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The map label for this gene is ilvD [H]

Identifier: 161870035

GI number: 161870035

Start: 1047855

End: 1049942

Strand: Reverse

Name: ilvD [H]

Synonym: NMCC_1068

Alternate gene names: 161870035

Gene position: 1049942-1047855 (Counterclockwise)

Preceding gene: 161870036

Following gene: 161870034

Centisome position: 48.76

GC content: 57.28

Gene sequence:

>2088_bases
ATGCACCCGTTGATTTTTGGGACGTATCCAAAGCCGTCGCGATTGCCCGCGCCTGAACCCGTCCCCGCATTCCTGCGGGG
ATTTTCTTTTTTGCCGCACGCCGTTTCAATCCCGCAAAATTCCGATACTTGGTATAAAATACCCTCTTTTCCCACTCTAA
AAAACCGTACCCGATACCGTCTGAAACAGCCCTGTCTTTCAGACGGTATAGGCACAAGGAAACACACTATGCCAGAATAC
CGCTCCAAAACCTCTACCCACGGCCGCAATATGGCAGGCGCACGCGCATTGTGGCGTGCGACCGGCGTGATGGAAACCGA
CTTCGGCAAGCCCATCATCGCCGTTGCCAACTCCTTCACCCAATTCGTGCCCGGCCATGTCCACCTGCACAATATGGGCC
AGCTGGTTGCCCGCGAAATCGAAAAAGCCGGCGCAATCGCCAAAGAATTCAACACCATCGCCATCGACGACGGCATCGCT
ATGGGACACAGCGGCATGCTGTACTCCCTGCCCAGCCGCGATTTGATTGCCGACTCTATCGAATATATGGTCAACGCCCA
CTGCGCCGACGCGCTGGTGTGCATTTCCAACTGCGACAAAATCACCCCGGGCATGCTGATTGCCGCGATGCGCCTGAACA
TCCCCACCATCTTCGTCTCCGGCGGCCCGATGGAAGCAGGTAAAGTTATCGGCGTGGCAAACATCCAACCCGAACGCCGT
TTGGACTTGATTGACGCGATGATCGAATCGGCAGACGACAATGTCAGCAACCGGCAAGTCGAAGAAGTCGAACAAAACGC
CTGCCCGACCTGCGGCTCGTGTTCGGGTATGTTTACGGCAAACTCGATGAACTGCCTGACCGAAGCACTCGGCCTTTCCC
TGCCCGGCAACGGTTCGTATTTGGCGACCCACGCCGGCCGCAAAGAATTGTTCCTCGAAGCAGGCCGTATGATTGTCGAA
ATCACCAAACGCTATTACGAGCAAGACGACGAAACCGTACTGCCGCGCAGCATCGCCACCAAAAAAGCGTTTGAAAACGC
TATGACGATGGACATTGCGATGGGCGGCTCTACCAACACCATCCTGCATTTGCTCGCCGTCGCCAACGAAGCGGGCGTGG
ATTTCAAAATGGCCGACATCGACCGCTTAAGCCGCGTCGTGCCCTGCATCTGCAAAACCGCGCCCAACAACCACGACTAC
TATATGGAAGACGTGCACCGAGCCGGCGGCATCTTCGCCATCCTGAAAGAATTGGACAAAGCGGGCAAACTGCACACCGA
CGTGCACACTATCCACGCACCGACGCTGAAAGACGCGATTGAAAAATGGGACGTAACCAACCCTGAAAACACCCGCGCCA
TCGAACGCTTCAAAGCCGCGCCCGGCGGCGTACGTACCACCCAAGCGTTCTCGCAAAACCGTATGTGGAAAACCCTCGAC
CTCGACCGCGAAAAAGGCTGTATCCGCGACGTGGCACACGCCTACTCGCAAGACGGCGGTTTGGCGGTCTTGTTCGGCAA
CATCGCCGAACGCGGCTGCGTGGTAAAAACCGCAGGCGTGGATGAGAGCATCCTCAAATTCACCGGCCGCGCCCGCGTGT
TTGAAAGCCAAGAAGACGCAGTAGAAGGCATTTTGGGCAACCAAATCGTCGCCGGCGACATCGTCATCATCCGCTACGAA
GGCCCGAAAGGCGGCCCGGGCATGCAGGAAATGCTGTATCCGACTTCCTACCTGAAATCTAAAGGCCTCGGCAAAGCCTG
CGCTCTCTTAACCGACGGACGCTTCTCCGGCGGCACATCAGGTTTGTCCATCGGACACGCCTCGCCCGAAGCGGCGGAAG
GTGGCGCGATCGGTTTGGTACACGAAGGCGATACCGTCGAAATCGACATCCCCAACCGCAGCATCCACCTTGCCATTTCC
GATGAAGAGCTTGCCGCACGCCGTGCCGAAATGGAAGCGCGCGGCAGCAAAGCATGGAAGCCTAAAAACCGCGACCGCTA
CGTCTCCGCCGCATTAAGAGCTTACGGCGCGATGGCGACTTCCGCCGACAAAGGCGCGGTGCGCGACGTAGCGCAAATCG
AAAGATAA

Upstream 100 bases:

>100_bases
GAATTGGACGACCTGATCGGCAAATGGGCGGCAGAACGCAATATCGGCGAAGGTTTCGGCGATTTCGCCATACGGACGGG
CATCGTCAAACCCGTATTAA

Downstream 100 bases:

>100_bases
GCCCCAAAACGTGCGGCAAATGCTGTCTCGTCTGAACAGTAAAGGTCTGATGATGGACAAATTTATCTGGGCGATGGCGG
TATTTTCCGCAATTTTGGCC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 695; Mature: 695

Protein sequence:

>695_residues
MHPLIFGTYPKPSRLPAPEPVPAFLRGFSFLPHAVSIPQNSDTWYKIPSFPTLKNRTRYRLKQPCLSDGIGTRKHTMPEY
RSKTSTHGRNMAGARALWRATGVMETDFGKPIIAVANSFTQFVPGHVHLHNMGQLVAREIEKAGAIAKEFNTIAIDDGIA
MGHSGMLYSLPSRDLIADSIEYMVNAHCADALVCISNCDKITPGMLIAAMRLNIPTIFVSGGPMEAGKVIGVANIQPERR
LDLIDAMIESADDNVSNRQVEEVEQNACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSYLATHAGRKELFLEAGRMIVE
ITKRYYEQDDETVLPRSIATKKAFENAMTMDIAMGGSTNTILHLLAVANEAGVDFKMADIDRLSRVVPCICKTAPNNHDY
YMEDVHRAGGIFAILKELDKAGKLHTDVHTIHAPTLKDAIEKWDVTNPENTRAIERFKAAPGGVRTTQAFSQNRMWKTLD
LDREKGCIRDVAHAYSQDGGLAVLFGNIAERGCVVKTAGVDESILKFTGRARVFESQEDAVEGILGNQIVAGDIVIIRYE
GPKGGPGMQEMLYPTSYLKSKGLGKACALLTDGRFSGGTSGLSIGHASPEAAEGGAIGLVHEGDTVEIDIPNRSIHLAIS
DEELAARRAEMEARGSKAWKPKNRDRYVSAALRAYGAMATSADKGAVRDVAQIER

Sequences:

>Translated_695_residues
MHPLIFGTYPKPSRLPAPEPVPAFLRGFSFLPHAVSIPQNSDTWYKIPSFPTLKNRTRYRLKQPCLSDGIGTRKHTMPEY
RSKTSTHGRNMAGARALWRATGVMETDFGKPIIAVANSFTQFVPGHVHLHNMGQLVAREIEKAGAIAKEFNTIAIDDGIA
MGHSGMLYSLPSRDLIADSIEYMVNAHCADALVCISNCDKITPGMLIAAMRLNIPTIFVSGGPMEAGKVIGVANIQPERR
LDLIDAMIESADDNVSNRQVEEVEQNACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSYLATHAGRKELFLEAGRMIVE
ITKRYYEQDDETVLPRSIATKKAFENAMTMDIAMGGSTNTILHLLAVANEAGVDFKMADIDRLSRVVPCICKTAPNNHDY
YMEDVHRAGGIFAILKELDKAGKLHTDVHTIHAPTLKDAIEKWDVTNPENTRAIERFKAAPGGVRTTQAFSQNRMWKTLD
LDREKGCIRDVAHAYSQDGGLAVLFGNIAERGCVVKTAGVDESILKFTGRARVFESQEDAVEGILGNQIVAGDIVIIRYE
GPKGGPGMQEMLYPTSYLKSKGLGKACALLTDGRFSGGTSGLSIGHASPEAAEGGAIGLVHEGDTVEIDIPNRSIHLAIS
DEELAARRAEMEARGSKAWKPKNRDRYVSAALRAYGAMATSADKGAVRDVAQIER
>Mature_695_residues
MHPLIFGTYPKPSRLPAPEPVPAFLRGFSFLPHAVSIPQNSDTWYKIPSFPTLKNRTRYRLKQPCLSDGIGTRKHTMPEY
RSKTSTHGRNMAGARALWRATGVMETDFGKPIIAVANSFTQFVPGHVHLHNMGQLVAREIEKAGAIAKEFNTIAIDDGIA
MGHSGMLYSLPSRDLIADSIEYMVNAHCADALVCISNCDKITPGMLIAAMRLNIPTIFVSGGPMEAGKVIGVANIQPERR
LDLIDAMIESADDNVSNRQVEEVEQNACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSYLATHAGRKELFLEAGRMIVE
ITKRYYEQDDETVLPRSIATKKAFENAMTMDIAMGGSTNTILHLLAVANEAGVDFKMADIDRLSRVVPCICKTAPNNHDY
YMEDVHRAGGIFAILKELDKAGKLHTDVHTIHAPTLKDAIEKWDVTNPENTRAIERFKAAPGGVRTTQAFSQNRMWKTLD
LDREKGCIRDVAHAYSQDGGLAVLFGNIAERGCVVKTAGVDESILKFTGRARVFESQEDAVEGILGNQIVAGDIVIIRYE
GPKGGPGMQEMLYPTSYLKSKGLGKACALLTDGRFSGGTSGLSIGHASPEAAEGGAIGLVHEGDTVEIDIPNRSIHLAIS
DEELAARRAEMEARGSKAWKPKNRDRYVSAALRAYGAMATSADKGAVRDVAQIER

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=617, Percent_Identity=71.6369529983793, Blast_Score=938, Evalue=0.0,
Organism=Escherichia coli, GI1786464, Length=524, Percent_Identity=31.6793893129771, Blast_Score=196, Evalue=4e-51,
Organism=Escherichia coli, GI2367371, Length=535, Percent_Identity=29.7196261682243, Blast_Score=192, Evalue=5e-50,
Organism=Escherichia coli, GI1788157, Length=541, Percent_Identity=28.2809611829945, Blast_Score=182, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6322476, Length=611, Percent_Identity=38.2978723404255, Blast_Score=362, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 75446; Mature: 75446

