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The map label for this gene is pntB [H]

Identifier: 161869890

GI number: 161869890

Start: 923772

End: 925157

Strand: Reverse

Name: pntB [H]

Synonym: NMCC_0921

Alternate gene names: 161869890

Gene position: 925157-923772 (Counterclockwise)

Preceding gene: 161869891

Following gene: 161869881

Centisome position: 42.96

GC content: 54.98

Gene sequence:

>1386_bases
ATGTCTTCAGGACTCGTAACAGCGGCGTATATCGTTGCCGCAATTTTATTCATCTTCTCACTGGCGGGGCTGTCCAAACA
GGAAACCGCCAAACAGGGCTGCTATTCCGGTATCGCCGGTATGGCGGTCGCCCTTTTTGTAACTGTTTTTTCCGACAATA
CCCACGGACTGGGCTGGATCATCATCGCCATGCTCATCGGCGCGGCAATCGGCATCTACAAAGCCAAAAAGGTGGAAATG
ACCGAAATGCCCGAACTGATTGCCCTGCTGCACAGCTTCGTCGGCCTAGCGGCGGTTTTGGTCGGCTTCAACAGCTATAT
CGCGCCGGGCAACGTTTCGCACGATATGCACACCATCCATCTGGTCGAAGTCTATTTGGGCATTTTCATCGGCGCGGTAA
CCTTTACCGGCTCGCTGGTCGCATTCGGCAAGCTCAACGGCAAAATCAGCAGCAGCCCGCTGCAACTGCCCGCCAAACAC
AAGCTCAACGCACTGGCACTTGGCGTATCGTTTGTGTTGCTGCTCGTATTCGTCGGCATTGACGGCAGCGGCTTCATCCT
GCTGATTATGACCCTGATTGCCCTCGCATTCGGCTGGCACTTGGTCGCCTCCATCGGCGGCGCAGATATGCCCGTGGTCG
TATCTATGCTCAACTCCTACTCCGGCTGGGCGGCCGCAGCGGCAGGCTTTATGCTCTCCAACGACCTGCTCATCGTTACC
GGCGCGCTGGTCGGCTCAAGCGGCGCAATTCTGTCCTACATTATGTGCAAAGCCATGAACCGCTCGTTTGTCTCGGTAAT
TGCCGGTGGTTTCGGCAGCGACAGCGGCACATCATCTTCCGGCAGCCAAGAGATAGGGGAATACCGAGAAGTCAAAGCTG
CCGATGTTGCCGAAATGCTGAAAGGCGCAAACAGTGTCATCATTACCCCGGGCTACGGTATGGCAGTCGCACAAGCGCAA
TACCCCGTTGCCGAAATCACCGAGCTTTTGCGTAAAAACGGCACAGAAGTACGCTTCGGCATCCACCCCGTCGCCGGCCG
CCTGCCCGGTCATATGAACGTACTGCTTGCCGAAGCCAAAGTCCCCTACGACATCGTGTTGGAAATGGACGAAATCAACG
ACGACTTCCCCGAAACCGATGTGGTCTTGGTGATTGGTGCGAACGATACCGTCAATCCTGCCGCCCAAACCGACCCGAAC
AGCCCGATTGCGGGTATGCCCGTGTTGGAAGTATGGAAGGCAAAAGAAGTCGTCGTCTTCAAACGCTCGATGAATACCGG
CTACGCAGGTGTACAAAACCCGCTGTTCTTCAACGAAAACAGCGTAATGTGTTTCGGAGATGCGAAGAAAACCGTGGATG
ACATTCTGTCCGAACTGAAAAAATAA

Upstream 100 bases:

>100_bases
CCTGCACCGTCGGGCTGTTTGTCGCGGCTGCTTGAAACAGATACCGTCTGAACAGTTCGGACGGCATTGAAAACAAATCA
TCGAAAATCGGAGAATTTCC

Downstream 100 bases:

>100_bases
TGCCGTCTGAACAATTCGGCGCAGGTTTTCAATCTGTTTGATTTGAAAAAATCACTGCAAACCCCGTTTATGAAGGTTTG
CAGTGATTTTTTTTGCATTG

Product: pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit beta; Pyridine nucleotide transhydrogenase subunit beta [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MSSGLVTAAYIVAAILFIFSLAGLSKQETAKQGCYSGIAGMAVALFVTVFSDNTHGLGWIIIAMLIGAAIGIYKAKKVEM
TEMPELIALLHSFVGLAAVLVGFNSYIAPGNVSHDMHTIHLVEVYLGIFIGAVTFTGSLVAFGKLNGKISSSPLQLPAKH
KLNALALGVSFVLLLVFVGIDGSGFILLIMTLIALAFGWHLVASIGGADMPVVVSMLNSYSGWAAAAAGFMLSNDLLIVT
GALVGSSGAILSYIMCKAMNRSFVSVIAGGFGSDSGTSSSGSQEIGEYREVKAADVAEMLKGANSVIITPGYGMAVAQAQ
YPVAEITELLRKNGTEVRFGIHPVAGRLPGHMNVLLAEAKVPYDIVLEMDEINDDFPETDVVLVIGANDTVNPAAQTDPN
SPIAGMPVLEVWKAKEVVVFKRSMNTGYAGVQNPLFFNENSVMCFGDAKKTVDDILSELKK

Sequences:

>Translated_461_residues
MSSGLVTAAYIVAAILFIFSLAGLSKQETAKQGCYSGIAGMAVALFVTVFSDNTHGLGWIIIAMLIGAAIGIYKAKKVEM
TEMPELIALLHSFVGLAAVLVGFNSYIAPGNVSHDMHTIHLVEVYLGIFIGAVTFTGSLVAFGKLNGKISSSPLQLPAKH
KLNALALGVSFVLLLVFVGIDGSGFILLIMTLIALAFGWHLVASIGGADMPVVVSMLNSYSGWAAAAAGFMLSNDLLIVT
GALVGSSGAILSYIMCKAMNRSFVSVIAGGFGSDSGTSSSGSQEIGEYREVKAADVAEMLKGANSVIITPGYGMAVAQAQ
YPVAEITELLRKNGTEVRFGIHPVAGRLPGHMNVLLAEAKVPYDIVLEMDEINDDFPETDVVLVIGANDTVNPAAQTDPN
SPIAGMPVLEVWKAKEVVVFKRSMNTGYAGVQNPLFFNENSVMCFGDAKKTVDDILSELKK
>Mature_460_residues
SSGLVTAAYIVAAILFIFSLAGLSKQETAKQGCYSGIAGMAVALFVTVFSDNTHGLGWIIIAMLIGAAIGIYKAKKVEMT
EMPELIALLHSFVGLAAVLVGFNSYIAPGNVSHDMHTIHLVEVYLGIFIGAVTFTGSLVAFGKLNGKISSSPLQLPAKHK
LNALALGVSFVLLLVFVGIDGSGFILLIMTLIALAFGWHLVASIGGADMPVVVSMLNSYSGWAAAAAGFMLSNDLLIVTG
ALVGSSGAILSYIMCKAMNRSFVSVIAGGFGSDSGTSSSGSQEIGEYREVKAADVAEMLKGANSVIITPGYGMAVAQAQY
PVAEITELLRKNGTEVRFGIHPVAGRLPGHMNVLLAEAKVPYDIVLEMDEINDDFPETDVVLVIGANDTVNPAAQTDPNS
PIAGMPVLEVWKAKEVVVFKRSMNTGYAGVQNPLFFNENSVMCFGDAKKTVDDILSELKK

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG1282

COG function: function code C; NAD/NADP transhydrogenase beta subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNT beta subunit family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=461, Percent_Identity=50.9761388286334, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI122939153, Length=461, Percent_Identity=50.9761388286334, Blast_Score=446, Evalue=1e-125,
Organism=Escherichia coli, GI1787886, Length=468, Percent_Identity=77.1367521367521, Blast_Score=706, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17550456, Length=465, Percent_Identity=48.8172043010753, Blast_Score=412, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012136
- InterPro:   IPR004003 [H]

Pfam domain/function: PF02233 PNTB [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 48452; Mature: 48321

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSGLVTAAYIVAAILFIFSLAGLSKQETAKQGCYSGIAGMAVALFVTVFSDNTHGLGWI
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
IIAMLIGAAIGIYKAKKVEMTEMPELIALLHSFVGLAAVLVGFNSYIAPGNVSHDMHTIH
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
LVEVYLGIFIGAVTFTGSLVAFGKLNGKISSSPLQLPAKHKLNALALGVSFVLLLVFVGI
HHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
DGSGFILLIMTLIALAFGWHLVASIGGADMPVVVSMLNSYSGWAAAAAGFMLSNDLLIVT
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEE
GALVGSSGAILSYIMCKAMNRSFVSVIAGGFGSDSGTSSSGSQEIGEYREVKAADVAEML
EEHHCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
KGANSVIITPGYGMAVAQAQYPVAEITELLRKNGTEVRFGIHPVAGRLPGHMNVLLAEAK
CCCCCEEEECCCCCCHHHCCCCHHHHHHHHHCCCCEEEEECCHHCCCCCCCCEEEEECCC
VPYDIVLEMDEINDDFPETDVVLVIGANDTVNPAAQTDPNSPIAGMPVLEVWKAKEVVVF
CCEEEEEEEHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEEE
KRSMNTGYAGVQNPLFFNENSVMCFGDAKKTVDDILSELKK
EECCCCCCCCCCCCEEECCCCEEEECCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SSGLVTAAYIVAAILFIFSLAGLSKQETAKQGCYSGIAGMAVALFVTVFSDNTHGLGWI
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
IIAMLIGAAIGIYKAKKVEMTEMPELIALLHSFVGLAAVLVGFNSYIAPGNVSHDMHTIH
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
LVEVYLGIFIGAVTFTGSLVAFGKLNGKISSSPLQLPAKHKLNALALGVSFVLLLVFVGI
HHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
DGSGFILLIMTLIALAFGWHLVASIGGADMPVVVSMLNSYSGWAAAAAGFMLSNDLLIVT
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEE
GALVGSSGAILSYIMCKAMNRSFVSVIAGGFGSDSGTSSSGSQEIGEYREVKAADVAEML
EEHHCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
KGANSVIITPGYGMAVAQAQYPVAEITELLRKNGTEVRFGIHPVAGRLPGHMNVLLAEAK
CCCCCEEEECCCCCCHHHCCCCHHHHHHHHHCCCCEEEEECCHHCCCCCCCCEEEEECCC
VPYDIVLEMDEINDDFPETDVVLVIGANDTVNPAAQTDPNSPIAGMPVLEVWKAKEVVVF
CCEEEEEEEHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEEE
KRSMNTGYAGVQNPLFFNENSVMCFGDAKKTVDDILSELKK
EECCCCCCCCCCCCEEECCCCEEEECCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]