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The map label for this gene is hexR [H]

Identifier: 161870263

GI number: 161870263

Start: 1305821

End: 1306669

Strand: Reverse

Name: hexR [H]

Synonym: NMCC_1304

Alternate gene names: 161870263

Gene position: 1306669-1305821 (Counterclockwise)

Preceding gene: 161870264

Following gene: 161870262

Centisome position: 60.68

GC content: 55.71

Gene sequence:

>849_bases
ATGTTAAGCAAAATCAGCGAATCACTGGCAAACCTTTCCGGTGCGGAACGCAAAGTCGCCGAATGTGCATTGGCGGAACC
CAAATGGTTCGTCCATGCCGCCGTTGCCGAAATTGCCGAACGTGCGTCCGTCAGCCAGCCGACCGTCATCCGATTCTGCC
GCAGCTTGGGTTATAAAGGGCTGCCCGAGTTCAAGCTCGCCTTGTCCGCCAGCATCGGTCATGAGGGTATGCCCTATGTC
CACGAAGAACTCAACGCCGACGACGATATGGCAAGCGTGGTCGAGAAAGTGTTGGGCAATGCCGCCGCCTCGCTGTTGGG
CGAACGCCGCTTCCTGAAAGAGTCGGAGCTGGAAAACGCCATTGCCACGCTGATGCACGCCCGTCGCGTCGAGTTTTACG
GTGTCGGCAATTCCGGCATTGTGGCACAGGACGCGCAGCATAAATTTTTCCGTTTCGGCATGTCCACCGTCGCCTATGTC
GATACGCACACGCAGCTGATGGCGGCATCTGTTTTGAGCGATCAGGATGTTTTGGTTGCCATTTCCAACACGGGTTCGTC
TATCGAACTTTTGGATGCGGTCAGCATCGCCAAAGAAAACGGCGCGTCTGTCATCGCACTGACCCGCAACGATTCGCCTC
TGGCGCAACTTGCCGACTGCGTGTTGAGCGTTGCCACACAGGAAAATGCCGAACTCTACACGCCCATGGTTTCCCGCCTC
TTGCAGCTTGCCGTCATCGACATTCTCGCCATCGGACTTGCCCTGCGCTTGGGCGATGCTGCCAGCCTGCAATTGCAGAA
AAGCAAAAAAAGCATACACAACAAGCACATCGATTACGACAAAGATTGA

Upstream 100 bases:

>100_bases
GGAATTTCCGGTGCGGCTGCGGCTCTCGACAACCATTTGAGAAACGTTTAACCACAGCGGCTCCTTGCAGCGGGGCTGCA
TTATCGAAGGGCATATCATT

Downstream 100 bases:

>100_bases
CCTTCAGACGGCATCCCACAAATGCCGTCTGAAATGCCGAACAACGGTCGTCGGCGGCTTGCGGCAGTTTCCAGCAGCCT
TTTCATCCCACAACAAAAAA

Product: transcriptional regulator

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MLSKISESLANLSGAERKVAECALAEPKWFVHAAVAEIAERASVSQPTVIRFCRSLGYKGLPEFKLALSASIGHEGMPYV
HEELNADDDMASVVEKVLGNAAASLLGERRFLKESELENAIATLMHARRVEFYGVGNSGIVAQDAQHKFFRFGMSTVAYV
DTHTQLMAASVLSDQDVLVAISNTGSSIELLDAVSIAKENGASVIALTRNDSPLAQLADCVLSVATQENAELYTPMVSRL
LQLAVIDILAIGLALRLGDAASLQLQKSKKSIHNKHIDYDKD

Sequences:

>Translated_282_residues
MLSKISESLANLSGAERKVAECALAEPKWFVHAAVAEIAERASVSQPTVIRFCRSLGYKGLPEFKLALSASIGHEGMPYV
HEELNADDDMASVVEKVLGNAAASLLGERRFLKESELENAIATLMHARRVEFYGVGNSGIVAQDAQHKFFRFGMSTVAYV
DTHTQLMAASVLSDQDVLVAISNTGSSIELLDAVSIAKENGASVIALTRNDSPLAQLADCVLSVATQENAELYTPMVSRL
LQLAVIDILAIGLALRLGDAASLQLQKSKKSIHNKHIDYDKD
>Mature_282_residues
MLSKISESLANLSGAERKVAECALAEPKWFVHAAVAEIAERASVSQPTVIRFCRSLGYKGLPEFKLALSASIGHEGMPYV
HEELNADDDMASVVEKVLGNAAASLLGERRFLKESELENAIATLMHARRVEFYGVGNSGIVAQDAQHKFFRFGMSTVAYV
DTHTQLMAASVLSDQDVLVAISNTGSSIELLDAVSIAKENGASVIALTRNDSPLAQLADCVLSVATQENAELYTPMVSRL
LQLAVIDILAIGLALRLGDAASLQLQKSKKSIHNKHIDYDKD

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=278, Percent_Identity=42.0863309352518, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI87082369, Length=256, Percent_Identity=28.90625, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI87082130, Length=233, Percent_Identity=31.3304721030043, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1788767, Length=271, Percent_Identity=28.4132841328413, Blast_Score=108, Evalue=5e-25,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 30382; Mature: 30382

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00356 HTH_LACI_1 ; PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSKISESLANLSGAERKVAECALAEPKWFVHAAVAEIAERASVSQPTVIRFCRSLGYKG
CCHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
LPEFKLALSASIGHEGMPYVHEELNADDDMASVVEKVLGNAAASLLGERRFLKESELENA
CCHHHHHHHHCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IATLMHARRVEFYGVGNSGIVAQDAQHKFFRFGMSTVAYVDTHTQLMAASVLSDQDVLVA
HHHHHHHHHHEEEECCCCCCEECHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEE
ISNTGSSIELLDAVSIAKENGASVIALTRNDSPLAQLADCVLSVATQENAELYTPMVSRL
EECCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LQLAVIDILAIGLALRLGDAASLQLQKSKKSIHNKHIDYDKD
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLSKISESLANLSGAERKVAECALAEPKWFVHAAVAEIAERASVSQPTVIRFCRSLGYKG
CCHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
LPEFKLALSASIGHEGMPYVHEELNADDDMASVVEKVLGNAAASLLGERRFLKESELENA
CCHHHHHHHHCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IATLMHARRVEFYGVGNSGIVAQDAQHKFFRFGMSTVAYVDTHTQLMAASVLSDQDVLVA
HHHHHHHHHHEEEECCCCCCEECHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEE
ISNTGSSIELLDAVSIAKENGASVIALTRNDSPLAQLADCVLSVATQENAELYTPMVSRL
EECCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LQLAVIDILAIGLALRLGDAASLQLQKSKKSIHNKHIDYDKD
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 1704005; 7567469 [H]