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPLIFGTYPKPSRLPAPEPVPAFLRGFSFLPHAVSIPQNSDTWYKIPSFPTLKNRTRYR
CCCCEECCCCCCCCCCCCCCHHHHHHHHHHCCCEEECCCCCCCEEECCCCCCCCCCHHHH
LKQPCLSDGIGTRKHTMPEYRSKTSTHGRNMAGARALWRATGVMETDFGKPIIAVANSFT
HHCCHHHCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHCCCEECCCCCHHHHHHHHHH
QFVPGHVHLHNMGQLVAREIEKAGAIAKEFNTIAIDDGIAMGHSGMLYSLPSRDLIADSI
HHCCCEEEEHHHHHHHHHHHHHHCCHHHHCCEEEEECCCEECCCCCEEECCCCHHHHHHH
EYMVNAHCADALVCISNCDKITPGMLIAAMRLNIPTIFVSGGPMEAGKVIGVANIQPERR
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCHHH
LDLIDAMIESADDNVSNRQVEEVEQNACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSY
HHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCE
LATHAGRKELFLEAGRMIVEITKRYYEQDDETVLPRSIATKKAFENAMTMDIAMGGSTNT
EEECCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHCCEEEEEEECCCHHH
ILHLLAVANEAGVDFKMADIDRLSRVVPCICKTAPNNHDYYMEDVHRAGGIFAILKELDK
HHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHH
AGKLHTDVHTIHAPTLKDAIEKWDVTNPENTRAIERFKAAPGGVRTTQAFSQNRMWKTLD
CCCEECCHHEEECCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCEEEEC
LDREKGCIRDVAHAYSQDGGLAVLFGNIAERGCVVKTAGVDESILKFTGRARVFESQEDA
CCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEECCCCHHHHHHCCCHHEECCHHHH
VEGILGNQIVAGDIVIIRYEGPKGGPGMQEMLYPTSYLKSKGLGKACALLTDGRFSGGTS
HHHHHCCEEEECCEEEEEECCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCC
GLSIGHASPEAAEGGAIGLVHEGDTVEIDIPNRSIHLAISDEELAARRAEMEARGSKAWK
CCCCCCCCCCCCCCCEEEEEECCCEEEEEECCCEEEEEECCHHHHHHHHHHHHCCCCCCC
PKNRDRYVSAALRAYGAMATSADKGAVRDVAQIER
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MHPLIFGTYPKPSRLPAPEPVPAFLRGFSFLPHAVSIPQNSDTWYKIPSFPTLKNRTRYR
CCCCEECCCCCCCCCCCCCCHHHHHHHHHHCCCEEECCCCCCCEEECCCCCCCCCCHHHH
LKQPCLSDGIGTRKHTMPEYRSKTSTHGRNMAGARALWRATGVMETDFGKPIIAVANSFT
HHCCHHHCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHCCCEECCCCCHHHHHHHHHH
QFVPGHVHLHNMGQLVAREIEKAGAIAKEFNTIAIDDGIAMGHSGMLYSLPSRDLIADSI
HHCCCEEEEHHHHHHHHHHHHHHCCHHHHCCEEEEECCCEECCCCCEEECCCCHHHHHHH
EYMVNAHCADALVCISNCDKITPGMLIAAMRLNIPTIFVSGGPMEAGKVIGVANIQPERR
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCHHH
LDLIDAMIESADDNVSNRQVEEVEQNACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSY
HHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCE
LATHAGRKELFLEAGRMIVEITKRYYEQDDETVLPRSIATKKAFENAMTMDIAMGGSTNT
EEECCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHCCEEEEEEECCCHHH
ILHLLAVANEAGVDFKMADIDRLSRVVPCICKTAPNNHDYYMEDVHRAGGIFAILKELDK
HHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHH
AGKLHTDVHTIHAPTLKDAIEKWDVTNPENTRAIERFKAAPGGVRTTQAFSQNRMWKTLD
CCCEECCHHEEECCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCEEEEC
LDREKGCIRDVAHAYSQDGGLAVLFGNIAERGCVVKTAGVDESILKFTGRARVFESQEDA
CCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEECCCCHHHHHHCCCHHEECCHHHH
VEGILGNQIVAGDIVIIRYEGPKGGPGMQEMLYPTSYLKSKGLGKACALLTDGRFSGGTS
HHHHHCCEEEECCEEEEEECCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCC
GLSIGHASPEAAEGGAIGLVHEGDTVEIDIPNRSIHLAISDEELAARRAEMEARGSKAWK
CCCCCCCCCCCCCCCEEEEEECCCEEEEEECCCEEEEEECCHHHHHHHHHHHHCCCCCCC
PKNRDRYVSAALRAYGAMATSADKGAVRDVAQIER
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA