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The map label for this gene is thrC [H]

Identifier: 161870110

GI number: 161870110

Start: 1137817

End: 1139226

Strand: Direct

Name: thrC [H]

Synonym: NMCC_1149

Alternate gene names: 161870110

Gene position: 1137817-1139226 (Clockwise)

Preceding gene: 161870109

Following gene: 161870111

Centisome position: 52.84

GC content: 53.83

Gene sequence:

>1410_bases
ATGAAATACATCAGCACGCGCGGCGAAACCGCACACAAACCGTTCAGCGAAGTTTTATTGATGGGGCTTGCACCCGACGG
CGGCCTGATGCTGCCGGAACATTATCCGCAAATCGGGCGCGAAACCTTGGACAAATGGCGCGGTTTGGCTTATCCCGAAT
TGGCGTTTGAAATTATGCGCCTGTTTGTTACGGATATTCCGGAGGACGATTTGCGCGACATTCTGAACCGTACTTACACG
GAAGCGGCGTTCGGTACTAAGGAAATCACCCCCGTCCGCACGCTTTCAGACGGCATCAAAATCCAAGCCTTGTCCAACGG
CCCGACGCTGGCGTTCAAAGATATGGCAATGCAGTTTTTGGGCAATGCGTTTGAATATGTTTTAAACAAAGAAGGCAAAA
AACTCAATATCTTGGGCGCGACCAGCGGCGATACGGGTTCGGCTGCGGAATATGCCTTGCGCGGCAAAAAGGGCGTGAAC
GTATTTATGTTGTCGCCCGACGGTAAAATGAGCGCGTTCCAACGCGCGCAAATGTACAGCCTGCAAGACGAGAATATCCA
CAATATCGCCGTGAAGGGAATGTTTGACGACTGTCAGGACATTGTGAAGGCGGTGCAAAACGATGCCGCGTTCAAGGAAA
AATACCATATCGGTACGGTCAATTCGATCAACTGGGGACGCATCGTCGCGCAAGTGGTTTATTACTTTGCAGGCTATTTC
AAAGCGACGCAAAGCAATGACGAGCAAGTCAGCTTCTGCGTGCCGAGCGGCAACTTCGGCAACGTTTGCGCGGGACACAT
CGCCAAACAGATGGGTTTGCCTATCCGCCGCCTGATTGTCGCGACCAATGAAAACGATGTGTTGGACGAGTTTTTCAAAA
CCGGTGCATACCGCCCGCGCAACAGCGCGCATACTTATGTTACCTCCAGCCCGTCGATGGACATTTCCAAAGCGTCCAAC
TTCGAGCGTTTCGTGTTCGACCTGATGGATCGCGATCCTCAGGAAATCAATACGCTGTGGGCGGAAGTAGCGGCGGGCAA
AGGCTTTGACCTGCGGTTTGCTTTAGAAAAAGTCGGTGGCAAATACGGTTTTACCTCCGGCAAATCCACCCACCCCGACC
GCCTCGCCACCATCAGACAGGTTTATGAGCAAGACCAAGAACTCATCGACCCGCACACTGCCGACGGCGTAAAAGTCGCC
CGCGAAGTGCGCGAAGAAGGGGAAACGGTTGTGTGTTTGGAAACCGCGTTGGCAGCGAAATTCGATGCGACCATACGCGA
AGCCGTCGGCGATGCCGCCATTCCGCGCCCCGCCGCGCTGGAAGGTTTGGAAACATTGCCGCAGCGCGTGCAAACCGTGC
CGAACAGTGCGGATGCGGTAAAAGGCATCATCGAACAAACCCTTGCCTGA

Upstream 100 bases:

>100_bases
CGCCTGCTTCAAACACCTGTACCGCTAACCTTCTTCAGACGGCATGAGGCAGATACCGTCTGAAGCCGTTTTCCTGCAAT
TTCGACAGACGAGAAAAATC

Downstream 100 bases:

>100_bases
TGTTCCGTATGGGCGGCATTCCGTCCGAACTTAAGATTGAAAGAAAATGACCTTACCTATGCAGGAAACCCGTTTTTCCA
TACTGCTGGACGAATTGGCG

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MKYISTRGETAHKPFSEVLLMGLAPDGGLMLPEHYPQIGRETLDKWRGLAYPELAFEIMRLFVTDIPEDDLRDILNRTYT
EAAFGTKEITPVRTLSDGIKIQALSNGPTLAFKDMAMQFLGNAFEYVLNKEGKKLNILGATSGDTGSAAEYALRGKKGVN
VFMLSPDGKMSAFQRAQMYSLQDENIHNIAVKGMFDDCQDIVKAVQNDAAFKEKYHIGTVNSINWGRIVAQVVYYFAGYF
KATQSNDEQVSFCVPSGNFGNVCAGHIAKQMGLPIRRLIVATNENDVLDEFFKTGAYRPRNSAHTYVTSSPSMDISKASN
FERFVFDLMDRDPQEINTLWAEVAAGKGFDLRFALEKVGGKYGFTSGKSTHPDRLATIRQVYEQDQELIDPHTADGVKVA
REVREEGETVVCLETALAAKFDATIREAVGDAAIPRPAALEGLETLPQRVQTVPNSADAVKGIIEQTLA

Sequences:

>Translated_469_residues
MKYISTRGETAHKPFSEVLLMGLAPDGGLMLPEHYPQIGRETLDKWRGLAYPELAFEIMRLFVTDIPEDDLRDILNRTYT
EAAFGTKEITPVRTLSDGIKIQALSNGPTLAFKDMAMQFLGNAFEYVLNKEGKKLNILGATSGDTGSAAEYALRGKKGVN
VFMLSPDGKMSAFQRAQMYSLQDENIHNIAVKGMFDDCQDIVKAVQNDAAFKEKYHIGTVNSINWGRIVAQVVYYFAGYF
KATQSNDEQVSFCVPSGNFGNVCAGHIAKQMGLPIRRLIVATNENDVLDEFFKTGAYRPRNSAHTYVTSSPSMDISKASN
FERFVFDLMDRDPQEINTLWAEVAAGKGFDLRFALEKVGGKYGFTSGKSTHPDRLATIRQVYEQDQELIDPHTADGVKVA
REVREEGETVVCLETALAAKFDATIREAVGDAAIPRPAALEGLETLPQRVQTVPNSADAVKGIIEQTLA
>Mature_469_residues
MKYISTRGETAHKPFSEVLLMGLAPDGGLMLPEHYPQIGRETLDKWRGLAYPELAFEIMRLFVTDIPEDDLRDILNRTYT
EAAFGTKEITPVRTLSDGIKIQALSNGPTLAFKDMAMQFLGNAFEYVLNKEGKKLNILGATSGDTGSAAEYALRGKKGVN
VFMLSPDGKMSAFQRAQMYSLQDENIHNIAVKGMFDDCQDIVKAVQNDAAFKEKYHIGTVNSINWGRIVAQVVYYFAGYF
KATQSNDEQVSFCVPSGNFGNVCAGHIAKQMGLPIRRLIVATNENDVLDEFFKTGAYRPRNSAHTYVTSSPSMDISKASN
FERFVFDLMDRDPQEINTLWAEVAAGKGFDLRFALEKVGGKYGFTSGKSTHPDRLATIRQVYEQDQELIDPHTADGVKVA
REVREEGETVVCLETALAAKFDATIREAVGDAAIPRPAALEGLETLPQRVQTVPNSADAVKGIIEQTLA

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=455, Percent_Identity=33.4065934065934, Blast_Score=244, Evalue=2e-64,
Organism=Homo sapiens, GI153792148, Length=456, Percent_Identity=34.8684210526316, Blast_Score=226, Evalue=4e-59,
Organism=Escherichia coli, GI1786185, Length=465, Percent_Identity=29.4623655913978, Blast_Score=185, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6319901, Length=464, Percent_Identity=41.8103448275862, Blast_Score=343, Evalue=3e-95,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 51783; Mature: 51783

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYISTRGETAHKPFSEVLLMGLAPDGGLMLPEHYPQIGRETLDKWRGLAYPELAFEIMR
CCCCCCCCCCCCCCHHHHHHHEECCCCCEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LFVTDIPEDDLRDILNRTYTEAAFGTKEITPVRTLSDGIKIQALSNGPTLAFKDMAMQFL
HHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCEEEEEECCCCCCHHHHHHHHHH
GNAFEYVLNKEGKKLNILGATSGDTGSAAEYALRGKKGVNVFMLSPDGKMSAFQRAQMYS
HHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHC
LQDENIHNIAVKGMFDDCQDIVKAVQNDAAFKEKYHIGTVNSINWGRIVAQVVYYFAGYF
CCCCCCCEEEEECCHHHHHHHHHHHHCCHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHH
KATQSNDEQVSFCVPSGNFGNVCAGHIAKQMGLPIRRLIVATNENDVLDEFFKTGAYRPR
HHCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEHEEEECCCCHHHHHHHHCCCCCCC
NSAHTYVTSSPSMDISKASNFERFVFDLMDRDPQEINTLWAEVAAGKGFDLRFALEKVGG
CCCCEEEECCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCC
KYGFTSGKSTHPDRLATIRQVYEQDQELIDPHTADGVKVAREVREEGETVVCLETALAAK
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEHHHHHHH
FDATIREAVGDAAIPRPAALEGLETLPQRVQTVPNSADAVKGIIEQTLA
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKYISTRGETAHKPFSEVLLMGLAPDGGLMLPEHYPQIGRETLDKWRGLAYPELAFEIMR
CCCCCCCCCCCCCCHHHHHHHEECCCCCEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LFVTDIPEDDLRDILNRTYTEAAFGTKEITPVRTLSDGIKIQALSNGPTLAFKDMAMQFL
HHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCEEEEEECCCCCCHHHHHHHHHH
GNAFEYVLNKEGKKLNILGATSGDTGSAAEYALRGKKGVNVFMLSPDGKMSAFQRAQMYS
HHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHC
LQDENIHNIAVKGMFDDCQDIVKAVQNDAAFKEKYHIGTVNSINWGRIVAQVVYYFAGYF
CCCCCCCEEEEECCHHHHHHHHHHHHCCHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHH
KATQSNDEQVSFCVPSGNFGNVCAGHIAKQMGLPIRRLIVATNENDVLDEFFKTGAYRPR
HHCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEHEEEECCCCHHHHHHHHCCCCCCC
NSAHTYVTSSPSMDISKASNFERFVFDLMDRDPQEINTLWAEVAAGKGFDLRFALEKVGG
CCCCEEEECCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCC
KYGFTSGKSTHPDRLATIRQVYEQDQELIDPHTADGVKVAREVREEGETVVCLETALAAK
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEHHHHHHH
FDATIREAVGDAAIPRPAALEGLETLPQRVQTVPNSADAVKGIIEQTLA
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8117070 [H]