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The map label for this gene is mutL [H]

Identifier: 161870311

GI number: 161870311

Start: 1365734

End: 1367710

Strand: Direct

Name: mutL [H]

Synonym: NMCC_1353

Alternate gene names: 161870311

Gene position: 1365734-1367710 (Clockwise)

Preceding gene: 161870306

Following gene: 161870312

Centisome position: 63.42

GC content: 58.32

Gene sequence:

>1977_bases
ATGCCACGCATTGCCGCCCTGCCCGACCATCTCGTCAACCAAATCGCCGCCGGCGAAGTAGTCGAACGCCCTGCCAACGC
CTTGAAAGAAATCGTTGAAAACAGTATCGATGCAGGCGCAACGGCGATTGATGTCGAGCTGGACGGCGGCGGCATCCGCC
TGATTCGCGTCAGCGACAACGGCAGCGGTATCCATCCGGACGACATCGAACTCGCGCTCCACCGCCACGCCACCAGCAAA
ATCAAAACCTTAAACGATTTGGAACACGTTGCCAGCATGGGCTTTCGCGGCGAAGGCTTGGCAAGCATCGCCTCCGTCAG
CCGCCTGACCCTGACCAGCCGTCAAGAAGACAGTTCGCACGCAACCCAAGTCAAAGCCGAAGACGGCAAACTCAGCAGCC
CCACCGCCGCCGCCCACCCCGTCGGCACCACCATCGAAGCTGCCGAACTCTTCTTCAACACCCCCGCGCGGCGCAAGTTT
CTCAAGTCCGAAAACACCGAATACGCCCACTGCGCCACCATGCTCGAACGCCTCGCGCTGGCGCATCCGCACATCGCCTT
CTCACTCAAACGCGACGGCAAACCAGTGTTCAAACTTCCTGCCCAAAGCCTGCATGAACGGATTGCCGCCATTGTCGGCG
ATGACTTTCAGACGGCATCCCTGGAAATCGACAGCGGCAACGGCGCATTGCGGCTCTATGGCGCGATTGCCAAGCCAACC
TTTGCCAAAGGCAAAACCGACAAACAATACTGCTTCGTCAACCATCGTTTTGTCCGTGACAAAGTCATGCTCCATGCCGT
CAAGCAGGCATACCGCGACGTATTGCACAACGCGCTGACGCCTGCTTTCGTCCTCTTTCTCGACCTGCCGCCCGAAGCCG
TGGATGTCAACGTCCATCCGACCAAAACCGAAATCCGCTTCCGCGACAGCCGGCAGGTGCACCAACTCGTGTTCCACACG
CTCAACAAAGCCCTTGCCGACACGCGCGCCGACTTGACCGAAAGCGTCAGCAACGCAGGCGAAGTGTTGCATGACATTAC
CGGCGTTACGCCTGCCCCAATGCCGTCTGAAAACGACAGCGAAAATCTGTTTGATAGCGCATCCGACTACCCGACAGGCA
ACAAACCCGATACACGCAATGCCTTTGGTTCATCAGGCAAAACCGCGCCCATGCCTTACCAAGCCGCGCGTGCGCCGCAA
CAACACAGCCTGTCCCTGCGCGAAAGCCGCGCGGCAATGAATACTTACGCCGAGCTTTACAAAAAAACCGACGACATCGA
CCTTGAGTTAAGCCGATTAGAGCAGGCGCGTTTCGGCAATATGCCGTCTGAAACGCCTATCCCAAAAACAGATACGCCGC
TTTCAGACGGCATCCCGTCCCAATCCGAACTGCCGCCGCTCGGCTTCGCCATTGCCCAATTATTGGGCATCTACATCCTC
GCCCAAGCCGAAGACAGCCTGCTGCTCATCGATATGCACGCTGCCGCCGAACGCGTCAACTACGAGAAAATGAAACGCCA
ACGGCAGGAAAACGGCAAGCTGCAAAGCCAACGCCTGCTTATTCCCGTAACCTTTGCCGCGTCCCACGAAGAATGCGCCG
CCCTTGCCGATTATGCCGAAACGCTGGCAGGCTTCGGCTTGGAATTGTCCGATATGGGCGGCAACACCCTCGCCGTCCGC
GCAGTTCCCGCCATGCTCGGTAAAGCCGACGTTGTTTCGCTGGCCAAAGATGTATTGGGCGAACTCGCCCAAGTCGGCAG
CAGCCAAACCATCGAAGAACACGAAAACCACATCCTCGCCACCATGTCCTGCCACGGCTCCGTCCGCGCCGGCCGCCAAC
TGACCTTGCCTGAAATGAATGCGCTCCTGCGCGATATGGAAAACACGCCGCGCAGCAACCAGTGCAACCACGGCAGGCCG
ACTTGGGTCAAACTGACTTTGAAAGAATTGGACGCACTGTTCTTGCGCGGACAGTAA

Upstream 100 bases:

>100_bases
TATTTTCCAAACGGGATAAACGGCTTTTATCAAGAATACAGGCAGAAAGATAAGGGGTTTTATTATAGAATAAAGCGTTT
TTGCAACGGAAGCCTACCTT

Downstream 100 bases:

>100_bases
GCCGAAAGTGCTAGAATACGCCGCCCGAAGCCGCCGTTCAGACGGCATTCCGACGCACCGACAGAAACATCACGACCGAA
ACCAAGAGAAAAATATGGCC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 658; Mature: 657

Protein sequence:

>658_residues
MPRIAALPDHLVNQIAAGEVVERPANALKEIVENSIDAGATAIDVELDGGGIRLIRVSDNGSGIHPDDIELALHRHATSK
IKTLNDLEHVASMGFRGEGLASIASVSRLTLTSRQEDSSHATQVKAEDGKLSSPTAAAHPVGTTIEAAELFFNTPARRKF
LKSENTEYAHCATMLERLALAHPHIAFSLKRDGKPVFKLPAQSLHERIAAIVGDDFQTASLEIDSGNGALRLYGAIAKPT
FAKGKTDKQYCFVNHRFVRDKVMLHAVKQAYRDVLHNALTPAFVLFLDLPPEAVDVNVHPTKTEIRFRDSRQVHQLVFHT
LNKALADTRADLTESVSNAGEVLHDITGVTPAPMPSENDSENLFDSASDYPTGNKPDTRNAFGSSGKTAPMPYQAARAPQ
QHSLSLRESRAAMNTYAELYKKTDDIDLELSRLEQARFGNMPSETPIPKTDTPLSDGIPSQSELPPLGFAIAQLLGIYIL
AQAEDSLLLIDMHAAAERVNYEKMKRQRQENGKLQSQRLLIPVTFAASHEECAALADYAETLAGFGLELSDMGGNTLAVR
AVPAMLGKADVVSLAKDVLGELAQVGSSQTIEEHENHILATMSCHGSVRAGRQLTLPEMNALLRDMENTPRSNQCNHGRP
TWVKLTLKELDALFLRGQ

Sequences:

>Translated_658_residues
MPRIAALPDHLVNQIAAGEVVERPANALKEIVENSIDAGATAIDVELDGGGIRLIRVSDNGSGIHPDDIELALHRHATSK
IKTLNDLEHVASMGFRGEGLASIASVSRLTLTSRQEDSSHATQVKAEDGKLSSPTAAAHPVGTTIEAAELFFNTPARRKF
LKSENTEYAHCATMLERLALAHPHIAFSLKRDGKPVFKLPAQSLHERIAAIVGDDFQTASLEIDSGNGALRLYGAIAKPT
FAKGKTDKQYCFVNHRFVRDKVMLHAVKQAYRDVLHNALTPAFVLFLDLPPEAVDVNVHPTKTEIRFRDSRQVHQLVFHT
LNKALADTRADLTESVSNAGEVLHDITGVTPAPMPSENDSENLFDSASDYPTGNKPDTRNAFGSSGKTAPMPYQAARAPQ
QHSLSLRESRAAMNTYAELYKKTDDIDLELSRLEQARFGNMPSETPIPKTDTPLSDGIPSQSELPPLGFAIAQLLGIYIL
AQAEDSLLLIDMHAAAERVNYEKMKRQRQENGKLQSQRLLIPVTFAASHEECAALADYAETLAGFGLELSDMGGNTLAVR
AVPAMLGKADVVSLAKDVLGELAQVGSSQTIEEHENHILATMSCHGSVRAGRQLTLPEMNALLRDMENTPRSNQCNHGRP
TWVKLTLKELDALFLRGQ
>Mature_657_residues
PRIAALPDHLVNQIAAGEVVERPANALKEIVENSIDAGATAIDVELDGGGIRLIRVSDNGSGIHPDDIELALHRHATSKI
KTLNDLEHVASMGFRGEGLASIASVSRLTLTSRQEDSSHATQVKAEDGKLSSPTAAAHPVGTTIEAAELFFNTPARRKFL
KSENTEYAHCATMLERLALAHPHIAFSLKRDGKPVFKLPAQSLHERIAAIVGDDFQTASLEIDSGNGALRLYGAIAKPTF
AKGKTDKQYCFVNHRFVRDKVMLHAVKQAYRDVLHNALTPAFVLFLDLPPEAVDVNVHPTKTEIRFRDSRQVHQLVFHTL
NKALADTRADLTESVSNAGEVLHDITGVTPAPMPSENDSENLFDSASDYPTGNKPDTRNAFGSSGKTAPMPYQAARAPQQ
HSLSLRESRAAMNTYAELYKKTDDIDLELSRLEQARFGNMPSETPIPKTDTPLSDGIPSQSELPPLGFAIAQLLGIYILA
QAEDSLLLIDMHAAAERVNYEKMKRQRQENGKLQSQRLLIPVTFAASHEECAALADYAETLAGFGLELSDMGGNTLAVRA
VPAMLGKADVVSLAKDVLGELAQVGSSQTIEEHENHILATMSCHGSVRAGRQLTLPEMNALLRDMENTPRSNQCNHGRPT
WVKLTLKELDALFLRGQ

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=310, Percent_Identity=37.0967741935484, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI4505913, Length=329, Percent_Identity=31.306990881459, Blast_Score=139, Evalue=1e-32,
Organism=Homo sapiens, GI310128478, Length=329, Percent_Identity=31.306990881459, Blast_Score=139, Evalue=1e-32,
Organism=Homo sapiens, GI4505911, Length=325, Percent_Identity=28.3076923076923, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI189458898, Length=325, Percent_Identity=28.3076923076923, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI189458896, Length=316, Percent_Identity=28.4810126582279, Blast_Score=122, Evalue=2e-27,
Organism=Homo sapiens, GI263191589, Length=225, Percent_Identity=32.8888888888889, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI91992160, Length=262, Percent_Identity=30.9160305343511, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI91992162, Length=262, Percent_Identity=30.9160305343511, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI310128480, Length=290, Percent_Identity=28.2758620689655, Blast_Score=100, Evalue=5e-21,
Organism=Escherichia coli, GI1790612, Length=640, Percent_Identity=35.15625, Blast_Score=315, Evalue=5e-87,
Organism=Caenorhabditis elegans, GI71991825, Length=399, Percent_Identity=32.3308270676692, Blast_Score=187, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17562796, Length=358, Percent_Identity=26.536312849162, Blast_Score=143, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6323819, Length=332, Percent_Identity=36.144578313253, Blast_Score=209, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6324247, Length=357, Percent_Identity=29.1316526610644, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6325093, Length=743, Percent_Identity=22.3418573351279, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323063, Length=354, Percent_Identity=23.4463276836158, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17136968, Length=310, Percent_Identity=35.8064516129032, Blast_Score=198, Evalue=8e-51,
Organism=Drosophila melanogaster, GI17136970, Length=421, Percent_Identity=26.3657957244656, Blast_Score=118, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 71665; Mature: 71534

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRIAALPDHLVNQIAAGEVVERPANALKEIVENSIDAGATAIDVELDGGGIRLIRVSDN
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEEECC
GSGIHPDDIELALHRHATSKIKTLNDLEHVASMGFRGEGLASIASVSRLTLTSRQEDSSH
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCH
ATQVKAEDGKLSSPTAAAHPVGTTIEAAELFFNTPARRKFLKSENTEYAHCATMLERLAL
HHEEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHH
AHPHIAFSLKRDGKPVFKLPAQSLHERIAAIVGDDFQTASLEIDSGNGALRLYGAIAKPT
CCCCEEEEECCCCCCEEECCHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEEECCCCC
FAKGKTDKQYCFVNHRFVRDKVMLHAVKQAYRDVLHNALTPAFVLFLDLPPEAVDVNVHP
CCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEECCC
TKTEIRFRDSRQVHQLVFHTLNKALADTRADLTESVSNAGEVLHDITGVTPAPMPSENDS
CCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
ENLFDSASDYPTGNKPDTRNAFGSSGKTAPMPYQAARAPQQHSLSLRESRAAMNTYAELY
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCHHHCHHHHHHHHHHHHHHHHH
KKTDDIDLELSRLEQARFGNMPSETPIPKTDTPLSDGIPSQSELPPLGFAIAQLLGIYIL
HCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHEEE
AQAEDSLLLIDMHAAAERVNYEKMKRQRQENGKLQSQRLLIPVTFAASHEECAALADYAE
EECCCCEEEEEEHHHHHHCCHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHH
TLAGFGLELSDMGGNTLAVRAVPAMLGKADVVSLAKDVLGELAQVGSSQTIEEHENHILA
HHHHCCCEEECCCCCEEEEEEHHHHHCHHHHHHHHHHHHHHHHHCCCCCCHHHHCCEEEE
TMSCHGSVRAGRQLTLPEMNALLRDMENTPRSNQCNHGRPTWVKLTLKELDALFLRGQ
EEECCCCCCCCCEECCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHCCC
>Mature Secondary Structure 
PRIAALPDHLVNQIAAGEVVERPANALKEIVENSIDAGATAIDVELDGGGIRLIRVSDN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEEECC
GSGIHPDDIELALHRHATSKIKTLNDLEHVASMGFRGEGLASIASVSRLTLTSRQEDSSH
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCH
ATQVKAEDGKLSSPTAAAHPVGTTIEAAELFFNTPARRKFLKSENTEYAHCATMLERLAL
HHEEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHH
AHPHIAFSLKRDGKPVFKLPAQSLHERIAAIVGDDFQTASLEIDSGNGALRLYGAIAKPT
CCCCEEEEECCCCCCEEECCHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEEECCCCC
FAKGKTDKQYCFVNHRFVRDKVMLHAVKQAYRDVLHNALTPAFVLFLDLPPEAVDVNVHP
CCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEECCC
TKTEIRFRDSRQVHQLVFHTLNKALADTRADLTESVSNAGEVLHDITGVTPAPMPSENDS
CCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
ENLFDSASDYPTGNKPDTRNAFGSSGKTAPMPYQAARAPQQHSLSLRESRAAMNTYAELY
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCHHHCHHHHHHHHHHHHHHHHH
KKTDDIDLELSRLEQARFGNMPSETPIPKTDTPLSDGIPSQSELPPLGFAIAQLLGIYIL
HCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHEEE
AQAEDSLLLIDMHAAAERVNYEKMKRQRQENGKLQSQRLLIPVTFAASHEECAALADYAE
EECCCCEEEEEEHHHHHHCCHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHH
TLAGFGLELSDMGGNTLAVRAVPAMLGKADVVSLAKDVLGELAQVGSSQTIEEHENHILA
HHHHCCCEEECCCCCEEEEEEHHHHHCHHHHHHHHHHHHHHHHHCCCCCCHHHHCCEEEE
TMSCHGSVRAGRQLTLPEMNALLRDMENTPRSNQCNHGRPTWVKLTLKELDALFLRGQ
EEECCCCCCCCCEECCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA