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The map label for this gene is hom [H]

Identifier: 161870071

GI number: 161870071

Start: 1094761

End: 1096068

Strand: Direct

Name: hom [H]

Synonym: NMCC_1109

Alternate gene names: 161870071

Gene position: 1094761-1096068 (Clockwise)

Preceding gene: 161870066

Following gene: 161870072

Centisome position: 50.84

GC content: 55.96

Gene sequence:

>1308_bases
ATGAAGCCAGTAAACATCGGTCTTTTAGGTTTGGGTACGGTCGGCGGCGGTACGGCTGCCGTGTTGCGGGACAATGCGGC
GGAAATCAGCCGCCGTTTGGGACGCGAAATCCGTATTTCTGCCGTATGCGACTTGAGCGAAGAAAAAGCCCGCCAAACCT
GCCCGTCCGCAGCCTTCGTCAAAGACCCGTTCGAACTGGTTGCGCGCGAAGACGTGGATGTCGTCGTCGAATTGTTCGGC
GGCACGGGCATCGCCAAAGACGCGGTGTTGAAAGCCATTGAAAACGGCAAACACATCGTTACCGCCAACAAAAAACTGCT
CGCCGAATACGGCAACGAAATCTTCCCGCTGGCGGAAAAACAAAACGTCATCGTCCAATTTGAAGCGGCAGTCGCCGGCG
GCATCCCGATTATCAAAGCCCTGCGCGAAGGTTTGGCAGCAAACAGGATTAAATCCATCGCCGGCATCATCAACGGTACC
AGCAACTTCATCCTCTCCGAAATGCGCGAAAAAGGCAGCGCGTTTGCCGACGTATTGAAAGAAGCACAGGCATTGGGCTA
CGCCGAGGCCGACCCCACCTTCGACATCGAAGGACATGACGCGGGCCATAAAATCACCATCATGAGCGCGCTGGCATTCG
GCACGCCGATGAACTTCTCCGCCTGCTACCTCGAAGGCATCAGCAAACTCGACAGCCGCGACATCAAATACGCCGAAGAA
CTTGGCTATCGCATCAAACTGTTGGGCATTACCCGCAAAACCGGCAAAGGCATCGAATTGCGCGTCCACCCTACCCTGAT
TCCCGAAAGCCGCCTCTTGGCAAACGTCAACGGCGTGATGAACGCCGTGCGCGTCAACGCCGATATGGTCGGCGAAACCT
TATATTACGGCGCGGGCGCGGGCGCATTGCCGACCGCTTCCGCCGTGGTTGCCGATATCATCGACATCGCCCGCCTGATC
GAAGCCGATACAGGCCACCGCGTACCGCATCTGGCGTTCCAACCCGCCCAAGTCCAAGCGCAAACCATCCTGCCTATGGA
CGAAATTACCAGCAGCTACTACCTGCGCGTCCAAGCCAAAGATGAACCGGGCACGCTGGGGCAAATCGCCGCGCTTTTGG
CACAAGAAAACGTGTCTATCGAAGCCTTAATCCAAAAAGGCGTGATTGATCAGAGCACTGCCGAAATCGTGATTCTGACC
CACAGCACGGTCGAAAAATACATCAAGTCGGCAATCGCAGCCATCGAAGCACTGGATTGCGTGGAAAAACCGATTACCAT
GATCCGCATGGAAAGCCTGCATGACTGA

Upstream 100 bases:

>100_bases
ATTTCAGACGGCATTTGATTCAAAGTGCGGCACAATTATATCGGCAGCGGATATTTTCGTCTTTATATATTTACATTCAA
TCGGCTTGCAAGGAGACACA

Downstream 100 bases:

>100_bases
GCCGAAACACGAAATGCTGACGAAAGAGCAGGTTGCCGCGCGCAAAAAAGCAAAAGCCAAAATCCGCACCATCCGCATTT
GGGCGTGGGTCATTTTGGCG

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MKPVNIGLLGLGTVGGGTAAVLRDNAAEISRRLGREIRISAVCDLSEEKARQTCPSAAFVKDPFELVAREDVDVVVELFG
GTGIAKDAVLKAIENGKHIVTANKKLLAEYGNEIFPLAEKQNVIVQFEAAVAGGIPIIKALREGLAANRIKSIAGIINGT
SNFILSEMREKGSAFADVLKEAQALGYAEADPTFDIEGHDAGHKITIMSALAFGTPMNFSACYLEGISKLDSRDIKYAEE
LGYRIKLLGITRKTGKGIELRVHPTLIPESRLLANVNGVMNAVRVNADMVGETLYYGAGAGALPTASAVVADIIDIARLI
EADTGHRVPHLAFQPAQVQAQTILPMDEITSSYYLRVQAKDEPGTLGQIAALLAQENVSIEALIQKGVIDQSTAEIVILT
HSTVEKYIKSAIAAIEALDCVEKPITMIRMESLHD

Sequences:

>Translated_435_residues
MKPVNIGLLGLGTVGGGTAAVLRDNAAEISRRLGREIRISAVCDLSEEKARQTCPSAAFVKDPFELVAREDVDVVVELFG
GTGIAKDAVLKAIENGKHIVTANKKLLAEYGNEIFPLAEKQNVIVQFEAAVAGGIPIIKALREGLAANRIKSIAGIINGT
SNFILSEMREKGSAFADVLKEAQALGYAEADPTFDIEGHDAGHKITIMSALAFGTPMNFSACYLEGISKLDSRDIKYAEE
LGYRIKLLGITRKTGKGIELRVHPTLIPESRLLANVNGVMNAVRVNADMVGETLYYGAGAGALPTASAVVADIIDIARLI
EADTGHRVPHLAFQPAQVQAQTILPMDEITSSYYLRVQAKDEPGTLGQIAALLAQENVSIEALIQKGVIDQSTAEIVILT
HSTVEKYIKSAIAAIEALDCVEKPITMIRMESLHD
>Mature_435_residues
MKPVNIGLLGLGTVGGGTAAVLRDNAAEISRRLGREIRISAVCDLSEEKARQTCPSAAFVKDPFELVAREDVDVVVELFG
GTGIAKDAVLKAIENGKHIVTANKKLLAEYGNEIFPLAEKQNVIVQFEAAVAGGIPIIKALREGLAANRIKSIAGIINGT
SNFILSEMREKGSAFADVLKEAQALGYAEADPTFDIEGHDAGHKITIMSALAFGTPMNFSACYLEGISKLDSRDIKYAEE
LGYRIKLLGITRKTGKGIELRVHPTLIPESRLLANVNGVMNAVRVNADMVGETLYYGAGAGALPTASAVVADIIDIARLI
EADTGHRVPHLAFQPAQVQAQTILPMDEITSSYYLRVQAKDEPGTLGQIAALLAQENVSIEALIQKGVIDQSTAEIVILT
HSTVEKYIKSAIAAIEALDCVEKPITMIRMESLHD

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=140, Percent_Identity=28.5714285714286, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322599, Length=139, Percent_Identity=35.2517985611511, Blast_Score=73, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46523; Mature: 46523

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS01042 HOMOSER_DHGENASE ; PS00318 HMG_COA_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPVNIGLLGLGTVGGGTAAVLRDNAAEISRRLGREIRISAVCDLSEEKARQTCPSAAFV
CCCEEEEEEEECCCCCCEEEEEECCHHHHHHHCCCEEEEEEEECCCHHHHHHCCCCCHHH
KDPFELVAREDVDVVVELFGGTGIAKDAVLKAIENGKHIVTANKKLLAEYGNEIFPLAEK
CCHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHCCCEEEECCHHHHHHHCCCEECCCCC
QNVIVQFEAAVAGGIPIIKALREGLAANRIKSIAGIINGTSNFILSEMREKGSAFADVLK
CCEEEEEECHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHH
EAQALGYAEADPTFDIEGHDAGHKITIMSALAFGTPMNFSACYLEGISKLDSRDIKYAEE
HHHHCCCCCCCCCEEECCCCCCCEEEEEEHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHH
LGYRIKLLGITRKTGKGIELRVHPTLIPESRLLANVNGVMNAVRVNADMVGETLYYGAGA
CCCEEEEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCHHHHCCHHEECCCC
GALPTASAVVADIIDIARLIEADTGHRVPHLAFQPAQVQAQTILPMDEITSSYYLRVQAK
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCHHHHHHCCCHHHCCCEEEEEEEEC
DEPGTLGQIAALLAQENVSIEALIQKGVIDQSTAEIVILTHSTVEKYIKSAIAAIEALDC
CCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHH
VEKPITMIRMESLHD
HHHHHHHHHHHHCCC
>Mature Secondary Structure
MKPVNIGLLGLGTVGGGTAAVLRDNAAEISRRLGREIRISAVCDLSEEKARQTCPSAAFV
CCCEEEEEEEECCCCCCEEEEEECCHHHHHHHCCCEEEEEEEECCCHHHHHHCCCCCHHH
KDPFELVAREDVDVVVELFGGTGIAKDAVLKAIENGKHIVTANKKLLAEYGNEIFPLAEK
CCHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHCCCEEEECCHHHHHHHCCCEECCCCC
QNVIVQFEAAVAGGIPIIKALREGLAANRIKSIAGIINGTSNFILSEMREKGSAFADVLK
CCEEEEEECHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHH
EAQALGYAEADPTFDIEGHDAGHKITIMSALAFGTPMNFSACYLEGISKLDSRDIKYAEE
HHHHCCCCCCCCCEEECCCCCCCEEEEEEHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHH
LGYRIKLLGITRKTGKGIELRVHPTLIPESRLLANVNGVMNAVRVNADMVGETLYYGAGA
CCCEEEEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCHHHHCCHHEECCCC
GALPTASAVVADIIDIARLIEADTGHRVPHLAFQPAQVQAQTILPMDEITSSYYLRVQAK
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCHHHHHHCCCHHHCCCEEEEEEEEC
DEPGTLGQIAALLAQENVSIEALIQKGVIDQSTAEIVILTHSTVEKYIKSAIAAIEALDC
CCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHH
VEKPITMIRMESLHD
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]