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The map label for this gene is purM [H]

Identifier: 161870095

GI number: 161870095

Start: 1119252

End: 1120286

Strand: Reverse

Name: purM [H]

Synonym: NMCC_1133

Alternate gene names: 161870095

Gene position: 1120286-1119252 (Counterclockwise)

Preceding gene: 161870101

Following gene: 161870094

Centisome position: 52.02

GC content: 51.21

Gene sequence:

>1035_bases
ATGAGTACTTCATTGAGTTACCGCGATGCGGGCGTCGATATCGACGCAGGCGACCAACTGGTCGAAAACATCAAACCGTT
TGCCAAACGCACCATGCGTCCGGAAGTATTGGGGGATTTGGGCGGTTTTGGCGCATTGGTCGAAATCGGCAAGAAATATA
AAAATCCCGTATTGGTCAGCGGTACGGACGGCGTGGGTACCAAGCTCAAACTTGCCTTTGATTGGGATAAACACGATACG
GTGGGCATTGACCTTGTTGCAATGAGTGTCAACGATATTTTGGTTCAAGGAGCAGAACCTCTGTTTTTCTTGGATTATTT
CGCCTGCGGCAAATTGGATGTTCCGCGCGCAACCGATGTCATCAAAGGCATTGCACAAGGTTGCGAAGAATCCGGCTGCG
CCCTGATTGGCGGGGAAACTGCCGAAATGCCGGGCATGTATCCCGTCGGAGAATACGATTTGGCGGGTTTTGCCGTCGGC
GTAGTGGAAAAAGAGAATGTCATTACCGGCCGCAGCATCGGCGCGGGCGATGTGGTATTGGGTTTGGCTTCCAACGGCGC
ACATTCAAACGGCTATTCCCTTATCCGTAAAATCATCGAACGCGACAATCCCGATTTGGATGCCGAGTTTGATAATGGCA
AAACCTTGCGTGAGGCTGTTATTGCGCCGACCCGTCTGTATGTGAAACCGATTCTTGCCGCTTTGGAAAAATTTACCATT
AAAGGTATGGCGCACATTACCGGCGGCGGCATTACCGAAAACGTGCCGCGCGTGTTGCCTGAAAACACGGTTGCACAAAT
CGATGCTAAATCGTGGGAATTGCCCAAGCTCTTCCAATGGCTTCAAAAGGCGGGCAATGTGGAAACCCAAGAAATGTACC
GAACCTTTAACTGCGGCATCGGCATGGTCGTTATTGTTGCTGCCGAAGATGCCGATGCGGTTCAGGGTCTCTTGGGTGAA
CAAGGTGAAACAGTTTACCGTTTAGGTTTGATCCGTGAGCGTCAGGGAGACGAGCATCAAACCCAGGTTGCCTGA

Upstream 100 bases:

>100_bases
GTTTACAATATTGTCTAAAAATCTGAACCTGCAAACGTGAAATAAGGTAGAATACGCCCCGTTATTTTACCGTCCAATCC
CCATTTACCAAGGAAAAATG

Downstream 100 bases:

>100_bases
TTGCTTCTATAGCGAAATGCCGTCTCAAACATGGGTTTGGACGGCATTTTTATAGTGGATTAACAAAAATCAGGACAAGG
CGACGAAGCCGCAGACAGTA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MSTSLSYRDAGVDIDAGDQLVENIKPFAKRTMRPEVLGDLGGFGALVEIGKKYKNPVLVSGTDGVGTKLKLAFDWDKHDT
VGIDLVAMSVNDILVQGAEPLFFLDYFACGKLDVPRATDVIKGIAQGCEESGCALIGGETAEMPGMYPVGEYDLAGFAVG
VVEKENVITGRSIGAGDVVLGLASNGAHSNGYSLIRKIIERDNPDLDAEFDNGKTLREAVIAPTRLYVKPILAALEKFTI
KGMAHITGGGITENVPRVLPENTVAQIDAKSWELPKLFQWLQKAGNVETQEMYRTFNCGIGMVVIVAAEDADAVQGLLGE
QGETVYRLGLIRERQGDEHQTQVA

Sequences:

>Translated_344_residues
MSTSLSYRDAGVDIDAGDQLVENIKPFAKRTMRPEVLGDLGGFGALVEIGKKYKNPVLVSGTDGVGTKLKLAFDWDKHDT
VGIDLVAMSVNDILVQGAEPLFFLDYFACGKLDVPRATDVIKGIAQGCEESGCALIGGETAEMPGMYPVGEYDLAGFAVG
VVEKENVITGRSIGAGDVVLGLASNGAHSNGYSLIRKIIERDNPDLDAEFDNGKTLREAVIAPTRLYVKPILAALEKFTI
KGMAHITGGGITENVPRVLPENTVAQIDAKSWELPKLFQWLQKAGNVETQEMYRTFNCGIGMVVIVAAEDADAVQGLLGE
QGETVYRLGLIRERQGDEHQTQVA
>Mature_343_residues
STSLSYRDAGVDIDAGDQLVENIKPFAKRTMRPEVLGDLGGFGALVEIGKKYKNPVLVSGTDGVGTKLKLAFDWDKHDTV
GIDLVAMSVNDILVQGAEPLFFLDYFACGKLDVPRATDVIKGIAQGCEESGCALIGGETAEMPGMYPVGEYDLAGFAVGV
VEKENVITGRSIGAGDVVLGLASNGAHSNGYSLIRKIIERDNPDLDAEFDNGKTLREAVIAPTRLYVKPILAALEKFTIK
GMAHITGGGITENVPRVLPENTVAQIDAKSWELPKLFQWLQKAGNVETQEMYRTFNCGIGMVVIVAAEDADAVQGLLGEQ
GETVYRLGLIRERQGDEHQTQVA

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=336, Percent_Identity=50.297619047619, Blast_Score=347, Evalue=8e-96,
Organism=Homo sapiens, GI209869995, Length=336, Percent_Identity=50.297619047619, Blast_Score=347, Evalue=8e-96,
Organism=Homo sapiens, GI209869993, Length=336, Percent_Identity=50.297619047619, Blast_Score=347, Evalue=8e-96,
Organism=Escherichia coli, GI1788845, Length=336, Percent_Identity=58.9285714285714, Blast_Score=417, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17567511, Length=345, Percent_Identity=44.0579710144928, Blast_Score=279, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6321203, Length=341, Percent_Identity=49.5601173020528, Blast_Score=348, Evalue=5e-97,
Organism=Drosophila melanogaster, GI24582400, Length=274, Percent_Identity=44.5255474452555, Blast_Score=240, Evalue=1e-63,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36947; Mature: 36815

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSLSYRDAGVDIDAGDQLVENIKPFAKRTMRPEVLGDLGGFGALVEIGKKYKNPVLVS
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHCCCEEEE
GTDGVGTKLKLAFDWDKHDTVGIDLVAMSVNDILVQGAEPLFFLDYFACGKLDVPRATDV
CCCCCCCEEEEEEECCCCCCCEEEEEEEEHHHHHHCCCCCEEEEEHHCCCCCCCCHHHHH
IKGIAQGCEESGCALIGGETAEMPGMYPVGEYDLAGFAVGVVEKENVITGRSIGAGDVVL
HHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCEEECCCCCCCCEEE
GLASNGAHSNGYSLIRKIIERDNPDLDAEFDNGKTLREAVIAPTRLYVKPILAALEKFTI
EEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHH
KGMAHITGGGITENVPRVLPENTVAQIDAKSWELPKLFQWLQKAGNVETQEMYRTFNCGI
CCEEEECCCCCCCCCCHHCCCCCCEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCC
GMVVIVAAEDADAVQGLLGEQGETVYRLGLIRERQGDEHQTQVA
EEEEEEEECCHHHHHHHHCCCCCEEEEEHHHHHCCCCCHHCCCC
>Mature Secondary Structure 
STSLSYRDAGVDIDAGDQLVENIKPFAKRTMRPEVLGDLGGFGALVEIGKKYKNPVLVS
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHCCCEEEE
GTDGVGTKLKLAFDWDKHDTVGIDLVAMSVNDILVQGAEPLFFLDYFACGKLDVPRATDV
CCCCCCCEEEEEEECCCCCCCEEEEEEEEHHHHHHCCCCCEEEEEHHCCCCCCCCHHHHH
IKGIAQGCEESGCALIGGETAEMPGMYPVGEYDLAGFAVGVVEKENVITGRSIGAGDVVL
HHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCEEECCCCCCCCEEE
GLASNGAHSNGYSLIRKIIERDNPDLDAEFDNGKTLREAVIAPTRLYVKPILAALEKFTI
EEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHH
KGMAHITGGGITENVPRVLPENTVAQIDAKSWELPKLFQWLQKAGNVETQEMYRTFNCGI
CCEEEECCCCCCCCCCHHCCCCCCEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCC
GMVVIVAAEDADAVQGLLGEQGETVYRLGLIRERQGDEHQTQVA
EEEEEEEECCHHHHHHHHCCCCCEEEEEHHHHHCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA