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The map label for this gene is trpE [H]

Identifier: 161869933

GI number: 161869933

Start: 964902

End: 966524

Strand: Reverse

Name: trpE [H]

Synonym: NMCC_0965

Alternate gene names: 161869933

Gene position: 966524-964902 (Counterclockwise)

Preceding gene: 161869934

Following gene: 161869932

Centisome position: 44.88

GC content: 55.95

Gene sequence:

>1623_bases
ATGGAAACAATACCGGCAGCGCAAAACAAAGCCGTAAGCCCGTCTTTTTCAGACGGCATCTCCGGTCAGACTGTCAACAA
TTCCGATAAAATGCTATACTCGCGCCCGTTGCCGCGCCGTCCGAAACCGCCCTTTGGGAAAGCAGAAATGATCAGCAAAC
AAGAATACCAAGCCCAAGCCGCCCAAGGCTACAACCGCATCCCGCTCGTGCAAGAACTCCTTGCCGATTTGGATACGCCG
CTTTCCCTCTATCTCAAACTCGCCAACCGCCCCTATACCTACCTGCTCGAATCCGTTGTCGGTGGCGAACGTTTCGGCCG
CTATTCTTTTATCGGCCTGCCTTGCAGCCACTATCTCAAAGCCAGCGGCAAACACGTCGATGTTTATCAAAACGGCGAAA
TTGTCGAGCAACACGACGGCAACCCCCTGCCCTTTATCGAAGCCTTCCACAACCGCTTCAAAACACCCGAAATCCCAAGC
CTGCCGCGCTTTACCGGCGGACTGGTCGGCTACTTCGGTTACGAAACCATCTACAATTTTGAACACTTCGCCCACCGCCT
GAAAAACACCACCAAAGCCGACCCGCTCGGCACGCCCGACATCTTGCTGATGCTGTCGCAAGAATTGGCGGTGATCGACA
ATTTGAGCGGCAAAATCCATCTCGTCGTTTACGCCGATCCGTCGCAGCCCGACGGCTACGAACGCGCCCGCGAACGCCTC
GAAGACATCCGCACCCAGTTGCGCCAAAGCTGCGCCATCCCGCTCTCGCTCGGCAGCAAACACACCGAAGCCGTCAGCGA
ATTTGGCGAAGAGCCGTTCAAAGCCTGCGTCGATAAAATCAAAGACTACATCTTTGCAGGCGACTGCATGCAGGTTGTCC
CCAGCCAGCGCATGAGCATGGAATTCACCGACAGCCCGCTCGCCCTCTACCGCGCCTTGCGCACGCTCAATCCTTCGCCT
TACCTCTTTTACTACGATTTCGGCGATTTCCACATCGTCGGCTCCTCGCCTGAAATCCTCGTCCGCCGCGAACGCGACGA
TGTCATCGTCCGCCCCATCGCCGGCACGCGCCTGCGCGGCAAAACCCCCGCCGAAGACCTTGCCAATGAACAAGACTTAT
TAAGCGACGCCAAAGAAATCGCAGAACACGTCATGCTTATCGATTTAGGACGCAACGATGTCGGCCGCATCAGCAAAACG
GGCGAAGTCAAAGTAACCGACAAAATGGTGATTGAAAAATACTCCCATGTGATGCACATCGTTTCCAACGTCGAAGGCCG
TCTGAAAGACGGCATCACTAACATGAACATCCTCGCCGCCACCTTCCCCGCCGGCACACTTTCAGGTGCACCCAAAATCC
GCGCTATGGAAATCATCGAAGAAGTCGAACCGAGCAAACGCGGCATCTACGGCGGCGCCGTCGGCGTATGGGGCTTCAAC
AACGACATGGATTTGGCAATCGCCATCCGCACCGCCGTAGTAAAAAACAACACGCTATACGTCCAAAGCGGCGCGGGCGT
GGTTGCCGACTCCGATCCGGCCTCCGAATGGCAGGAAACACAAAACAAAGCCCGAGCCGTTATACGCGCCGCGCAGATGG
TGCAGGAAGGGTTGGATAAATGA

Upstream 100 bases:

>100_bases
TGAATCAATCGGTCGCACCCGGTTCTTTACCTTGGTATGCATCATGGACGTTCAAAACCATCTTAGCCCTGATTCCCGTA
ACCGCAGGTTATCTGTTTAA

Downstream 100 bases:

>100_bases
CTTATGAAAAACTTTATGAGCTTCGCCAAACACTCAGACCGACTACCAAAGACGGTCTCTATACAGATAATGAAAAAAGT
CGAGAAATCCTAACGGTTAG

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 540; Mature: 540

Protein sequence:

>540_residues
METIPAAQNKAVSPSFSDGISGQTVNNSDKMLYSRPLPRRPKPPFGKAEMISKQEYQAQAAQGYNRIPLVQELLADLDTP
LSLYLKLANRPYTYLLESVVGGERFGRYSFIGLPCSHYLKASGKHVDVYQNGEIVEQHDGNPLPFIEAFHNRFKTPEIPS
LPRFTGGLVGYFGYETIYNFEHFAHRLKNTTKADPLGTPDILLMLSQELAVIDNLSGKIHLVVYADPSQPDGYERARERL
EDIRTQLRQSCAIPLSLGSKHTEAVSEFGEEPFKACVDKIKDYIFAGDCMQVVPSQRMSMEFTDSPLALYRALRTLNPSP
YLFYYDFGDFHIVGSSPEILVRRERDDVIVRPIAGTRLRGKTPAEDLANEQDLLSDAKEIAEHVMLIDLGRNDVGRISKT
GEVKVTDKMVIEKYSHVMHIVSNVEGRLKDGITNMNILAATFPAGTLSGAPKIRAMEIIEEVEPSKRGIYGGAVGVWGFN
NDMDLAIAIRTAVVKNNTLYVQSGAGVVADSDPASEWQETQNKARAVIRAAQMVQEGLDK

Sequences:

>Translated_540_residues
METIPAAQNKAVSPSFSDGISGQTVNNSDKMLYSRPLPRRPKPPFGKAEMISKQEYQAQAAQGYNRIPLVQELLADLDTP
LSLYLKLANRPYTYLLESVVGGERFGRYSFIGLPCSHYLKASGKHVDVYQNGEIVEQHDGNPLPFIEAFHNRFKTPEIPS
LPRFTGGLVGYFGYETIYNFEHFAHRLKNTTKADPLGTPDILLMLSQELAVIDNLSGKIHLVVYADPSQPDGYERARERL
EDIRTQLRQSCAIPLSLGSKHTEAVSEFGEEPFKACVDKIKDYIFAGDCMQVVPSQRMSMEFTDSPLALYRALRTLNPSP
YLFYYDFGDFHIVGSSPEILVRRERDDVIVRPIAGTRLRGKTPAEDLANEQDLLSDAKEIAEHVMLIDLGRNDVGRISKT
GEVKVTDKMVIEKYSHVMHIVSNVEGRLKDGITNMNILAATFPAGTLSGAPKIRAMEIIEEVEPSKRGIYGGAVGVWGFN
NDMDLAIAIRTAVVKNNTLYVQSGAGVVADSDPASEWQETQNKARAVIRAAQMVQEGLDK
>Mature_540_residues
METIPAAQNKAVSPSFSDGISGQTVNNSDKMLYSRPLPRRPKPPFGKAEMISKQEYQAQAAQGYNRIPLVQELLADLDTP
LSLYLKLANRPYTYLLESVVGGERFGRYSFIGLPCSHYLKASGKHVDVYQNGEIVEQHDGNPLPFIEAFHNRFKTPEIPS
LPRFTGGLVGYFGYETIYNFEHFAHRLKNTTKADPLGTPDILLMLSQELAVIDNLSGKIHLVVYADPSQPDGYERARERL
EDIRTQLRQSCAIPLSLGSKHTEAVSEFGEEPFKACVDKIKDYIFAGDCMQVVPSQRMSMEFTDSPLALYRALRTLNPSP
YLFYYDFGDFHIVGSSPEILVRRERDDVIVRPIAGTRLRGKTPAEDLANEQDLLSDAKEIAEHVMLIDLGRNDVGRISKT
GEVKVTDKMVIEKYSHVMHIVSNVEGRLKDGITNMNILAATFPAGTLSGAPKIRAMEIIEEVEPSKRGIYGGAVGVWGFN
NDMDLAIAIRTAVVKNNTLYVQSGAGVVADSDPASEWQETQNKARAVIRAAQMVQEGLDK

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=402, Percent_Identity=38.8059701492537, Blast_Score=241, Evalue=9e-65,
Organism=Escherichia coli, GI1788114, Length=464, Percent_Identity=28.6637931034483, Blast_Score=198, Evalue=8e-52,
Organism=Escherichia coli, GI1786809, Length=218, Percent_Identity=28.8990825688073, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI87082077, Length=223, Percent_Identity=27.8026905829596, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6320935, Length=494, Percent_Identity=38.8663967611336, Blast_Score=296, Evalue=7e-81,
Organism=Saccharomyces cerevisiae, GI6324361, Length=503, Percent_Identity=24.8508946322068, Blast_Score=125, Evalue=2e-29,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 60018; Mature: 60018

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METIPAAQNKAVSPSFSDGISGQTVNNSDKMLYSRPLPRRPKPPFGKAEMISKQEYQAQA
CCCCCCCCCCCCCCCCCCCCCCCEECCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
AQGYNRIPLVQELLADLDTPLSLYLKLANRPYTYLLESVVGGERFGRYSFIGLPCSHYLK
HCCCCCCHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHCCHHCCCEEEECCCHHHHHH
ASGKHVDVYQNGEIVEQHDGNPLPFIEAFHNRFKTPEIPSLPRFTGGLVGYFGYETIYNF
CCCCEEEEEECCCEEECCCCCCCHHHHHHHHHCCCCCCCCCCCHHCCHHHHHHHHHHHHH
EHFAHRLKNTTKADPLGTPDILLMLSQELAVIDNLSGKIHLVVYADPSQPDGYERARERL
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHH
EDIRTQLRQSCAIPLSLGSKHTEAVSEFGEEPFKACVDKIKDYIFAGDCMQVVPSQRMSM
HHHHHHHHHHCCCEECCCCHHHHHHHHHCCCHHHHHHHHHHHHEECCHHHHHCCCCCCCE
EFTDSPLALYRALRTLNPSPYLFYYDFGDFHIVGSSPEILVRRERDDVIVRPIAGTRLRG
EECCCHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCCEEEEECCCCEEEECCCCCCCCC
KTPAEDLANEQDLLSDAKEIAEHVMLIDLGRNDVGRISKTGEVKVTDKMVIEKYSHVMHI
CCCHHHHCCHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHH
VSNVEGRLKDGITNMNILAATFPAGTLSGAPKIRAMEIIEEVEPSKRGIYGGAVGVWGFN
HHHCCHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEECCCC
NDMDLAIAIRTAVVKNNTLYVQSGAGVVADSDPASEWQETQNKARAVIRAAQMVQEGLDK
CCCEEEEEEEEHEEECCEEEEECCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
METIPAAQNKAVSPSFSDGISGQTVNNSDKMLYSRPLPRRPKPPFGKAEMISKQEYQAQA
CCCCCCCCCCCCCCCCCCCCCCCEECCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
AQGYNRIPLVQELLADLDTPLSLYLKLANRPYTYLLESVVGGERFGRYSFIGLPCSHYLK
HCCCCCCHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHCCHHCCCEEEECCCHHHHHH
ASGKHVDVYQNGEIVEQHDGNPLPFIEAFHNRFKTPEIPSLPRFTGGLVGYFGYETIYNF
CCCCEEEEEECCCEEECCCCCCCHHHHHHHHHCCCCCCCCCCCHHCCHHHHHHHHHHHHH
EHFAHRLKNTTKADPLGTPDILLMLSQELAVIDNLSGKIHLVVYADPSQPDGYERARERL
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHH
EDIRTQLRQSCAIPLSLGSKHTEAVSEFGEEPFKACVDKIKDYIFAGDCMQVVPSQRMSM
HHHHHHHHHHCCCEECCCCHHHHHHHHHCCCHHHHHHHHHHHHEECCHHHHHCCCCCCCE
EFTDSPLALYRALRTLNPSPYLFYYDFGDFHIVGSSPEILVRRERDDVIVRPIAGTRLRG
EECCCHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCCEEEEECCCCEEEECCCCCCCCC
KTPAEDLANEQDLLSDAKEIAEHVMLIDLGRNDVGRISKTGEVKVTDKMVIEKYSHVMHI
CCCHHHHCCHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHH
VSNVEGRLKDGITNMNILAATFPAGTLSGAPKIRAMEIIEEVEPSKRGIYGGAVGVWGFN
HHHCCHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEECCCC
NDMDLAIAIRTAVVKNNTLYVQSGAGVVADSDPASEWQETQNKARAVIRAAQMVQEGLDK
CCCEEEEEEEEHEEECCEEEEECCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10417653 [H]