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The map label for this gene is trxA [H]

Identifier: 161870236

GI number: 161870236

Start: 1278938

End: 1279270

Strand: Direct

Name: trxA [H]

Synonym: NMCC_1277

Alternate gene names: 161870236

Gene position: 1278938-1279270 (Clockwise)

Preceding gene: 161870234

Following gene: 161870238

Centisome position: 59.39

GC content: 56.16

Gene sequence:

>333_bases
ATGAGCAGCGAATTAATCGTACACACCGGCGATGCCGCTTTCGAGCAAGATGTTTTGAAATCCGACCTCCCCGTCCTGCT
GGACTTTTGGGCTCCGTGGTGCGGCCCCTGCAAAATGATTGCCCCGATTTTGGACGACATCGCCGCCGAATTTGAAGGCC
GTCTGAAAGTAGTCAAAATCAACATCGACGACAACGAAGCCACCCCGTCCCGTTTCGGCGTGCGCGGCATTCCGACCCTG
ATGGTGTTCAAAAACGGCGACGTCGTCGCCACCAAAGTCGGCGCATTGGCAAAAGGTCAGCTGACCGCCTTTGTCGAAGC
CTCTATCGCCTGA

Upstream 100 bases:

>100_bases
GGTACAGAAAAACTATTATCCCGCCCGCCCACTTGAAATTTTTATGCCCAAGCCCTATCCTGCACGCTATCGTGCCAATC
CCAACCGAAAAGGAAAAATA

Downstream 100 bases:

>100_bases
TAAAGCGCAATCGAAAAAGCCGCCGGAAGATTCCGGCGGCTTTTTCGCACCCTTAAGATTCGTGGCGGATTTCCCAGCAC
CTATGGATTTTTTTGTTGCG

Product: thioredoxin I

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 110; Mature: 109

Protein sequence:

>110_residues
MSSELIVHTGDAAFEQDVLKSDLPVLLDFWAPWCGPCKMIAPILDDIAAEFEGRLKVVKINIDDNEATPSRFGVRGIPTL
MVFKNGDVVATKVGALAKGQLTAFVEASIA

Sequences:

>Translated_110_residues
MSSELIVHTGDAAFEQDVLKSDLPVLLDFWAPWCGPCKMIAPILDDIAAEFEGRLKVVKINIDDNEATPSRFGVRGIPTL
MVFKNGDVVATKVGALAKGQLTAFVEASIA
>Mature_109_residues
SSELIVHTGDAAFEQDVLKSDLPVLLDFWAPWCGPCKMIAPILDDIAAEFEGRLKVVKINIDDNEATPSRFGVRGIPTLM
VFKNGDVVATKVGALAKGQLTAFVEASIA

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=97, Percent_Identity=39.1752577319588, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI5031973, Length=90, Percent_Identity=30, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=61.1111111111111, Blast_Score=149, Evalue=3e-38,
Organism=Escherichia coli, GI1788936, Length=106, Percent_Identity=46.2264150943396, Blast_Score=107, Evalue=2e-25,
Organism=Escherichia coli, GI87081747, Length=91, Percent_Identity=35.1648351648352, Blast_Score=67, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=97, Percent_Identity=35.0515463917526, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71998175, Length=96, Percent_Identity=37.5, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71980565, Length=98, Percent_Identity=33.6734693877551, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17556044, Length=86, Percent_Identity=34.8837209302326, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=74, Percent_Identity=43.2432432432432, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=72, Percent_Identity=37.5, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=87, Percent_Identity=36.7816091954023, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17509965, Length=67, Percent_Identity=37.3134328358209, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=85, Percent_Identity=40, Blast_Score=67, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6321648, Length=82, Percent_Identity=34.1463414634146, Blast_Score=60, Evalue=5e-11,
Organism=Drosophila melanogaster, GI28573567, Length=96, Percent_Identity=37.5, Blast_Score=82, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24639826, Length=88, Percent_Identity=40.9090909090909, Blast_Score=82, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24664269, Length=87, Percent_Identity=35.632183908046, Blast_Score=72, Evalue=7e-14,
Organism=Drosophila melanogaster, GI17648013, Length=85, Percent_Identity=38.8235294117647, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24583090, Length=85, Percent_Identity=38.8235294117647, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI19921434, Length=81, Percent_Identity=35.8024691358025, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21358065, Length=96, Percent_Identity=34.375, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11817; Mature: 11686

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSELIVHTGDAAFEQDVLKSDLPVLLDFWAPWCGPCKMIAPILDDIAAEFEGRLKVVKI
CCCCEEEECCCCHHHHHHHHCCCCCEEHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEE
NIDDNEATPSRFGVRGIPTLMVFKNGDVVATKVGALAKGQLTAFVEASIA
EECCCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCCCCEEEEEEEECC
>Mature Secondary Structure 
SSELIVHTGDAAFEQDVLKSDLPVLLDFWAPWCGPCKMIAPILDDIAAEFEGRLKVVKI
CCCEEEECCCCHHHHHHHHCCCCCEEHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEE
NIDDNEATPSRFGVRGIPTLMVFKNGDVVATKVGALAKGQLTAFVEASIA
EECCCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10224002; 10984043 [H]