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The map label for this gene is nuoL [H]

Identifier: 161870809

GI number: 161870809

Start: 1940441

End: 1942465

Strand: Reverse

Name: nuoL [H]

Synonym: NMCC_1891

Alternate gene names: 161870809

Gene position: 1942465-1940441 (Counterclockwise)

Preceding gene: 161870810

Following gene: 161870808

Centisome position: 90.2

GC content: 52.25

Gene sequence:

>2025_bases
ATGAACGACATGACTTTATATCTCATCATTGCCCTCGTGCCTTTGGCAGGCTCGCTGATTGCGGGTTTGTTCGGCAACAA
AATTGGTCGTGCCGGTGCGCATACGGTTACGATACTCGGCGTGGCTGTGTCCGCCGTGCTGTCGGCTTATGTGCTGTGGG
GCTTTATCGACGGCAGCCGCGCCAAGTTTGACGAGAATGTCTATACCTGGCTGACGATGGGCGGTTTGGATTTCTCCGTC
GGCTTCTTGGTCGATACGATGACGGCGATGATGATGGTCGTGGTCACCGGCGTATCGCTGATGGTGCATATCTATACCAT
CGGTTATATGCACGATGAGAAAGTCGGCTACCAACGCTTCTTCAGCTACATTTCTTTGTTTACTTTCAGTATGTTGATGC
TGATTATGAGCAACAACTTCATCCAGCTCTTCTTCGGCTGGGAAGCTGTGGGCTTGGTGTCGTATCTCTTGATCGGTTTC
TATTTCAAACGTCCGAGCGCAACATTTGCCAACCTGAAAGCCTTTTTGATCAACCGTGTCGGCGACTTCGGCTTTTTGCT
CGGTATCGGCTTGGTGCTTGCTTATTTTGGCGGCAGCCTGCGCTATCAGGACGTATTCGCTTATCTGCCCAACGTCCAAA
ATGCCACCATCCAGCTCTTCCCCGGTGTGGAATGGTCTTTGATTACCGTAACCTGTTTGCTCTTGTTTGTGGGTGCGATG
GGTAAATCGGCACAATTCCCGCTGCACGTCTGGCTGCCTGATTCGATGGAAGGCCCGACCCCGATTTCCGCATTGATTCA
CGCTGCGACGATGGTTACGGCGGGTCTGTTTATGGTATCGCGTATGTCGCCGATTTACGAAATGAGCAGCACTGCGCTGT
CCGTTATCATGGTGATCGGTGCGATTACCGCCCTGTTTATGGGCTTCTTGGGCGTGATTCAAAACGACATCAAACGTGTG
GTTGCGTATTCCACCCTGTCGCAACTGGGCTATATGACCGTGGCTTTGGGCGCGTCTGCCTATTCCGTGGCGATGTTCCA
TGTGATGACCCACGCCTTCTTTAAAGCCCTGTTGTTCTTGGCGGCAGGCAGCGCGATTATCGGTATGCACCACGACCAAG
ACATGCGCCATATGGGCAATCTGAAAAAATATATGCCGGTTACTTGGCTGACCATGCTGATCGGTAACTTGTCGCTGATT
GGTACGCCGTTCTTCTCCGGCTTCTACTCCAAAGATTCGATTATCGAAGCGGCGAAATACAGCACACTGCCGGGCAGCGG
CTTTGCCTATTTTGCCGTCCTCGCCAGCGTGTTTGTTACCGCGTTTTACGCGTTCCGCCAATACTTTATGGTGTTCCACG
GCGAAGAGAAATGGCGCAGCCTGCCCGAACACCATTCAGACGGCCACGGCGAAGAACATCACGGTTTGGGTAAAAACGAC
AATCCGCACGAAAGCCCGTTGGTGGTTACCCTGCCTTTGATTTTGCTTGCCGTTCCGTCCGTCATCATCGGCTACATCGC
CATCGAACCCATGCTTTACGGCGATTTCTTCAAAGACGTGATTTTTGTTAATGCCGATGCGCATCCGACCATGCACATTA
TGAAAGAAGAGTTCCACGGCGCATTGGCGATGGTGTCGCACAGCCTGCATTCGCCCGTTCTCTATCTCGCTATCGCAGGC
GTATTGAGCGCATGGCTTTTGTACGTCAAACTGCCGCACCTGCCTGCGAAAATCGCGCAGGCGTTCCGTCCGGTTTACGT
TTTGTTTGAAAACAAATACTACCTTGATGCCCTGTATTTCAACGTTTTCGCCAAAGGCACACGCGCATTGGGTACCTTCT
TCTGGAAAGTCGGCGATACCGCCATTATCGACAACGGTATTGTCAACGGCTCTGCCAGACTGGTCGGCGCGGTTGCCGCG
CAAGTGCGTAAAGTCCAAACAGGCTTTATCTACACCTACGCTGCCGCTATGGTGTTCGGCGTATTGGTCTTGCTCGGTAT
GACCTTCTGGGGATTGTTCAGATAA

