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The map label for this gene is pdxA [H]

Identifier: 161870867

GI number: 161870867

Start: 2006012

End: 2007001

Strand: Reverse

Name: pdxA [H]

Synonym: NMCC_1955

Alternate gene names: 161870867

Gene position: 2007001-2006012 (Counterclockwise)

Preceding gene: 161870872

Following gene: 161870866

Centisome position: 93.2

GC content: 60.51

Gene sequence:

>990_bases
ATGAAACAGCCTGTTTTTGCCGTTACTTCCGGCGAGCCTGCCGGCATCGGCCCCGATATTTGTTTGGACTTGGCGTTTGC
ACGCCTGCCCTGCCGCTGCGCGGTATTGGGCGACAAACACCTGTTGCGCGCGCGCGCCGAAGCCTTGGGCAAAAGCGTCG
TCCTGCGCGACTTCGATCCAGAATCAGGCGGCGCGGCATACGGCGAGCTGGAAGTGCTGCACATCCCTGCCGCCGAAGCG
GTTGAGGCGGGCAAACTCAATCCCGCCAACGCCGCCTATGTGCTGCAACTTTTGGACACCGCGCTCGCAGGCATTTCAGA
CGGCATTTTCGACGGCATCGTTACCGCGCCGCTGCACAAAGGCATCATCAACGACGCGCGCGCAAGCACAGGTTTTTTCA
GCGGACACACCGAATATCTGGCGGAAAAAAGCGGCACGGGGCAGGTCGTGATGATGCTTGCCGGCAAAGGCCTGCGCGTC
GCCCTCGTAACGACCCACCTGCCGCTGAAAGACGTTGCCGCCGCCATCACGCAACCGCTGATTGAAAGCGTCGCACGCAT
TTTGCATCACGACTTAAAACACAAATTCTGCATCAAAAATCCCAAAATCCTGGTCGCCGGACTCAACCCCCACGCCGGTG
AGGGCGGACACCTCGGACACGAAGAAACCGACACCATTATCCCCGCGCTCGAAAACCTGCGCCGCGAAAGGATAAACCTC
GCCGGCCCGTATCCGGCGGACACATTGTTCCAACCGTTTATGCTCGAAGGTGCGGATGCCGTATTGGCGATGTACCACGA
CCAAGGGCTGCCCGTGTTGAAATACCACAGTTTCGGGCAGGGCGTGAACATCACACTGGGGCTGCCCTTTATCCGCACCT
CCGTCGATCACGGCACCGCGCTCGATTTGGCGGCAACCGGCAGGGCGGATTCCGGCAGCCTGATAACTGCCGTGGAGACC
GCCGTCGAGATGGCGCGCGGCAGCCTTTAA

Upstream 100 bases:

>100_bases
TTGTAAACGCCCATTCTAGCAGATTGTCAACAAAATCAGAAAAATTTACATCGCCGCGCGGCTGCGGCGTTAGAATCGCA
TTTTGTTTGGAGCAAACACG

Downstream 100 bases:

>100_bases
AGATGATAAAAGACCCGTCATTTCCGCGCAGGCGGGAATCCGGTCTGTTCGGTTTCAGTTGTTTTTGGGTTTCGGGTAAT
TTCCAAATCGTCATTCCCGC

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase [H]

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MKQPVFAVTSGEPAGIGPDICLDLAFARLPCRCAVLGDKHLLRARAEALGKSVVLRDFDPESGGAAYGELEVLHIPAAEA
VEAGKLNPANAAYVLQLLDTALAGISDGIFDGIVTAPLHKGIINDARASTGFFSGHTEYLAEKSGTGQVVMMLAGKGLRV
ALVTTHLPLKDVAAAITQPLIESVARILHHDLKHKFCIKNPKILVAGLNPHAGEGGHLGHEETDTIIPALENLRRERINL
AGPYPADTLFQPFMLEGADAVLAMYHDQGLPVLKYHSFGQGVNITLGLPFIRTSVDHGTALDLAATGRADSGSLITAVET
AVEMARGSL

Sequences:

