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The map label for this gene is mdmC [H]

Identifier: 161870309

GI number: 161870309

Start: 1364727

End: 1365242

Strand: Reverse

Name: mdmC [H]

Synonym: NMCC_1351

Alternate gene names: 161870309

Gene position: 1365242-1364727 (Counterclockwise)

Preceding gene: 161870310

Following gene: 161870308

Centisome position: 63.4

GC content: 54.84

Gene sequence:

>516_bases
TTGGTTTGGCTGGCAAAGCTGATCCGTGCGGAAAAATATCTGGAAATCGGCGTATTTACCGGATACAGCAGCACCGCGCT
TGCATTGGCGTTGCCCGAACACGGGCGGATTACCGCCTGCGACATCAATGTAAGCTTTACCGATACGGCGCGTCAGGTTT
GGAACGAGGCCGGTGTGGCACATAAAATCAGCCTGCACCTGCAACCCGCATTGCTGACATTGGATGATTTGATTGCACAG
GGTGAAGCCGGAAGCTACGATTTGGCACTGATAGACGCAGACAAACCGCCCACGCCGCGATATTTCGAGCGTTGCCTCAA
ACTCGTCCGTCAAGGCGGCATCATCGCCATCGACAATATTTTGCTGAACGGAAGGGTGATGCGCGAAGCGGCTTCCGATG
CGCCGCCCAGCGTCGGCATCCTCAAAGATTTCAATCAAAACCTGCCGAACGATACGCGGATTGTCCCCATCACCCTGCCC
GTCGGCGACGGCTTGACCCTGCTTCTGAAAAAATAA

Upstream 100 bases:

>100_bases
CATCGGCGAACCTGAACATCCCGTTTTGACGCGGCTGCGTGAGAAGACCGGGCATCACCGTATGGGCAAAATGGCGATTG
CGCGCGAACAGGCGGCGGTT

Downstream 100 bases:

>100_bases
TGAAGACCAAATTACCGCTTTTTATCATTTGGCTGTCCGTATCCGCCGCCTGTTCTTCCCCTGTTTCCCGCAATATTCAG
GATATGCGGCCCGAACCGCA

Product: methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 171; Mature: 171

Protein sequence:

>171_residues
MVWLAKLIRAEKYLEIGVFTGYSSTALALALPEHGRITACDINVSFTDTARQVWNEAGVAHKISLHLQPALLTLDDLIAQ
GEAGSYDLALIDADKPPTPRYFERCLKLVRQGGIIAIDNILLNGRVMREAASDAPPSVGILKDFNQNLPNDTRIVPITLP
VGDGLTLLLKK

Sequences:

>Translated_171_residues
MVWLAKLIRAEKYLEIGVFTGYSSTALALALPEHGRITACDINVSFTDTARQVWNEAGVAHKISLHLQPALLTLDDLIAQ
GEAGSYDLALIDADKPPTPRYFERCLKLVRQGGIIAIDNILLNGRVMREAASDAPPSVGILKDFNQNLPNDTRIVPITLP
VGDGLTLLLKK
>Mature_171_residues
MVWLAKLIRAEKYLEIGVFTGYSSTALALALPEHGRITACDINVSFTDTARQVWNEAGVAHKISLHLQPALLTLDDLIAQ
GEAGSYDLALIDADKPPTPRYFERCLKLVRQGGIIAIDNILLNGRVMREAASDAPPSVGILKDFNQNLPNDTRIVPITLP
VGDGLTLLLKK

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=167, Percent_Identity=45.5089820359281, Blast_Score=147, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI72001028, Length=167, Percent_Identity=38.3233532934132, Blast_Score=105, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17565612, Length=168, Percent_Identity=33.9285714285714, Blast_Score=102, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI25148771, Length=175, Percent_Identity=33.7142857142857, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI72001127, Length=164, Percent_Identity=33.5365853658537, Blast_Score=91, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 18628; Mature: 18628

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVWLAKLIRAEKYLEIGVFTGYSSTALALALPEHGRITACDINVSFTDTARQVWNEAGVA
CHHHHHHHHHHHEEEEEEEECCCCCEEEEEECCCCCEEEEEEEEEECHHHHHHHHHCCCE
HKISLHLQPALLTLDDLIAQGEAGSYDLALIDADKPPTPRYFERCLKLVRQGGIIAIDNI
EEEEEEECHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEE
LLNGRVMREAASDAPPSVGILKDFNQNLPNDTRIVPITLPVGDGLTLLLKK
EECCCHHHHHHCCCCCCCCHHHHHHCCCCCCCEEEEEEEECCCCEEEEEEC
>Mature Secondary Structure
MVWLAKLIRAEKYLEIGVFTGYSSTALALALPEHGRITACDINVSFTDTARQVWNEAGVA
CHHHHHHHHHHHEEEEEEEECCCCCEEEEEECCCCCEEEEEEEEEECHHHHHHHHHCCCE
HKISLHLQPALLTLDDLIAQGEAGSYDLALIDADKPPTPRYFERCLKLVRQGGIIAIDNI
EEEEEEECHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEE
LLNGRVMREAASDAPPSVGILKDFNQNLPNDTRIVPITLPVGDGLTLLLKK
EECCCHHHHHHCCCCCCCCHHHHHHCCCCCCCEEEEEEEECCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]