Upstream 100 bases:

>100_bases
AGCTGTGGCACGCAAACGATTGGAGCGTGTTGGATTTGTTTTTCCGAAGTAATTTTGTACGAAACAAACATAGATTTTTA
AATCAATCGGATTCAATCAA

Downstream 100 bases:

>100_bases
AAATGAGATTTTCAGACGACGTTTAGGTCGTCTGAAAAAAGAAACTTGAGAAACAATGTCAAACACACAAACCATCCGCT
CTGCCGACTTCACCACTTCC

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 674; Mature: 674

Protein sequence:

>674_residues
MNDMTLYLIIALVPLAGSLIAGLFGNKIGRAGAHTVTILGVAVSAVLSAYVLWGFIDGSRAKFDENVYTWLTMGGLDFSV
GFLVDTMTAMMMVVVTGVSLMVHIYTIGYMHDEKVGYQRFFSYISLFTFSMLMLIMSNNFIQLFFGWEAVGLVSYLLIGF
YFKRPSATFANLKAFLINRVGDFGFLLGIGLVLAYFGGSLRYQDVFAYLPNVQNATIQLFPGVEWSLITVTCLLLFVGAM
GKSAQFPLHVWLPDSMEGPTPISALIHAATMVTAGLFMVSRMSPIYEMSSTALSVIMVIGAITALFMGFLGVIQNDIKRV
VAYSTLSQLGYMTVALGASAYSVAMFHVMTHAFFKALLFLAAGSAIIGMHHDQDMRHMGNLKKYMPVTWLTMLIGNLSLI
GTPFFSGFYSKDSIIEAAKYSTLPGSGFAYFAVLASVFVTAFYAFRQYFMVFHGEEKWRSLPEHHSDGHGEEHHGLGKND
NPHESPLVVTLPLILLAVPSVIIGYIAIEPMLYGDFFKDVIFVNADAHPTMHIMKEEFHGALAMVSHSLHSPVLYLAIAG
VLSAWLLYVKLPHLPAKIAQAFRPVYVLFENKYYLDALYFNVFAKGTRALGTFFWKVGDTAIIDNGIVNGSARLVGAVAA
QVRKVQTGFIYTYAAAMVFGVLVLLGMTFWGLFR

Sequences:

>Translated_674_residues
MNDMTLYLIIALVPLAGSLIAGLFGNKIGRAGAHTVTILGVAVSAVLSAYVLWGFIDGSRAKFDENVYTWLTMGGLDFSV
GFLVDTMTAMMMVVVTGVSLMVHIYTIGYMHDEKVGYQRFFSYISLFTFSMLMLIMSNNFIQLFFGWEAVGLVSYLLIGF
YFKRPSATFANLKAFLINRVGDFGFLLGIGLVLAYFGGSLRYQDVFAYLPNVQNATIQLFPGVEWSLITVTCLLLFVGAM
GKSAQFPLHVWLPDSMEGPTPISALIHAATMVTAGLFMVSRMSPIYEMSSTALSVIMVIGAITALFMGFLGVIQNDIKRV
VAYSTLSQLGYMTVALGASAYSVAMFHVMTHAFFKALLFLAAGSAIIGMHHDQDMRHMGNLKKYMPVTWLTMLIGNLSLI
GTPFFSGFYSKDSIIEAAKYSTLPGSGFAYFAVLASVFVTAFYAFRQYFMVFHGEEKWRSLPEHHSDGHGEEHHGLGKND
NPHESPLVVTLPLILLAVPSVIIGYIAIEPMLYGDFFKDVIFVNADAHPTMHIMKEEFHGALAMVSHSLHSPVLYLAIAG
VLSAWLLYVKLPHLPAKIAQAFRPVYVLFENKYYLDALYFNVFAKGTRALGTFFWKVGDTAIIDNGIVNGSARLVGAVAA
QVRKVQTGFIYTYAAAMVFGVLVLLGMTFWGLFR
>Mature_674_residues
MNDMTLYLIIALVPLAGSLIAGLFGNKIGRAGAHTVTILGVAVSAVLSAYVLWGFIDGSRAKFDENVYTWLTMGGLDFSV
GFLVDTMTAMMMVVVTGVSLMVHIYTIGYMHDEKVGYQRFFSYISLFTFSMLMLIMSNNFIQLFFGWEAVGLVSYLLIGF
YFKRPSATFANLKAFLINRVGDFGFLLGIGLVLAYFGGSLRYQDVFAYLPNVQNATIQLFPGVEWSLITVTCLLLFVGAM
GKSAQFPLHVWLPDSMEGPTPISALIHAATMVTAGLFMVSRMSPIYEMSSTALSVIMVIGAITALFMGFLGVIQNDIKRV
VAYSTLSQLGYMTVALGASAYSVAMFHVMTHAFFKALLFLAAGSAIIGMHHDQDMRHMGNLKKYMPVTWLTMLIGNLSLI
GTPFFSGFYSKDSIIEAAKYSTLPGSGFAYFAVLASVFVTAFYAFRQYFMVFHGEEKWRSLPEHHSDGHGEEHHGLGKND
NPHESPLVVTLPLILLAVPSVIIGYIAIEPMLYGDFFKDVIFVNADAHPTMHIMKEEFHGALAMVSHSLHSPVLYLAIAG
VLSAWLLYVKLPHLPAKIAQAFRPVYVLFENKYYLDALYFNVFAKGTRALGTFFWKVGDTAIIDNGIVNGSARLVGAVAA
QVRKVQTGFIYTYAAAMVFGVLVLLGMTFWGLFR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=429, Percent_Identity=36.8298368298368, Blast_Score=269, Evalue=5e-72,
Organism=Escherichia coli, GI1788614, Length=614, Percent_Identity=36.4820846905537, Blast_Score=338, Evalue=6e-94,
Organism=Escherichia coli, GI1788829, Length=349, Percent_Identity=29.2263610315186, Blast_Score=135, Evalue=1e-32,
Organism=Escherichia coli, GI1788831, Length=352, Percent_Identity=27.2727272727273, Blast_Score=125, Evalue=1e-29,
Organism=Escherichia coli, GI1788827, Length=457, Percent_Identity=28.0087527352298, Blast_Score=115, Evalue=1e-26,
Organism=Escherichia coli, GI2367154, Length=136, Percent_Identity=30.1470588235294, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1788613, Length=420, Percent_Identity=25.2380952380952, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI145693160, Length=250, Percent_Identity=26.4, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 74247; Mature: 74247

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHCC
>Mature Secondary Structure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HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]