>Translated_329_residues
MKQPVFAVTSGEPAGIGPDICLDLAFARLPCRCAVLGDKHLLRARAEALGKSVVLRDFDPESGGAAYGELEVLHIPAAEA
VEAGKLNPANAAYVLQLLDTALAGISDGIFDGIVTAPLHKGIINDARASTGFFSGHTEYLAEKSGTGQVVMMLAGKGLRV
ALVTTHLPLKDVAAAITQPLIESVARILHHDLKHKFCIKNPKILVAGLNPHAGEGGHLGHEETDTIIPALENLRRERINL
AGPYPADTLFQPFMLEGADAVLAMYHDQGLPVLKYHSFGQGVNITLGLPFIRTSVDHGTALDLAATGRADSGSLITAVET
AVEMARGSL
>Mature_329_residues
MKQPVFAVTSGEPAGIGPDICLDLAFARLPCRCAVLGDKHLLRARAEALGKSVVLRDFDPESGGAAYGELEVLHIPAAEA
VEAGKLNPANAAYVLQLLDTALAGISDGIFDGIVTAPLHKGIINDARASTGFFSGHTEYLAEKSGTGQVVMMLAGKGLRV
ALVTTHLPLKDVAAAITQPLIESVARILHHDLKHKFCIKNPKILVAGLNPHAGEGGHLGHEETDTIIPALENLRRERINL
AGPYPADTLFQPFMLEGADAVLAMYHDQGLPVLKYHSFGQGVNITLGLPFIRTSVDHGTALDLAATGRADSGSLITAVET
AVEMARGSL

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=326, Percent_Identity=55.521472392638, Blast_Score=338, Evalue=3e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 34645; Mature: 34645

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQPVFAVTSGEPAGIGPDICLDLAFARLPCRCAVLGDKHLLRARAEALGKSVVLRDFDP
CCCCEEEEECCCCCCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHCCEEEEEECCC
ESGGAAYGELEVLHIPAAEAVEAGKLNPANAAYVLQLLDTALAGISDGIFDGIVTAPLHK
CCCCCCCCEEEEEECCCHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
GIINDARASTGFFSGHTEYLAEKSGTGQVVMMLAGKGLRVALVTTHLPLKDVAAAITQPL
HHHHHHHCCCCCCCCCHHHHHCCCCCCCEEEEEECCCEEEEEEEECCCHHHHHHHHHHHH
IESVARILHHDLKHKFCIKNPKILVAGLNPHAGEGGHLGHEETDTIIPALENLRRERINL
HHHHHHHHHHHHHHHEECCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
AGPYPADTLFQPFMLEGADAVLAMYHDQGLPVLKYHSFGQGVNITLGLPFIRTSVDHGTA
CCCCCHHHHCCHHHHCCCCEEEEEEECCCCCEEEEECCCCCEEEEEECHHHEECCCCCCE
LDLAATGRADSGSLITAVETAVEMARGSL
EEEEECCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKQPVFAVTSGEPAGIGPDICLDLAFARLPCRCAVLGDKHLLRARAEALGKSVVLRDFDP
CCCCEEEEECCCCCCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHCCEEEEEECCC
ESGGAAYGELEVLHIPAAEAVEAGKLNPANAAYVLQLLDTALAGISDGIFDGIVTAPLHK
CCCCCCCCEEEEEECCCHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
GIINDARASTGFFSGHTEYLAEKSGTGQVVMMLAGKGLRVALVTTHLPLKDVAAAITQPL
HHHHHHHCCCCCCCCCHHHHHCCCCCCCEEEEEECCCEEEEEEEECCCHHHHHHHHHHHH
IESVARILHHDLKHKFCIKNPKILVAGLNPHAGEGGHLGHEETDTIIPALENLRRERINL
HHHHHHHHHHHHHHHEECCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
AGPYPADTLFQPFMLEGADAVLAMYHDQGLPVLKYHSFGQGVNITLGLPFIRTSVDHGTA
CCCCCHHHHCCHHHHCCCCEEEEEEECCCCCEEEEECCCCCEEEEEECHHHEECCCCCCE
LDLAATGRADSGSLITAVETAVEMARGSL
EEEEECCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]