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The map label for this gene is kdsA [H]

Identifier: 161870157

GI number: 161870157

Start: 1188423

End: 1189265

Strand: Direct

Name: kdsA [H]

Synonym: NMCC_1196

Alternate gene names: 161870157

Gene position: 1188423-1189265 (Clockwise)

Preceding gene: 161870156

Following gene: 161870158

Centisome position: 55.19

GC content: 51.25

Gene sequence:

>843_bases
ATGGATATTAAAATCAACGACTTCACCCTCGGCAACAACTCGCCCTTCGTCCTATTCGGCGGCATCAACGTTTTGGAAAG
CTTGGATTCCACCCTCCAAACCTGCGCGCATTACGTCGAAGTAACCCGCAAACTCGGAATTCCCTATATCTTTAAAGCCT
CTTTCGACAAGGCAAATCGTTCCTCCATCCATTCTTATCGCGGCGTAGGCTTGGAAGAAGGCTTAAAGATTTTTGAAAAA
GTCAAAGCAGAGTTCGGCATCCCCGTCATTACCGACGTACACGAACCCCATCAGTGCCAACCCGTCGCCGAAGTGTGCGA
TGTCATCCAGCTTCCCGCCTTTCTTGCGCGGCAGACCGATTTAGTGGTTGCCATGGCAAAAACTGGCAACGTCGTCAACA
TCAAAAAACCTCAGTTCCTCAGCCCCTCTCAAATGAAAAACATTGTGGAAAAATTCCACGAAGCCGGCAACGGGAAACTG
ATTTTATGCGAACGCGGCAGCAGCTTCGGCTACGACAACCTCGTTGTCGATATGCTCGGTTTCGGCGTGATGAAACAGAC
TTGCGGCAACCTGCCGGTTATTTTCGACGTTACCCATTCCCTGCAAACCCGCGATGCCGGTTCTGCCGCATCCGGCGGTC
GTCGCGCACAGGCTTTGGATTTGGCACTTGCAGGCATGGCAACCCGCCTTGCCGGTCTGTTCCTCGAATCGCACCCCGAT
CCGAAACTGGCAAAATGCGACGGCCCCAGCGCGCTGCCGCTGCACCTTTTAGAAGATTTTTTAATCCGCATCAAAGCATT
GGACGATTTAATCAAATCACAACCGATTTTAACAATCGAGTAA

Upstream 100 bases:

>100_bases
ACCCAAAGTCGTCTTGGTAGACGGAAACAACAAAATCCGCGACATCATCTCCTATGAGCCGCCGCACACCGTGCTGTAAT
TCCGCAAACGGACATCGATT

Downstream 100 bases:

>100_bases
CACGGTTTCGCCTTATGATGCAGACTTTCCGAAAAATCAGCCTGTATGCCGCAACCTTGTGGCTCGGTATGCAGATTATG
GCGGGTTATATCGTCGCGCC

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MDIKINDFTLGNNSPFVLFGGINVLESLDSTLQTCAHYVEVTRKLGIPYIFKASFDKANRSSIHSYRGVGLEEGLKIFEK
VKAEFGIPVITDVHEPHQCQPVAEVCDVIQLPAFLARQTDLVVAMAKTGNVVNIKKPQFLSPSQMKNIVEKFHEAGNGKL
ILCERGSSFGYDNLVVDMLGFGVMKQTCGNLPVIFDVTHSLQTRDAGSAASGGRRAQALDLALAGMATRLAGLFLESHPD
PKLAKCDGPSALPLHLLEDFLIRIKALDDLIKSQPILTIE

Sequences:

>Translated_280_residues
MDIKINDFTLGNNSPFVLFGGINVLESLDSTLQTCAHYVEVTRKLGIPYIFKASFDKANRSSIHSYRGVGLEEGLKIFEK
VKAEFGIPVITDVHEPHQCQPVAEVCDVIQLPAFLARQTDLVVAMAKTGNVVNIKKPQFLSPSQMKNIVEKFHEAGNGKL
ILCERGSSFGYDNLVVDMLGFGVMKQTCGNLPVIFDVTHSLQTRDAGSAASGGRRAQALDLALAGMATRLAGLFLESHPD
PKLAKCDGPSALPLHLLEDFLIRIKALDDLIKSQPILTIE
>Mature_280_residues
MDIKINDFTLGNNSPFVLFGGINVLESLDSTLQTCAHYVEVTRKLGIPYIFKASFDKANRSSIHSYRGVGLEEGLKIFEK
VKAEFGIPVITDVHEPHQCQPVAEVCDVIQLPAFLARQTDLVVAMAKTGNVVNIKKPQFLSPSQMKNIVEKFHEAGNGKL
ILCERGSSFGYDNLVVDMLGFGVMKQTCGNLPVIFDVTHSLQTRDAGSAASGGRRAQALDLALAGMATRLAGLFLESHPD
PKLAKCDGPSALPLHLLEDFLIRIKALDDLIKSQPILTIE

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family [H]

Homologues:

Organism=Escherichia coli, GI1787466, Length=270, Percent_Identity=71.1111111111111, Blast_Score=405, Evalue=1e-114,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269 [H]

Pfam domain/function: PF00793 DAHP_synth_1 [H]

EC number: =2.5.1.55 [H]

Molecular weight: Translated: 30518; Mature: 30518

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIKINDFTLGNNSPFVLFGGINVLESLDSTLQTCAHYVEVTRKLGIPYIFKASFDKANR
CCEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCH
SSIHSYRGVGLEEGLKIFEKVKAEFGIPVITDVHEPHQCQPVAEVCDVIQLPAFLARQTD
HHHHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCC
LVVAMAKTGNVVNIKKPQFLSPSQMKNIVEKFHEAGNGKLILCERGSSFGYDNLVVDMLG
EEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHH
FGVMKQTCGNLPVIFDVTHSLQTRDAGSAASGGRRAQALDLALAGMATRLAGLFLESHPD
HHHHHHHHCCCCEEEEECHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
PKLAKCDGPSALPLHLLEDFLIRIKALDDLIKSQPILTIE
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEC
>Mature Secondary Structure
MDIKINDFTLGNNSPFVLFGGINVLESLDSTLQTCAHYVEVTRKLGIPYIFKASFDKANR
CCEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCH
SSIHSYRGVGLEEGLKIFEKVKAEFGIPVITDVHEPHQCQPVAEVCDVIQLPAFLARQTD
HHHHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCC
LVVAMAKTGNVVNIKKPQFLSPSQMKNIVEKFHEAGNGKLILCERGSSFGYDNLVVDMLG
EEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHH
FGVMKQTCGNLPVIFDVTHSLQTRDAGSAASGGRRAQALDLALAGMATRLAGLFLESHPD
HHHHHHHHCCCCEEEEECHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
PKLAKCDGPSALPLHLLEDFLIRIKALDDLIKSQPILTIE
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA