GC content: 60.08

Gene sequence:

>1047_bases
ATGATTCCGGCCACCTACACCCTGTCCCAAATCACCGCACAGCTCGGCGGCGAATGGCGCGGCGAGGACATTTCCGTTAC
CGCCGTGCGCCCGCTCGCAGACGCGCAGGCGGAACACATCAGCTTCCTTGCCAATCCGAAATACAAAGCCGAAGTCCACG
ACAGCAGCGCGGGCGCGGTCATCGTTTCCGCCAAAGCGGCAGACGGATTTGAAGGGCGCAACCTGATTGTCGCCGACGAC
CCCTATCTCTATTTCGCCAAAGTCGCCCGCCTGTTTTCACCCGTCGTCAAAGCGCGCGGCGGCATCCATCCGACCGCCGT
CGTCGAACCGAGTGCCACCGTTCCCGCAAGCTGCGAAATCGGCGCGAACGCCTACATCGGCGCAAACACCGTGCTCGGCG
AAGGCTGCCGCATCTTGGCAAACGCCGTCGTCCAACACGATTGCAAACTGGGCGACGAAGTCGTCCTGCATCCCAACGCC
GTCGTTTATTACGGCTGCACACTGGGCAGACGCGTCGAAATCCACAGCGGCGCGGTCATCGGCGCGGACGGTTTCGGACT
CGCTTTTGCCGGCGATTCATGGTTTAAAATCCCGCAAACCGGCGCGGTAACGCTGGGCGACGACGTGGAAATCGGCTCGA
ACACCAACATCGACCGCGGCGCGATGAGCGACACCACCGTCGGCAACGGCACCAAAATCGACAACCAAGTCCAAATCGGA
CACAACTGCAAAATCGGTTCGCACACCGTCATCGCCGCCAAAACCGGCATCTCAGGCAGCGTAACCATAGGCAGCTACTG
CATCATCGGCGGCGGCGTCGGTACGGTCGGACACATCGAAATCGCCGACAAAACCACCATCGGCGGCGGCACGTCCGTCA
CCCACAGCATTACCGAAAGCGGCAAACACCTCGCCGGCATCTTCCCGATGTCCACCCATAAAGAATGGGCGCGCAACGCT
GTTTACATCCACCGCTTAAGCGAAATGAACAAACGGCTCAAAACACTGGAGCAGCAGCTTTCAGATGCCGGTCAAGACAG
CAAATAA

Upstream 100 bases:

>100_bases
ACGTGATTTACGTCAACACCCAATACGACGTTACCGACAGCGTCATTAAAGAAATGAACGCCCGCTGACCCTTTCAGACG
GCATATCGAACAGGAAAACC

Downstream 100 bases:

>100_bases
CCAAACCGACTTTATTCAAGGAATACGACAGACATGGACGTACAACTCCCCATCGAAGCCAAAGACATCCAAAAACTCAT
CCCCCACCGCTATCCGTTTC

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MIPATYTLSQITAQLGGEWRGEDISVTAVRPLADAQAEHISFLANPKYKAEVHDSSAGAVIVSAKAADGFEGRNLIVADD
PYLYFAKVARLFSPVVKARGGIHPTAVVEPSATVPASCEIGANAYIGANTVLGEGCRILANAVVQHDCKLGDEVVLHPNA
VVYYGCTLGRRVEIHSGAVIGADGFGLAFAGDSWFKIPQTGAVTLGDDVEIGSNTNIDRGAMSDTTVGNGTKIDNQVQIG
HNCKIGSHTVIAAKTGISGSVTIGSYCIIGGGVGTVGHIEIADKTTIGGGTSVTHSITESGKHLAGIFPMSTHKEWARNA
VYIHRLSEMNKRLKTLEQQLSDAGQDSK

Sequences:

>Translated_348_residues
MIPATYTLSQITAQLGGEWRGEDISVTAVRPLADAQAEHISFLANPKYKAEVHDSSAGAVIVSAKAADGFEGRNLIVADD
PYLYFAKVARLFSPVVKARGGIHPTAVVEPSATVPASCEIGANAYIGANTVLGEGCRILANAVVQHDCKLGDEVVLHPNA
VVYYGCTLGRRVEIHSGAVIGADGFGLAFAGDSWFKIPQTGAVTLGDDVEIGSNTNIDRGAMSDTTVGNGTKIDNQVQIG
HNCKIGSHTVIAAKTGISGSVTIGSYCIIGGGVGTVGHIEIADKTTIGGGTSVTHSITESGKHLAGIFPMSTHKEWARNA
VYIHRLSEMNKRLKTLEQQLSDAGQDSK
>Mature_348_residues
MIPATYTLSQITAQLGGEWRGEDISVTAVRPLADAQAEHISFLANPKYKAEVHDSSAGAVIVSAKAADGFEGRNLIVADD
PYLYFAKVARLFSPVVKARGGIHPTAVVEPSATVPASCEIGANAYIGANTVLGEGCRILANAVVQHDCKLGDEVVLHPNA
VVYYGCTLGRRVEIHSGAVIGADGFGLAFAGDSWFKIPQTGAVTLGDDVEIGSNTNIDRGAMSDTTVGNGTKIDNQVQIG
HNCKIGSHTVIAAKTGISGSVTIGSYCIIGGGVGTVGHIEIADKTTIGGGTSVTHSITESGKHLAGIFPMSTHKEWARNA
VYIHRLSEMNKRLKTLEQQLSDAGQDSK

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=335, Percent_Identity=39.4029850746269, Blast_Score=236, Evalue=1e-63,
Organism=Escherichia coli, GI1786378, Length=199, Percent_Identity=27.6381909547739, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_NEIM0 (A9M3S8)

Other databases:

- EMBL:   CP000381
- RefSeq:   YP_001600057.1
- ProteinModelPortal:   A9M3S8
- SMR:   A9M3S8
- EnsemblBacteria:   EBNEIT00000011079
- GeneID:   5796250
- GenomeReviews:   CP000381_GR
- KEGG:   nmn:NMCC_1972
- GeneTree:   EBGT00050000020532
- HOGENOM:   HBG469615
- OMA:   CFVGKNT
- ProtClustDB:   PRK00892
- BioCyc:   NMEN374833:NMCC_1972-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 36335; Mature: 36335

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPATYTLSQITAQLGGEWRGEDISVTAVRPLADAQAEHISFLANPKYKAEVHDSSAGAV
CCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCHHCCHHHEEEECCCCEEEEECCCCCCEE
IVSAKAADGFEGRNLIVADDPYLYFAKVARLFSPVVKARGGIHPTAVVEPSATVPASCEI
EEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCEEC
GANAYIGANTVLGEGCRILANAVVQHDCKLGDEVVLHPNAVVYYGCTLGRRVEIHSGAVI
CCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCEEEEEECCCCCEEEEECCEEE
GADGFGLAFAGDSWFKIPQTGAVTLGDDVEIGSNTNIDRGAMSDTTVGNGTKIDNQVQIG
CCCCCEEEEECCCEEECCCCCEEEECCCEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEC
HNCKIGSHTVIAAKTGISGSVTIGSYCIIGGGVGTVGHIEIADKTTIGGGTSVTHSITES
CCCCCCCEEEEEEECCCCCCEEECCEEEEECCCCCEEEEEECCCEECCCCCCEEHHHHHC
GKHLAGIFPMSTHKEWARNAVYIHRLSEMNKRLKTLEQQLSDAGQDSK
CCEEEEECCCCCCHHHHHCEEEEHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIPATYTLSQITAQLGGEWRGEDISVTAVRPLADAQAEHISFLANPKYKAEVHDSSAGAV
CCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCHHCCHHHEEEECCCCEEEEECCCCCCEE
IVSAKAADGFEGRNLIVADDPYLYFAKVARLFSPVVKARGGIHPTAVVEPSATVPASCEI
EEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCEEC
GANAYIGANTVLGEGCRILANAVVQHDCKLGDEVVLHPNAVVYYGCTLGRRVEIHSGAVI
CCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCEEEEEECCCCCEEEEECCEEE
GADGFGLAFAGDSWFKIPQTGAVTLGDDVEIGSNTNIDRGAMSDTTVGNGTKIDNQVQIG
CCCCCEEEEECCCEEECCCCCEEEECCCEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEC
HNCKIGSHTVIAAKTGISGSVTIGSYCIIGGGVGTVGHIEIADKTTIGGGTSVTHSITES
CCCCCCCEEEEEEECCCCCCEEECCEEEEECCCCCEEEEEECCCEECCCCCCEEHHHHHC
GKHLAGIFPMSTHKEWARNAVYIHRLSEMNKRLKTLEQQLSDAGQDSK
CCEEEEECCCCCCHHHHHCEEEEHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA